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Masters Degrees (Multiple Sclerosis)

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Master's specialisation in Medical Epigenomics. The only Master’s specialisation in the Netherlands covering the function of our epigenome, a key factor in regulating gene expression and in a wide range of diseases. Read more

Master's specialisation in Medical Epigenomics

The only Master’s specialisation in the Netherlands covering the function of our epigenome, a key factor in regulating gene expression and in a wide range of diseases.

Our skin cells, liver cells and blood cells all contain the same genetic information. Yet these are different types of cells, each performing their own specific tasks. How is this possible? The explanation lies in the epigenome: a heritable, cell-type specific set of chromosomal modifications, which regulates gene expression. Radboud University is specialised in studying the epigenome and is the only university in the Netherlands to offer a Master’s programme in this field of research.

Health and disease

The epigenome consists of small and reversible chemical modifications of the DNA or histone proteins, such as methylation, acetylation and phosphorylation. It changes the spatial structure of DNA, resulting in gene activation or repression. These processes are crucial for our health and also play a role in many diseases, like autoimmune diseases, cancer and neurological disorders. As opposed to modifications of the genome sequence itself, epigenetic modifications are reversible. You can therefore imagine the great potential of drugs that target epigenetic enzymes, so-called epi-drugs.

Big data

In this specialisation, you’ll look at a cell as one big and complex system. You’ll study epigenetic mechanisms during development and disease from different angles. This includes studying DNA and RNA by next-generation sequencing (epigenomics) and analysing proteins by mass spectrometry (proteomics). In addition, you‘ll be trained to design computational strategies that allow the integration of these multifaceted, high-throughput data sets into one system.

Why study Medical Epigenomics at Radboud University?

- Radboud University combines various state-of-the-art technologies – such as quantitative mass spectrometry and next-generation DNA sequencing – with downstream bioinformatics analyses in one department. This is unique in Europe.

- This programme allows you to work with researchers from the Radboud Institute for Molecular Life sciences (RIMLS), one of the leading multidisciplinary research institutes within this field of study worldwide.

- We have close contacts with high-profile medically oriented groups on the Radboud campus and with international institutes (EMBL, Max-Planck, Marie Curie, Cambridge, US-based labs, etc). As a Master’s student, you can choose to perform an internship in one of these related departments.

- Radboud University coordinates BLUEPRINT, a 30 million Euro European project focusing on the epigenomics of leukaemia. Master’s students have the opportunity to participate in this project.

Career prospects

As a Master’s student of Medical Epigenomics you’re trained in using state-of-the art technology in combination with biological software tools to study complete networks in cells in an unbiased manner. For example, you’ll know how to study the effects of drugs in the human body.

When you enter the job market, you’ll have:

- A thorough background of epigenetic mechanisms in health and disease, which is highly relevant in strongly rising field of epi-drug development

- Extensive and partly hands-on experience in state-of-the-art ‘omics’ technologies: next-generation sequencing, quantitative mass spectrometry and single cell technologies;

- Extensive expertise in designing, executing and interpreting scientific experiments in data-driven research;

- The computational skills needed to analyse large ‘omics’ datasets.

With this background, you can become a researcher at a:

- University or research institute;

- Pharmaceutical company, such as Synthon or Johnson & Johnson;

- Food company, like Danone or Unilever;

- Start-up company making use of -omics technology.

Apart from research into genomics and epigenomics, you could also work on topics such as miniaturising workflows, improving experimental devices, the interface between biology and informatics, medicine from a systems approach.

Or you can become a:

- Biological or medical consultant;

- Biology teacher;

- Policy coordinator, regarding genetic or medical issues;

- Patent attorney;

- Clinical research associate;

PhD positions at Radboud University

Each year, the Molecular Biology department (Prof. Henk Stunnenberg, Prof. Michiel Vermeulen) and the Molecular Developmental Biology department (Prof. Gert-Jan Veenstra) at the RIMLS offer between five and ten PhD positions. Of course, many graduates also apply for a PhD position at related departments in the Netherlands, or abroad.

