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Masters Degrees (Protein Purification)

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In the last 10-15 years the study of plant sciences has been revolutionised by the development of new tools and technologies which have allowed unprecedented progress in the study of plant biology - knowledge which is being applied to develop sustainable solutions to some of the major challenges of the 21st century. Read more

In the last 10-15 years the study of plant sciences has been revolutionised by the development of new tools and technologies which have allowed unprecedented progress in the study of plant biology - knowledge which is being applied to develop sustainable solutions to some of the major challenges of the 21st century.

This programme provides training in modern molecular aspects of plant science. Teaching is delivered by academics from the University’s Centre for Plant Sciences (CPS) and is often related to their areas of expertise and current research projects.

You’ll benefit from the research of international experts in DNA recombination and repair mechanisms and explore the wide range of approaches used in bio-imaging alongside the range of modern techniques and methodologies that underpin contemporary biomolecular sciences. You’ll explore the key topic areas of molecular biology; structural biology; cell imaging and flow cytometry; high throughput techniques; and transgenic organisms.

Our Facilities

You’ll study in a stimulating environment which houses cutting-edge facilities. The CPS laboratories feature a state-of-the-art plant growth unit, including tissue culture suites with culture rooms, growth rooms and cabinets alongside glass-houses to meet a range of growth requirements.

Course content

You’ll gain an overview of a range of modern techniques and methodologies that underpin contemporary biomolecular sciences through the investigation of five topic areas: molecular biology; structural biology; cell imaging and flow cytometry; high throughput techniques; and transgenic organisms. You’ll also conduct an extended practical investigation in the form of a laboratory-based project, involving practical training in a range of modern molecular biology and protein engineering techniques such as gene cloning, PCR, mutagenesis, protein expression, protein purification and analysis.

A module on plant biotechnology will address topics such as the engineering of plants, development of stress-tolerant crop varieties and techniques for gene expression and gene silencing. You’ll have the opportunity to benefit from the research of international experts in DNA recombination and repair mechanisms and their importance for transgene integration and biotechnological applications; biogenesis of mitochondria, chloroplast and peroxisomes; and the biosynthesis, structure and function of plant cell walls. You’ll also explore the wide range of approaches used in bio-imaging and their relative advantages and disadvantages for analysing protein and cellular function.

In the final part of the course you'll work on an independent laboratory-based research project related to your course options. You’ll receive extensive training in experimental design, the practical use of advanced techniques and technologies, data analysis and interpretation, and will be assigned a research project supervisor who will support and guide you through your project.

Course structure

Compulsory modules

  • Bioimaging 10 credits
  • Topics in Plant Science 10 credits
  • Practical Bioinformatics 10 credits
  • Plant Biotechnology 10 credits
  • High-throughput Technologies 10 credits
  • MSc Bioscience Research Project Proposal 5 credits
  • Research Planning and Scientific Communication 10 credits
  • Advanced Biomolecular Technologies 20 credits
  • Protein Engineering Laboratory Project 15 credits
  • Bioscience MSc Research Project 80 credits

For more information on typical modules, read Plant Science and Biotechnology MSc in the course catalogue

Learning and teaching

We provide the very best learning resources and academic support and our teaching draws on the University’s world-class research base and highly-qualified professionals from industry, non-governmental organisations and charities.

You’ll experience wide range of teaching methods including formal lectures, interactive workshops, problem-solving, practical classes and demonstrations.

Through your research project and specialist plant science and biotechnology modules, you’ll receive substantial subject-specific training. Our teaching and assessment methods are designed to develop you into a scientist who is able to think independently, solve problems, communicate effectively and demonstrate a high level of practical ability.

Assessment

We use a variety of assessment methods: multiple-choice testing, practical work, data handling and problem solving exercises, group work, discussion groups (face-to-face and online), computer-based simulation, essays, posters and oral presentations.

Career opportunities

The strong research element of the Plant Science and Biotechnology MSc, along with the specialist and generic skills you develop, mean you’re equipped for a wide range of careers.

Our graduates work in diverse posts, ranging from bioscience-related research through to scientific publication, teacher training, health and safety and pharmaceutical market research.

