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MPhil in Genomic Medicine


Course Description

The overall aims of the programme are to:

- provide professionally relevant teaching and learning informed by research in an integrated clinical and research environment;
- develop and create a cohort of doctors and other professionals allied to medicine able to pursue and develop their roles in a rapidly-changing and challenging environment of genomic medicine;
- prepare healthcare professionals for the adoption of genomic technologies and the increasing use of genomic information as part of the diagnostic and treatment pathway;
- develop a cohort of doctors and other professionals allied to medicine with the confidence to lead service improvement for safe and high quality patient care, and with the required knowledge, skills and capability to have a positive personal impact on the work of others;
- develop a cohort of doctors and other professionals allied to medicine with an understanding of research methodologies and clinical opportunities relevant to genomic medicine;
- encourage a commitment to intellectual challenge and evidence-based clinical practice informed by the latest conceptual and theoretical knowledge of genomic medicine;
- develop students' intellectual, practical and transferable skills related to genomic medicine;
encourage critical thinking related to genomic medicine;
- conduct systematic research relevant to their professional practice.

See the website http://www.graduate.study.cam.ac.uk/courses/directory/cvmgmpgnm

Learning Outcomes

The over-arching learning outcomes are:

- Knowledge and understanding -

- To enhance the students’ knowledge and critical understanding of recent developments in genomic medicine relevant to their present and future roles.
- To develop students’ knowledge and understanding of genomic medicine informed by research in a rapidly-changing integrated clinical and research environment.
- To enable deployment of new knowledge in their clinical practice, and to have a positive personal impact on the work of others in their clinical team and wider service.
- To develop an understanding of genomic technologies and to be able to use genomic information as part of the diagnostic and treatment pathway.
- To develop students’ knowledge so that they have the confidence to lead service improvement for safe and high quality patient care.
- To update and extend students’ understanding of research methodologies and clinical opportunities.
- To demonstrate knowledge, abilities and skills to engage in focused, professionally-relevant, independent learning, and through the production of a dissertation.

- Skills and other attributes -

- The skills necessary to locate, read, interpret and analyse primary and secondary sources of material enabling the development of a conceptual and theoretical understanding of recent developments in genomic medicine.
- Skills to evaluate current scholarship and research critically and to place this knowledge within the context of their own situation and practice as clinical leaders.
- The ability to formulate a research topic relevant to their clinical context, to collect and analyse primary and/or secondary sources of data, and to undertake professionally relevant research.
- The facility to communicate the results of their ideas, research and its conclusions in a written form acceptable as a work of scholarship potentially publishable in a professional or academic journal.

Format

The MPhil comprises either:

- eight modules, plus a research project and associated dissertation of 10-12,000 words, or
- ten modules, plus a literature-based research project and associated dissertation of 5-6,000 words.

Students must complete seven Core Modules and one/three further modules chosen from a range of Option Modules, with additional between-module reflection, study and assignment work.

The modules are structured as follows:

- Core Module 1: An introduction to human genetics and genomics
- Core Module 2: Omics techniques and the application to genomic medicine
- Core Module 3: Genomics of common and rare disease
- Core Module 4: Molecular pathology of cancer and application in cancer diagnosis, screening, and treatment
- Core Module 5: Application of genomics to infectious disease
- Core Module 6: Pharmacogenetics and stratified healthcare
- Core Module 7: Bioinformatics, interpretation, and data quality assurance in genome analysis

Option modules will be selected from the following list. Not all options may be offered every year.

- Option Module 1: Ethical, Legal and Social Implications in applied genomics (ELSI) **
- Option Module 2: Counselling skills for genomics
- Option Module 3: Professional and research skills
- Option Module 4: Advanced Bioinformatics – from genomes to systems
- Option Module 5: Epigenetics and epigenomics
- Option Module 6: Expanding the content of the MPhil in genomic medicine with a workplace-based module

Each core module will involve around 30 hours of contact time, including lectures, group work and online teaching.

Placements

The research project element of the course may be undertaken in a number of scientific institutions, within and without the University. This may include the University's School of Clinical Medicine, the School of Biological Sciences, the European Bioinformatics Institute, Welcome Trust Sanger Institute and, subject to approval, other suitable research institutions.

Assessment

Students must submit a dissertation of 5-6,000 words or 10-12,000 words, depending on the options selected. This will be worth 1/6th or 1/3rd of the overall mark for the course, respectively.

For each of the taught modules, students must complete summative assignments of 2500-3500 words or equivalent (except where other methods of module assessment are indicated in individual module descriptions)

Each student is allocated a named supervisor, who will meet regularly with the student to discuss progress and provide feedback and support as required. Written supervision reports are accessed via the online supervision system. Students are given feedback on the assessments conducted at the end of each module.

All students will meet with the programme director on a termly basis to discuss progress and to provide their feedback on the course.

How to apply: http://www.graduate.study.cam.ac.uk/applying

Funding Opportunities

Funding is available from Health Education England to pay course fees for NHS employees wishing to apply for this course. Prospective students wishing to apply for HEE funding should refer to the application process published by HEE at http://www.genomicseducation.hee.nhs.uk/msc-funding-info/and ensure that access to this funding is approved before applying for the course.

General Funding Opportunities http://www.graduate.study.cam.ac.uk/finance/funding

Visit the MPhil in Genomic Medicine page on the University of Cambridge website for more details!

Entry Requirements

Applicants for this course should have achieved a UK II.i Honours Degree.

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Recipient: University of Cambridge

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