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Masters Degrees (Next Generation Sequencing)

We have 23 Masters Degrees (Next Generation Sequencing)

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The aim of this programme is to provide individuals with a platform to explore, analyse and interpret contemporary biological data. Read more
The aim of this programme is to provide individuals with a platform to explore, analyse and interpret contemporary biological data. This course offers Masters level instruction in Bioinformatics with a focus on genomic bioinformatics. You will develop key skills for the analyses of omics data including genomics data from next generation sequencing technologies. Additional skills around emerging omics including metabolomics and proteomics will also be developed.

This programme has been designed with the needs of academic research, biotechnology and the pharmaceutical and health care industries in mind. We will provide instruction in computational and statistical biosciences and students will foster these additional complementary skills required to enable individuals to work effectively within a multidisciplinary bioinformatics arena.

Distinctive features

• This course was first established over a decade ago in response to the emerging informatics needs of the genetics and genomics communities following the completion of the first drafts of the human genome project. Subsequent advances in research technologies and analytic approaches have dictated the continuing evolution of this programme to provide contemporary instruction in these new essential skills.

• Providing a strong platform for students entering from the biological, mathematical or computational sciences, this course provides modules in core complementary areas such as in computation/scripting, statistics and molecular biology; the fundamental building blocks necessary to succeed in bioinformatic analysis and interpretation.

• As an introduction – you will be taught essential organisational and coding skills required for effective bioinformatics and biostatistical analysis.

• One of the unique components of this course is the extended instruction in statistics provided by the Statistics for Bioinformatics and Genetic Epidemiology module.

• You will also be introduced to the molecular and cellular biology behind the data. This is invaluable if you are entering from a non-life sciences background to make informed decisions around data interpretation.

• You will extend your bioinformatics studies by focusing on next generation sequencing technologies and other developing omics platforms such as proteomics and metabolomics.

We are committed to developing transferable skills and to improving graduate employability. We want highly capable graduate informaticians who can fulfil the growing bioinformatics needs of local, national and international employers.

Structure

The course can be completed in one year with full-time study or in three years by part-time study.

Both full-time and part-time students register initially for the MSc Bioinformatics and Genetic Epidemiology

A Postgraduate Certificate exit point is available for students successfully completing 60 credits of the taught element (module restrictions apply).

A Postgraduate Diploma exit point is available for students successfully completing 120 credits of the taught element (module restrictions apply).

Core modules:

Computing for Bioinformatics and Genetic Epidemiology
Statistics for Bioinformatics and Genetic Epidemiology
Introduction to Bioinformatics
Case Studies in Bioinformatics and Biostatistics
Next Generation Sequencing
Protein Biology and Omics
Dissertation in Bioinformatics

Teaching

The programme is delivered as face-2-face learning. You will find course materials, links to related materials and assessments via Cardiff University’s Virtual Learning Environment (VLE) ‘Learning Central'

Career Prospects

This programme has been designed with the needs of academic research, the biotechnology, pharmaceutical and health care industries in mind. Instruction in computational and statistical biosciences will enable individuals to work effectively within a multidisciplinary bioinformatics arena.

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The increasing impact of genetics in healthcare and the development of newer sophisticated technologies requires contributions from research scientists, clinical laboratory scientists and clinicians to investigate the causes of, and therefore permit optimal management for, diseases for which alterations in the genome, either at the DNA sequence level or epigenetic level, play a significant role. Read more
The increasing impact of genetics in healthcare and the development of newer sophisticated technologies requires contributions from research scientists, clinical laboratory scientists and clinicians to investigate the causes of, and therefore permit optimal management for, diseases for which alterations in the genome, either at the DNA sequence level or epigenetic level, play a significant role. Collaboration between staff from the University of Glasgow and the NHS West of Scotland Genetics Service enables the MSc in Medical Genetics and Genomics to provide a state-of-the-art view of the application of modern genetic and genomic technologies in medical genetics research and diagnostics, and in delivery of a high quality genetics service to patients, as well as in design of targeted therapies.

Why this programme

◾This is a fully up-to-date Medical Genetics degree delivered by dedicated, multi-award-winning teaching and clinical staff of the University, with considerable input from hospital-based Regional Genetics Service clinicians and clinical scientists.
◾The full spectrum of genetic services is represented, from patient and family counselling to diagnostic testing of individuals and screening of entire populations for genetic conditions: eg the NHS prenatal and newborn screening programmes.
◾The MSc Medical Genetics Course is based on the south side of the River Clyde in the brand new (2015) purpose built Teaching & Learning Centre, at the Queen Elizabeth University Hospitals (we are located 4 miles from the main University Campus). The Centre also houses state of the art educational resources, including a purpose built teaching laboratory, computing facilities and a well equipped library. The West of Scotland Genetic Services are also based here at the Queen Elizabeth Campus allowing students to learn directly from NHS staff about the latest developments to this service.
◾The Medical Genetics MSc Teaching Staff have won the 2014 UK-wide Prospects Postgraduate Awards for the category of Best Postgraduate Teaching Team (Science, Technology & Engineering). These awards recognise and reward excellence and good practice in postgraduate education.
◾The close collaboration between university and hospital staff ensures that the Medical Genetics MSc provides a completely up-to-date representation of the practice of medical genetics and you will have the opportunity to observe during clinics and visit the diagnostic laboratories at the new Southern General Hospital laboratory medicine building.
◾The Medical Genetics degree explores the effects of mutations and variants as well as the current techniques used in NHS genetics laboratory diagnostics and recent developments in diagnostics (including microarray analysis and the use of massively parallel [“next-generation”] sequencing).
◾New developments in medical genetics are incorporated into the lectures and interactive teaching sessions very soon after they are presented at international meetings or published, and you will gain hands-on experience and guidance in using software and online resources for genetic diagnosis and for the evaluation of pathogenesis of DNA sequence variants.
◾You will develop your skills in problem solving, experimental design, evaluation and interpretation of experimental data, literature searches, scientific writing, oral presentations, poster presentations and team working.
◾This MSc programme will lay the academic foundations on which some students may build in pursuing research at PhD level in genetics or related areas of biomedical science or by moving into related careers in diagnostic services.
◾The widely used textbook “Essential Medical Genetics” is co-authored by a member of the core teaching team, Professor Edward Tobias.
◾For doctors: The Joint Royal Colleges of Physicians’ Training Board (JRCPTB) in the UK recognises the MSc in Medical Genetics and Genomics (which was established in 1984) as counting for six months of the higher specialist training in Clinical Genetics.
◾The Medical Council of Hong Kong recognises the MSc in Medical Genetics and Genomics from University of Glasgow in it's list of Quotable Qualifications.

Programme structure

Genetic Disease: from the Laboratory to the Clinic

This course is designed in collaboration with the West of Scotland Regional Genetics Service to give students a working knowledge of the principles and practice of Medical Genetics and Genomics which will allow them to evaluate, choose and interpret appropriate genetic investigations for individuals and families with genetic disease. The link from genotype to phenotype, will be explored, with consideration of how this knowledge might contribute to new therapeutic approaches.