Links with industry

We have a proactive Industrial Advisory Board who advise us on what they look for in graduates and on employability-related skills within our programmes.

We collaborate with a wide range of organisations in the public and commercial sectors. Many of these are represented on our Industrial Advisory Board. They include:

  • GlaxoSmithKline
  • Ernst and Young
  • The Food and Environment Research Agency
  • The Health Protection Agency
  • MedImmune
  • Thermofisher Scientific
  • Hays Life Sciences
  • European Bioinformatics Institute
  • Smaller University spin-out companies, such as Lumora

Industrial research placements

Some of our partners offer MSc research projects in their organisations, allowing students to develop their commercial awareness and build their network of contacts.

Further study

A substantial proportion of our graduates undertake further study at Leeds or elsewhere. Recent graduates have gone on to:

  • PhD positions in the UK, USA and overseas eg at the Max Planck Institute, Germany
  • research post at Harvard School of Public Health, Botswana.

Careers support

We encourage you to prepare for your career from day one. That’s one of the reasons Leeds graduates are so sought after by employers.

The Careers Centre and staff in your faculty provide a range of help and advice to help you plan your career and make well-informed decisions along the way, even after you graduate. Find out more at the Careers website.




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Molecular medicine is transforming the way we understand and treat human diseases, from cancers to neurodegenerative disorders. Read more
Molecular medicine is transforming the way we understand and treat human diseases, from cancers to neurodegenerative disorders. Combining contemporary medical studies with biochemistry and molecular biology, this rapidly advancing area creates a bridge between the subjects, and draws on other fields such as physics, chemistry, biology and medicine.

This course examines how normal cellular processes are affected by disease. You gain an understanding of the core foundations of molecular medicine, studying the topics most relevant to the real world, and how this science may be used in the prevention, diagnosis, and treatment of diseases.

You learn about and appraise the approaches that can be used to address global health problems, including cancer as well as genetic and infectious diseases. The foundations that support investigations of molecular disease mechanisms and the search for new diagnostic tools and treatments will be laid, as you explore topics including:
-Gene and protein technology.
-Synthetic biology
-Bioinformatics
-Genomics

This course has a very high proportion of practical and bioinformatic work that provides valuable experience for your career. This includes our optional module Creating and Growing a New Business Venture, which challenges you to think creatively and increases your value to organisations, including small enterprises, which are a growing part of the biopharmaceutical sector.

Your research project is a major component of your course, in which you perform novel laboratory and/or bioinformatic research in one of our academic laboratories or (subject to approval) carry out research in an industrial or hospital setting.

Two-thirds of our research is rated “world-leading” or “internationally excellent” (REF 2014), and you learn from and work alongside our expert staff.

Our expert staff

As one of the largest schools at our University, we offer a lively, friendly and supportive environment with research-led study and high quality teaching. You benefit from our academics’ wide range of expertise and research on important national and international problems using cutting-edge techniques.

The University of Essex has a Women's Network to support female staff and students and was awarded the Athena SWAN Institutional Bronze Award in November 2013 in recognition of its continuing work to support women in STEM.

Specialist facilities

Recent investment has provided modern facilities for functional genomics, computational biology and imaging biological systems. On our course you have the opportunity to:
-Work in an open and friendly department, with shared staff-student social spaces
-Conduct your research alongside academics and PhD students in shared labs
-Learn to use state-of-the-art research facilities, from protein purification, to cell culture and imaging, to molecular modelling

Your future

Contribute to a growing industry and gain the skills and knowledge to pursue a career in biomedical research and industry, or continue your studies further in postgraduate science and medical degrees.

Advances in molecular medicine will continue to drive growth of new services and products in health care, biomedical and pharmaceutical organisations and companies, and our graduates are well placed to take advantage of employment opportunities in the life science, biotech and pharmaceutical industries and hospitals.

Many of our Masters students progress to study for their PhD, and we offer numerous studentships to support our students in their studies.

We work with our university’s Employability and Careers Centre to help you find out about further work experience, internships, placements, and voluntary opportunities.