Our approach to this field

- Systems biology

In the Medical Epigenomics specialisation you won’t zoom in on only one particular gene, protein or signalling pathway. Instead, you’ll regard the cell as one complete system. This comprehensive view allows you to, for example, model the impact of one particular epigenetic mutation on various parts and functions of the cell, or study the effects of a drug in an unbiased manner. One of the challenges of this systems biology approach is the processing and integration of large amounts of data. That’s why you’ll also be trained in computational biology. Once graduated, this will be a great advantage: you’ll be able to bridge the gap between biology, technology and informatics , and thus have a profile that is desperately needed in modern, data-driven biology.

- Multiple OMICS approaches

Studying cells in a systems biology approach means connecting processes at the level of the genome (genomics), epigenome (epigenomics), transcriptome (transcriptomics), proteome (proteomics), etc. In the Medical Epigenomics specialisation, you’ll get acquainted with all these different fields of study.

- Patient and animal samples

Numerous genetic diseases are not caused by genetic mutations, but by epigenetic mutations that influence the structure and function of chromatin. Think of:

- Autoimmune diseases, like rheumatoid arthritis and lupus

- Cancer, in the forms of leukaemia, colon cancer, prostate cancer and cervical cancer

- Neurological disorders, like Rett Syndrome, Alzheimer, Parkinson, Multiple Sclerosis, schizophrenia and autism

We investigate these diseases on a cellular level, focusing on the epigenetic mutations and the impact on various pathways in the cell. You’ll get the chance to participate in that research, and work with embryonic stem cell, patient, Xenopus or zebra fish samples.

See the website http://www.ru.nl/masters/medicalbiology/epigenomics



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EXCITING NEWS. new pathways and modules have been added to this programme, developed with Oxford Brookes Centre for Rehabilitation, the ARNI Instititute and the Multiple Sclerosis Society. Read more
EXCITING NEWS: new pathways and modules have been added to this programme, developed with Oxford Brookes Centre for Rehabilitation, the ARNI Instititute and the Multiple Sclerosis Society.

This innovative and dynamic MSc course is appropriate for all health, social care and exercise professionals working with different patient or client groups, adults or children. A strength of the course is the opportunity it provides to work with practitioners from different professions, from different patient and client groups and from a variety of countries which all helps promote a diverse view of rehabilitation.

This course enables practitioners to examine their own rehabilitation practice in light of the analysis of key concepts and theories. The ICF (International Classification of Functioning, Disability and Health, WHO 2001) - a key framework used internationally to guide rehabilitation practice, research and policy - will be used as a framework throughout the course. This will allow you to focus on rehabilitation from impairment through to activity and participation levels, taking into account contextual factors.

See the website http://www.brookes.ac.uk/courses/postgraduate/rehabilitation-musculoskeletal-neurological-posture-management-pathways/

Why choose this course?

- It provides a wide range of teaching and learning strategies, enabling you to develop relevant skills, for example in research and leadership. It offers five pathways: Neurological; Musculoskeletal; Paediatric Neurological; Exercise; Posture Management. (Please note for this pathway, you have to enter with 60 CATS credits from the Posture Management course, offered by the Oxford Centre for Enablement, Nuffield Orthopaedic Centre NHS Trust, Oxford.)

- It has a strong practice focus achieved through the way we consistently link theory to practice. You have opportunities to work within the CLEAR unit and engage with the latest rehabilitation research.

- It is structured in such a way that it moves from generic content (PG Cert Rehabilitation) with a focus on rehabilitation concepts, pathophysiological aspects and evidence-based rehabilitation, to pathway-specific (PG Diploma) content. These pathways enable you to focus on rehabilitation generally, relating to your own area of practice through the assessments, and then to focus on pathway-specific modules, which you can relate to your own practice.

- It offers health, social care and exercise professionals highly flexible continuing professional development (CPD) study opportunities in rehabilitation, with part-time, full-time and mixed mode options (including opportunities for e-learning, blended and distance learning).

- Our teaching team is multiprofessional, promoting interprofessional learning and teaching, and offering excellent opportunities for shared learning.

- All of the course team are experienced practitioners, educators and/or researchers in rehabilitation. They have all published articles and books in the area of rehabilitation, and have presented at key rehabilitation conferences. Many of them have reputations for excellence and have established links with colleagues, organisations and institutions at national and international level.