Case Investigations in Medical Genetics and Genomics

Students will work in groups to investigate complex clinical case scenarios: decide appropriate testing, analyse results from genetic tests, reach diagnoses where appropriate and, with reference to the literature, generate a concise and critical group report.

Clinical Genomics

Students will take this course OR Omic Technologies for Biomedical Sciences OR Frontiers in Cancer Science.

This course will provide an overview of the clinical applications of genomic approaches to human disorders, particularly in relation to clinical genetics, discussion the methods and capabilities of the new technologies. Tuition and hands-on experience in data analysis will be provided, including the interpretation of next generation sequencing reports.

Omic technologies for the Biomedical Sciences: from Genomics to Metabolomics

Students will take this course OR Clinical Genomics OR Frontiers in Cancer Science.

Visit the website for further information

Career prospects

Research: About half of our graduates enter a research career and most of these graduates undertake and complete PhDs; the MSc in Medical Genetics and Genomics facilitates acquisition of skills relevant to a career in research in many different bio-molecular disciplines.

Diagnostics: Some of our graduates enter careers with clinical genetic diagnostic services, particularly in molecular genetics and cytogenetics.

Clinical genetics: Those of our graduates with a prior medical / nursing training often utilise their new skills in careers as clinical geneticists or genetic counsellors.

Other: Although the focus of teaching is on using the available technologies for the purpose of genetic diagnostics, many of these technologies are used in diverse areas of biomedical science research and in forensic DNA analysis. Some of our numerous graduates, who are now employed in many countries around the world, have entered careers in industry, scientific publishing, education and medicine.

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The increasing impact of genetics in healthcare and the development of newer sophisticated technologies requires close collaboration between research scientists, clinical laboratory scientists and clinicians to deliver a high quality service to patients. Read more

The increasing impact of genetics in healthcare and the development of newer sophisticated technologies requires close collaboration between research scientists, clinical laboratory scientists and clinicians to deliver a high quality service to patients. The Clinical Genetics MSc has a specific focus on delivery of the clinical service to patients including risk analysis and application of modern genetic and genomic technologies in medical genetics research and in diagnostics and population screening.

Why This Programme

  • This is a fully up-to-date Clinical Genetics degree delivered by dedicated, multi-award-winning teaching and clinical staff of the University, with considerable input from hospital-based Regional Genetics Service clinicians and clinical scientists.
  • The full spectrum of genetic services is represented, from patient and family counselling to diagnostic testing of individuals and screening of entire populations for genetic conditions: eg the NHS prenatal and newborn screening programmes.
  • The Clinical Genetics MSc Teaching Staff won the 2014 UK-wide Prospects Postgraduate Awards for the category of Best Postgraduate Teaching Team (Science, Technology & Engineering). These awards recognise and reward excellence and good practice in postgraduate education. 
  • The close collaboration between university and hospital staff ensures that the Clinical Genetics MSc provides a completely up-to-date representation of the practice of medical genetics and you will have the opportunity to observe during clinics at the new Queen Elizabeth University Hospital laboratory medicine building.
  • The Clinical Genetics degree explores the effects of mutations and variants as well as the theoretically basis of current techniques used in NHS genetics laboratory diagnostics and recent developments in diagnostics (including microarray analysis and the use of massively parallel [“next-generation”] sequencing).
  • New developments in genetics are incorporated into the lectures and interactive teaching sessions very soon after they are presented at international meetings or published, and you will gain hands-on experience and guidance in using software and online resources for genetic diagnosis and for the evaluation of pathogenesis of DNA sequence variants.
  • You will develop your skills in problem solving, evaluation and interpretation of genetic data, literature searches, scientific writing, oral presentations, poster presentations and team working.
  • This MSc programme will lay the academic foundations on which some students with prior MBChB or MBBS may build in pursuing careers in Clinical Genetics.
  • The widely used textbook “Essential Medical Genetics” is co-authored by a member of the core teaching team, Professor Edward Tobias.
  • For doctors: The Joint Royal Colleges of Physicians’ Training Board (JRCPTB) in the UK recognises the MSc in Clinical Genetics (which was established in 1984) as counting for six months of the higher specialist training in Clinical Genetics.

Programme Structure

Genetic Disease and Clinical Practice

This course is designed in collaboration with the West of Scotland Regional Genetics Service to give students a working knowledge of the principles and practice of Clinical Genetics and Genomics which will allow them to evaluate, choose and interpret appropriate genetic investigations for individuals and families with genetic disease. The link from genotype to phenotype, will be explored, with consideration of how this knowledge might contribute to new therapeutic approaches.

Distress or Disorder: Reactions to a medical diagnosis

This course outlines the process of psychosocial adjustment to a diagnosis or test result allowing participants to establish if and when a distress reaction develops into an adjustment disorder. The implications of diagnosis are explored and evidence considered allowing informed decisions about appropriate referrals to other agencies.

Patient Empowerment: Supporting decisions relating to new diagnoses

This course reflects on evidence and experience to explore the psychological and social impact of a diagnosis, or illness, and provides strategies to support resilience and coping in patients. Factors related to lived experience, personal beliefs and values, culture, adjustment processes, decision-making, misconceptions, secrecy and guilt are considered to equip participants in the promotion of patient-centred care.

Effective listening and communication skills

With a focus on experiential learning and student led study, this course outlines the role of counselling skills to facilitate adjustment and to allow an individual to come to terms with change in a safe way to minimise impact. The focus will be on the theory supporting counselling, developing key listening and communication skills and on establishing reflective practice.

Case Investigations in Medical Genetics and Genomics

Students will work in groups to investigate complex clinical case scenarios: decide appropriate testing, analyse results from genetic tests, reach diagnoses where appropriate and, with reference to the literature, generate a concise and critical group report.

Clinical Genomics

This course will provide an overview of the clinical applications of genomic approaches to human disorders, particularly in relation to clinical genetics, discussion the methods and capabilities of the new technologies. Tuition and hands-on experience in data analysis will be provided, including the interpretation of next generation sequencing reports.

Disease Screening in Populations

This course will cover the rationale for, and requirements of, population screening programmes to detect individuals at high risk of particular conditions, who can then be offered diagnostic investigations. Students will work in groups to investigate and report on, a screening programme of their choice from any country.

Dissertation

The course will provide students with the opportunity to carry out an independent investigative project in the field of Medical Genetics and Genomics.

Teaching and Learning Methods

A variety of methods are used, including problem-based learning, case-based learning, lectures and tutorials. These are supplemented by a wide range of course-specific electronic resources for additional learning and self-assessment. As a result, you will develop a wide range of skills relevant to careers in clinical genetics. These skills include team-working and data interpretation. You will use the primary scientific literature as an information resource, although textbooks such as our own Essential Medical Genetics will also be useful. You will have the options of: attending genetic counselling clinics and gaining hands-on experience and guidance in using software and online resources for genetic diagnosis and for the evaluation of pathogenicity of DNA sequence variants.

Career Prospects

This programme would be beneficial for anyone with a previous MBChB or similar degree, and would facilitate a career as a Clinical Geneticist.