Example structure

-Research Project: MSc Molecular Medicine
-Protein Technologies
-Gene Technology and Synthetic Biology
-Professional Skills and the Business of Molecular Medicine
-Molecular Medicine and Biotechnology
-Genomics
-Advanced Medical Microbiology (optional)
-Human Molecular Genetics (optional)
-Cancer Biology (optional)
-Creating and Growing a New Business Venture (optional)
-Rational Drug Design (optional)
-Molecular and Developmental Immunology (optional)
-Cell Signalling (optional)
-Mechanisms of Neurological Disease (optional)

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The need to develop new strategies to combat diseases remains a major global challenge. Read more

The need to develop new strategies to combat diseases remains a major global challenge. This programme provides advanced training in the mechanisms underpinning a spectrum of infectious and non-infectious diseases, including viral, bacterial and parasitic infections, cancer, neurodegeneration, cardiovascular disease and chromosomal abnormalities. You’ll also explore current and emerging diagnostic and treatment strategies.

You’ll learn about the latest molecular, genetic and cellular approaches being used to understand, diagnose and treat human disease, including traditional methods such as polymerase chain reaction (PCR) and enzyme-linked immunosorbent assay (ELISA), and novel methods involving genome and proteome analysis. You’ll have the opportunity to investigate the role of the immune system in the response to infection and disease, covering topics such as innate and adaptive immunity, allergy and immune evasion.

You’ll study in a faculty ranked 6th in the UK for its research impact in the recent Research Excellence Framework (REF 2014), and you’ll graduate with the solid base of scientific knowledge and specialist skills valued by employers.

Course content

You’ll gain an overview of a range of modern techniques and methodologies that underpin contemporary biomolecular sciences through the investigation of five topic areas: molecular biology, structural biology, cell imaging and flow cytometry, high throughput techniques and transgenic organisms. You’ll also conduct an extended practical investigation in the form of a laboratory-based project, involving practical training in a range of modern molecular biology and protein engineering techniques such as gene cloning, PCR, mutagenesis, protein expression, protein purification and analysis.

Added to this is an independent research project in an area of infection, immunity or human disease which provides substantial subject-specific training.

Specialist taught modules make up the remaining part of the programme and cover topics such as infectious and non-infectious disease, advanced immunology, medical diagnostics and treatment of infectious diseases and cancer. If you have have previous experience of immunology, you could opt to investigate the structure, regulation and development of the pharmaceutical manufacturing sector, or explore aspects of human toxicology, including the actions of toxicants on the cardiovascular, immune and nervous systems, kidneys, liver and lungs, genetic toxicology and chemical carcinogenesis, and the effects of chemicals on fetal development.

In the final part of the course you'll work on an independent laboratory-based research project related to your course options. You’ll receive extensive training in experimental design, the practical use of advanced techniques and technologies, data analysis and interpretation, and will be assigned a research project supervisor who will support and guide you through your project.

Course structure

Compulsory modules

  • Advanced Immunology 10 credits
  • Infectious & Non-infectious Diseases 10 credits
  • Practical Bioinformatics 10 credits
  • Medical Diagnostics 10 credits
  • MSc Bioscience Research Project Proposal 5 credits
  • Treatment of Infectious Disease and Cancer 10 credits
  • Research Planning and Scientific Communication 10 credits
  • Advanced Biomolecular Technologies 20 credits
  • Protein Engineering Laboratory Project 15 credits
  • Bioscience MSc Research Project 80 credits

For more information on typical modules, read Infection, Immunity and Human Disease MSc in the course catalogue

Learning and teaching

We provide the very best learning resources and academic support and our teaching draws on the University’s world-class research base and highly-qualified professionals from industry, non-governmental organisations and charities.

You’ll experience wide range of teaching methods including formal lectures, interactive workshops, problem-solving, practical classes and demonstrations.

Through your research project and specialist modules, you’ll receive substantial subject-specific training. Our teaching and assessment methods are designed to develop you into a scientist who is able to think independently, solve problems, communicate effectively and demonstrate a high level of practical ability.

Assessment

We use a variety of assessment methods: multiple-choice testing, practical work, data handling and problem solving exercises, group work, discussion groups (face-to-face and online), computer-based simulation, essays, posters and oral presentations.

