Masters Degrees in Molecular Genetics, United Kingdom

The increasing impact of genetics in healthcare and the development of newer sophisticated technologies requires contributions from research scientists, clinical laboratory scientists and clinicians to investigate the causes of, and therefore permit optimal management for, diseases for which alterations in the genome, either at the DNA sequence level or epigenetic level, play a significant role. Collaboration between staff from the University of Glasgow and the NHS West of Scotland Genetics Service enables the MSc in Medical Genetics and Genomics to provide a state-of-the-art view of the application of modern genetic and genomic technologies in medical genetics research and diagnostics, and in delivery of a high quality genetics service to patients, as well as in design of targeted therapies.

Why this programme

◾This is a fully up-to-date Medical Genetics degree delivered by dedicated, multi-award-winning teaching and clinical staff of the University, with considerable input from hospital-based Regional Genetics Service clinicians and clinical scientists.
◾The full spectrum of genetic services is represented, from patient and family counselling to diagnostic testing of individuals and screening of entire populations for genetic conditions: eg the NHS prenatal and newborn screening programmes.
◾The MSc Medical Genetics Course is based on the south side of the River Clyde in the brand new (2015) purpose built Teaching & Learning Centre, at the Queen Elizabeth University Hospitals (we are located 4 miles from the main University Campus). The Centre also houses state of the art educational resources, including a purpose built teaching laboratory, computing facilities and a well equipped library. The West of Scotland Genetic Services are also based here at the Queen Elizabeth Campus allowing students to learn directly from NHS staff about the latest developments to this service.
◾The Medical Genetics MSc Teaching Staff have won the 2014 UK-wide Prospects Postgraduate Awards for the category of Best Postgraduate Teaching Team (Science, Technology & Engineering). These awards recognise and reward excellence and good practice in postgraduate education.
◾The close collaboration between university and hospital staff ensures that the Medical Genetics MSc provides a completely up-to-date representation of the practice of medical genetics and you will have the opportunity to observe during clinics and visit the diagnostic laboratories at the new Southern General Hospital laboratory medicine building.
◾The Medical Genetics degree explores the effects of mutations and variants as well as the current techniques used in NHS genetics laboratory diagnostics and recent developments in diagnostics (including microarray analysis and the use of massively parallel [“next-generation”] sequencing).
◾New developments in medical genetics are incorporated into the lectures and interactive teaching sessions very soon after they are presented at international meetings or published, and you will gain hands-on experience and guidance in using software and online resources for genetic diagnosis and for the evaluation of pathogenesis of DNA sequence variants.
◾You will develop your skills in problem solving, experimental design, evaluation and interpretation of experimental data, literature searches, scientific writing, oral presentations, poster presentations and team working.
◾This MSc programme will lay the academic foundations on which some students may build in pursuing research at PhD level in genetics or related areas of biomedical science or by moving into related careers in diagnostic services.
◾The widely used textbook “Essential Medical Genetics” is co-authored by a member of the core teaching team, Professor Edward Tobias.
◾For doctors: The Joint Royal Colleges of Physicians’ Training Board (JRCPTB) in the UK recognises the MSc in Medical Genetics and Genomics (which was established in 1984) as counting for six months of the higher specialist training in Clinical Genetics.
◾The Medical Council of Hong Kong recognises the MSc in Medical Genetics and Genomics from University of Glasgow in it's list of Quotable Qualifications.

Programme structure

Genetic Disease: from the Laboratory to the Clinic

This course is designed in collaboration with the West of Scotland Regional Genetics Service to give students a working knowledge of the principles and practice of Medical Genetics and Genomics which will allow them to evaluate, choose and interpret appropriate genetic investigations for individuals and families with genetic disease. The link from genotype to phenotype, will be explored, with consideration of how this knowledge might contribute to new therapeutic approaches.

Case Investigations in Medical Genetics and Genomics

Students will work in groups to investigate complex clinical case scenarios: decide appropriate testing, analyse results from genetic tests, reach diagnoses where appropriate and, with reference to the literature, generate a concise and critical group report.

Clinical Genomics

Students will take this course OR Omic Technologies for Biomedical Sciences OR Frontiers in Cancer Science.

This course will provide an overview of the clinical applications of genomic approaches to human disorders, particularly in relation to clinical genetics, discussion the methods and capabilities of the new technologies. Tuition and hands-on experience in data analysis will be provided, including the interpretation of next generation sequencing reports.

Omic technologies for the Biomedical Sciences: from Genomics to Metabolomics

Students will take this course OR Clinical Genomics OR Frontiers in Cancer Science.

Visit the website for further information

Career prospects

Research: About half of our graduates enter a research career and most of these graduates undertake and complete PhDs; the MSc in Medical Genetics and Genomics facilitates acquisition of skills relevant to a career in research in many different bio-molecular disciplines.

