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MSc in Medical Epigenomics


Course Description

Master's specialisation in Medical Epigenomics

The only Master’s specialisation in the Netherlands covering the function of our epigenome, a key factor in regulating gene expression and in a wide range of diseases.
Our skin cells, liver cells and blood cells all contain the same genetic information. Yet these are different types of cells, each performing their own specific tasks. How is this possible? The explanation lies in the epigenome: a heritable, cell-type specific set of chromosomal modifications, which regulates gene expression. Radboud University is specialised in studying the epigenome and is the only university in the Netherlands to offer a Master’s programme in this field of research.

Health and disease

The epigenome consists of small and reversible chemical modifications of the DNA or histone proteins, such as methylation, acetylation and phosphorylation. It changes the spatial structure of DNA, resulting in gene activation or repression. These processes are crucial for our health and also play a role in many diseases, like autoimmune diseases, cancer and neurological disorders. As opposed to modifications of the genome sequence itself, epigenetic modifications are reversible. You can therefore imagine the great potential of drugs that target epigenetic enzymes, so-called epi-drugs.

Big data

In this specialisation, you’ll look at a cell as one big and complex system. You’ll study epigenetic mechanisms during development and disease from different angles. This includes studying DNA and RNA by next-generation sequencing (epigenomics) and analysing proteins by mass spectrometry (proteomics). In addition, you‘ll be trained to design computational strategies that allow the integration of these multifaceted, high-throughput data sets into one system.

Why study Medical Epigenomics at Radboud University?

- Radboud University combines various state-of-the-art technologies – such as quantitative mass spectrometry and next-generation DNA sequencing – with downstream bioinformatics analyses in one department. This is unique in Europe.
- This programme allows you to work with researchers from the Radboud Institute for Molecular Life sciences (RIMLS), one of the leading multidisciplinary research institutes within this field of study worldwide.
- We have close contacts with high-profile medically oriented groups on the Radboud campus and with international institutes (EMBL, Max-Planck, Marie Curie, Cambridge, US-based labs, etc). As a Master’s student, you can choose to perform an internship in one of these related departments.
- Radboud University coordinates BLUEPRINT, a 30 million Euro European project focusing on the epigenomics of leukaemia. Master’s students have the opportunity to participate in this project.

Career prospects

As a Master’s student of Medical Epigenomics you’re trained in using state-of-the art technology in combination with biological software tools to study complete networks in cells in an unbiased manner. For example, you’ll know how to study the effects of drugs in the human body.
When you enter the job market, you’ll have:
- A thorough background of epigenetic mechanisms in health and disease, which is highly relevant in strongly rising field of epi-drug development
- Extensive and partly hands-on experience in state-of-the-art ‘omics’ technologies: next-generation sequencing, quantitative mass spectrometry and single cell technologies;
- Extensive expertise in designing, executing and interpreting scientific experiments in data-driven research;
- The computational skills needed to analyse large ‘omics’ datasets.

With this background, you can become a researcher at a:
- University or research institute;
- Pharmaceutical company, such as Synthon or Johnson & Johnson;
- Food company, like Danone or Unilever;
- Start-up company making use of -omics technology.

Apart from research into genomics and epigenomics, you could also work on topics such as miniaturising workflows, improving experimental devices, the interface between biology and informatics, medicine from a systems approach.

Or you can become a:
- Biological or medical consultant;
- Biology teacher;
- Policy coordinator, regarding genetic or medical issues;
- Patent attorney;
- Clinical research associate;

PhD positions at Radboud University

Each year, the Molecular Biology department (Prof. Henk Stunnenberg, Prof. Michiel Vermeulen) and the Molecular Developmental Biology department (Prof. Gert-Jan Veenstra) at the RIMLS offer between five and ten PhD positions. Of course, many graduates also apply for a PhD position at related departments in the Netherlands, or abroad.

Our approach to this field

- Systems biology
In the Medical Epigenomics specialisation you won’t zoom in on only one particular gene, protein or signalling pathway. Instead, you’ll regard the cell as one complete system. This comprehensive view allows you to, for example, model the impact of one particular epigenetic mutation on various parts and functions of the cell, or study the effects of a drug in an unbiased manner. One of the challenges of this systems biology approach is the processing and integration of large amounts of data. That’s why you’ll also be trained in computational biology. Once graduated, this will be a great advantage: you’ll be able to bridge the gap between biology, technology and informatics , and thus have a profile that is desperately needed in modern, data-driven biology.

