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Masters Degrees (Mitochondria)

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The aims of the MRC Mitochondrial Biology Unit are to study the biology of the mitochondria, the powerhouses of the cell. Read more

Overview

The aims of the MRC Mitochondrial Biology Unit are to study the biology of the mitochondria, the powerhouses of the cell. There is a growing realisation that the dysfunction of various aspects of mitochondrial biology are connected to major neurodegenerative diseases including Parkinson's and Alzheimer's, and that as the major source of reactive oxygen species, the mitochondrion is likely also to be involved in ageing. Therefore, the Unit is developing its interests in the cell biology of mitochondria and is linking its activities to clinical science.

See the website http://www.graduate.study.cam.ac.uk/courses/directory/blmbmpbsc

Learning Outcomes

For students wishing to continue on to the PhD, the MPhil provides a good foundation. For students not wishing to continue, the MPhil provides specialist training in scientific methodology relevant to the project subject area and based on the expertise of the supervisor and research group.

Teaching

MPhil is by research. The MBU has a programme of seminars and lectures delivered by visiting speakers and members of the Unit. Journal classes are Journal Clubs, organised by the Unit's graduate students and postdoctoral scientists.

- Feedback
Feedback is given both formally and informally on a regular basis by the supervisor and/or adviser. Regular reports are provided by the supervisor via the University's online reporting system.

Assessment

- Thesis
MPhil (research): Examination is by thesis.
The scheme of examination for the one-year full-time or two-year part-time course of study in Biological Science for the degree of Master of Philosophy shall consist of a thesis, of not more than 20,000 words in length, exclusive of tables, footnotes, bibliography, and appendices, on a subject approved by the Degree Committee for the Faculty of Biology. The examination shall include an oral examination on the thesis and on the general field of knowledge within which it falls. The thesis shall provide evidence to satisfy the Examiners that a candidate can design and carry out an original investigation, assess and interpret the results obtained, and place the work in the wider perspective of the subject.

Funding Opportunities

There are no specific funding opportunities advertised for this course. For information on more general funding opportunities, please follow the link below.

General Funding Opportunities http://www.graduate.study.cam.ac.uk/finance/funding

Find out how to apply here http://www.graduate.study.cam.ac.uk/courses/directory/blmbmpbsc/apply

See the website http://www.graduate.study.cam.ac.uk/courses/directory/blmbmpbsc

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The aims of the MRC Mitochondrial Biology Unit are to study the biology of the mitochondria, the powerhouses of the cell. Read more
The aims of the MRC Mitochondrial Biology Unit are to study the biology of the mitochondria, the powerhouses of the cell. There is a growing realisation that the dysfunction of various aspects of mitochondrial biology are connected to major neurodegenerative diseases including Parkinson's and Alzheimer's, and that as the major source of reactive oxygen species, the mitochondrion is likely also to be involved in ageing. Therefore, the Unit is developing its interests in the cell biology of mitochondria and is linking its activities to clinical science.

Visit the website: http://www.graduate.study.cam.ac.uk/courses/directory/blmbmpbsc

Course detail

This MPhil is by research. The MBU has a programme of seminars and lectures delivered by visiting speakers and members of the Unit. Journal classes are Journal Clubs, organised by the Unit's graduate students and postdoctoral scientists.

- One to one supervision: 4 hours per week
- Seminars & classes : 2 hours per week
- Lectures: 1 hour per week
- Journal clubs: 2 hours per week

Assessment

The scheme of examination for the one-year full-time or two-year part-time course of study in Biological Science for the degree of Master of Philosophy shall consist of a thesis, of not more than 20,000 words in length, exclusive of tables, footnotes, bibliography, and appendices, on a subject approved by the Degree Committee for the Faculty of Biology. The examination shall include an oral examination on the thesis and on the general field of knowledge within which it falls. The thesis shall provide evidence to satisfy the Examiners that a candidate can design and carry out an original investigation, assess and interpret the results obtained, and place the work in the wider perspective of the subject.

Continuing

For students wishing to continue on to the PhD, the MPhil provides a good foundation. For students not wishing to continue, the MPhil provides specialist training in scientific methodology relevant to the project subject area and based on the expertise of the supervisor and research group.

How to apply: http://www.graduate.study.cam.ac.uk/applying

Funding Opportunities

There are no specific funding opportunities advertised for this course. For information on more general funding opportunities, please follow the link below.

General Funding Opportunities http://www.2016.graduate.study.cam.ac.uk/finance/funding

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We have a strong international reputation for making original contributions to Bayesian methodology, bioinformatics and biostatistics. Read more
We have a strong international reputation for making original contributions to Bayesian methodology, bioinformatics and biostatistics. We invite postgraduate research proposals in any of these three areas.

As a research postgraduate in the School of Mathematics and Statistics you will be supported by a team of experts in your chosen field. You will also have the opportunity to develop and enhance your skill set through appropriate research training.

To help you identify a topic and potential supervisor, we encourage you to find out more about our staff specialisms and read about the PhD projects undertaken by some of our recent postgraduate students. A list of example statistical projects currently offered is also available.

As a PhD student you will be supported by team supervision. You will also go through a research training analysis to identify any skills that you need to develop.

