We invite postgraduate research proposals in a number of disease areas that impact significantly on patient care. We focus on exploring the mechanisms of disease, understanding the ways disease impacts patients’ lives, utilising new diagnostic and therapeutic techniques and developing new treatments.
As a student you will be registered with a University research institute, for many this is the Institute for Cellular Medicine (ICM). You will be supported in your studies through a structured programme of supervision and training via our Faculty of Medical Sciences Graduate School.
We undertake the following areas of research and offer MPhil, PhD and MD supervision in:
Newcastle hosts one of the most comprehensive organ transplant programmes in the world. This clinical expertise has developed in parallel with the applied immunobiology and transplantation research group. We are investigating aspects of the immunology of autoimmune diseases and cancer therapy, in addition to transplant rejection. We have themes to understand the interplay of the inflammatory and anti-inflammatory responses by a variety of pathways, and how these can be manipulated for therapeutic purposes. Further research theme focusses on primary immunodeficiency diseases.
There is strong emphasis on the integration of clinical investigation with basic science. Our research include:
We also research the effects of UVR on the skin including mitochondrial DNA damage as a UV biomarker.
This area emphasises on translational research, linking clinical- and laboratory-based science. Key research include:
Focus is on applied research and aims to underpin future clinical applications. Technology-oriented and demand-driven research is conducted which relates directly to health priority areas such as:
This research is sustained through extensive internal and external collaborations with leading UK and European academic and industrial groups, and has the ultimate goal of deploying next-generation diagnostic and therapeutic systems in the hospital and health-care environment.
There is a number of research programmes into the genetics, immunology and physiology of kidney disease and kidney transplantation. We maintain close links between basic scientists and clinicians with many translational programmes of work, from the laboratory to first-in-man and phase III clinical trials. Specific areas:
We have particular interests in:
Novel non-invasive methodologies using magnetic resonance are developed and applied to clinical research. Our research falls into two categories:
Our studies cover a broad range of topics (including diabetes, dementia, neuroscience, hepatology, cardiovascular, neuromuscular disease, metabolism, and respiratory research projects), but have a common theme of MR technical development and its application to clinical research.
We focus on connective tissue diseases in three, overlapping research programmes. These programmes aim to understand:
This research theme links with other local, national and international centres of excellence and has close integration of basic and clinical researchers and hosts the only immunotherapy centre in the UK.
Genetic approaches to the individualisation of drug therapy, including anticoagulants and anti-cancer drugs, and in the genetics of diverse non-Mendelian diseases, from diabetes to periodontal disease, are a focus. A wide range of knowledge and experience in both genetics and clinical sciences is utilised, with access to high-throughput genotyping platforms.
Our scientists and clinicians use in situ cellular technologies and large-scale gene expression profiling to study the normal and pathophysiological remodelling of vascular and uteroplacental tissues. Novel approaches to cellular interactions have been developed using a unique human tissue resource. Our research themes include:
We also have preclinical molecular biology projects in breast cancer research.
We conduct a broad range of research activities into acute and chronic lung diseases. As well as scientific studies into disease mechanisms, there is particular interest in translational medicine approaches to lung disease, studying human lung tissue and cells to explore potential for new treatments. Our current areas of research include:
Our research projects are concerned with the harmful effects of chemicals, including prescribed drugs, and finding ways to prevent and minimise these effects. We are attempting to measure the effects of fairly small amounts of chemicals, to provide ways of giving early warning of the start of harmful effects. We also study the adverse side-effects of medicines, including how conditions such as liver disease and heart disease can develop in people taking medicines for completely different medical conditions. Our current interests include: environmental chemicals and organophosphate pesticides, warfarin, psychiatric drugs and anti-cancer drugs.
Our new School of Pharmacy has scientists and clinicians working together on all aspects of pharmaceutical sciences and clinical pharmacy.
This MRes Cancer Biology course will give you advanced knowledge of cellular systems. You will learn about the pathogenesis of cancer, cardiovascular disease, diabetes and kidney fibrosis, along with an exploration of current approaches to cancer gene therapy and immunotherapy.
Visit us on campus throughout the year, find and register for our next open event on http://www.ntu.ac.uk/pgevents.
The Centre for Inflammation Research (CIR) aims to promote the prevention, diagnosis and treatment of inflammatory diseases through interdisciplinary study of the initiation, regulation and resolution of inflammatory responses and provision of an outstanding environment for research training in the field.
CIR investigators aim to characterise and manipulate key control points in inflammation. We focus on:
We have particular interest in inflammatory diseases of the lung and kidney but the principles derived will have ready application to inflammatory responses in the liver, bowel, bone/joint and skin. There is also increasing development of research in the CIR into the links between inflammation and cancer.
The Centre was formally established in 1998.
Generic training in presentation skills, project management and writing skills is delivered through the University of Edinburgh's transferable skills programme.
The CIR is a multidisciplinary team of research groups under the directorship of Professor John Iredale. The CIR consists of more than 180 researchers, is equipped with state-of-the-art apparatus and is supported by external grant funding. The CIR is now located in the purpose-built Queen's Medical Research Institute along with the centres for Reproductive Biology and Cardiovascular Sciences.
The department of Surgery is headed by Professor O James Garden and has an international profile in surgical research.
Strong research themes include liver injury and regeneration, innate immunity, the role of the macrophage in chronic kidney-graft rejection, foetal liver stem-cell research, cancer inflammation, medical imaging using microbubbles, modification of stress response pathways and aspects of clinical research in hepatobiliary surgery and transplantation.
We cater for our wide range of disciplines with extensive facilities and critical investment in order to create the perfect environment for discovery.