Career opportunities

The strong research element of the Infection, Immunity and Human Disease MSc, along with the specialist and generic skills you develop, mean you’re equipped for a wide range of careers.

Our graduates work in diverse posts, ranging from bioscience-related research through to scientific publication, teacher training, health and safety and pharmaceutical market research.

Links with industry

We have a proactive Industrial Advisory Board who advise us on what they look for in graduates and on employability-related skills within our programmes.

We collaborate with a wide range of organisations in the public and commercial sectors. Many of these are represented on our Industrial Advisory Board. They include:

  • GlaxoSmithKline
  • Ernst and Young
  • The Food and Environment Research Agency
  • The Health Protection Agency
  • MedImmune
  • Thermofisher Scientific
  • Hays Life Sciences
  • European Bioinformatics Institute
  • Smaller University spin-out companies, such as Lumora

Industrial research placements

Some of our partners offer MSc research projects in their organisations, allowing students to develop their commercial awareness and build their network of contacts.

Further study

A substantial proportion of our graduates undertake further study at Leeds or elsewhere. Recent graduates have gone on to:

  • PhD positions in the UK, USA and overseas eg at the Max Planck Institute, Germany
  • research post at Harvard School of Public Health, Botswana.

Careers support

We encourage you to prepare for your career from day one. That’s one of the reasons Leeds graduates are so sought after by employers.

The Careers Centre and staff in your faculty provide a range of help and advice to help you plan your career and make well-informed decisions along the way, even after you graduate. Find out more at the Careers website.



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Accelerated training for the Biopharmaceutical Industry. This unique professional training course delivered in collaboration with the multinational company. Read more

Accelerated training for the Biopharmaceutical Industry

  • This unique professional training course delivered in collaboration with the multinational company Covance has been designed to train future leaders in the biopharmaceutical industry.
  • The course is 20 months in duration covering campus-based taught modules in the first six months, followed by a 12-month guaranteed paid placement in industry. You can expect to earn approximately £20,000 over the duration of your placement.
  • This course will provide you with an integrated understanding of the full biological drug development pathway and the regulatory framework. We are focusing mainly on large molecule drugs: monoclonal antibodies like Herceptin, bio-similars and antibody-drug conjugates; gene therapies and the technologies that underpin the discovery and development pathway.
  • You will be taught by leading industrialists and internationally renowned academics working at the forefront of their fields in the areas of science that underpin drug development.
  • You will access cutting edge practical technologies and gain hands-on practical training in protein purification, characterisation, formulation and assessment of binding function. In addition you will use cell-based assays to look at drug potency, all performed in a strict regulated environment to prepare you for working in this regulated industry.

Many pharmaceutical companies are expanding their biopharmaceutical capability, which is creating demand, and thus opportunities, for talented, well-trained people. At the same time, these companies report difficulties in recruiting employees with relevant skill sets and those with broad industrial experience are greatly sought after.

To address this skills gap, the University of Leeds and Covance have formed this partnership to train the next generation of scientists for the biopharmaceutical industry.

Course content

This course will provide you with an understanding of biological drug development focusing on each of the major steps of the process:

  • discovery
  • manufacturing
  • pre-clinical testing
  • clinical trials
  • market access and
  • the regulatory and legal aspects framework that ensure safe practice and the development of safe and effective medicines.

Course structure

The course is 20 months in duration, covering the campus-based taught elements in six to seven months, followed by a 12-month guaranteed paid work placement involving a research project where you will experience at first hand the working environment of this industry.

Work placement: an integral part of the training

An integral part of this course is your first paid job in industry. This is a 12-month guaranteed work and research experience in industry or placement hosted within the university research laboratories developed and co-supervised with industry. Students can expect to earn up to £20,000 over the duration of their placement.

The placements will all include a practical research project where you will gain in-depth practical experience of at least one technical function of the drug development process (discovery, manufacturing, pre-clinical testing, clinical safety and efficacy).

You will commence your project in April, six-months after the start of the programme and will be completed by the following April. Graduation is scheduled immediately thereafter, making you available for employment immediately after your placement.

Find out more about the modules you will study.

