Research in the Division of Genetics and Genomics aims to advance understanding of complex animal systems and the development of improved predictive models through the application of numerical and computational approaches in the analysis, interpretation, modelling and prediction of complex animal systems from the level of the DNA and other molecules, through cellular and gene networks, tissues and organs to whole organisms and interacting populations of organisms.
The biology and traits of interest include: growth and development, body composition, feed efficiency, reproductive performance, responses to infectious disease and inherited diseases.
Research encompasses basic research in bioscience and mathematical biology and strategic research to address grand challenges, e.g. food security.
Research is focussed on, but not restricted to, target species of agricultural importance including cattle, pigs, poultry, sheep; farmed fish such as salmon; and companion animals. The availability of genome sequences and the associated genomics toolkits enable genetics research in these species.
Expertise includes genetics (molecular, quantitative), physiology (neuroendocrinology, immunology), ‘omics (genomics, functional genomics) with particular strengths in mathematical biology (quantitative genetics, epidemiology, bioinformatics, modelling).
The Division has 18 Group Leaders and 4 career track fellows who supervise over 30 postgraduate students.
Studentships are of 3 or 4 years duration and students will be expected to complete a novel piece of research which will advance our understanding of the field. To help them in this goal, students will be assigned a principal and assistant supervisor, both of whom will be active scientists at the Institute. Student progress is monitored in accordance with School Postgraduate (PG) regulations by a PhD thesis committee (which includes an independent external assessor and chair). There is also dedicated secretarial support to assist these committees and the students with regard to University and Institute matters.
All student matters are overseen by the Schools PG studies committee. The Roslin Institute also has a local PG committee and will provide advice and support to students when requested. An active staff:student liaison committee and a social committee, which is headed by our postgraduate liaison officer, provide additional support.
Students are expected to attend a number of generic training courses offered by the Transkills Programme of the University and to participate in regular seminars and laboratory progress meetings. All students will also be expected to present their data at national and international meetings throughout their period of study.
In 2011 The Roslin Institute moved to a new state-of-the-art building on the University of Edinburgh's veterinary campus at Easter Bush. Our facilities include: rodent, bird and livestock animal units and associated lab areas; comprehensive bioinformatic and genomic capability; a range of bioimaging facilities; extensive molecular biology and cell biology labs; café and auditorium where we regularly host workshops and invited speakers.
The University's genomics facility Edinburgh Genomics is closely associated with the Division of Genetics and Genomics and provides access to the latest genomics technologies, including next-generation sequencing, SNP genotyping and microarray platforms (genomics.ed.ac.uk).
In addition to the Edinburgh Compute and Data Facility’s high performance computing resources, The Roslin Institute has two compute farms, including one with 256 GB of RAM, which enable the analysis of complex ‘omics data sets.
The Clinical Genomics MSc for Clinical Geneticists in training is a flagship NHS and St George's University of London partnership delivering bespoke education and training, recognising the unique needs of an expert workforce in the genomics era.
You are only eligible for this course if you have previously studied or are currently studying the Postgraduate Certificate in Interpretation and Clinical Application of Genomic Data (PgCert ICAG).
The use of genomic data is revolutionising the NHS, transforming patient diagnosis and treatment. The MSc Clinical Genomics will equip you with the ability and understanding to interpret genomic data when making clinical management decisions. It will also give you the opportunity to undertake a research project and extend your learning to areas of genomics that are of particular interest to you. The course will provide you with the knowledge, skills and attitudes to disseminate your expert knowledge through the wider medical workforce.
The MSc Clinical Genomics combines:
There is currently a worldwide shortage in graduates qualified in Bioinformatics and the skills to interpret the data that is going to underpin advances in biology and medicine in 21st Century. With the advent of Personalised Medicine, the demand for specialists in Computational Biology and Bioinformatics will further increase. This gives you the opportunity to build your transferable skill set across a range of cutting edge technologies and start building a career in this central facet of modern biology.
Students completing the MSc course in Bioinformatics and Computational Genomics will have the necessary skills and knowledge to undertake research and development in industry (Biotechnology, Pharmaceutical, Diagnostic companies), in medical research centres and in academic institutions worldwide.
Computational, statistical and machine learning methods form an integral part of modern research in Molecular Biology, Cell Biology, Pharmacology, Public Health Care and in Medicine. The past decade has seen enormous progress in the development of molecular and biomedical technologies. Today’s high-throughput array and sequencing techniques produce data in the range of terabytes on a daily basis and new technologies continuously emerge. This will further increase the stream of data available for biomedical research. For this reason analyzing, visualizing and managing this huge amount of data is a challenging task. The Queen’s MSc course in Bioinformatics and Computational Genomics targets these data-driven challenges of modern science. The course is open to graduates in computer science, life sciences, physics or statistics.
