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Masters Degrees (Methylation)

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The MSc Molecular Genetics course aims to provide instruction in current concepts and techniques of molecular genetics as applied in modern research. Read more
The MSc Molecular Genetics course aims to provide instruction in current concepts and techniques of molecular genetics as applied in modern research. The MSc offers practical experience of experimental techniques and provides a framework to develop skills to plan research and devise strategies to achieve specific goals. The MSc acts as a springboard for graduates who want employment in molecular, biomedical or biotechnological research, or for entry to PhD programmes.

The MSc was established in 1988 and has been developed over the years to reflect the research strengths within the Faculty. Our students find the course to be demanding and challenging but also exciting, stimulating and rewarding.

The MSc consists of 180 course credits and is split into two phases:
Taught Phase 60 credits September - January
Research Project 120 credits January - August

Taught Phase
The taught phase is based around a series of taught practical experiments that introduce a variety of modern molecular techniques and research strategies. The experiments are run Tuesday-Friday of each week in the period September-December, with the Monday being reserved for a supporting lecture programme. The practical experiments are intensive and are used to help students develop analytical and reasoning skills as well as to learn how to plan and execute experimental investigations. There are some weeks set aside for students to complete written assignments and prepare for exams.

Research Project
For the research project students become part of an active research group and choose from a broad range of projects offered by departments of the Faculty of Medicine and Biological Sciences, the MRC Toxicology Unit, or collaborating research institutes or industrial partners (when available). The spread of projects covers a wide variety of disciplines involving molecular genetics and a variety of organisms.

Below are examples of project titles from a previous year:

• Molecular engineering of novel ligands with therapeutic potential

• Detection of oxidative damage to DNA in specific gene sequences

• Analyzing human disease genes in yeast

• Single molecule methods for watching the assembly of splicing complexes

• Secretory protein expression in pancreatic β-cells

• The iron responsive regulatory system of Campylobacter jejuni

• Non-recombining segments of the human genome as tools to study evolutionary history

• Analysis of telomere length dynamics in mice that lack telomerase by the amplification of single mouse telomeres.

• Molecular mechanisms underlying antisense-RNA mediated CpG island methylation in mammalian cells

• Mutations in the LMNA Gene in Emery Dreyfuss Muscular Dystrophy – consequences for in vitro differentiation of muscle cell cultures

• Alternative lengthening of telomeres in chronic lymphocytic leukaemia

Assessment of the research project is based on:
• Research performance (60 credits)
• A written report on the research (50 credits)
• A research seminar (10 credits).

Students submit the project report in August and the research seminars are held near the end of August.

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The only Master’s specialisation in the Netherlands covering the function of our epigenome, a key factor in regulating gene expression and in a wide range of diseases. Read more

Master's specialisation in Medical Epigenomics

The only Master’s specialisation in the Netherlands covering the function of our epigenome, a key factor in regulating gene expression and in a wide range of diseases.
Our skin cells, liver cells and blood cells all contain the same genetic information. Yet these are different types of cells, each performing their own specific tasks. How is this possible? The explanation lies in the epigenome: a heritable, cell-type specific set of chromosomal modifications, which regulates gene expression. Radboud University is specialised in studying the epigenome and is the only university in the Netherlands to offer a Master’s programme in this field of research.

Health and disease

The epigenome consists of small and reversible chemical modifications of the DNA or histone proteins, such as methylation, acetylation and phosphorylation. It changes the spatial structure of DNA, resulting in gene activation or repression. These processes are crucial for our health and also play a role in many diseases, like autoimmune diseases, cancer and neurological disorders. As opposed to modifications of the genome sequence itself, epigenetic modifications are reversible. You can therefore imagine the great potential of drugs that target epigenetic enzymes, so-called epi-drugs.

Big data

In this specialisation, you’ll look at a cell as one big and complex system. You’ll study epigenetic mechanisms during development and disease from different angles. This includes studying DNA and RNA by next-generation sequencing (epigenomics) and analysing proteins by mass spectrometry (proteomics). In addition, you‘ll be trained to design computational strategies that allow the integration of these multifaceted, high-throughput data sets into one system.