- Multiple OMICS approaches
Studying cells in a systems biology approach means connecting processes at the level of the genome (genomics), epigenome (epigenomics), transcriptome (transcriptomics), proteome (proteomics), etc. In the Medical Epigenomics specialisation, you’ll get acquainted with all these different fields of study.

- Patient and animal samples
Numerous genetic diseases are not caused by genetic mutations, but by epigenetic mutations that influence the structure and function of chromatin. Think of:
- Autoimmune diseases, like rheumatoid arthritis and lupus
- Cancer, in the forms of leukaemia, colon cancer, prostate cancer and cervical cancer
- Neurological disorders, like Rett Syndrome, Alzheimer, Parkinson, Multiple Sclerosis, schizophrenia and autism

We investigate these diseases on a cellular level, focusing on the epigenetic mutations and the impact on various pathways in the cell. You’ll get the chance to participate in that research, and work with embryonic stem cell, patient, Xenopus or zebra fish samples.

See the website http://www.ru.nl/masters/medicalbiology/epigenomics

Visit the MSc in Medical Epigenomics page on the Radboud University website for more details!

Videos
Student Profiles
(Scholarship)

Radboud Scholarship Programme - 20+ Awards

The Radboud Scholarship Programme is very selective and is only intended for talented students who have obtained outstanding study results and are highly motivated to pursue a Master's degree programme at Radboud University. You must have finalized your request for admission via our online application system OSIRIS Incoming Students before 1 April.The scholarship is not paid in money but instead covers the additional non-EEA expenses.
For example: a grant holder in 2017/2018 will pay a tuition fee of only €2,006, instead of €9,432 or €10,360. In addition the Radboud Scholarship also covers costs such as those for visa, residence permit, health insurance and liability insurance. This amounts to about €725.Each year about 30 Radboud Scholarships are awarded to selected talented non-EEA students for the duration of one of the Master's degree programmes *Learn more about other applicable scholarship programmes on the website of Radboud University.

Value of Scholarship(s)

legal instead of institutional tuition fees

Eligibility

The Radboud Scholarship Programme offers a selected number of talented prospective non-EEA students the opportunity to receive a scholarship to pursue an English-taught Master's degree programme at Radboud University Nijmegen.Selection criteria:1. talent: this means that you must have outstanding study results in your present field of study;
2. expected to be a promising students in your desired field of study at Radboud University;
3. proven academic quality and good results of your prior education for example through grades, test scores, publications.
4. quality of the recommendations in the two letters of recommendation;
5. motivation: based on your motivation letter.

Application Procedure

The application for admission and the application for the scholarship is fully integrated, there is no separate procedure for the scholarship. You apply for a Radboud Scholarship by indicating during your application for admission that you wish to apply for a Radboud Scholarship. You will then be requested to upload three additional documents: two recommendation letters and a curriculum vitae.

Further Information

http://www.ru.nl/rsp


(Scholarship)

Fullbright-Radboud Scholarships - No. of awards TBC

The Fulbright Center, sponsored by Radboud University, is offering scholarships to excellent American students for study and research purposes at graduate and PhD levels at Radboud University Nijmegen. The Fulbright Center's mission is to promote mutual understanding between Dutch and American citizens by providing financial assistance for study, research and teaching. To qualify for a scholarship, applicants must have American nationality, have excellent academic marks, engage in extracurricular activities and be admitted to Radboud University Nijmegen.The grant will be paid in 12 monthly instalments of €1050. International travel will be reimbursed up to a maximum of €900. The cost of the residence permit (approximately €350) will be covered as well. An extra allowance of €1150 will be paid on arrival, and can be used to cover the cost of the tuition fee or the costs of settling in. Tuition fees are not waived, and differ per program.
Application for 2016-2017 opens on 1 May 2016 and closes on 13 October 2016.

Value of Scholarship(s)

12 monthly instalments of €1050 + extra allowance for travel and additional costs

Eligibility

For American students.
The Fulbright Centre, sponsored by Radboud University, is offering scholarships for talented American students to study at Radboud University.

Application Procedure

For more information please see the Fulbright website.