These are typical modules/components studied and may change from time to time. Read more in our Terms and conditions.

Year 1

Over the first six to seven months starting in September you will study 100 credits worth of taught modules .

Compulsory modules:

  • Biopharmaceutical Development Pathway 5 credits
  • Biopharmaceutical Drug Discovery 10 credits
  • Manufacturing Biopharmaceuticals 20 credits
  • Biopharmaceutical Development: Pre-clinical 10 credits
  • Integrated Drug Development Plan 10 credits
  • Biopharmaceutical Development: Clinical 10 credits
  • Commercialising Biopharmaceutical Products 10 credits
  • Practical Skills for a Regulatory Environment 25 credits

Year 2

Seven months after the start of the course (April/May), you will start a 12-month industrial placement where you will undertake a research project worth 80 credits.

Compulsory modules:

  • Industrial Placement & Research Project 80 credits

For more information on typical modules, read Biopharmaceutical Development MSc in the course catalogue

Learning and teaching

The learning and teaching on the course has been constructed to align with activities performed in industry.

This course will challenge you to think creatively, solve problems and develop strong communication and teamwork skills. You’ll experience a wide range of teaching methods, including formal lectures, interactive workshops, practical classes and industry site visits.

There will be extensive use of real-life, industry specific case studies to illustrate theoretical and practical concepts and multiple opportunities to work in teams, including the opportunity to lead a team. A wide range of ‘authentic’ assessments will be used that students will experience in the workplace including submissions to regulatory authorities, client reports and presentations to industry panel members.

Career opportunities

First steps into an industrial career

The course is designed to train talented scientists wishing to pursue a career in drug development in the international biopharmaceutical industry.

You will be exposed to senior industrialists working as tutors throughout the course and can take this opportunity to obtain career advice. Furthermore, you will work in industry full-time for 12 months, which represents an outstanding opportunity to develop a competitive career plan.

On completion of the course, you will have the relevant knowledge and experience to fast-track your career as, for example, an analytical scientist, project manager, or coordinator, in areas such as research, quality control, manufacturing, project management, non clinical, clinical, and market access.

All students on the programme will have the opportunity to be assigned to an industry-mentor and will be assigned a personal tutor (academic member of staff) for the duration of their studies. You will be supported in your career planning through sessions that develop your CVs and applications.

Careers support

We encourage you to prepare for your career from day one. That’s one of the reasons Leeds graduates are so sought after by employers.

The Careers Centre and staff in your faculty provide a range of help and advice to help you plan your career and make well-informed decisions along the way, even after you graduate. Find out more at the Careers website.



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You'll receive the highest-quality teaching in the leading Institute of Pharmacy & Biomedical Sciences in Scotland by staff dedicated to your personal and scientific development. Read more
You'll receive the highest-quality teaching in the leading Institute of Pharmacy & Biomedical Sciences in Scotland by staff dedicated to your personal and scientific development.

This course will provide you with a comprehensive three-part postgraduate life sciences training.

First, unlike many MSc courses, we offer you dedicated training in a broad suite of practical laboratory skills.

Secondly, this is complemented by two unique classes that develop your transferable skills in statistics, presentations, career development, and ethics, as well as honing your science writing skills and your ability to design experiments and analyse sophisticated datasets.

Thirdly, our taught classes capture the excitement of cutting-edge research fields and you will be taught by active researchers or practising clinical professionals. There is a choice of classes that allows you to select a pathway to suit your future aspirations.

Our MSc Molecular Microbiology focuses on the molecular biology of important microbial pathogens and industrial microorganisms.

Students study the molecular mechanisms by which bacteria cause disease or can be exploited for the synthesis of biotechnologically important products.

The course content and research projects are driven by the expertise in microbial genomics, genetics and biochemistry research that exists within the institute.

State-of-the-art research facilities, such as our own genome sequencer, protein purification facilities, mass spectrometers and fluorescence microscopes means that students obtain first-hand experience in the latest molecular microbiological techniques.

Together, the course provides the perfect springboard to future training at PhD level or gives you a range of skills and experience that will prove attractive to employers from industry or the health-care provision sector.