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Bioinformatics is a branch of the life sciences that focus on analysing and integrating big data acquired in biomedical experimentation. Read more

Bioinformatics is a branch of the life sciences that focus on analysing and integrating big data acquired in biomedical experimentation.

Over the last couple of years '-omics' technologies have transformed healthcare practice, biomedical research and industry, and there is a shortage of biomedical graduates with bioinformatics training in the advanced healthcare sector.

Our programme will provide you with essential skills in both molecular and computational techniques. You will learn how to design and perform experiments, and efficiently analyse next-generation sequencing data. You will acquired research data mining skills for Biological Sciences, Transcriptomics, Genomics, Proteomics and Metagenomics. 

It will equip you for careers in the private (e.g. pharmaceutical, biotechnology or food industry, forensic/veterinary laboratories) or public (e.g. academia, NHS) sectors.

What you will study

Modules

Core

Facilities

Our facilities are cutting-edge, and include the unique Centre for Skin Sciences and the Institute of Cancer Therapeutics, as well as the Analytical Centre.

These centres feature specialised equipment and are in the forefront of research and development of the understanding and treatment of health related challenges in the modern world.

Career prospects

Employability is a key focus of the programmes here at Bradford. We collaborate with industry partners through our Industry Advisory Board and their input shapes the curriculum, ensuring you gain the skills employers in the sector value and that are currently in short supply. You’ll have the opportunity to work on and contribute to real life research projects whilst you’re studying.

The University is committed to helping students develop and enhance employability and this is an integral part of many programmes. Specialist support is available throughout the course from Career and Employability Services including help to find part-time work while studying, placements, vacation work and graduate vacancies. Students are encouraged to access this support at an early stage and to use the extensive resources on the Careers website.

Discussing options with specialist advisers helps to clarify plans through exploring options and refining skills of job-hunting. In most of our programmes there is direct input by Career Development Advisers into the curriculum or through specially arranged workshops.

Study support

Our comprehensive support services will help you to achieve your full potential – both academically and personally. 

We provide all you need to make the very best of your time with us, and successfully progress through your studies and on into the world of graduate employment. 

Our support services include: 

  • Personal tutors 
  • Disability services 
  • Counselling services 
  • MyBradford student support centres 
  • The Students’ Union 
  • Chaplaincy and faith advisers 
  • An on-campus nursery 
  • Halls wardens 

We have well-stocked libraries and excellent IT facilities across campus. These facilities are open 24 hours a day during term time, meaning you’ll always find a place to get things done on campus. 

Our Academic Skills Advice Service will work with you to develop your academic, interpersonal and transferable skills. 

Research

The programme encourages cutting-edge cross-disciplinary research. It offers an opportunity for students to become global leaders in the biomedical industry.

There is a rapid and exponential rise in the amount of genomics sequence data (in all its forms), and UK research councils have identified the bioinformatics sector as a key driver for growth in the industrial and medical biotechnology, pharmaceutical and health markets, and have made it a key priority area for investment.

Our staff are research active and embed outcomes of their world leading research into the design of our courses, ensuring that you are equipped not just for the job market today, but are well prepared for the future.



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The practice of medicine, especially in the disciplines of Pathology and Genetics is increasingly reliant on Genomic technology. Read more

The practice of medicine, especially in the disciplines of Pathology and Genetics is increasingly reliant on Genomic technology. The aim of this programme is to increase the knowledge and capability of scientific and clinical staff using genetic data in their daily work allowing them to engage confidently with the scientific concepts of Molecular Pathology and Genomic Medicine, and to use their skills to improve patient care. The programme could also provide a foundation for those students interested in developing a clinical academic career.

The University of Edinburgh is at the forefront of Genomic Technology. To adequately realise the potential of these technologies in a diagnostic setting this programme will cover the scientific underpinning and clinical application of genomic technology to enable clinicians and scientists to provide maximum benefit to patients.

The programme will provide a structured environment for students wishing to develop cutting edge knowledge and practical skills in Clinical Genomics and Molecular Pathology. The programme structure is designed around three central themes: scientific foundation, diagnostics, and patient management and treatment.

Programme structure

The PG Cert is comprised of four compulsory courses, totalling 60 credits.

Students will learn via a mixture of guided online activities, in-person tutorials, and in course four, an extended project. In addition to structured learning, students are expected to conduct independent study and read around the subject area.

Students will develop their critical analysis skills through evaluation of primary research articles and reviews. Students will learn how to perform variant analysis and next generation sequencing data analysis using relevant bioinformatics tools. Students can also expect to develop the communication skills required for interacting with the major stakeholders of genomic information: clinical scientists, doctors and patients.

Teaching is performed by a variety of staff who are leaders in their field, as well as experienced educators. The core teaching team is comprised of staff from the NHS Lothian Clinical Genetics Service and Pathology departments. Additional teaching is performed by clinical and scientific staff from across Edinburgh University and the UK. In addition, the programme has a dedicated teaching teaching fellow, who will provide academic and pastoral support throughout all courses.

Postgraduate Professional Development (PPD)

Aimed at working professionals who want to advance their knowledge through a postgraduate-level course(s), without the time or financial commitment of a full Postgraduate Certificate.

You may take a maximum of 50 credits worth of courses over two years through our PPD scheme. These lead to a University of Edinburgh postgraduate award of academic credit. Alternatively, after one year of taking courses you can choose to transfer your credits and continue on to studying towards a higher award on the Postgraduate Certificate programme. Any time spent studying PPD will be deducted from the amount of time you will have left to complete a Postgraduate Certificate programme.

Learning outcomes

  1. Explain how genetic variation is involved in human disease and the development of cancer
  2. Critically evaluate molecular pathology diagnostics and select the appropriate diagnostic for disease stratification to determine patient treatment
  3. Analyse next generation sequence data in the context of germline mutations that cause human genetic disease, and somatic mutations involved in cancer
  4. Understand how genetic variation can be a major determinant of patient treatment and apply this knowledge to clinical scenarios in Genomic Medicine and Molecular Pathology

The programme will adopt a blended learning format, with teaching delivered via online as a eLectures and interviews, in-person tutorials, and online interactive content.

Programme materials and resources will all be available in the virtual learning environment, Learn. Learn provides an interactive forum for students to engage with other learners and the programme teaching staff. Multiple feedback opportunities will be integrated within each course and will comprise of weekly interactive online quizzes, discussion boards and office hours. In-person tutorials will also represent an important feedback opportunity for students. Assessment will vary slightly with each course, common assessment modalities include structured written assignments, presentations and data analysis reports.

Career opportunities

The programme is aimed primarily at NHS laboratory and clinical staff. It is designed for anyone wishing to expand their understanding of molecular pathology and how it applies to clinical diagnostics. The PG Cert will be of use to a wide range of individuals as it can be used to support FRC Path, Clinical Scientist Development and Genetic Technologist Registration. It can be used as a component of STP and could potentially contribute the first 60 credits of MSc. It will also provide the scientific underpinning for Genetic Counselling.