Further Information

http://www.ru.nl/masters/fulbright


(Scholarship)

Global Education Programme - No. of awards TBC

The Russian government has initiated a new scholarship programme to support Russians studying abroad, the Global Education Programme (GEP). The scholarship opened in September 2014 for Russian students studying abroad on Master's and PhD programmes.The scholarship covers the following costs up to 1,381,000 rubles/year (ca. 22,400 EUR)
• Tuiton fee
• Living expenses
• Books
• Health Insurance
• Travel costsStudents may apply for a maximum of 2 years of scholarship.The Global Education Programme (GEP) will last for 3 years (2014-2016). A total amount of 4.41 billion rubles is available for this period, or 1.47 billion per year. The assumed total number of grantees is at least 718.Students who already receive a scholarship, e.g. from the European Union such as ERANET, Erasmus Mundus or other Master's grants do not qualify.

Value of Scholarship(s)

about 16,000

Eligibility

• Russian citizenship
• Admitted to Radboud University (or another university from the list) in one of the selected disciplines
• Study full time at Master's or PhD level
• Ready to return to Russia upon completion of their studies and to obtain employment in accordance with the qualification gained for a period of 3 years ( you can find a list of employers on the official website of the Programme)

Application Procedure

For more information visit the Global Education Programme's webpage

Further Information

http://www.ru.nl/masters/global-education


(Scholarship)

Orange Tulip Scholarship - Brazil Programme - 10 Awards

Through the Orange Tulip Scholarship (OTS) programme, Dutch higher education institutions offer incentive scholarships to attract highly qualified Brazilians to follow a study programme at Master's level.Instead of the institutional tuition fees, non-EEA students pay the legal tuition fees (€2,006 in 2017/2018). Also, visa and residence permit costs, liability insurance and health insurance are covered

Value of Scholarship(s)

legal instead of institutional tuition fees

Eligibility

For students from Brazil who study at Master's level at Radboud University.

Application Procedure

The application deadline for the Orange Tulip Scholarship Brazil is 1 April. For more information about how to apply, please visit Nuffic Neso Brazil's website.

Further Information

http://www.ru.nl/ots/brazil


(Scholarship)

Orange Tulip Scholarship - Mexico Programme - 5 Awards

Through the Orange Tulip Scholarship (OTS) programme, Dutch higher education institutions offer incentive scholarships to attract highly qualified Mexicans to follow a study programme at Master's level. Instead of the institutional tuition fees, non-EEA students pay the legal tuition fees (€2,006 in 2017/2018). Also, visa and residence permit costs, liability insurance and health insurance are covered.

Value of Scholarship(s)

legal instead of institutional tuition fees

Eligibility

For Mexican students who study at Master's level at Radboud University.

Application Procedure

The application deadline for the Orange Tulip Scholarship Mexico is 1 April. For more information about how to apply, please visit the Nuffic Neso OTS Mexico website.

Further Information

http://www.ru.nl/ots/mexico


(Scholarship)

Orange Tulip Scholarship - Indonesia Programme - 6 Awards

For Indonesian students, Radboud University offers one Orange Tulip Scholarships which are available for all English-taught Master’s programmes at Radboud University (with the exception of Erasmus Mundus Master's programmes, joint or double-degree Master's programmes and the Master's programme in Theology).Instead of the institutional tuition fees, non-EEA students pay the legal tuition fees (€2,006 in 2017/2018). Also, visa and residence permit costs, liability insurance and health insurance are covered .

Value of Scholarship(s)

legal instead of institutional tuition fees

Eligibility

For Indonesian students who study at a Master's level at Radboud University.

Application Procedure

The application deadline for the Orange Tulip Scholarship Indonesia is 1 April.You can find more information about the Orange Tulip Scholarship Indonesia, and how to apply, on the Nuffic Neso Indonesia website.

Further Information

http://www.ru.nl/ots/indonesia


(Scholarship)

Orange Tulip Scholarship - China Programme - 6 Awards

The Orange Tulip Scholarship programme (OTS) was launched by Nuffic Neso China in 2008. The success of the programme relies on the support from not only the Dutch academic sector, but also the Dutch business sector in China. The purpose of this initiative is to offer valuable study opportunities for young Chinese talents to study in the Netherlands through joint contributions from the Dutch higher education institutions and China-based Dutch companies.Instead of the institutional tuition fees, non-EEA students pay the legal tuition fees (€2,006 in 2017/2018). Also, visa and residence permit costs, liability insurance and health insurance are covered.

Value of Scholarship(s)

legal instead of institutional tuition fees

Eligibility

The Orange Tulip Scholarship China programme is only open to qualified students from Mainland China who study at a Master's level at Radbout University.