Diagnostics: Some of our graduates enter careers with clinical genetic diagnostic services, particularly in molecular genetics and cytogenetics.

Clinical genetics: Those of our graduates with a prior medical / nursing training often utilise their new skills in careers as clinical geneticists or genetic counsellors.

Other: Although the focus of teaching is on using the available technologies for the purpose of genetic diagnostics, many of these technologies are used in diverse areas of biomedical science research and in forensic DNA analysis. Some of our numerous graduates, who are now employed in many countries around the world, have entered careers in industry, scientific publishing, education and medicine.

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The science of human genetics has been transformed in the past decade. Following the sequencing of the entire human genome, a wealth of resources is now available to researchers aiming to identify the genetic variants that influence human health. These findings will shed light on the underlying molecular pathology of many diseases that are poorly understood at present, eventually paving the way for novel treatment and prevention strategies. The speed at which these discoveries are being made is accelerating, and it is likely that molecular genetics will soon underpin much of modern medicine.

Career Pathways:
The MSc in Human Molecular Genetics programme is designed to prepare you for a genetics research career, either in human gene function and genetic disease, or molecular approaches to diagnosis and health care biotechnology. It provides a broad grounding in Human Genetics, with emphasis on molecular aspects, to give a solid basis for subsequent academic or industrial research, or for entry to NHS Genetics training. Approximately 40% of our students go on to do a PhD, 40% become research assistants/associates, while others go on to jobs in industry or further studies (bioinformatics/computing medicine). One or two students every year enter the NHS in clinical genetics training posts.

Programme Structure:
You will study the fundamentals of human and molecular genetics, models of inheritance for rare and common/ complex polygenic diseases, cytogenetics, analytical methods in human genetics and genomics, animal models and transgenesis, gene therapy, epigenetics, cancer genetics and an introduction to clinical genetics and genetic counselling services.

There are four weeks of intensive laboratory practical sessions, as well as computer science practicals applied to problems in genetics, genomics and bioinformatics, regular research seminars on site, student seminar and journal presentations, study group activities and a six-month full-time research project in the summer.

The programme is based on an average 20 hours contact time per week. This will vary between 15 hours in most weeks and approximately 40 hours during intensive practicals and projects. Private study time is included within the schedule: you are expected to contribute an additional 10-15 hours private study per week to the course. We do not recommend you try to support yourself by taking a part-time employment whilst studying as your work may suffer.

Assessment:
There are 3 x 3-hour written papers in late February, coursework assessments (poster presentation, analytical methods in genetics, oral presentation), a project report and a viva examination in September.

Programme Location:
The programme is primarily based at Hammersmith Campus in West London although some teaching modules are held at St Mary's Campus and the Northwick Park Campus.

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The Genetics of Human Disease MSc aims to provide students with an in-depth knowledge of molecular genetics, quantitative and statistical genetics and human disease and how this can be applied to improve healthcare through the development and application of diagnostic tests and therapeutic agents.

About this degree

The programme provides a thorough grounding in modern approaches to the understanding of the genetics of disease alongside the cutting-edge research methods and techniques used to advance our understanding of development of disease. Core modules provide a broad coverage of the genetics of disease, research skills and social aspects, whilst specialised streams in Inherited Diseases, Pharmacogenetics and Computational Genomics, in which students can qualify, and the research project allow more in-depth analysis in areas of genetics.

Students undertake modules to the value of 180 credits.

The programme consists of four core modules (60 credits) and two specialist modules (30 credits) and a research project culminating in a dissertation (90 credits).

A Postgraduate Diploma consisting of six modules (four core modules in term one and two modules within the selected stream in term two) is offered, full-time nine months.

A Postgraduate Certificate consisting of four core modules in term one (60 credits) is offered, full-time three months.

Core modules

• Advanced Human Genetics: Research Principles
• Understanding Bioinformatics Resources and their Applications
• Human Genetics: Core Skills
• Basic Statistics for Medical Sciences

Specialist modules

In term two you will take specialist modules depending on the specialist stream you select: Inherited Disease (A); Pharmacogenetics (B); Computational Genomics (C). 

• Applications in Human Genetics (A)
• Either Genetics of Cardiovascular Disease or Genetics of Neurological Disease (A)
• Clinical Applications of Pharmacogenetic Tests (B)
• Anti-Cancer Personalised Medicine or Pharmacogenomics, adverse drug reactions and biomarkers (B)
• Applications in Human Genetics (C)
• Statistics for Interpreting Genetic Data (C)

Dissertation/report

Students undertake an original research project investigating topical questions in genetics and genetics of human disease which culminates in a dissertation of 12,000 to 14,000 words and an oral presentation.

Teaching and learning

Students develop their knowledge and understanding of genetics of human diseases through a combination of lectures, seminars, tutorials, presentations and journal clubs. Taught modules are assessed by unseen written examination and/or, written reports, oral presentations and coursework. The research project is assessed by the dissertation and oral presentation. 