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This new and innovative course builds upon the integrated nature of the School of Dentistry’s clinical and basic science divisions, and aims to prepare future researchers, from scientific or clinical backgrounds for research careers based in addressing oral health needs. Read more

This new and innovative course builds upon the integrated nature of the School of Dentistry’s clinical and basic science divisions, and aims to prepare future researchers, from scientific or clinical backgrounds for research careers based in addressing oral health needs. You’ll gain a thorough background in oral sciences, the investigative, cutting edge technologies that enable oral scientific discovery and the necessary training in research governance and rigour. All areas of translational research pathways will be addressed, including aspects of commercialisation which will be taught through the Leeds University Business School (LUBS). Disease focused modules provide opportunities for in-depth exploration with research experts in the fields of Cancer, Musculoskeletal and Oral and systemic disease links.

Our teaching staff includes world leading experts with track records in translating research discoveries into novel healthcare products and practices. Student integration within the wider Dental school will be facilitated by undertaking recently updated modules shared with students from other MSc programmes.

Aimed at dental and biosciences graduates, the course will facilitate a career path focussed on oral research and its translation into positive impacts on health.

Course content

The programme will:

  • provide structured individualised learning and training in a research environment of international excellence.
  • be delivered by academics at the forefront of knowledge generation ranging from molecular discovery to translational application
  • engage students in research projects using the latest technologies that generate results with scientific impact and potential for improving patient health
  • equip students for the full process of translational oral research, which will be relevant for a range of biomedical scientific careers, providing the skills and insight to excel in multidisciplinary research.

For more information on typical modules, read Translational Research in Oral Sciences MSc in the course catalogue

Learning and teaching

Teaching will be split between the Dental school on the main campus and the Wellcome Trust Brenner Building (WTBB) at the St James’s University Hospital. The WTBB is a modern purpose built research facility, housing cutting edge facilities in imaging, tissue and microbiological culture and next generation sequencing technologies. On the main campus students can benefit from all the expertise, facilities (such as the Leeds Dental Translational and Clinical Research Unit) and support provided by the Dental school.

Our course emphasises student directed and multidisciplinary learning. Teaching methods include lectures, seminars and workshops, complemented by e-learning and will be delivered by research active scientists and clinicians with additional input from industrial partners and Leeds University Business School (LUBS) academics.

Assessment

Summative assessment will provide you with on-going feedback on your depth of subject knowledge and skills. Assessment methods for formative and summative assessment will include oral and poster presentations, unseen examinations and literature reviews. Exercises to identify research questions formulate research plans and prepare mock applications for funding and ethical/ governance approvals will also contribute to assessment.

Career opportunities

You will gain insight into all stages of translational research, preparing you for a career working across multi-disciplinary teams within research and innovation management. The course aims to enhance your career prospects of securing PhD studentship positions, whether that be in pre-clinical or clinical research.

The innovation management in practice module enables you to learn about the commercial aspects of translational research. It may be that you want to go into the oral healthcare industry, so knowledge of business skills will be a useful transferable skill.

You may want to go into academic teaching positions within your own country; this MSc will provide the knowledge required to teach oral biology at undergraduate level. 



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Research training opportunity based on a single project in molecular, environmental or medical microbiology. Note. Financial support/funding for your training may be available - please see below. Read more

Research training opportunity based on a single project in molecular, environmental or medical microbiology.

Note: Financial support/funding for your training may be available - please see below.

For further details please go to http://www.kingston.ac.uk/research/research-degrees/fees/

The project can start at any time. Training duration (full time) - 1 year.

The candidates will be able to select a title from the list below, or suggest their own project relevant to research conducted in the host laboratory. Our priority areas of studies are: molectual mechanisms of interaction between pathogenic bacteria and host cells, virulence factors, mechanisms of bacterial stress response, molecular genetics and genomics with a focus on Campylobacter jejuni and other bacterial pathogens.

Examples of potential research projects:

(1) Investigation of host-pathogen interaction (e.g. to study of adhesins of Campylobacter jejuni and cognate host cell receptors)

(2) Application of IonTorrent Next Generation Sequencing for comparative analysis of bacterial pathogens (e.g. to study genetic mechanisms responsible for structural variation of a capsular polysaccharide of Campylobacter jejuni)

The research will employ a wide range of state of the art microbiological and molecular biology techniques, and a successful candidate will receive extensive training and support from an experienced supervisor.

It is expected that the student will actively participate in scientific meetings and writing research articles with a possibility to progress to a PhD, and a postdoctoral post in future (depending on performance).

Personal requirements:

- enthusiastic and eager to learn;

- keen on research in molecular microbiology in general, and in investigation of bacterial pathogens in particular.

- some basic skills in bench work would be beneficial.

Entry requirements can be found at:

http://www.kingston.ac.uk/research/research-degrees/available-degrees/ma-and-msc-by-research/

To apply:

Please fill-in the application form available at

http://www.kingston.ac.uk/postgraduate/apply-now/documents/ku_postgrad_application_and_reference_form.pdf

Email this along with evidence of educational qualification and any other supporting documents (e.g. University Certificates and exam transcripts, English Language test Certificate if applicatble, etc) to Prof. A. Karlyshev -

Please also ask two referees who are familiar with your academic ability (or any relevant work experience) to email references to Prof. A. Karlyshev -

Financial support

You may be eligible to apply for a studentship/bursary to support your training, and may find useful the following links and contact details: Funding opportunities listed at Faculty of Science, Engineering and Computing

http://sec.kingston.ac.uk/applicants/pg-scholarships/

General info and links

http://www.kingston.ac.uk/international/fees-and-funding/scholarships/

Loyalty bursaries for alumni and families

http://www.kingston.ac.uk/international/fees-and-funding/scholarships/loyalty-bursaries/#alumni

Postgraduate scholarships

http://www.kingston.ac.uk/international/fees-and-funding/scholarships/international-scholarships/postgraduate-scholarships/

Annual Fund scholarships

http://www.kingston.ac.uk/postgraduate/fees-and-funding/funding-your-course/scholarships/annual-fund-scholarship/

Funding/Financial support enquiries:

Postgraduate Admissions Office

Faculty of Science, Engineering and Computing

Accessible via Switchboard tel. +44 (0)20 8417 9000

Scholarships Department

Tel: +44(0)20 8417 3221

Email:

Development Office

Tel: +44 (0)20 8417 3112

Email:

Development Office

Tel: +44 (0)20 8417 3112

Email:

Note: any further enquiries regarding these training opportunities (not related to funding) should be addressed to Prof. A. Karlyshev

Supervisor profile:

http://sec.kingston.ac.uk/about-SEC/people/academic/view_profile.php?id=80

Selected publications:

1.Karlyshev A. V., et al. (2008) Campylobacter jejuni Capsular Polysaccharide. In: Campylobacter 3rd Edition, Edited by: I. Nachamkin C. M. Szymanski and M. J. Blaser.

2.Karlyshev A. V. and Wren B. W. (2005) Development and application of an insertional system for gene delivery and expression in Campylobacter. Applied and Environmental Microbiology 71:4004-13.

3.Karlyshev A. V., et al. (2005) The Campylobacter glycome. FEMS Reviews, 29:377-390.

