Inflammatory bowel disease (IBD) is characterised by chronic inflammation of the Gastrointestinal (GI) tract. Studies have shown activation of hypoxia-inducible pathways can promote the resolution of inflammatory disease. This occurs, in part, through regulation of autophagy and endoplasmic reticulum (ER)-stress/unfolded protein response (UPR) pathways, and potentially, their co-ordinated action. Not surprisingly, there is considerable interest in harnessing hypoxia-inducible pathways for potential IBD therapies; however this can only be achieved once we fully understand the biological mechanisms.
This clinically-relevant project would look to examine the functional effects of hypoxia on IBD using an in vitro model of IBD and a range of techniques, including mammalian cell culture, immunoblotting and qPCR, confocal microscopy and immunohistochemistry. In particular, it would focus on the importance of UPR and autophagic pathways and how they functionally intersect to resolve hypoxia-induced inflammation in IBD. This model and the research data generated from its will ultimately advance our understanding of the cellular and molecular mechanisms contributing to IBD.
A first degree (at least a 2.1) ideally in biomedical sciences or equivalent discipline with a good fundamental knowledge of cell biology and molecular biology associated techniques.
IELTS score must be at least 6.5 (with not less than 6.0 in each of the four components). Other, equivalent qualifications will be accepted. Full details of the University’s policy are available online.
• Experience of fundamental GLP, record keeping, troubleshooting, data handling and presentation skills
• Competent in basic laboratory skills
• Knowledge of cell biology and analytical techniques
• Good written and oral communication skills
• Strong motivation, with evidence of independent research skills relevant to the project
• Good time management
Prior laboratory experience in mammalian cell culture and molecular biology is desirable
MSc by Research (tuition and bench fees funded)
Applications are invited for a fees-funded MSc by Research available within the School of Life Sciences, Pharmacy and Chemistry, Faculty of Science, Engineering and Computing, Kingston University.
Fee level of sponsorship: UK/EU fee level - international candidates will need to demonstrate that they can fund the difference in fees (if applicable)
Annual stipend: £ NO STIPEND
We are pleased to announce the availability of fees-funded 1 year Masters by Research project for the 2018/19 academic year entitled ‘Understanding bladder smooth muscle repair capacity in healthy and overactive bladders’. The funding, supported by Kingston Hospital Charity, will cover both tuition fees and bench fees (consumables costs). Please note that a stipend to cover living expenses is not included. The project will be co-supervised by Dr Natasha Hill, Associate Professor at Kingston University, and Dr Eduardo Cortes, Consultant Gynaecologist at Kingston Hospital, in collaboration with Dr Graham Knee, Clinical Director of Histopathology at Kingston Hospital.
The project will involve analysis of clinical biopsy samples from healthy and overactive bladders (OABs). OAB is a seriously debilitating condition with a high incidence in the elderly group leading to increased risk of fractures, isolation, and depression. The successful candidate will use qRT-PCR, western blotting, immunohistochemistry and tissue culture to quantify expression of particular splice variants involved in muscle repair and regeneration and perform mechanistic analysis. Full training in relevant techniques will be provided, in addition to training in both research and transferable skills including experiment planning and design, data analysis, presentation and communication. This is an excellent opportunity to develop cell and molecular biology expertise in a clinical setting.
Self-funded Masters by Research projects are also available in other areas within the School, please see our research pages at the link below, and you can contact any member of staff to find out more.
For further details please contact: Dr Natasha Hill, Kingston University, UK.
Email: [email protected]
Applicants will need to have achieved, or be expected to achieve, a good BSc Hons degree in a relevant subject.
English Language: If you are not from an English speaking country, or have not studied at an English university before, you will need to show proof of internet-based IELTS 6.5 overall (or equivalent qualification). For IELTS, you need a minimum score 6.0 in Writing and 5.5 in all other elements. Please see these pages for further information http://www.kingston.ac.uk/international/studying-at-kingston/language-requirements/
Deadline for applications: 30 July, 5 pm
Expected start date: October 2018
Duration: 1 year full-time
Please send the following to [email protected] with the email subject “MScR“
• A completed postgraduate application form
• An academic CV
• Copies of your academic certificates (degree level onwards)
• A covering letter stating why you consider you are suitable for the position (maximum 2 pages A4)
• A copy of your English language qualification, if applicable (see ‘English Language’ above)
References do not need to be included with the application, but will be required for shortlisted applicants.
Please ensure that all required documents are submitted together with your application as we are unable to consider incomplete applications.
You should assume that your application has been unsuccessful if you have not heard from us by 4 weeks after the closing date.