You'll study

-Vital transferable skills in statistics, communication, ethics, science writing and critical analysis of data
-Two semesters of postgraduate laboratories, giving you the practical abilities and interpretational skills that will prepare you for your project and future career
-Short optional classes in in vivo biology or drug discovery
-A compulsory Microbiology class together with a choice of either – Clinical Microbiology or Applied Microbiology
-A summer research project in molecular microbiology in an active research laboratory

Facilities

The course is taught in the Strathclyde Institute for Pharmacy & Biomedical Sciences. It’s located in our new building with state-of-the-art laboratories.

Course content

Compulsory classes
-Generic Skills for Biomedical & Pharmaceutical Students
-Entrepreneurship
-Statistics
-Advanced Techniques in Biomedical Research 1 & 2
-Postgraduate Studies in Microbiology
-Research project

Elective classes
-In Vivo Biology
-Drug Discovery
-Postgraduate Studies in Clinical Biochemistry
-Postgraduate Studies in Applied Microbiology

The course is delivered through lectures, tutorials and hands-on practical sessions.

If you successfully complete the required taught classes you may undertake a laboratory project for the MSc.

Assessment of taught classes is through multiple choice tests, computer quizzes, problem-solving scenarios, poster and oral presentations, essays, and formal written exams.

The laboratory project is assessed through a written thesis.

Careers

After graduating you should be ideally qualified for positions in biotechnology and pharmaceutical industries as well as hospitals and universities.

You may wish to continue studies for an MPhil or PhD.

This course provides the background training for a career in:
-Pharmaceutical & biotechnology industry laboratory research posts
-Laboratory technical support
-Medical/pharmaceutical/life science sales
-Academia – following a further PhD route

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This programme will give you hands-on practical experience of both laboratory and bioinformatics techniques. You will also be trained in biotechnology research strategies. Read more
This programme will give you hands-on practical experience of both laboratory and bioinformatics techniques. You will also be trained in biotechnology research strategies. A strong practical foundation is provided in the first semester (Semester A) when you study two modules: 'Cellular Molecular Biology' and 'Core Genetics and Protein Biology'. These modules concentrate on the basic principles and the techniques used in modern molecular biology investigations, and on aspects of cellular molecular biology and development.

The second semester (Semester B) has a problem-based learning approach to the application of the knowledge you gained in Semester A. You will study two modules: 'Industrial Biotechnology' and 'Molecular Biotechnology'. These modules will give you an in depth understanding of the application of molecular biological approaches to the production of industrial and medicinal proteins. You will also learn how to apply and design industrial and environmental biotechnology processes, such as process kinetics and design, reactor design and oxygen transfer, sterilization kinetics and the application of biotechnology processes for the bioremediation of contaminated sites.

In the third semester (Semester C) you undertake a research project to develop your expertise further. The research project falls into different areas and may include aspects of fermentation biotechnology, genetic manipulation and protein engineering, bioinformatics, microbial physiology and environmental biotechnology.

Why choose this course?

-This course gives in-depth knowledge of biotechnology and molecular biology for biosciences or biological chemistry graduates
-It has a strong practical basis giving you training in biotechnology research strategies and hand-on experience of laboratory and bioinformatics techniques
-It equips you for research and development positions in the biotechnology and pharmaceutical industries, as well as a wide range of non-research roles in industry
-Biosciences research facilities cover fermentation biotechnology, high performance liquid chromatography, (HPLC), cell culture, molecular biology and pharmacology
-There are excellent facilities for chemical and biomedical analysis, genetics and cell biology studies and students have access to the latest equipment for chemical synthesis and purification, PCR, qPCR and 2D protein gel analysis systems for use during their final year projects
-The School of Life and Medical Science will move into a brand new science building opening in September 2015 providing us with world class laboratories for our teaching and research. At a cost of £50M the new building provides spacious naturally lit laboratories and social spaces creating an environment that fosters multi-disciplinary learning and research

Careers

On successful completion of the programme you will be well qualified for research and development positions in the biotechnology and pharmaceutical industries, to progress to a research degree or to consider non-research roles in industry such as management, manufacturing and marketing.