4.Karlyshev A. V., et al. (2005) Analysis of Campylobacter jejuni capsular loci reveals multiple mechanisms for the generation of structural diversity and the ability to form complex heptoses. Molecular Microbiology, 55:90-103.

5. Karlyshev, A. V., et al. (2005) The polysaccharide capsule of Campylobacter jejuni. In: Campylobacter: Molecular and Cellular Biology: 249-258 (Horizon Bioscience).

6.Karlyshev A. V., et al. (2004) The Campylobacter jejuni general glycosylation system is important for attachment to human epithelial cells and in the colonization of chicks. Microbiology 150:1957-64.

7.Karlyshev A. V., et al. (2003) Further strategies for signature-tagged mutagenesis and the application of oligonucleotide microarrays for the quantitation of DNA-tagged strains. In: Methods in Microbiology: Functional Microbial Genomics, 33: 167-184 (Elsevier Science).

8.Karlyshev A. V., et al. (2002) Multiple paralogous genes of C. jejuni essential for flagella biosynthesis and phase variation. Microbiology, 148:473-480.

9.Karlyshev A. V., et al. (2001) Application of High-Density Array-Based Signature-Tagged Mutagenesis To Discover Novel Yersinia Virulence-Associated Genes. Infection and Immunity, 69:7810–7819.

Visit the MSc by Research in Molecular Microbiology page on the Kingston University website for more details! 



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Course description. Our MRes Infection Biology programme will equip you with the knowledge and skills required to join the global fight against infectious diseases which threaten humanity. Read more

Course description

Our MRes Infection Biology programme will equip you with the knowledge and skills required to join the global fight against infectious diseases which threaten humanity.

Infectious disease remains a major cause of human death but the efficacy of antimicrobial interventions continues to decline. The discovery of novel preventative and therapeutic interventions now critically dependent upon a detailed mechanistic understanding of disease processes, their impact upon human pathobiology and the feasibility of therapeutically targeting such mechanisms.

With a view to training a generation of infection biologists equipped with the skills to tackle this global challenge, the MRes in Infection Biology provides outstanding academic and research training in the molecular and cellular basis of host-microbe interactions in health and disease.

You will learn directly from internationally recognised scientists through joint research, thereby securing a sustained interaction with expert mentors for the duration of the course.

The course provides research training in fundamental aspects of infectious diseases, microbial pathogenesis, host interactions, antimicrobial immunity, and antimicrobial therapy. For the talented student this course provides an excellent training prior to registration for a PhD.

This course will equip you with:

  • a detailed theoretical and practical understanding of molecular microbiology and antimicrobial immunology;
  • a thorough understanding of methods for analysing the biological functions and physiological relevance of microbial virulence factors and host responses to pathogenic challenge; 
  • a working knowledge of mechanistic approaches to problem-solving in molecular and cellular biomedical science;
  • an understanding of a wide repertoire of cutting edge scientific methods including flow cytometry, single cell technologies, imaging and proteomics;
  • transferable skills in critical reasoning and reflection, collaborative team working, scientific communication, use of IT/health informatics, innovation in the application of knowledge to practice and logical/systematic approaches to solving problems and making decisions.

Aims

This course aims to:

  • equip you with a detailed theoretical and practical understanding of molecular microbiology and immunology, delivered in-context during laboratory-based research and self-directed research of the literature;
  • enable you to integrate molecular and cellular information to understand the genetic basis of microbial virulence, host responses to pathogen challenge, and complexity of infectious disease, diagnostics, and antimicrobial therapies;
  • give you an understanding of the principles of modelling of host and microbial aspects of infection to help characterise the host-pathogen interaction;
  • equip you with an understanding of methods for analysing the biological functions and physiological relevance of microbial virulence factors and host responses to pathogenic challenge;
  • provide you with a working knowledge of mechanistic approaches to problem-solving in molecular and cellular biomedical science;
  • ensure you have a working understanding of the application of a wide repertoire of advanced scientific methods at the cutting edge of scientific research, including flow cytometry, single cell technologies, imaging and proteomics;
  • give you transferable skills in critical reasoning and reflection, collaborative team working, communication, use of IT/health informatics, innovation in the application of knowledge to practice and logical/systematic approaches to solving problems and making decisions.


Special features

  • In regular technology workshops you will learn, from the skilled experimental officers and technicians who support these key technologies, how to harness modern research technologies including single cell methodologies, live cell imaging, CRISPR, flow cytometry, proteomics, and next generation sequencing technologies to address cutting edge questions in infectious diseases research.
  • You will learn from clinician scientists and global leaders in infectious diseases research by attending our fortnightly seminars in infection.
  • In our grant writing exercise you will learn how to budget for, and become competitive in, securing funding for scientific research programmes.
  • You will benefit from studying amongst a small, talented and motivated peer group, selected at interview for their competitive potential.


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This specialist postgraduate degree provides you with high-quality postgraduate training in bioinformatics. It provides a foundation for the development of essential bioinformatics knowledge and skills, as well as an introduction to the emerging field of systems biology. Read more
This specialist postgraduate degree provides you with high-quality postgraduate training in bioinformatics. It provides a foundation for the development of essential bioinformatics knowledge and skills, as well as an introduction to the emerging field of systems biology. The course is run in parallel with an MRes course that includes a larger research component.

The programme is designed for students from a range of scientific backgrounds, who want to pursue research training in the interdisciplinary field of bioinformatics and systems biology. It is relevant to those seeking a future career in both academia and industry.

On successful completion of this programme, students from all backgrounds should be able to:

- Understand the core concepts and statistical fundamentals that underpin the field of bioinformatics, most notably in the area of sequence analysis.
- Program in Python, and design and query databases using SQL. Experience of more advanced programming practices (such as software testing and application development) will also be gained.
- Explain core biological concepts (such as genes and genomes, protein structure and function) and growth areas such as Next Generation Sequencing and (at least at an introductory level) systems modelling.

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STUDY CELL-TO-CELL SIGNALLING IN DEVELOPMENT AND DISEASE. Do you have a clear and specific interest in cancer, stem cells or developmental biology? Join our programme and combine research in oncology, molecular developmental biology and genetics. Read more

STUDY CELL-TO-CELL SIGNALLING IN DEVELOPMENT AND DISEASE

Do you have a clear and specific interest in cancer, stem cells or developmental biology? Join our programme and combine research in oncology, molecular developmental biology and genetics. Discover the mysteries of embryonic growth, stem cells, signalling, gene regulation, evolution, and development as they relate to health and disease.

CONTRIBUTE TO A BETTER UNDERSTANDING OF DISEASE TREATMENT AND PREVENTION

Given that fundamental developmental processes are so often impacted by disease, an understanding of these processes is vital to the better understanding of disease treatment and prevention. Adult physiology is regulated by developmental genes and mechanisms which, if deregulated, may result in pathological conditions.

Become an expert on molecular and cellular aspects of development and disease and create a better understanding of processes underlying cancer and developmental biology. Use techniques and applications of post-genomic research, including single cell and next generation sequencing, proteomics, metabolomics and advanced microscopy techniques.