Further information on modules and degree structure available on the UCL Genetics Institute website.

Further information on modules and degree structure is available on the department website: Genetics of Human Disease MSc

Careers

Advanced training in genetic techniques including bioinformatic and statistical approaches positions graduates well for PhD studentships in laboratories using genetic techniques to examine diseases such as heart disease, cancer and neurological disorders. Another large group will seek research jobs in the pharmaceutical industry, or jobs related to genetics in healthcare organisations.

Recent career destinations for this degree

• Laboratory Specialist, King Abdullah Medical Complex
• Non-Clinical Research Associate, University of Oxford
• Trainee Geneticist, Oxford University Hospitals NHS Trust
• PhD in Cardiovascular Science, UCL
• Genomic Research Technician, Genome Centre

Employability

The MSc in Genetics of Human Disease facilitates acquisition of knowledge and skills relevant to a career in research in many different biomedical disciplines. About half of our graduates enter a research career by undertaking and completing PhDs and working as research associates/scientists in academia. Some of our graduates go on to jobs in the pharmaceutical industry, while others enter careers with clinical genetic diagnosis services, particularly in molecular genetics, in healthcare organisations and hospitals around the world. Those graduates with a prior medical training often utilise their new skills as clinical geneticists.

Careers data is taken from the ‘Destinations of Leavers from Higher Education’ survey undertaken by HESA looking at the destinations of UK and EU students in the 2013–2015 graduating cohorts six months after graduation.

Why study this degree at UCL?

UCL is in a unique position to offer both the basic science and application of modern genetics to improve human health. The programme is a cross-faculty initiative with teaching from across the School of Life and Medical Sciences (SLMS) at UCL.

Students will be based at the UCL Genetics Institute (UGI), a world-leading centre which develops and applies biostatistical and bioinformatic approaches to human and population genetics. Opportunities to conduct laboratory or computational-based research projects are available in the laboratories of world-leading geneticists affiliated to the UGI.

Research Excellence Framework (REF)

The Research Excellence Framework, or REF, is the system for assessing the quality of research in UK higher education institutions. The 2014 REF was carried out by the UK's higher education funding bodies, and the results used to allocate research funding from 2015/16.

The following REF score was awarded to the department: Division of Biosciences

82% rated 4* (‘world-leading’) or 3* (‘internationally excellent’)

Learn more about the scope of UCL's research, and browse case studies, on our Research Impact website.

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Molecular genetics is the study of genes at the molecular level. It focuses on the processes that underlie the expression of the genetic information from the DNA into the functional proteins that execute the genetic programme. Within the School of Life Sciences research in molecular genetics is concentrated in the Human Genetics, Fungal Biology, and Developmental Genetics and Gene Control groups. In the Human Genetics group research in this area includes studies of the molecular basis of myotonic dystrophy and the identification of genes involved in cardiac development; the molecular genetics of muscle disease; mouse models of muscle disorders and molecular genetic approaches to anthropology and human population genetics. In the Fungal Biology group there are studies on the molecular events that determine stress responses during polarised growth, protein folding and secretion in yeasts and filamentous fungi; the molecular and cellular effects of stress on yeast cells and the genetic mechanisms that control sex in fungi. The Developmental Genetics and Gene Control group focuses on the mechanisms of eukaryotic gene expression and the genetics of vertebrate embryonic development. Developmental studies are focussed largely upon the mechanisms that control stem cell fate. Projects on the control of gene expression address the machinery used by cells to achieve appropriate levels of functional transcripts. These studies include control of transcription and the mechanisms of RNA maturation.

APPLICATION PROCEDURES
After identifying which Masters you wish to pursue please complete an on-line application form
https://pgapps.nottingham.ac.uk/
Mark clearly on this form your choice of course title, give a brief outline of your proposed research and follow the automated prompts to provide documentation. Once the School has your application and accompanying documents (eg referees reports, transcripts/certificates) your application will be matched to an appropriate academic supervisor and considered for an offer of admission.

COURSE STRUCTURE
The MRes degree course consists of two elements:
160 credits of assessed work. The assessed work will normally be based entirely on a research project and will be the equivalent of around 10 ½ months full-time research work. AND
20 credits of non-assessed generic training. Credits can be accumulated from any of the courses offered by the Graduate School. http://www.nottingham.ac.uk/gradschool/research-training/index.phtml The generic courses should be chosen by the student in consultation with the supervisor(s).

ASSESSMENT
The research project will normally be assessed by a dissertation of a maximum of 30,000 to 35,000 words, or equivalent as appropriate*. The examiners may if they so wish require the student to attend a viva.
*In consultation with the supervisor it maybe possible for students to elect to do a shorter research project and take a maximum of 40 credits of assessed modules.

The School of Life Sciences will provide each postgraduate research student with a laptop for their exclusive use for the duration of their studies in the School.