- The faculty has a strong research profile, with experienced researchers working in established areas of cancer care, children and families, drug and alcohol, physical rehabilitation and enablement, and interprofessional education and collaborative practice. The programme links with the Centre for Rehabilitation at Oxford Brookes University which is renowned for its research in to movement science.

- Oxford Brookes is a student-centred institution that is fully committed to each individual being supported to achieve their potential. To support this, we offer a broad range of student support schemes to facilitate learning and development.

- We have an excellent track record of high levels of student satisfaction, low student attrition rates and high employability.

Please note: this course also has a start date in September and January. There are opportunities to take individual modules as well as a longer award.

Teaching and learning

Teaching, learning and assessment strategies are intended to promote an interprofessional, patient-centred and practice-focused approach to rehabilitation.

Opportunities for interprofessional learning - sharing existing and developing skills, knowledge and experience - are maximised. All teaching, learning experiences and specific assessments is focused on the individual and their rehabilitation programme. If you are not in practice, or not from a health care background, the sharing of knowledge and experience can be of particular value. To make the most of the range of experience, skills and knowledge within the group, a variety of teaching and learning strategies will be employed.

Assessment methods used within the course are varied; they are designed to be stimulating as well as academically rigorous, and are based on your learning needs, individual aims, content, and the academic standards expected for the course. Assessment is based on coursework consisting of academic and reflective essays and case studies.

The course team is committed to providing flexibility, and is exploring ways of offering blended-learning approaches.

Examples of pathways

- Physiotherapist taking the Functional Stroke module to develop their skills and knowledge around exercise and stroke.

- Occupational Therapist taking the Paediatric Pathway working in rehabilitation wanting to develop their expertise and knowledge around children.

- Rehabilitation professionals working with adults and children with neurological disorders taking the paediatric disability module.

- Specialist MS nurse practitioner taking the Long Term Chronic Illness module and then crediting that towards the MSc Neurological Rehabilitation.

- Exercise professional working in a gym taking the Exercise Prescription Module to obtain REPS 4 accreditation.

Careers

This course helps you to develop your own professional practice, enabling you to deal with rehabilitation issues using a critical problem-solving approach based on research and theoretical perspectives and models. This might enable you to move more into a leadership role or a specialist role. Students who have graduated from the course have changed their jobs, for example going into rehabilitation leadership roles or specialist type roles, moving into specialist rehabilitation units or settings, or moving into education or research-type roles.

Free language courses for students - the Open Module

Free language courses are available to full-time undergraduate and postgraduate students on many of our courses, and can be taken as a credit on some courses.

Please note that the free language courses are not available if you are:
- studying at a Brookes partner college
- studying on any of our teacher education courses or postgraduate education courses.

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Neuroscience is a discipline concerned with the scientific study of the nervous system in health and disease. Research in the neurosciences is of considerable clinical impact considering the debilitating and costly effects of neurological and psychiatric disease. Read more
Neuroscience is a discipline concerned with the scientific study of the nervous system in health and disease. Research in the neurosciences is of considerable clinical impact considering the debilitating and costly effects of neurological and psychiatric disease. In this regard, a major goal of modern neuroscience research is to elucidate the underlying causes (genetic or environmental) of major brain diseases, and to produce more effective treatments for major psychiatric disorders such as schizophrenia and depression, and neurological disorders such as multiple sclerosis, Parkinson's disease, Alzheimer's disease, motor neurone disease and epilepsy. Improved treatment strategies for brain disorders relies entirely on increased understanding gained from research which integrates molecular, cellular and clinical aspects of disease. In this regard it is clear that interdisciplinary approaches are necessary to understand the complex processes which underlie brain function in health and disease. This interdisciplinary philosophy is adopted in the delivery of our M.Sc. programme in Neuroscience, which is underpinned by the diverse research expertise available within Trinity College Institute of Neuroscience (TCIN).

Course Content:

This one-year M.Sc. course aims to provide a multidisciplinary training in the neurosciences, in topics ranging from molecular to behavioural. The course is ideal for students wishing to extend their specialised knowledge, and for those wishing to convert from their original degree discipline. The programme will equip participants with the skills necessary to progress into a career in biomedical, pharmaceutical or neuropsychological research. Instruction for the course consists of approximately 200 contact hours over two academic Terms to include lectures, laboratory practical sessions, journal club workshops and student-based seminars. Modules are assessed by a mixture of in course assessment and written examinations.

