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Psoriasis arthritis pathogenesis

Course Description

The aim of the project is to decipher how genes which are associated with susceptibility to psoriatic disease influence inflammatory responses of joint and skin associated cells. Products from many of those genes could potentially interfere with intracellular signalling pathways (e.g. MAPK, NF-B). The project will focus on expression of such genes (e.g. A20) and their influence on signalling pathways, using cells grown from patients with or without psoriatic arthritis. Techniques include Western Blot, flow cytometric analysis, luciferase assays (NF-B), ELISA, transfection (e.g. A20 plasmid, shRNA), cell culture of primary human cells.

Deadline 5pm 5 September 2012

Entry Requirements

BSc 2.1 or higher in Biological Sciences or Biochemistry aiming to start a career in research. Informal enquiries - Miriam Wittmann (), Martin Stacey () or Neil Turner (). The studentship will pay the tuition fee (Home or European students only) and laboratory consumable costs. There are no bench fees. Students will be expected to self finance their own accommodation and living expenses as no stipend is offered.Applications in the first instance should include your CV (including nomination of two referees) and covering letter stating why you wish to undertake this MRes. Applications should be sent electronically to .

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Recipient: University of Leeds

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