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Translational Medicine (Interdisciplinary Molecular Medicine) (MRes)

Course content

Our Master of Research (MRes) in Translational Medicine will give you the research skills you need to use state-of-the-art biotechnologies to rapidly translate disease research into improved clinical healthcare.

Our understanding of the molecular basis of disease and drug mechanisms has improved dramatically in recent years, yet there is a distinct shortage of individuals able to apply this knowledge into effective clinical benefit. The core aim is to train the next generation of scientists able to 'fast-track' biological and scientific data into advanced therapies and diagnostics tools.

With advances in technology, graduates are faced with heightened expectations to conduct effective bioscience research. Employers demand skillsets with biological, medical, physical and computational characteristics, and our course is designed to provide this breadth of training.

You will learn omics skills and techniques such as genetics, genomics, transcriptomics, proteomics and metabolomics. Our training in metabolomic techniques is novel for a UK course, while our teaching on the integration of different omic platforms and data in a systems medicine strategy is also unique.

The MRes course consists of four taught units - which together make up the PGCert - plus an extended 35-week project that can be undertaken at the University, the Manchester Cancer Research Centre or a teaching hospital in Greater Manchester.

You can choose from a range of projects covering areas such as the use of gene expression profiling, proteomics, metabolomics, stem cell research, tissue culture or pharmacogenetics in the biology of cancer, cardiovascular disease, infectious diseases, stroke or diabetes.

Completing our course will open up a route into PhD research. You may also pursue a career in academia or the pharmaceutical or biotechnology industries, or as a clinical academic.

Special features

Extensive research experience

The 35-week research project for the MRes award offers the chance to conduct ambitious projects in areas such as cancer, cardiovascular disease, inflammation, mental health, infectious diseases, stroke or diabetes, using methods such as stem cell research, proteomics, metabolomics, tissue culture or pharmacogenetics.

Integrated focus on key topics

Our course has a strong and integrated focus on genetics, genomics, proteomics and metabolomics biotechnology and data interpretation, which are strengths within Manchester and are identified as core areas of bioscience growth.

Teaching and learning

Teaching comprises four taught units delivered using a variety of face-to-face, workshop and e-learning approaches and an extended 35-week research project for the MRes award.

Examples of research projects include the following.

  • Statins in translational cerebral ischemia: systematic review and meta-analysis of pre-clinical studies.
  • Parallel gene expression profiling and histological analysis of tumour tissue microarrays.
  • Development of a New Drug For Alzheimer's Disease by Drug Repositioning.
  • Identification of genetic variants predisposing to autoimmune idiopathic inflammatory myopathies.
  • Effects of differentiating agents on breast cancer stem cells and their sensitivity to DNA-damaging therapies.
  • Molecular characterisation of prostate cancer.
  • Inhibitors of IAPP Aggregation and Toxicity. 
  • New Therapies for Type II Diabetes.
  • Identifying novel monotherapy and combination therapies for the treatment of Glioma.
  • Translation of in vitro to in vivo: investigating the utility of in vitro drug transporter assays to predict inductive effects in the clinic.
  • In vivo mechanistic analysis of cancer drug combination therapies.
  • Using silk as a biomaterial for nerve regeneration.
  • The role of the local tissue environment in immune activation following myocardial damage.
  • Identifying genes that drive Breast Cancer to Bone Metastasis
  • High throughput genetic testing in rare disease: applications of personalised medicine.
  • Drug resistance and heterogeneity in CML following treatment with imatinib and following perturbation caused by nanoparticle delivery of miRNAs.
  • Investigation of a panel of drugs to inhibit the pro-tumourgenic actions of macrophages in breast cancer.
  • 3D anatomical reconstruction and molecular mapping of the atrioventricular ring tissues in human embryonic heart and adult rat heart.
  • Identification of the genetic basis of disorders associated with the presence of intracranial calcification.
  • Species variability in metabolism as a translational factor influencing susceptibility to adverse drug reactions in man.

Find out more by visiting the postgraduate teaching and learning page.

Career opportunities

More than 50% of our graduates progress into PhD research at Manchester or other universities such as Cambridge, Imperial College London, Newcastle, Glasgow, Liverpool and Bristol.

Around 15% pursue a career in the pharmaceutical or biotechnology industry in the UK or abroad.

Approximately 25% are intercalating medics who complete their medical education. An estimated 10% pursue an undergraduate medical degree.

Visit the Translational Medicine (Interdisciplinary Molecular Medicine) (MRes) page on the University of Manchester website for more details!




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Recipient: University of Manchester

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