Specialist modules covered include:

Form and Function of the Nervous System, Biochemical Basis of Neuropharmacology, Neuropharmacology, Drug Development, Advanced Neuroimmunology, Experimental Neuroscience, Scientific Literature Skills, Neural Engineering, Neuroimaging Technology, Current Topics in Neuroscience, Cellular Neuroscience, and Research Skills.

The third Term consists of a research project on novel aspects of Neuroscience. Trinity College Institute of Neuroscience is a dynamic research environment with research spanning molecular/cellular neuroscience to clinical/translational neuroscience. Projects across these research areas may be undertaken in consultation with an expert supervisor. For students interested in a project in cellular/molecular neuroscience a range of cellular techniques such as tissue culture, immunocytochemistry, western immunobloting and immunoprecipitation, confocal microscopy, Immunoassays, flow cytometry, Real-time PCR, and high performance liquid chromatography are available. In addition, some projects will involve assessing behavioural, electrophysiological and neurochemical endpoints using in vivo models of neurological and psychiatric disease. For those with an interest in experimentation on human subjects, projects will be offered utilizing techniques such as functional magnetic resonance imaging and neurocognitive testing. A selection of national and international projects is also available, which involve collaboration with other academic institutes and pharmaceutical companies, in Ireland, UK and across Europe.

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Students will study at the world-renowned Queen Square, and will be taught by internationally recognised experts in the field. Students have the opportunity to interact freely with our neurologists, and undertake a specialist attachment during the second six months of their programme. Read more

Students will study at the world-renowned Queen Square, and will be taught by internationally recognised experts in the field. Students have the opportunity to interact freely with our neurologists, and undertake a specialist attachment during the second six months of their programme.

About this degree

Students gain knowledge of the clinical features and scientific basis of the following neurological areas and disorders: nerve and muscle; epilepsy; pain; movement disorders and Parkinson's disease; neuro-otology and neuro-ophthalmology; stroke; neuropsychiatry and cognition; infections of the nervous system; multiple sclerosis and neuroimmunology; autonomic function and neuro-urology; neuro-oncology and ITU neurology.

Students undertake modules to the value of 180 credits.

The programme consists of five core modules (105 credits), one optional module (15 credits) and a research project (60 credits).

A Postgraduate Diploma (full-time six months is offered).

Core modules

  • Epilepsy, Pain, Tumours and Special Senses
  • Motor Systems and Disease
  • Higher Functions of the Brain
  • Practical Neurology
  • Theoretical Neurology

Optional modules include

Students can choose one 15-credit module from the available options below:

  • Clinical Neuroscience of Neurodegenerative Diseases
  • Skeletal Muscle and Associated Diseases
  • Peripheral Nerves and Associated Diseases
  • Clinical Manifestations of Stroke
  • Treatment (HASU and Service Delivery)
  • Neurorehabilitation

Dissertation/report

All MSc students undertake an independent research project, which takes the form of a scientific investigation and culminates in a dissertation of 10,000 words.

Teaching and learning

The programme is delivered through lectures, seminars, clinical teaching (including outpatients, inpatients, workshops, training for history taking and clinical examination and case demonstrations). Assessment is through written examination, MCQ, short case clinical examination, viva voce, continuous assessment and the research dissertation.

Placement

Students are offered the opportunity to undertake a clinical attachment with one or two consultants at the National Hospital for Neurology and Neurosurgery from April to September each year.

International Students will bear any costs incurred in acquiring certification equivalent to DBS in their home country.

Further information on modules and degree structure is available on the department website: Clinical Neurology MSc

Careers

This programme provides an excellent basis for a clinical or research career in clinical neurology and related disciplines. 

Recent career destinations for this degree

  • Doctor, Government of Cameroon
  • Doctor, Indraprastha Apollo Hospital
  • Specialist Registrar in Neurology, Tikrit Teaching Hospital
  • Neurologist, National Hospital for Neurology and Neurosurgery (NHS)
  • Neurology Resident, University of Missouri

Employability

For students starting out on their clinical careers the programme will give them skills and experience to move towards specialist training. For more established clinicians it is an opportunity to refresh and refine their clinical practice. All students benefit from exposure to the scientific underpinning of neurology, and the opportunity to undertake an original research project, and a specialist attachment, studying alongside the internationally renowned neurologists at Queen Square.