WHY YOU SHOULD STUDY CANCER, STEM CELLS AND DEVELOPMENTAL BIOLOGY AT UTRECHT UNIVERSITY

  • Study with a unique emphasis on developmental biology, a process with many connections to cancer
  • Carry out two extensive research projects at renowned research groups
  • Collaborate with national and international research institutes, and gain valuable experience at partner institutions all around the world
  • Take courses, seminars and masterclasses led by renowned specialists in the field. The courses are interactive, and challenge you to further improve your writing and presenting skills
  • Focus on fundamental molecular aspects of disease related questions, particularly questions related to cancer and the use of stem cells in regenerative medicine


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The MSc in Genetic and Genomic Counselling is designed to give students a working knowledge of the principles and practice of Genetic Counselling which will qualify them to practice as Genetic and Genomic Counsellors. Read more
The MSc in Genetic and Genomic Counselling is designed to give students a working knowledge of the principles and practice of Genetic Counselling which will qualify them to practice as Genetic and Genomic Counsellors. The programme will be delivered by University of Glasgow staff in collaboration with NHS staff from the West of Scotland Genetics Service, so that a current perspective on both laboratory diagnostics and clinical services will be obtained. This programme is accredited by the UK Genetic Counsellor Registration Board.

Why this programme

-◾Teaching is based at the Queen Elizabeth University Hospital (QEUH), which includes adult services, children’s services and maternity services, as well as one of the largest diagnostic laboratories in Europe, and a new, purpose-built teaching and learning facility. The close collaboration between University and NHS staff ensures that the MSc in Genetic and Genomic Counselling provides a completely up-to-date representation of genetic services.
◾Counselling and psychology theoretical and research-focused courses are delivered by University staff trained in psychology, providing a firm foundation for the subsequent acquisition of knowledge and skills in genetic counselling facilitated by GCRB-registered Genetic Counsellors.
◾The University of Glasgow Medical Genetics Teaching Staff won the 2014 UK-wide Prospects Postgraduate Awards for the category of Best Postgraduate Teaching Team (Science, Technology & Engineering), to recognise and reward excellence and good practice; they were also finalists in the 2013 awards and are finalists in the category of "Outstanding support for students" in The Herald Higher Education Awards for Scotland in association with UWS 2016.
◾You will develop your skills in problem solving, evaluation and interpretation of diagnostic data, communication of the results of genome testing to patients, literature searches, scientific writing, oral presentations, poster presentations and team working.
◾The widely used textbook “Essential Medical Genetics” is co-authored by a member of the core teaching team, Professor Edward Tobias.

Programme structure

Component courses are as follows:

Genetic Disease in Clinical Practice

This course is designed in collaboration with the West of Scotland Genetics Service to give students a working knowledge of the principles and practice of Clinical Genetics which will allow them to evaluate, choose and interpret appropriate genetic investigations for individuals and families with genetic disease, and explore the links between genotype and phenotype.

Case Investigations in Medical Genetics

Students will work in groups to investigate complex clinical case scenarios: decide appropriate testing, analyse results from genetic tests, reach diagnoses where appropriate and, with reference to the literature, generate a concise and critical group report.

Distress or disorder: reactions to a medical diagnosis

Note: this 10 credit course may be taken by visiting students, for example as professional development.

This course outlines the process of psychosocial adjustment to a diagnosis or test result allowing participants to establish if and when a distress reaction develops into an adjustment disorder. The implications of diagnosis are explored and evidence considered allowing informed decisions about appropriate referrals to other agencies.

Patient empowerment: supporting decisions relating to new diagnoses

Note: this 10 credit course may be taken by visiting students, for example as professional development.

This course reflects on evidence and experience to explore the psychological and social impact of a diagnosis, or illness, and provides strategies to support resilience and coping in patients. Factors related to lived experience, personal beliefs and values, culture, adjustment processes, decision-making, misconceptions, secrecy and guilt are considered to equip participants in the promotion of patient-centred care.

Effective listening and communication skills

Note: this 10 credit course may be taken by visiting students, for example as professional development.

With a focus on experiential learning and student led study, this course outlines the role of counselling skills to facilitate adjustment and to allow an individual to come to terms with change in a safe way to minimise impact. The focus will be on the theory supporting counselling, developing key listening and communication skills and on establishing reflective practice.

Genetic counselling in clinical practice

This course is designed in collaboration with the West of Scotland Clinical Service, and will be delivered by NHS staff, to provide students with in depth understanding of the practical skills required in genetic counselling. The course will facilitate development of appropriate critical understanding, reflective practice and skills in relation to genetic counselling for providing accurate complex genetic information for patients and their families.

Social science research methods

The research methods course will focus on developing students’ research skills primarily in questionnaire-based qualitative and quantitative observational research methods and students will be introduced to ethics procedures for the college of MVLS.

Community placements 1 & 2

These placements, for 16 days and 20 days respectively, will each take place in one or more care settings for individuals with complex needs (adults or children or both) to enable students to gain insight into effects of complex needs on affected individuals and on their family.

Genetic counselling placement 1 & 2

These placements, for eight weeks and six weeks respectively, in different genetics centres will allow students to observe clinical practice in a variety of contexts, and to undertake relevant tasks under supervision within a clinical team that is delivering a genetic service, to enable the student to develop their own skills as a future genetic counsellor. Following each placement students will discuss and share experiences, facilitated by one of the NHS lead team and a counselling supervisor, to further develop their ability to deal with practical and emotional challenges in genetic counselling.

Clinical genomics

This course will provide an overview of the clinical applications of genomic approaches to human disorders, particularly in relation to clinical genetics, discussing the methods and capabilities of the new technologies. Tuition and hands-on experience in data analysis will be provided, including the interpretation of next generation sequencing reports.

Career prospects

The programme aims to provide students with skills to work as Genetic Counsellors. This programme is accredited by the Genetic Counsellor Registration Board (GCRB) producing graduates who are eligible for entry as a ‘trainee genetic counsellor’.

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Our MPhil/PhD research degree programme offers you. Wide variety of research interests. Research interests of the group include plant-microbe interactions, cell cycle and cell signalling. Read more
Our MPhil/PhD research degree programme offers you:

Wide variety of research interests
Research interests of the group include plant-microbe interactions, cell cycle and cell signalling. In general, the group use molecular biology, plant pathology, proteomics, genetics, microscopy and bioinformatics to investigate the functional role of genes in various conditions. These include biotic stress, flowering, cell cycling, circadian rhythm, receptor-ligand interactions, identification of pathogen secreted molecules and their function, targeted genome editing using CRISPR technology, comparisons of bacterial genomes using next generation sequencing and bioinformatics.

Excellent supervision
Benefit from a professional and challenging relationship with your supervisory team, drawn from experienced academics working at the forefront of their disciplines. The team members have collaborations within and outside the UK, thus possibilities for travelling and longer term visits exist at national and international partner universities.

Resources
Access to the University of Worcester’s virtual resources and its state of the art library facilities. The Institute of Science and the Environment has an excellent range of resources available to support your learning and your research project.

