One of the most rapidly developing areas of toxicology is the use of molecular, cell biology and omics to identify adverse outcome pathways (AOPs) and to develop a mechanistic understanding of chemical toxicity at the cellular and molecular level. This is not only of fundamental interest (i.e., understanding the mechanism of action) but it also relates to an increased need for a mechanistic component in chemical risk assessment and development of high throughput screens for chemical toxicity.
The MRes in Molecular Mechanistic Toxicology is a one-year full-time programme that provides students with a research-orientated training in a lively, highly interactive teaching and research environment.
The programme is coordinated by the School of Biosciences, which is recognised internationally as a major centre for both teaching and research in Toxicology. Molecular Toxicology is a major component of the School of Biosciences research activities along with interactions with other departments including Chemistry and the Medical School.
Specific areas of active research include:
- Mechanisms of cell toxicity - Development of novel DNA binding chemicals - Cellular proliferation and differentiation - Environmental genomics and metabolomics - Molecular biomarkers of genotoxicity, oxidative stress and cellular responses - Role of environmental and genetic factors in disease - Learning and teaching
Two five-week taught modules are held in Semester 1 in conjunction with the taught MSc in Toxicology programme. Training in generic and laboratory research skills is also an important element of the programme. The programme also includes a six-month research project, which provides students with an opportunity for further advanced research training and hands-on experience of molecular and cellular biology techniques embedded in a research laboratory. Research projects can take place either in academic or industrial institutions.
About the School of Biosciences
As one of the top biosciences departments in the UK, our research covers the entire spectrum of cutting-edge biosciences. We are home to the Institute of Microbiology and Infection and part of the University’s Systems Science for Health initiative. Our research focuses on a number of important themes that run through modern biological and biochemical research: Biosystems and Environmental Change; Microbiology and Infection; Molecules, Cells, Signalling and Health; and Plant Science. Our postgraduate students join a diverse international community of staff and students. For students on research degrees, the annual Biosciences Graduate Research Symposium, organised by PhD students, is an example of an event where the whole School comes together to talk about science. We have extensive high-technology facilities in areas such as functional genomics, proteomics and metabolomics, including a world-class Advanced Mass Spectrometry Facility. Our cutting-edge facilities extend to protein structure determination and analysis, confocal microscopy, drug discovery, horticulture, structural biology and optical imaging. The £8 million Phenome Centre Birmingham is a large metabolic phenotyping facility led by internationally recognised metabolomics and clinical experts at the University of Birmingham, in collaboration with Birmingham Health Partners.