SCHOLARSHIPS FOR INTERNATIONAL STUDENTS
http://www.nottingham.ac.uk/studywithus/international-applicants/scholarships-fees-and-finance/scholarships/masters-scholarships.aspx

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Overview
Advances in molecular biology have enabled major developments in biotechnology which in turn has lead to huge advances in medicine, molecular biology and industry. Students choosing this MSc degree will enjoy a comprehensive course that covers the key aspects of practical and theoretical medically-related molecular biology, developing advanced skills in this area.

Description
The course is composed of a modular 120-credit taught component and a 60-credit research project and dissertation. The taught component covers a broad range of medical molecular topics and techniques and includes thorough laboratory training. The course is run in conjuncture with our School of Medicine to ensure that students gain a broad view of modern molecular biology and laboratory techniques.

Overseas Students
A two-year course aimed at students from non-European Union countries who come to the UK requiring pre-MSc level training in English language and basic pre-MSc molecular biology. The first year of this course will bring students up to a level where they will be capable of studying for a full MSc degree and it will develop English language skills to the minimum level required for MSc level learning. Year one will be run in conjunction with ELCOS (English Language Courses for Overseas Students). Students can obtain the minimal English certification for MSc entry.

Module list (1st year of English-life sciences modules)
The English language content and life sciences teaching are integrated to enable students to undertake MSc level life-sciences modules through the medium of English

Life-sciences for none native English speakers - 50 credits
Academic Writing & Grammar
Speaking & Listening
Ad.Vocabulary Use & Reading
Near Native English 1
Near Native English 2

Modules list: (for first year of 1 year course and 2nd year of 2 year course)

Semester 1
Molecular and Medical Techniques
Techniques of molecular biology and biotechnology
Medical microbes viruses and parasites
Development, cancer and the human body
Genomes and Genetics
IT skills for medical and molecular research

Semester2
Project preparation course
Medical Biotechnology
Cellular causes of disease
Biomarkers in autoimmunity

Summer term
Research Project (Experimental research into a medical/molecular or genetics research topic)

Aims and Objectives
* Provide an excellent grounding in laboratory techniques and a critical approach to research planning and implementation.
* Develop understanding of molecular biology and the molecular basis of disease.
* Develop transferable skills, including their ability to work as a member of a team, and communicate in scientific writing and speech.
* Provide the opportunity for students to gain and enhance skills required by research organisations and biotechnology companies.
*Provide the ability to attain a level required to carry out research for a higher degree (PhD) in medical molecular and related areas.

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This course enables you to study cutting edge molecular methods employed for the understanding of molecular mechanisms of diseases and for their diagnosis and treatment. Your studies will be underpinned by essential knowledge in genetics, cell signalling and molecular medicine.

You will be offered the flexibility to select option modules that reflect your own interest in molecular biology and these will be combined with core modules and an independent research project. The course is suitable for newly qualified graduates, those employed in related work and those with medical qualifications.

Course structure

The following modules are indicative of what you will study on this course.

Core modules

• Molecular and Cellular Therapeutics
• Molecular Science and Diagnostics
• Principles of Molecular Medicine
• Postgraduate Research Methods
• Postgraduate Project

Optional module

• Cell Signalling and Genetics
• Extended Postgraduate Project
• Immunopathology
• Immunotherapy
• Molecular Bioinformatics
• Systems Biology

Professional recognition

The course is accredited by the Institute of Biomedical Science (IBMS).

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If you have a Bachelors degree in the biosciences, biochemistry, pharmacy or biological chemistry and you want to develop specialist knowledge in molecular biology then this postgraduate programme is for you. It will allow you to gain new skills and enhance your employability in the pharmaceutical and biotechnology industries or allow you to progress to a research degree.

About the course

The MSc Molecular Biology will give you hands on practical experience of both laboratory and bioinformatics techniques. You will also be trained in molecular biology research strategies. A strong practical foundation is provided in the first semester (Semester A) when you will study two modules:
-Cellular Molecular Biology - This module aims to help you develop a systematic understanding and knowledge of recombinant DNA technology, bioinformatics and associated research methodology.
-Core Genetics and Protein Biology - This module will provide you with an advanced understanding of genetics, proteins, the area of proteomics and the molecular basis of cellular differentiation and development.

The second semester (Semester B) has a problem-based learning approach to the application of the knowledge you gained in Semester A. You will study two modules:
-Molecular Medicine - You will study the areas of protein design, production and engineering, investigating specific examples of products through the use of case studies.
-Molecular Biotechnology - You will gain an in-depth understanding of the application of molecular biological approaches to the characterisation of selected diseases and the design of new drugs for their treatment.

In semester C you will undertake a research project to develop your expertise further. The research project falls into different areas of molecular biology and may include aspects of fermentation biotechnology, cardiovascular molecular biology, cancer, angiogenesis research, diabetes, general cellular molecular biology, bioinformatics, microbial physiology and environmental microbiology.