Recent research
Regulation of effectors by circadian rhythm; Identification of PAMPs and apoplastic effectors from downy mildew pathogen; Role of heterozygosity in effector-triggered immunity, investigating immune system of plants using genome editing technology and biopesticides.

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Research training opportunity based on a single project in molecular, environmental or medical microbiology. Note. Financial support/funding for your training may be available - please see below. Read more

Research training opportunity based on a single project in molecular, environmental or medical microbiology.

Note: Financial support/funding for your training may be available - please see below.

For further details please go to http://www.kingston.ac.uk/research/research-degrees/fees/

The project can start at any time. Training duration (full time) - 1 year.

The candidates will be able to select a title from the list below, or suggest their own project relevant to research conducted in the host laboratory. Our priority areas of studies are: molectual mechanisms of interaction between pathogenic bacteria and host cells, virulence factors, mechanisms of bacterial stress response, molecular genetics and genomics with a focus on Campylobacter jejuni and other bacterial pathogens.

Examples of potential research projects:

(1) Investigation of host-pathogen interaction (e.g. to study of adhesins of Campylobacter jejuni and cognate host cell receptors)

(2) Application of IonTorrent Next Generation Sequencing for comparative analysis of bacterial pathogens (e.g. to study genetic mechanisms responsible for structural variation of a capsular polysaccharide of Campylobacter jejuni)

The research will employ a wide range of state of the art microbiological and molecular biology techniques, and a successful candidate will receive extensive training and support from an experienced supervisor.

It is expected that the student will actively participate in scientific meetings and writing research articles with a possibility to progress to a PhD, and a postdoctoral post in future (depending on performance). 

Personal requirements:

- enthusiastic and eager to learn;

- keen on research in molecular microbiology in general, and in investigation of bacterial pathogens in particular.

- some basic skills in bench work would be beneficial. 

Entry requirements can be found at:

http://www.kingston.ac.uk/research/research-degrees/available-degrees/ma-and-msc-by-research/ 

To apply:

Please fill-in the application form available at

http://www.kingston.ac.uk/postgraduate/apply-now/documents/ku_postgrad_application_and_reference_form.pdf

Email this along with evidence of educational qualification and any other supporting documents (e.g. University Certificates and exam transcripts, English Language test Certificate if applicatble, etc) to Prof. A. Karlyshev -

Please also ask two referees who are familiar with your academic ability (or any relevant work experience) to email references to Prof. A. Karlyshev -

Financial support

You may be eligible to apply for a studentship/bursary to support your training, and may find useful the following links and contact details:

Funding opportunities listed at Faculty of Science, Engineering and Computing

http://sec.kingston.ac.uk/applicants/pg-scholarships/

General info and links

http://www.kingston.ac.uk/international/fees-and-funding/scholarships/

Loyalty bursaries for alumni and families

http://www.kingston.ac.uk/international/fees-and-funding/scholarships/loyalty-bursaries/#alumni

Postgraduate scholarships

http://www.kingston.ac.uk/international/fees-and-funding/scholarships/international-scholarships/postgraduate-scholarships/

Annual Fund scholarships

http://www.kingston.ac.uk/postgraduate/fees-and-funding/funding-your-course/scholarships/annual-fund-scholarship/

Funding/Financial support enquiries:

Postgraduate Admissions Office

Faculty of Science, Engineering and Computing

Accessible via Switchboard tel. +44 (0)20 8417 9000

Scholarships Department

Tel: +44(0)20 8417 3221

Email:

Development Office

Tel: +44 (0)20 8417 3112

Email:

Development Office

Tel: +44 (0)20 8417 3112

Email:

Note: any further enquiries regarding these training opportunities (not related to funding) should be addressed to Prof. A. Karlyshev  

Supervisor profile:

http://sec.kingston.ac.uk/about-SEC/people/academic/view_profile.php?id=80 

Visit the MSc by Research in Molecular Microbiology page on the Kingston University website for more details!

Entry Requirements

Please see course description

Course Fees

£3996 (home students) or £13,000 (overseas students), plus bench fees, £3,000.



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The course will enable biomedical & clinical students (including research midwives and nurses) to develop an academic and contemporary understanding of the biological and environmental influences that impact on pregnancy and the lifelong physical and mental wellbeing health of women and their infants. Read more

The course will enable biomedical & clinical students (including research midwives and nurses) to develop an academic and contemporary understanding of the biological and environmental influences that impact on pregnancy and the lifelong physical and mental wellbeing health of women and their infants

Students will gain insight and knowledge of how translation of basic science and clinical observation can lead to cutting edge research studies into new diagnostic and treatments both in the UK and in low resource settings globally. .

Students will develop scientific and clinical practical research skills, including statistics, so that they can confidently critically evaluate others research design and results, and apply these to their own research. They will also be given the necessary research knowledge and skills to design, plan, navigate research governance pathways, and conduct and analyse their own research project. Both scientific and clinical research projects are offered. 

Key Benefits

  • Substantial student-tutor contact time
  • Cross disciplinary teaching with a focus on translating research to the clinic and the global community
  • Research project in world class laboratories and research groups in Women’s, Perinatal and Child Health, Paediatric Allergy, Mental Health, Nutrition, Mental and Global Health.
  • Access to the latest leading cutting edge technologies housed at KCL and the NIHR Biomedical Research Centre including next generation sequencing, a range of ‘Omics and neonatal imaging, as well as dedicated clinical research units.
  • Lectures delivered by experienced and internationally recognised researchers and clinicians covering contemporary issues in Womens and Children’s health research 
  • Interactive tutorials and workshops on writing successful research grants, clinical study protocols and ethics applications.
  • The programme offers advanced practical experience and supervised training together with an in-depth research project
  • The programme prepares students for future MD and PhD study

Description

The MSc Women and Children's Health comprises three core taught modules, including ‘Fundamentals of Womens and Children’s Health’ which covers health and disease from the periconception period to birth and early childhood. Research led lectures will cover topics such as infertility, pre-pregnancy health, placentation, preeclampsia; immunology of pregnancy and autoimmune disease, metabolic disease in pregnancy, parturition and dysfunctional labour, miscarriage and preterm birth, lactation and infant nutrition, the developing brain and prematurity, childhood diet and dental health, premature infant and the neonatal lung, gut microbiome, obesity, childhood allergy, epigenetics and lifelong health, nutrition and global health and perinatal mental health.

The other required taught modules are Statistics and Research Governance, and Scientific and Clinical Research skills followed by an intensive six month core research projectwithin a lab or clinical research group.

Students can also select 1-2 optional taught module(s) to tailor the course to their developing interests, examples include Perinatal Mental Health, Ethics in Child Health, Regenerative Medicine, Principles of Implementation and Improvement, Science, Leadership and Management, Birth Defects, Assisted Conception, Regenerative Medicine and Global Women's Health.