Teaching methods

The course consists of five modules including a research project:
-Cellular Molecular Biology
-Core Genetics and Protein Biology
-Industrial Biotechnology
-Molecular Biotechnology
-Biosciences Research Methods for Masters
-Research project

All modules are 100% assessed by coursework which includes in-course tests.

Structure

Core Modules
-Biosciences Research Methods for Masters
-Cellular Molecular Biology
-Core Genetics and Protein Biology
-Industrial Biotechnology
-Molecular Biotechnology
-Project-Mol Biology, Biotechnology, Pharmacology

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Our modular distance learning programme provides you with a grounding in the structure of proteins, and the main techniques that are used to study protein structure. Read more
Our modular distance learning programme provides you with a grounding in the structure of proteins, and the main techniques that are used to study protein structure.

Structural biology allows you to understand how macromolecules work at the atomic level of detail. This is important, particularly in designing drugs which act at the molecular level to affect macromolecules. Increasingly, research uses a range of complementary biophysical and structural techniques to study protein-protein interactions. This requires that researchers have some understanding of what all these techniques can achieve. This programme is designed to give the theoretical background required to use this range of methods.

Why study this course at Birkbeck?

Study by distance learning, wherever you are in the world, with our internet-based teaching.
Graduates are well placed to study for PhDs, start professional research careers, or change disciplines to encompass this important area of modern molecular biology.
Part of the Institute of Structural and Molecular Biology, a joint initiative with University College London.
Birkbeck houses state-of-the-art equipment for X-ray crystallography, cryo-electron microscopy and tomography and associated image processing. We have excellent facilities for UV and CD spectroscopy, calorimetry, fluorescence spectroscopy, ultracentrifugation, and protein expression and purification in the biochemical and molecular biology laboratories. We have a 158 processor cluster for intensive data processing. All areas have specialised computer equipment for data analysis, molecular graphics and molecular modelling and programming.

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A Masters’ studentship is available in the group of Dr. Martin Schröder in the School of Biological and Biomedical Sciences at Durham University to study stress signaling mechanisms originating from the endoplasmic reticulum. Read more
A Masters’ studentship is available in the group of Dr. Martin Schröder in the School of Biological and Biomedical Sciences at Durham University to study stress signaling mechanisms originating from the endoplasmic reticulum. Endoplasmic reticulum (ER) stress contributes to the development and progression of many diverse diseases affecting secretory tissues, such as diabetes and neurodegenerative diseases. The successful candidate will employ modern genetic and molecular techniques to understand the underlying cell biological mechanisms in endoplasmic reticulum stress signaling that maintain the homeostasis of the endoplasmic reticulum.

The MRes student will investigate control of ER stress signaling specificity by the dosage of ER stress. You will use a range of molecular biology and biochemical techniques to study (a) how the severity of ER stress alters the signaling outputs of the ER stress sensing protein kinase-endoribonuclease IRE1 or (b) how ER stress regulates transcriptional responses through the Rpd3-Sin3 histone/lysine deacetylase (see for example Schröder et al., 2000; Schröder et al., 2004). These techniques include protein expression and purification, immunoprecipitation, chromatin immunoprecipitation, cloning, transfection, and RNA analysis by real-time PCR or Northern blotting.

Overall, the studentship will provide interdisciplinary training in molecular biology, genetics, and cell biology.

References

M. Schröder, Cell. Mol. Life Sci. 65 (2008) 862-894: Endoplasmic reticulum stress responses.
M. Schröder, C. Y. Liu, R. Clark, and R. J. Kaufman, EMBO J. 23 (2004) 2281-2292: The unfolded protein response represses differentiation through the RPD3-SIN3 histone deacetylase.
M. Schröder, J. S. Chang, and R. J. Kaufman, Genes Dev. 14 (2000) 2962-2975: The unfolded protein response represses nitrogen-starvation induced developmental differentiation in yeast.

To apply

To apply: send a CV including the names of two references and a one page personal statement describing clearly your background, interest and experience in scientific research to . In your cover letter you should clearly identify the funding source to cover living expenses, tuition fees and bench fees. Further information can be found at https://www.dur.ac.uk/martin.schroeder or by contacting Dr. Martin Schroeder.

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