Why choose this course?

-This course gives in-depth knowledge of molecular biology for biosciences graduates
-It has a strong practical basis giving you training in molecular biology research strategies and hand-on experience of laboratory and bioinformatics techniques
-It equips you for research and development positions in the biotechnology and pharmaceutical industries, as well as a wide range of non-research roles in industry
-Biosciences research facilities cover fermentation biotechnology, high performance liquid chromatography, (HPLC), cell culture, molecular biology and pharmacology
-There are excellent facilities for chemical and biomedical analysis, genetics and cell biology studies and students have access to the latest equipment for PCR, qPCR and 2D protein gel analysis systems for use during their final year projects
-The School of Life and Medical Science will move into a brand new science building opening in September 2016 providing us with world class laboratories for our teaching and research. At a cost of £50M the new building provides spacious naturally lit laboratories and social spaces creating an environment that fosters multi-disciplinary learning and research

Careers

Graduates of the programme will be qualified for research and development positions in the pharmaceutical and biotechnology industries, to progress to a research degree, or to consider non-research roles in industry such as management, manufacturing and marketing.

Teaching methods

The course consists of five modules including a research project. All modules are 100% assessed by coursework including in-class tests.
-Cellular Molecular Biology
-Core Genetics and Protein Biology
-Molecular Biotechnology
-Molecular Medicine Research
-Biosciences Research Methods for Masters
-Methods and Project

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The revolution in genetic mapping technology and the advent of whole genome sequences have turned quantitative genetics into one of the fastest growing areas of biology.

Based in the internationally renowned Institute of Evolutionary Biology, this MSc draws from the wealth of expertise available there, as well as the teaching, research expertise and facilities of Scotland’s Rural College, the University’s Centre for Molecular Medicine, the Medical Research Council’s Human Genetics Unit and the Roslin Institute (birthplace of Dolly the sheep).

Each year the syllabus is fine-tuned to suit current issues in evolutionary, plant, human and animal genetics.

This programme forms part of the quantitative genetics and genome analysis suite of programmes offering specialist routes, which also include Animal Breeding & Genetics and Human Complex Trait Genetics.

Programme structure

This programme consists of two semesters of taught courses followed by a research project, leading to a dissertation.

Courses are taught via lectures, tutorials, seminars and computer practicals. Assessment is by written examinations, in-course assignments and project work.

Compulsory courses:

• Population and Quantitative Genetics
• Genetic Interpretation
• Linkage and Association in Genome Analysis
• Statistics and Data Analysis
• Research Proposal
• Dissertation

Option courses:

• Molecular Phylogenetics
• Bioinformatics
• Molecular Evolution
• Genetics of Human Complex Traits
• Quantitative Genetic Models
• Functional Genomic Technologies
• Animal Genetic Improvement
• Evolutionary Quantitative Genetics

Learning outcomes

You will gain the knowledge and skills required to apply quantitative genetics theory to undertake research in evolutionary and quantitative genetics, population genetics and evolutionary genomics.

• A thorough understanding of general concepts in population and quantitative genetics and genomics
• In-depth knowledge of evolutionary genetics
• A solid grounding in the statistical methods required for quantitative biology
• Development of independent research skills through individual mini- and maxi-research projects
• Development of generic skills (IT skills, experience in writing scientific papers, the ability to work independently)
• Presentation skills through student seminars, scientific presentation of project work and independent research projects.

Career opportunities

You will develop the in-depth knowledge and specialised skills required to apply quantitative genetics theory to practical problems, in both the biomedical and animal science industries, and to undertake research in evolutionary genetics, population genetics and genome analysis.

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The MSc Molecular Genetics and Diagnostics is suitable for graduates in life sciences, biomedical sciences and allied subjects, as well as people already employed in related fields who wish to improve and update their knowledge and gain valuable experience.

The course is designed to explain the technology, theory and practical approaches of molecular genetic methods to the diagnosis and understanding of human disease.

The course has a start date in September,

The course aims to:

• Provide an advanced course of study in the theoretical and practical aspects of the genetic basis and diagnosis of human disease
• Allow students adequate time to integrate into an active research laboratory where they are able to develop the skills which are essential when considering a career in research
• Train students to carry out critical evaluation of published scientific papers so that they develop the ability to report and interpret results

The academic staff involved with the course are recognised at an international level for their work on the genetic basis of complex diseases, including chronic obstructive pulmonary disease (COPD), Alzheimer's disease and infectious disease caused by clinically relevant microbial pathogens such as Pseudomonas spp., Yersinia spp. and Staphylococcus spp. Colleagues working in Molecular Diagnostics and Clinical Genetics within the NHS also contribute to the teaching on the course.