The programme fosters intellectual skills of students through:

  • Critical assimilation and appraisal of the research literature pertaining to Womens and Children's Health.
  • Production of original pieces of written work that explain, review and evaluate primary research literature and using this evaluation to develop ideas and hypothesises.
  • Understand research governance and demonstrate compliance with research regulations.
  • Understand and apply scientific and clinical study design and statistical analysis principles.
  • Recognise the moral and ethical issues of investigations and appreciate the need for ethical standards and professional codes of conduct.
  • Think critically about their own work/research and to input into the synthesis and design of future hypotheses and experiments.
  • Use subject knowledge and understanding to explore and solve familiar and unfamiliar problems.
  • Collect, interpret and analyse data with a critical understanding of the appropriate contexts for their use through the study of primary research articles, and the student's own data.

Course format and assessment

Teaching

A typical week would be have approximately 10-15 hours teaching with the remaining hours dedicated to self-guided learning. In the final semester, research projects are full time with hours dedicated to practical and data collection, data analysis and writing.

You will study via a combination of lectures, journal clubs, group discussions, practicals, workshops and independent study.

Peer feedback, in course assignments such as data handling, research project and project report write-up, journal club, presentations and essays. All will be actively encouraged throughout the research project.

Typically, one credit equates to 10 hours of work.

Assessment

We will assess you through a combination of coursework, seen/unseen written exams, essays, problem directed learning exercises, case studies, ethical problem debate, data-handling, creation of clinical study materials such as patient information sheets and consent forms, research proposal, oral presentations, and a final research project report.

The study time and assessment methods detailed above are typical and give you a good indication of what to expect. However, they may change if the course modules change.

Career prospects

The course will prepare scientists and clinicians for further research into Womens & Children’s Health

Sign up for more information. Email now

Have a question about applying to King’s? Email now



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Master's specialisation in Medical Epigenomics. The only Master’s specialisation in the Netherlands covering the function of our epigenome, a key factor in regulating gene expression and in a wide range of diseases. Read more

Master's specialisation in Medical Epigenomics

The only Master’s specialisation in the Netherlands covering the function of our epigenome, a key factor in regulating gene expression and in a wide range of diseases.

Our skin cells, liver cells and blood cells all contain the same genetic information. Yet these are different types of cells, each performing their own specific tasks. How is this possible? The explanation lies in the epigenome: a heritable, cell-type specific set of chromosomal modifications, which regulates gene expression. Radboud University is specialised in studying the epigenome and is the only university in the Netherlands to offer a Master’s programme in this field of research.

Health and disease

The epigenome consists of small and reversible chemical modifications of the DNA or histone proteins, such as methylation, acetylation and phosphorylation. It changes the spatial structure of DNA, resulting in gene activation or repression. These processes are crucial for our health and also play a role in many diseases, like autoimmune diseases, cancer and neurological disorders. As opposed to modifications of the genome sequence itself, epigenetic modifications are reversible. You can therefore imagine the great potential of drugs that target epigenetic enzymes, so-called epi-drugs.

Big data

In this specialisation, you’ll look at a cell as one big and complex system. You’ll study epigenetic mechanisms during development and disease from different angles. This includes studying DNA and RNA by next-generation sequencing (epigenomics) and analysing proteins by mass spectrometry (proteomics). In addition, you‘ll be trained to design computational strategies that allow the integration of these multifaceted, high-throughput data sets into one system.

Why study Medical Epigenomics at Radboud University?

- Radboud University combines various state-of-the-art technologies – such as quantitative mass spectrometry and next-generation DNA sequencing – with downstream bioinformatics analyses in one department. This is unique in Europe.

- This programme allows you to work with researchers from the Radboud Institute for Molecular Life sciences (RIMLS), one of the leading multidisciplinary research institutes within this field of study worldwide.

- We have close contacts with high-profile medically oriented groups on the Radboud campus and with international institutes (EMBL, Max-Planck, Marie Curie, Cambridge, US-based labs, etc). As a Master’s student, you can choose to perform an internship in one of these related departments.

- Radboud University coordinates BLUEPRINT, a 30 million Euro European project focusing on the epigenomics of leukaemia. Master’s students have the opportunity to participate in this project.

Career prospects

As a Master’s student of Medical Epigenomics you’re trained in using state-of-the art technology in combination with biological software tools to study complete networks in cells in an unbiased manner. For example, you’ll know how to study the effects of drugs in the human body.

When you enter the job market, you’ll have:

- A thorough background of epigenetic mechanisms in health and disease, which is highly relevant in strongly rising field of epi-drug development

- Extensive and partly hands-on experience in state-of-the-art ‘omics’ technologies: next-generation sequencing, quantitative mass spectrometry and single cell technologies;

- Extensive expertise in designing, executing and interpreting scientific experiments in data-driven research;

- The computational skills needed to analyse large ‘omics’ datasets.

With this background, you can become a researcher at a:

- University or research institute;

- Pharmaceutical company, such as Synthon or Johnson & Johnson;

- Food company, like Danone or Unilever;

- Start-up company making use of -omics technology.

Apart from research into genomics and epigenomics, you could also work on topics such as miniaturising workflows, improving experimental devices, the interface between biology and informatics, medicine from a systems approach.

Or you can become a:

- Biological or medical consultant;

- Biology teacher;

- Policy coordinator, regarding genetic or medical issues;

- Patent attorney;

- Clinical research associate;

PhD positions at Radboud University

Each year, the Molecular Biology department (Prof. Henk Stunnenberg, Prof. Michiel Vermeulen) and the Molecular Developmental Biology department (Prof. Gert-Jan Veenstra) at the RIMLS offer between five and ten PhD positions. Of course, many graduates also apply for a PhD position at related departments in the Netherlands, or abroad.

Our approach to this field

- Systems biology

In the Medical Epigenomics specialisation you won’t zoom in on only one particular gene, protein or signalling pathway. Instead, you’ll regard the cell as one complete system. This comprehensive view allows you to, for example, model the impact of one particular epigenetic mutation on various parts and functions of the cell, or study the effects of a drug in an unbiased manner. One of the challenges of this systems biology approach is the processing and integration of large amounts of data. That’s why you’ll also be trained in computational biology. Once graduated, this will be a great advantage: you’ll be able to bridge the gap between biology, technology and informatics , and thus have a profile that is desperately needed in modern, data-driven biology.

- Multiple OMICS approaches

Studying cells in a systems biology approach means connecting processes at the level of the genome (genomics), epigenome (epigenomics), transcriptome (transcriptomics), proteome (proteomics), etc. In the Medical Epigenomics specialisation, you’ll get acquainted with all these different fields of study.

- Patient and animal samples

Numerous genetic diseases are not caused by genetic mutations, but by epigenetic mutations that influence the structure and function of chromatin. Think of:

- Autoimmune diseases, like rheumatoid arthritis and lupus

- Cancer, in the forms of leukaemia, colon cancer, prostate cancer and cervical cancer

- Neurological disorders, like Rett Syndrome, Alzheimer, Parkinson, Multiple Sclerosis, schizophrenia and autism

We investigate these diseases on a cellular level, focusing on the epigenetic mutations and the impact on various pathways in the cell. You’ll get the chance to participate in that research, and work with embryonic stem cell, patient, Xenopus or zebra fish samples.

See the website http://www.ru.nl/masters/medicalbiology/epigenomics



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