Careers data is taken from the ‘Destinations of Leavers from Higher Education’ survey undertaken by HESA looking at the destinations of UK and EU students in the 2013–2015 graduating cohorts six months after graduation.

Why study this degree at UCL?

The mission of the UCL Institute of Neurology is to carry out high-quality research, teaching and training in basic and clinical neurosciences. Together with our associated hospital, the National Hospital for Neurology and Neurosurgery, we form the world-renowned Queen Square and promote the translation of research that is of direct clinical relevance to improved patient care and treatment.

Students are given the opportunity to experience the full range of activities of a world-famous specialist hospital.

Research Excellence Framework (REF)

The Research Excellence Framework, or REF, is the system for assessing the quality of research in UK higher education institutions. The 2014 REF was carried out by the UK's higher education funding bodies, and the results used to allocate research funding from 2015/16.

The following REF score was awarded to the department: Institute of Neurology

83% rated 4* (‘world-leading’) or 3* (‘internationally excellent’)

Learn more about the scope of UCL's research, and browse case studies, on our Research Impact website.



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Changing demographics and growing demand for food, fuel and agricultural and environmental sustainability are among the key challenges the world faces today. Read more

Changing demographics and growing demand for food, fuel and agricultural and environmental sustainability are among the key challenges the world faces today.

In this MSc you will learn research and development skills to enable the creation of new products and services. You will investigate the economic basis for current biotechnology structures and areas of future demand, including the global pharmaceutical industry and carbon sequestration.

You will learn how technology can be applied to solve pressing real-world biological problems and gain the skills and expertise needed for future developments in biotechnology.

Programme structure

This programme consists of two semesters of taught courses followed by a research project or industrial placement, leading to a dissertation.

Compulsory courses:

  • Economics and Innovation in the Biotechnology Industry
  • Intelligent Agriculture
  • Principles of Industrial Biotechnology
  • Research Project Proposal
  • MSc Dissertation (Biotechnology).

Option courses:

  • Biobusiness
  • Biochemistry A & B
  • Bioinformatics
  • Bioinformatics Programming & System Management
  • Drug Discovery
  • Commercial Aspects of Drug Discovery
  • Environmental Gene-Mining and Metagenomics
  • Enzymology and Biological Production
  • Gene Expression and Microbial Regulation
  • Industry & Entrepreneurship in Biotechnology
  • Molecular Modelling and Database Mining
  • Practical Skills in Biochemistry A & B
  • Programming for the Life Sciences
  • Social Dimensions of Systems and Synthetic Biology
  • Stem Cells and Regenerative Medicine
  • Vaccines and Molecular Therapies

Research and laboratory work

There will be a considerable practical element to the programme. You will work in a biotechnology laboratory and learn how experimental technology is designed and operated.

Industrial placement

Your dissertation can be based on a laboratory-based project or an industrial placement. You can work with employers in the thriving Scottish biotechnology sector in areas such as multiple sclerosis research (Aquila BioMedical), vaccines research (BigDNA) or biorecovery and bioregeneration (Recyclatec).

Career opportunities

The programme will open up a wide variety of career opportunities, ranging from sales and marketing, to research and development, to manufacturing and quality control and assurance.



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This programme will provide a world-class education for advanced training in translational research, from preclinical discovery through to first-time-in-man studies in human and clinical trials in healthy volunteers and patients across neurology and neurodegeneration. Read more

This programme will provide a world-class education for advanced training in translational research, from preclinical discovery through to first-time-in-man studies in human and clinical trials in healthy volunteers and patients across neurology and neurodegeneration.

About this degree

The programme combines theoretical and practical teaching on both the breadth of, and complexity in conducting clinical research. Topics include clinical pharmacology, pharmacokinetics, research governance, statistics and the fundamental principle for using the correct enabling technologies within the context of medical research and drug development.

Students undertake modules to the value of 180 credits.

The programme consists of three core modules (60 credits), and a dissertation/report (120 credits).