Key Facts

• The MSc Molecular Genetics and Diagnostics was previously known as the MSc Molecular Diagnostics, and has been running since 2004
• One of the many strengths of the course is the five-month research project that is conducted in the laboratory with a member research staff within the School
• The latest Research Assessment Exercise (RAE) confirmed The University of Nottingham's position as a world class research-led institution. Over 60% of the University's RAE scores identified research as being of a level of international excellence.
• This achievement has helped put Nottingham in the world’s top 1% of Universities internationally according to the latest (2014) QS World University Ranking.
• The peer-reviewed research carried out within the Human Genetics and Molecular and Cellular Bacteriology groups is recognized as being of either international or world-class standard.
• The MSc Molecular Genetics and Diagnostics is coordinated by academic staff within the Molecular and Cellular Bacteriology Research Group, part of the School of Life Sciences. Staff are based either within the Centre for Biomedical Science, a new state of the art research and teaching centre, the adjacent medical school which itself is located in the Queen’s Medical Centre or the Nottingham City Hospital.
• Extensive IT facilities are available across all campuses, including several computer rooms within the medical school.
• The University library service provides access to more than a million books and journals. The Greenfield Medical Library houses a broadly-based collection of biomedical, nursing and healthcare-related books and periodicals and holds current subscriptions to 780 journals, reports and series titles. In addition to the print versions housed in the library, the majority of journals can be accessed electronically.

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Research profile

The MRC Human Genetics Unit discovers how changes in our DNA impact our lives.

We combine the latest computational and experimental technologies to investigate how our genomes work to control the function of molecules, cells and tissues in people and populations. For more than half a century our research has been dedicated to understanding human genetic disease.

Today we continue to apply our clinical and scientific expertise, harnessing the power of complex data, to improve health, and the lives of patients and their families. As well as delivering outstanding research, the institute creates a vibrant scientific community and a friendly research environment rich in both scientific and social opportunities.

Our PhD and MSc programmes harness strengths in different research disciplines (genetics, molecular biology, biochemistry and cell biology) tied to our scientific themes (disease mechanisms, biomedical genomics and genome regulation). Our programmes also provides a strong focus on computational biology, and state of the art imaging as part of the Edinburgh Super-Resolution Imaging Consortium. Over 30 principal investigators based in the MRC HGU contribute to these cross-disciplinary programmes spanning fundamental to clinical research.

The MRC Human Genetics unit offers 3 and 4 year PhD projects, please visit our programme website for current opportunities, and further details.

• MRC Human Genetics

Entry requirements are described below and different PhD projects have different funding restrictions. To apply for any of our PhD programmes please select one of the buttons and dates to the right (For 4 year programmes, please select “3-year”).

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The revolution in genetic mapping technology and the advent of whole genome sequences has turned quantitative genetics into one of the fastest growing areas of biology.

Quantitative Genetics & Genome Analysis is part of a suite of programmes offering specialist routes in Animal Breeding & Genetics, Evolutionary Genetics, or Human Complex Trait Genetics.

Based in the internationally renowned Institute of Evolutionary Biology, this MSc draws from the wealth of expertise available there, as well as the teaching, research expertise and facilities of Scotland’s Rural College, the University’s Centre for Molecular Medicine, the Medical Research Council’s Human Genetics Unit and the Roslin Institute (birthplace of Dolly the sheep).

Each year the syllabus is fine-tuned to suit current issues in evolutionary, plant, human and animal genetics.

Applicants who wish to select their area of specialisation during the programme should apply for this umbrella programme. Applicants with a preferred programme option should apply via the following links:

• Animal Breeding and Genetics
• Evolutionary Genetics
• Human Complex Trait Genetics

Programme structure

This programme consists of two semesters of taught courses followed by a research project, leading to a dissertation.

Compulsory courses

• Population and Quantitative Genetics
• Genetic Interpretation
• Statistics and Data Analysis
• Linkage and Association in Genome Analysis
• Research Proposal
• Dissertation

Option courses (selected according to degree specialisation):

• Quantitative Genetic Models
• Molecular Evolution
• Genetics of Human Complex Traits
• Animal Genetic Improvement
• Functional Genomic Technologies
• Molecular Phylogenetics
• Bioinformatics
• Evolutionary Quantitative Genetics

Career opportunities

You will develop the in-depth knowledge and specialised skills required to apply quantitative genetics theory to practical problems, in both the biomedical and animal science industries, and to undertake research in evolutionary genetics, population genetics and genome analysis.

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The Institute of Genetic Medicine brings together a strong team with an interest in clinical and developmental genetics. Our research focuses on the causes of genetic disease at the molecular and cellular level and its treatment. Research areas include: genetic medicine, developmental genetics, neuromuscular and neurological genetics, mitochondrial genetics and cardiovascular genetics.

As a research postgraduate in the Institute of Genetic Medicine you will be a member of our thriving research community. The Institute is located in Newcastle’s Life Science Centre. You will work alongside a number of research, clinical and educational organisations, including the Northern Genetics Service.

