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MRes Bioinformatics and SELEX technologies

Course Description

Centauri Therapeutics Ltd, in partnership with the School of Human and Life Sciences at Christchurch University is offering a MRes studentship in the area of Bioinformatics and SELEX technologies.
Systematic Evolution of Ligands by Exponential Enrichment (SELEX) enables the enrichment of oligonucleotide aptamers from highly diverse libraries of unique sequences. Nucleic acid aptamers are short, single-stranded oligonucleotides that form three-dimensional structures capable of high affinity binding to specific targets. High-affinity aptamers have been identified against a broad range of proteins, carbohydrates and small molecules. NGS technology and sophisticated bioinformatics analyses are applied to SELEX campaigns with the aim of early identification of aptamer families. The project will focus on the identification of novel aptamers to microbial targets. Bioinformatic analyses will be applied to understand and direct the outputs from SELEX screening campaigns.
Centauri Therapeutics is a UK-based biotechnology company focused on the discovery and development of novel molecules targeting life threatening diseases. We are interested in the application of SELEX technology to the identification of therapeutic aptamers. We are looking for highly-motivated and talented people who are about to complete, or have recently completed, their degree-level studies. Candidates must show enthusiasm and aptitude for bioinformatics (ideally with Unix/programming experience) alongside molecular and cellular biology laboratory research. The student will predominantly be based at Discovery Park, Sandwich but will also spend time at the Canterbury Campus of Christchurch University.
The studentships provide for UK/EU tuition fees and stipend, and are available from September 2016. Applicants should have a Molecular Biology or related degree, and in the first instance should submit an application letter and CV to Samit Kundu (CCCU, ) and Helen Lavender (Centauri Therapeutics, ) at the earliest opportunity. Applications will be considered on a continuing basis until the post is filled.

Entry Requirements

Molecular Biology or related degree

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Recipient: Canterbury Christ Church University
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