Application Procedure

The application deadline for the Orange Tulip Scholarship China is 1 April.

Further Information

http://www.ru.nl/ots/china


(Scholarship)

Orange Tulip Scholarship - Korea Programme - 3 Awards

Nuffic Neso South-Korea launched the Orange Tulip Scholarship (OTS) in January 2010 to provide opportunities for talented Korean students to study in Holland. The scholarship is available for all English-taught Master’s programmes at Radboud University (with the exception of Erasmus Mundus Master's programmes, joint or double-degree Master's programmes and the Master's programme in Theology).Instead of the institutional tuition fees, non-EEA students pay the legal tuition fees (€2,006 in 2017/2018). Also, visa and residence permit costs, liability insurance and health insurance are covered.

Value of Scholarship(s)

legal instead of institutional tuition fees

Eligibility

For Korean students, Radboud University offers three Orange Tulip Scholarships.

Application Procedure

The application deadline for the Orange Tulip Scholarship South Korea is 1 April.

Further Information

http://www.ru.nl/ots/korea


(Scholarship)

Orange Tulip Scholarship - Russia Programme - 8 Awards

For the first time, Nuffic Neso Russia has launched the Orange Tulip Scholarship (OTS), a special programme for talented Russian students to study in Holland. It is available for all English-taught Master's programmes at Radboud University (with the exception of Erasmus Mundus Master's programmes, joint or double-degree Master's programmes and the Master's programme in Theology).Instead of the institutional tuition fees, non-EEA students pay the legal tuition fees (€2,006 in 2016/2017). Also, visa and residence permit costs, liability insurance and health insurance are covered .

Value of Scholarship(s)

legal instead of institutional tuition fees

Eligibility

For Russian students, Radboud University offers eight Orange Tulip Scholarships.

Application Procedure

The deadline for applications for the Orange Tulip Scholarship Russia is 1 April. In order to apply for the scholarship, you must have already applied for a Master's programme at Radboud University. In order to receive the scholarship, you must be admitted to a Master's programme.

Further Information

http://www.ru.nl/ots/russia


(Scholarship)

Orange Tulip Scholarship - Vietnam Programme - 3 Awards

The Orange Tulip Scholarship Programme gives excellent students coming from one of these countries the opportunity to study at Radboud University. Radboud University participates in the OTS programme with several benefits for international students. Instead of the institutional tuition fees, non-EEA students pay the legal tuition fees (€2,006 in 2017/2018). Also, visa and residence permit costs, liability insurance and health insurance are covered .

Value of Scholarship(s)

legal instead of institutional tuition fees

Eligibility

For Vietnamese students, Radboud University offers three Orange Tulip Scholarships.

Application Procedure

The application deadline for the Orange Tulip Scholarship Vietnam is 1 April. For more information about how to apply, please visit Nuffic Neso Vietnam's website.

Further Information

http://www.ru.nl/ots/vietnam


(Scholarship)

The Holland Scholarship Programme - 12 Awards

The Holland Scholarship (HS) gives excellent students the opportunity to study at Radboud University. The HS is open to students with the following nationalities: Canadian, American, Indian and Turkish. All English-taught Master’s programmes are eligible for the HS and amount to € 5,000.-

Value of Scholarship(s)

The scholarship amounts to £ 3.700

Eligibility

The HS is open to students with the following nationalities: Canadian, American, Indian and Turkish. All English-taught Master’s programmes are eligible for the HS.

Application Procedure

You can apply for the Holland Scholarship at Radboud University when you apply for a Master's programme in Osiris. That means that the application for admission and the application for the scholarship are fully integrated.
The application deadline is 1 February. If not all scholarships will be given out, the second deadline is 1 May.

Further Information

http://www.ru.nl/holland-scholarship



Entry Requirements

• A completed Bachelor’s degree in one of the following fields of science: Medical Biology, Biomedical Sciences, Biology (with a minor in Medical Biology, Neurobiology or Medicine), Molecular Life Sciences, Science (Radboud University), or equivalent • Non-native speakers of English without a Dutch Bachelor’s degree or VWO diploma need one of the following: a TOEFL score of at least 575 (paper-based), 232 (computer-based), 90 (internet-based); an IELTS score of 6.5; a Cambridge Certificate in Advanced English (CAE) or Certificate of Proficiency in English (CPE) with a mark of C or higher.

Course Fees

€2,006 (from EEA countries); €10360 (from non-EEA countries)


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