Core modules

  • Research Integrity & Governance (15 credits)
  • Experimental Neurology (30 credits)
  • Research Methods, including Critical Appraisal, and Introduction to Statistics (15 credits)
  • Translational Neurology MRes Research Project (120 credits)

Optional modules

There are no optional modules for this programme.

Dissertation/report

All students undertake a research project which culminates in a dissertation of 15,000 words.

Teaching and learning

The programme will combine lectures, workshops and tutorials. Practicals will focus on the role of surrogate markers and emerging technologies in drug development e.g. preclinical discovery, first-time-in-man studies, and early phase clinical trials in healthy volunteers and patients. Assessment is through short answer unseen examinations, coursework and presentations..

Further information on modules and degree structure is available on the department website: Translational Neurology MRes

Careers

The programme is designed to cater to graduates in medicine and biomedical sciences who wish to gain valuable training in clinical research before embarking on a clinical PhD programme, medical training, or professional work in clinical trials. The successful completion of the MRes may also enhance opportunities for graduates to enter medical school or for MBBS graduates to progress to specialist medical training.

Employability

Whatever your chosen career pathway, the MRes in Translational Neurology will equip graduates to either get a first step on the ladder, change career directions or help them become more experienced with a specific expertise.

Why study this degree at UCL?

The programme is delivered by the UCL Institute of Neurology, a specialist postgraduate institute and a worldwide centre of excellence in clinical research across neurological diseases, including movement disorders (e.g. Parkinson’s disease), multiple sclerosis, neuro-inflammation, epilepsy, stroke, cognitive dysfunction, Alzheimer’s disease and other dementias.

Students will be taught by experts in the field and have the opportunity to network with internationally recognised opinion leaders in neurology and neurodegeneration.



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Neurophysiology is concerned with the investigation of function in the central and peripheral nervous system. Read more
Neurophysiology is concerned with the investigation of function in the central and peripheral nervous system. Clinicians specialising in neurophysiology investigate the function of the nervous system to diagnose and monitor disorders, including epilepsy, strokes, dementia, nerve and muscle dysfunction and multiple sclerosis among others.

You will develop practical skills to carry out experimental research and the critical evaluation and analysis skills required for literature reviews; assessing essential facts, concepts, principles and theories; legal requirements for human experiments and ethical issues relating to research with human subjects and human tissue relevant to your research.

Skills Lab - we provide students with a designated skills lab for multi-disciplinary clinical physiology run by practitioners. We have ECG machines, EMG (nerve and muscle testing), EEG, audiology (brain-stem potentials), stress and fitness testing all based in our bespoke science centre. The lab will be used as part of the taught sessions but students will be able to use it for independent study and research with the support of specialist technicians.

Unique module on 'leadership and management' - provides students with these essential skills that sit alongside clinical requirements which make the difference to career progression from practitioner to chief or principle neurophysiologist. You will be able to understand and apply the principles of leadership and management, health and safety, quality control, research and statistical methods in your professional life.

Cutting edge research - the research that is conducted at Middlesex impacts on how diagnostics are implemented in practice. What we teach will guide students into research directions which in the short term will have an impact on the way data is interpreted and diagnostics are implemented.

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Clinical neuropsychology is a specialty discipline within psychology which is focused on the associations between the brain and neuropsychological functions, including cognition, emotion and behaviour. Read more
Clinical neuropsychology is a specialty discipline within psychology which is focused on the associations between the brain and neuropsychological functions, including cognition, emotion and behaviour. Clinical neuropsychology is particularly interested in the effects of brain disorders and other clinical conditions affecting the brain on these functions.

Disorders and conditions comprise acquired or congenital neurological and neuropsychiatric conditions in children, adolescents and adults, such as ADHD, autism, stroke, brain tumor, traumatic brain injury, epilepsy, Alzheimer's disease, Parkinson's disease, multiple sclerosis, drug abuse, schizophrenia, bipolar disorder, depression, etc.

Clinical neuropsychologists can be involved in both the assessment and treatment of people with brain disorders in various applied and often clinical settings, but also in patient related research. Methods used in the field of clinical neuropsychology are neuropsychological tests, neuroimaging and electrophysiological techniques.

With the aging population, the number of people with neuropsychological disorders increases and with this also the demand for well trained clinical neuropsychologists.

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