The programme will consist of an Introductory short course (two weeks) in Cell Biology, followed by modules in:
• Genomics & Genetics
• Analysis of Gene Expression
• Scientific Programming & Statistical Computing
• Algorithmic Biology
• Statistical Biology
• Bioimaging Informatics
• Research project : MSc dissertation
The Genomic Medicine and Healthcare course has been developed for healthcare professionals including Specialist Medical Practitioners, General Medical Practitioners, Allied Health Professionals, Nurses and Midwives, Genetic Counsellors and those with related undergraduate degrees or equivalent professional qualifications and background experience. It will be of interest to health professionals in the UK and internationally and will provide a solid foundation in the core concepts of genetics and genomics applied to modern medicine and healthcare. Although there are other courses covering the subject area, none are completely online so they are difficult and costly for global healthcare professionals to get involved. This course will reach an international audience in a cost effective, flexible and inclusive way, helping to develop a worldwide network of genomic medical and healthcare leaders.
Our course is well timed given increasing public and professional interests in genetic and genome-level diagnostic and predictive testing for clinical management, disease risk evaluation, prevention of major complications and offering the prospect of improved prognosis. Personalised benefits include the option for reproductive choices and reducing lifetime medical or health risks by judicious use of new emerging preventive medicines and devices combined with lifestyle/behaviour modifications.
Our online 1 year Postgraduate Diploma in Genomic Medicine & Healthcare is designed to be practical and clinically focused. The course will provide an integrated approach to Genomic Medicine and Healthcare and focus on applying scientific principles to direct patient care. The Genomics Diploma course is worth 120 credits and comprises 6 modules of 20 credits each.
The Diploma course aims to equip graduates with critical knowledge and understanding of genomics medicine. Graduates will be able to apply knowledge for direct clinical benefit and future study. Our Genomics Medicine Diploma course caters to the educational needs of a primary and secondary care audience and is the only one of its kind that is completely accessible online.
Our Genomic Medicine Diploma has been designed for General Medical Practitioners, Specialist Medical Practitioners (for example Paediatrics, General Medicine, Obstetrics & Gynaecology, Medical Oncology), Allied Health Professionals (Clinical Psychologists, Occupational Therapists and Physiotherapists), Nurses (Cancer, Cardiac, Paediatric, Neurology etc.) and Midwives. In addition, the course would be of interest to those with related undergraduate degrees (e.g. Dietetics, Biomedical Science, Pharmacy) or equivalent professional qualifications and background experience
On completion you will demonstrate:
- a systematic understanding of genetics and genomic factors in human diseases
- a critical awareness of current issues affecting the management of inherited human diseases
- an advanced knowledge of clinical genomics that will facilitate decision-making in unpredictable and/or complex situations
- an ability to critically evaluate current research in applied and translational genetics and genomics
- an ability to deliver management strategies for the investigation and treatment of patients with inherited human diseases
- a basic understanding of the scope and effect of genomics on treatments including horizon scanning of potential new targeted treatments for wider population
The online course lasts one calendar year and is a part time distance learning course. It consists of 6 modules per year, each of 6 weeks duration.
Module 1 - Principles of Medical Genetics and Genomics
Module 2 - Genetic Counselling
Module 3 - Genomics and Society
Module 4 - Practice of Clinical Genomics
Module 5 - Reproductive Genomics
Module 6 - Genomic Healthcare
The course puts assessment at the heart of learning by using clinical scenarios to facilitate problem-solving, critical analysis and evidence-based care. The scenarios act as both the focus for learning and assessment thus embedding assessment within the learning process.
Each of the 6 modules have the same assessment format. Due to the online nature of the course, students are expected to login and participate in the course regularly throughout the module (ideally on a daily basis).
Students are split into groups of 10-15 students and are assigned a dedicated expert tutor who:
Facilitates clinical case discussions with the group.
Monitors, assesses and marks each student throughout the module.
Students use the skills gained during the lectures to engage with the different activities (see below).
Clinical case scenarios with case based discussion - 40%
Individual learning portfolio - 10%
Group/individual activity - 20%
Case based examination - 30%
Our programme will give you cross-disciplinary skills in a rare combination of areas of expertise, from bioinformatics and evolutionary inference to computational biology and fieldwork.