Attendance is flexible and agreed between you and your supervisors depending on the requirements of your research project. You are expected to undertake 40 hours of work per week, with an annual holiday entitlement of 35 days (including statutory and bank holidays).

Research areas

We have broad research interests covering applied and medical statistics, and a lively seminar programme.

Our work breaks down into the following research groups:
-Bayesian statistics
-Biostatistics
-Statistical bioinformatics and stochastic systems biology

Research funding

We undertake projects funded by the Research Councils, major trusts, government departments and the EU. Since 2008, members of the School have been named on over £16m of research awards. Many of these awards were for large interdisciplinary projects, in which the School played a vital role, including:
-A £5.5m Engineering and Physical Sciences Research Council grant to explore the potential of microorganisms to provide clean water
-A £1.5m European Commission project to study eukaryotic genomic origins, parasites, and the essential nature of mitochondria
-A £2.1m Medical Research Council funded project on ways to advance health and wellbeing in later life

In total, £3.5m of funding was attributed to the School.

Facilities

We are located in the Herschel building which has well-equipped seminar and meeting rooms. You will have access to online research facilities via your own desktop PC in a shared postgraduate work space. There is also a teaching cluster (of about 150 PCs) within the School. Computing support is provided by two specialist technical staff who are expert in providing assistance with fast numerical and distributed processing.

As well as the library resources provided by the main Robinson Library, you will have access to the School's mathematics and statistics library and reading room.

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The Institute of Genetic Medicine brings together a strong team with an interest in clinical and developmental genetics. Our research focuses on the causes of genetic disease at the molecular and cellular level and its treatment. Read more
The Institute of Genetic Medicine brings together a strong team with an interest in clinical and developmental genetics. Our research focuses on the causes of genetic disease at the molecular and cellular level and its treatment. Research areas include: genetic medicine, developmental genetics, neuromuscular and neurological genetics, mitochondrial genetics and cardiovascular genetics.

As a research postgraduate in the Institute of Genetic Medicine you will be a member of our thriving research community. The Institute is located in Newcastle’s Life Science Centre. You will work alongside a number of research, clinical and educational organisations, including the Northern Genetics Service.

We offer supervision for MPhil in the following research areas:

Cancer genetics and genome instability

Our research includes:
-A major clinical trial for chemoprevention of colon cancer
-Genetic analyses of neuroblastoma susceptibility
-Research into Wilms Tumour (a childhood kidney cancer)
-Studies on cell cycle regulation and genome instability

Cardiovascular genetics and development

We use techniques of high-throughput genetic analyses to identify mechanisms where genetic variability between individuals contributes to the risk of developing cardiovascular disease. We also use mouse, zebrafish and stem cell models to understand the ways in which particular gene families' genetic and environmental factors are involved in the normal and abnormal development of the heart and blood vessels.

Complex disease and quantitative genetics

We work on large-scale studies into the genetic basis of common diseases with complex genetic causes, for example autoimmune disease, complex cardiovascular traits and renal disorders. We are also developing novel statistical methods and tools for analysing this genetic data.

Developmental genetics

We study genes known (or suspected to be) involved in malformations found in newborn babies. These include genes involved in normal and abnormal development of the face, brain, heart, muscle and kidney system. Our research includes the use of knockout mice and zebrafish as laboratory models.

Gene expression and regulation in normal development and disease

We research how gene expression is controlled during development and misregulated in diseases, including the roles of transcription factors, RNA binding proteins and the signalling pathways that control these. We conduct studies of early human brain development, including gene expression analysis, primary cell culture models, and 3D visualisation and modelling.

Genetics of neurological disorders

Our research includes:
-The identification of genes that in isolation can cause neurological disorders
-Molecular mechanisms and treatment of neurometabolic disease
-Complex genetics of common neurological disorders including Parkinson's disease and Alzheimer's disease
-The genetics of epilepsy

Kidney genetics and development

Kidney research focuses on:
-Atypical haemolytic uraemic syndrome (aHUS)
-Vesicoureteric reflux (VUR)
-Cystic renal disease
-Nephrolithiasis to study renal genetics

The discovery that aHUS is a disease of complement dysregulation has led to a specific interest in complement genetics.

Mitochondrial disease

Our research includes:
-Investigation of the role of mitochondria in human disease
-Nuclear-mitochondrial interactions in disease
-The inheritance of mitochondrial DNA heteroplasmy
-Mitochondrial function in stem cells

Neuromuscular genetics

The Neuromuscular Research Group has a series of basic research programmes looking at the function of novel muscle proteins and their roles in pathogenesis. Recently developed translational research programmes are seeking therapeutic targets for various muscle diseases.

Stem cell biology

We research human embryonic stem (ES) cells, germline stem cells and somatic stem cells. ES cell research is aimed at understanding stem cell pluripotency, self-renewal, survival and epigenetic control of differentiation and development. This includes the functional analysis of genes involved in germline stem cell proliferation and differentiation. Somatic stem cell projects include programmes on umbilical cord blood stem cells, haematopoietic progenitors, and limbal stem cells.

Pharmacy

Our new School of Pharmacy has scientists and clinicians working together on all aspects of pharmaceutical sciences and clinical pharmacy.

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