Students are offered the opportunity to conduct research in the areas of Drug Safety and Pharmacology. These are specialist research strands forming part of the Masters in Research (MRes) in Biomedical Sciences & Translational Medicine. Drug Safety and Pharmacology strand students are mainly supervised by active researchers from the Department of Molecular & Clinical Pharmacology, but supervisors in other Departments performing relevant research also contribute. Students also participate in the lecture series and transferable skills offered as part of the wider MRes course.
1. Strand information for Drug Safety and Pharmacology:
MOLECULAR & CLINICAL PHARMACOLOGY
Students are provided with the opportunity for acquisition of research skills and knowledge across modern pharmacological issues. This encompasses fundamental mechanistic studies and clinical analyses to understand the mechanisms that underpin pharmacokinetics and pharmacodynamics for therapy of infectious diseases, cancer and CNS disorders. Students will be allocated research projects that will provide training in methodologies to address these issues.
Examples of techniques that may be acquired include: molecular biology, cell biology, mass spectrometry, genetic analysis, in silica approaches and/or cloning/transfection. Projects take place in research labs with strong international reputations in general areas such as drug safety and personalised medicine.
Drug Safety is an exciting branch of experimental science that combines Pharmacology and Toxicology which informs how to design safer drugs through knowledge of mechanisms of adverse drug reactions. The MRC Centre for Drug Safety Science has longstanding expertise in chemical, molecular, cellular and clinical aspects of research in adverse drug reactions, with particular expertise in biomarkers. Training will be carried out under the remit of the MRC Centre for Drug Safety Sciences, of which there is only one in the UK. We undertake a significant amount of research in collaboration with the pharmaceutical industry.
Examples of research projects include:
• Development of novel preclinical test systems to identify toxicological potential in new drug candidates;
• Development of novel clinical genotyping screens to identify susceptible individuals and inform their therapeutic management;
• Informing the drug design process at an early stage to avoid incorporation of potentially toxic chemical motifs.
2. An overview of the MRes (Master of Research) in Biomedical Sciences & Translational Medicine
The MRes in Biomedical Sciences and Translational Medicine provides students with high level research training within the six research departments contributing to the programme. The programme is divided into 11 strands and students choose a strand that matches their research interests; this then becomes the over-arching area of their research projects. The strands in the MRes in Biomedical Sciences & Translational Medicine are listed below:
• Biology of Cancer
• Cellular and Molecular Physiology
• Drug Safety
• Health Economics
• Medical Sciences
• Molecular and Clinical Gastroenterology
• Molecular and Clinical Pharmacology
• Nanomedicine and Biostatistics
• Stem Cells, Tissues and Disease
• Women’s, Children’s and Perinatal Health
of the MRes in Biomedical Sciences & Translational Medicine:
The twelve month, full-time programme is structured to allow for 3 hours lecture per week whilst the rest of the day is spent in the lab or carrying out other research project related work.
MRes in Biomedical Sciences & Translational Medicine students undertake 3 research projects that comprise of 10 weeks of lab work followed by 2 weeks in which to write a report. Students also present either a poster or talk at the end of every research project. During the project, all students are encouraged to suggest experiments, design experimental protocols, as well as being taught subject specific techniques and advanced knowledge in transferable skills. The research projects will include at least three different research techniques to enhance experimental training skills that need to be clearly stated at the end of each project.
The morning lectures relate to state-of-the-art research techniques, application of knowledge in scientific and clinical areas, and the development of personal and professional transferable skills. Important and innovative parts of the transferable skills students take part in include the following workshops “IP and Commercialization (our own version of Dragon’s Den)”, Demonstrator Training and “Writing a PhD Studentship”, as well as taking part in debates for public understanding of science.
Further information, including current handbook, for the MRes in Biomedical Sciences & Translational Medicine programme can be found on our webpage: http://www.liv.ac.uk/translational-medicine/postgraduate/mres/
for the MRes in Biomedical Sciences & Translational Medicine:
For 2016 entry we have 20 bursaries of £2000 each, providing partial funding of the MRes in Biomedical Sciences & Translational Medicine programme. For further information and a bursary application form please contact us at [email protected]
For students considering continuing on to a PhD, the Institute offers full and part funded competitive PhD studentships for those who successfully complete the MRes in Biomedical Sciences & Translational Medicine. All MRes students will be contacted about these studentships.
5. Applications can be made here: http://www.liv.ac.uk/study/postgraduate/applying/
. You should apply for the MRes in Biomedical Sciences & Translational Medicine and indicate in your application that you would like to join the Drug Safety or Pharmacology strands.
6. Information about the
Department of Molecular and Clinical Pharmacology
The Department (http://www.liv.ac.uk/pharmacology/
) provides excellent opportunities for basic and clinical research on drug safety science, immuno-pharmacology, individualized medicines, nanomedicines and HIV. We have state-of-the-art research facilities and funding from sources including MRC, BBSRC, Wellcome Trust, NIHR, Wolfson Foundation and the EU. Our focus is on research that is directed towards understanding disease processes, defining therapeutic strategies for intervention, and the scientific basis of drug safety.
The ultimate aim of this research is to translate laboratory findings into the clinic for the benefit of patients, the public and the healthcare system. The Department is among the most highly rated for research in the United Kingdom and hosts the MRC funded Centre for Drug Safety Science and the Wolfson Centre for Personalized Medicine.
1st, 2:1 or 2:2 science degree (or international equivalent). The minimum English Language requirement for EU and international applicants is IELTS = 6.5. Intercalating students are required to successfully complete their fourth year of study.
2016 tuition fees not yet set, please enquire for more information. (Bursaries available)