Why study Medical Epigenomics at Radboud University?

- Radboud University combines various state-of-the-art technologies – such as quantitative mass spectrometry and next-generation DNA sequencing – with downstream bioinformatics analyses in one department. This is unique in Europe.
- This programme allows you to work with researchers from the Radboud Institute for Molecular Life sciences (RIMLS), one of the leading multidisciplinary research institutes within this field of study worldwide.
- We have close contacts with high-profile medically oriented groups on the Radboud campus and with international institutes (EMBL, Max-Planck, Marie Curie, Cambridge, US-based labs, etc). As a Master’s student, you can choose to perform an internship in one of these related departments.
- Radboud University coordinates BLUEPRINT, a 30 million Euro European project focusing on the epigenomics of leukaemia. Master’s students have the opportunity to participate in this project.

Career prospects

As a Master’s student of Medical Epigenomics you’re trained in using state-of-the art technology in combination with biological software tools to study complete networks in cells in an unbiased manner. For example, you’ll know how to study the effects of drugs in the human body.
When you enter the job market, you’ll have:
- A thorough background of epigenetic mechanisms in health and disease, which is highly relevant in strongly rising field of epi-drug development
- Extensive and partly hands-on experience in state-of-the-art ‘omics’ technologies: next-generation sequencing, quantitative mass spectrometry and single cell technologies;
- Extensive expertise in designing, executing and interpreting scientific experiments in data-driven research;
- The computational skills needed to analyse large ‘omics’ datasets.

With this background, you can become a researcher at a:
- University or research institute;
- Pharmaceutical company, such as Synthon or Johnson & Johnson;
- Food company, like Danone or Unilever;
- Start-up company making use of -omics technology.

Apart from research into genomics and epigenomics, you could also work on topics such as miniaturising workflows, improving experimental devices, the interface between biology and informatics, medicine from a systems approach.

Or you can become a:
- Biological or medical consultant;
- Biology teacher;
- Policy coordinator, regarding genetic or medical issues;
- Patent attorney;
- Clinical research associate;

PhD positions at Radboud University

Each year, the Molecular Biology department (Prof. Henk Stunnenberg, Prof. Michiel Vermeulen) and the Molecular Developmental Biology department (Prof. Gert-Jan Veenstra) at the RIMLS offer between five and ten PhD positions. Of course, many graduates also apply for a PhD position at related departments in the Netherlands, or abroad.

Our approach to this field

- Systems biology
In the Medical Epigenomics specialisation you won’t zoom in on only one particular gene, protein or signalling pathway. Instead, you’ll regard the cell as one complete system. This comprehensive view allows you to, for example, model the impact of one particular epigenetic mutation on various parts and functions of the cell, or study the effects of a drug in an unbiased manner. One of the challenges of this systems biology approach is the processing and integration of large amounts of data. That’s why you’ll also be trained in computational biology. Once graduated, this will be a great advantage: you’ll be able to bridge the gap between biology, technology and informatics , and thus have a profile that is desperately needed in modern, data-driven biology.

- Multiple OMICS approaches
Studying cells in a systems biology approach means connecting processes at the level of the genome (genomics), epigenome (epigenomics), transcriptome (transcriptomics), proteome (proteomics), etc. In the Medical Epigenomics specialisation, you’ll get acquainted with all these different fields of study.

- Patient and animal samples
Numerous genetic diseases are not caused by genetic mutations, but by epigenetic mutations that influence the structure and function of chromatin. Think of:
- Autoimmune diseases, like rheumatoid arthritis and lupus
- Cancer, in the forms of leukaemia, colon cancer, prostate cancer and cervical cancer
- Neurological disorders, like Rett Syndrome, Alzheimer, Parkinson, Multiple Sclerosis, schizophrenia and autism

We investigate these diseases on a cellular level, focusing on the epigenetic mutations and the impact on various pathways in the cell. You’ll get the chance to participate in that research, and work with embryonic stem cell, patient, Xenopus or zebra fish samples.

See the website http://www.ru.nl/masters/medicalbiology/epigenomics

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