We offer supervision for MPhil in the following research areas:

Cancer genetics and genome instability

Our research includes:
-A major clinical trial for chemoprevention of colon cancer
-Genetic analyses of neuroblastoma susceptibility
-Research into Wilms Tumour (a childhood kidney cancer)
-Studies on cell cycle regulation and genome instability

Cardiovascular genetics and development

We use techniques of high-throughput genetic analyses to identify mechanisms where genetic variability between individuals contributes to the risk of developing cardiovascular disease. We also use mouse, zebrafish and stem cell models to understand the ways in which particular gene families' genetic and environmental factors are involved in the normal and abnormal development of the heart and blood vessels.

Complex disease and quantitative genetics

We work on large-scale studies into the genetic basis of common diseases with complex genetic causes, for example autoimmune disease, complex cardiovascular traits and renal disorders. We are also developing novel statistical methods and tools for analysing this genetic data.

Developmental genetics

We study genes known (or suspected to be) involved in malformations found in newborn babies. These include genes involved in normal and abnormal development of the face, brain, heart, muscle and kidney system. Our research includes the use of knockout mice and zebrafish as laboratory models.

Gene expression and regulation in normal development and disease

We research how gene expression is controlled during development and misregulated in diseases, including the roles of transcription factors, RNA binding proteins and the signalling pathways that control these. We conduct studies of early human brain development, including gene expression analysis, primary cell culture models, and 3D visualisation and modelling.

Genetics of neurological disorders

Our research includes:
-The identification of genes that in isolation can cause neurological disorders
-Molecular mechanisms and treatment of neurometabolic disease
-Complex genetics of common neurological disorders including Parkinson's disease and Alzheimer's disease
-The genetics of epilepsy

Kidney genetics and development

Kidney research focuses on:
-Atypical haemolytic uraemic syndrome (aHUS)
-Vesicoureteric reflux (VUR)
-Cystic renal disease
-Nephrolithiasis to study renal genetics

The discovery that aHUS is a disease of complement dysregulation has led to a specific interest in complement genetics.

Mitochondrial disease

Our research includes:
-Investigation of the role of mitochondria in human disease
-Nuclear-mitochondrial interactions in disease
-The inheritance of mitochondrial DNA heteroplasmy
-Mitochondrial function in stem cells

Neuromuscular genetics

The Neuromuscular Research Group has a series of basic research programmes looking at the function of novel muscle proteins and their roles in pathogenesis. Recently developed translational research programmes are seeking therapeutic targets for various muscle diseases.

Stem cell biology

We research human embryonic stem (ES) cells, germline stem cells and somatic stem cells. ES cell research is aimed at understanding stem cell pluripotency, self-renewal, survival and epigenetic control of differentiation and development. This includes the functional analysis of genes involved in germline stem cell proliferation and differentiation. Somatic stem cell projects include programmes on umbilical cord blood stem cells, haematopoietic progenitors, and limbal stem cells.

Pharmacy

Our new School of Pharmacy has scientists and clinicians working together on all aspects of pharmaceutical sciences and clinical pharmacy.

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The revolution in genetic mapping technology and the advent of whole genome sequences have turned quantitative genetics into one of the fastest growing areas of biology.

Based in the internationally renowned Institute of Evolutionary Biology, this MSc draws from the wealth of expertise available there, as well as the teaching, research expertise and facilities of Scotland’s Rural College, the University’s Centre for Molecular Medicine, the Medical Research Council’s Human Genetics Unit and the Roslin Institute (birthplace of Dolly the sheep).

Each year the syllabus is fine-tuned to suit current issues in evolutionary, plant, human and animal genetics.

This programme forms part of the quantitative genetics and genome analysis suite of programmes offering specialist routes, which include Animal Breeding & Genetics and Evolutionary Genetics.

Programme structure

This programme consists of two semesters of taught courses followed by a research project, leading to a dissertation.

Courses are taught via lectures, tutorials, seminars and computer practicals. Assessment is by written examinations, in-course assignments and project work.

Compulsory courses:

• Population and Quantitative Genetics
• Genetic Interpretation
• Linkage and Association in Genome Analysis
• Genetics of Human Complex Traits
• Quantitative Genetic Models
• Statistics and Data Analysis
• Research Project Proposal
• Dissertation.

Option courses:

• Molecular Phylogenetics
• Bioinformatics
• Molecular Evolution
• Quantitative Genetic Models
• Functional Genomic Technologies
• Animal Genetic Improvement
• Evolutionary Quantitative Genetics

Learning outcomes

You will gain the knowledge and skills required to apply quantitative genetics theory to practical problems in the biomedical industry, and to undertake research in quantitative and population genetics and genome analysis.

• A thorough understanding of general concepts in population and quantitative genetics and genomics
• In-depth knowledge of complex trait genetics in humans
• A solid grounding in the statistical methods required for quantitative biology
• Development of independent research skills through individual mini- and maxi-research projects
• Development of generic skills (IT skills, experience in writing scientific papers, the ability to work independently)
• Presentation skills through student seminars, scientific presentation of project work and independent research projects.

Career opportunities

You will develop the in-depth knowledge and specialised skills required to apply quantitative genetics theory to practical problems, in both the biomedical and animal science industries, and to undertake research in evolutionary genetics, population genetics and genome analysis.

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The MSc Molecular Genetics course aims to provide instruction in current concepts and techniques of molecular genetics as applied in modern research. The MSc offers practical experience of experimental techniques and provides a framework to develop skills to plan research and devise strategies to achieve specific goals. The MSc acts as a springboard for graduates who want employment in molecular, biomedical or biotechnological research, or for entry to PhD programmes.

The MSc was established in 1988 and has been developed over the years to reflect the research strengths within the Faculty. Our students find the course to be demanding and challenging but also exciting, stimulating and rewarding.

The MSc consists of 180 course credits and is split into two phases:
Taught Phase 60 credits September - January
Research Project 120 credits January - August

Taught Phase
The taught phase is based around a series of taught practical experiments that introduce a variety of modern molecular techniques and research strategies. The experiments are run Tuesday-Friday of each week in the period September-December, with the Monday being reserved for a supporting lecture programme. The practical experiments are intensive and are used to help students develop analytical and reasoning skills as well as to learn how to plan and execute experimental investigations. There are some weeks set aside for students to complete written assignments and prepare for exams.

Research Project
For the research project students become part of an active research group and choose from a broad range of projects offered by departments of the Faculty of Medicine and Biological Sciences, the MRC Toxicology Unit, or collaborating research institutes or industrial partners (when available). The spread of projects covers a wide variety of disciplines involving molecular genetics and a variety of organisms.

Below are examples of project titles from a previous year:

• Molecular engineering of novel ligands with therapeutic potential

• Detection of oxidative damage to DNA in specific gene sequences

• Analyzing human disease genes in yeast

• Single molecule methods for watching the assembly of splicing complexes

• Secretory protein expression in pancreatic β-cells

• The iron responsive regulatory system of Campylobacter jejuni

• Non-recombining segments of the human genome as tools to study evolutionary history

• Analysis of telomere length dynamics in mice that lack telomerase by the amplification of single mouse telomeres.

• Molecular mechanisms underlying antisense-RNA mediated CpG island methylation in mammalian cells

• Mutations in the LMNA Gene in Emery Dreyfuss Muscular Dystrophy – consequences for in vitro differentiation of muscle cell cultures

• Alternative lengthening of telomeres in chronic lymphocytic leukaemia


Assessment of the research project is based on:
• Research performance (60 credits)
• A written report on the research (50 credits)
• A research seminar (10 credits).

Students submit the project report in August and the research seminars are held near the end of August.

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About the course

This MSc gives students excellent postgraduate training, and leads to exciting careers in research, industry, the NHS and other clinical institutions. Many of our graduates have also gone on to study bioscience at PhD level.

You’ll develop an in-depth knowledge of medical and molecular genetics, and receive clinical genetics training to prepare you for a research project in a modern research facility. You’ll have the chance to collaborate with top genetics research laboratories and clinical partners.

This MSc was developed in partnership with the Sheffield Diagnostic Genetics Service (SDGS), which is a world-renowned clinical genetics facility. This relationship is unique to this course and gives you the opportunity to be taught by the SDGS Director and the Lead Scientist for Constitutional Genetics.

Where your masters can take you

Our graduates work in health care, pharmaceuticals, food safety and production, brewing and agrochemicals. Many of our masters students go on to do a PhD then pursue a career in research; others have gained entry to the prestigious NHS Scientist Training Programme (STP).

An international reputation

The 2014 Research Excellence Framework (REF) ranks Sheffield No 1 for biomedical research and in the UK top five for biological sciences generally. We have regular seminars from distinguished experts, and our motivated staff undertake collaborative research ranging from biotechnology to medicine.

Teaching and assessment

Our masters courses give you a solid grounding in experimental science, with personal supervision and tutorials by experienced scientists, based in modern and well-equipped labs, leading on to a research project in which you design and conduct your own research.

You will learn cutting-edge science from research leaders, and gain practice in reading the scientific literature and writing reports.

Assessment is based on a combination of coursework, project work, formal examinations and a dissertation.

Core modules

• Advanced Research Topics
• Laboratory Techniques in Molecular Bioscience
• Literature Review
• Research Project

Optional modules

Choose three from:

• Genome Stability and Genetic Change
• The Genetics of Human Disease
• Human Reproduction and Fertility
• Genomic Science
• Stem Cell Biology
• The RNA World

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