You will be taught by researchers who apply genomic methods to a wide range of issues in ecology and evolution, from bat food-webs and genome evolution to microbial biodiversity in natural and engineered ecosystems. For example, Professor Steve Rossiter carries out world-leading research on bat genome evolution; Dr Yannick Wurm has discovered a social chromosome in fire-ants; and Dr China Hanson is using genetic methods to study microbial biogeography. This means that teaching on our programme is informed by the latest developments in this field, and your individual research project can be at the forefront of current scientific discovery.
You will conduct your own substantive six-month research project, which may be jointly supervised by contacts from related institutes or within industry. You will also take part in a field course in Borneo - see photos from a recent trip on Flickr - giving you the opportunity to develop first hand experience of theory in action.
By choosing to study at a Russell Group university you will have access to excellent teaching and top class research. You can find out more about our research interests and view recent publications on the School of Biological and Chemical Science's Evolution and Genetics group page.
This MSc programme combines taught modules with individual and collaborative research projects. You will apply the knowledge and techniques from your taught modules in a practical setting and may be able to publish your project findings.
If you have any questions about the content or structure, contact the programme director Dr Christophe Eizaguirre.
Based on the indicative curriculum of Health Education England, NHS England and Genomics England LTD, the Genomic Medicine course will equip research scientists and Health Care Professionals with; knowledge and skills to understand and interpret genomic data, an understanding of genetic and genomic techniques in a clinical setting, bioinformatic approaches required for analysis of genomic data, advanced knowledge and skills, preparing graduates to develop and deliver personalised health care.
Genomic Medicine students will be introduced to:
Subsequent study will build on these foundations. Specific modules on the Genomic Medicine course focus on:
The Genomic Medicine course is primarily informed by the design developed to equip graduates, and a diverse range of healthcare professionals, with an appreciation and education in genomics and genomic technology. As an emerging field of expertise this knowledge and understanding of genomics will prepare Genomic Medicine graduates to translate their newfound knowledge of genomics into the clinical setting to inform patient care.
The Genomic Medicine course has been developed in line with Health Education England, NHS England and Genomics England Ltd.
Genomic Medicine students will be introduced to the fundamentals of human genetics and genomics along with techniques required for DNA and RNA sequencing to study genomic variation observed in the clinical setting. A third module entitled Data Analysis for Health and Medical Sciences, will introduce the bioinformatic approaches required for the analysis of genomic data.
Students will learn and be taught through a variety of methods including: lectures, workshops, tutorials, practical sessions, work-based learning and guest lectures by professionals, practitioners and respected academics.
Employability is key to the Genomic Medicine programme. Our students will be able to enhance their employability skills through their education and training in genomic medicine, transforming both the specialist and general workforce within the NHS. Furthermore, for non-NHS funded students, the MSc in Genomic Medicine will prepare graduates for careers in the clinical setting for which a knowledge of genomics will improve service delivery to patients.
The masters’ element of this programme will require students to complete a Research Project or in depth literature review. Genomic Medicine students will be encouraged to undertake their research project within the NHS, either within the students hosting NHS department or where they may expect to work following graduation.
Please note: fees of accepted, eligible NHS-based applicants will be paid by the Workforce Education and Development Services (WEDS).
Workforce Education and Development Services (WEDS) funding: WEDS is offering to pay the tuition fees for eligible staff working for the NHS in Wales, to study for the MSc, PG Dip or PG Cert in Genomic Medicine (part-time only).
Genomic technologies and information will transform practice across the clinical professions over the next decade.
This MSc is a new programme developed by Health Education England and being offered by a network of centres across England. It includes study of the genomics and informatics of rare and common diseases, cancer and infectious diseases, which can be applied to clinical practice and medical research, and enhance knowledge and skills, in this rapidly evolving field.
What does our MSc provide?
This programme, delivered by the Faculty of Medicine, will provide a comprehensive perspective in genomics applied to clinical practice and medical research, with particular emphasis on the 100,000 Genomes Project. It will equip students to bring benefit to their patients through improved diagnosis and personalised treatment, and disseminate knowledge to peers, patients and the public.
Who should study?
This programme is particularly suitable for health professionals as well as students seeking to make the most of genomics as it applies to their current or future career.
Our modular structure and blended learning formats are delivered flexibly as a one year full-time or two year part-time option, or as individual or grouped modules, to facilitate access from as wide as possible a range of healthcare professionals.
Genomic technologies and information will transform practice across the clinical professions over the next decade. Our MSc Genomic Medicine degree is designed to enhance knowledge and skills in this rapidly evolving field. The masters course has been developed by Health Education England and includes study of the genomics and informatics of rare and common diseases, cancer and infectious diseases, which can be applied to clinical practice and medical research. This degree is suitable for health professionals working in the NHS, as well as students seeking to make the most of genomics as it applies to their current or future career.
This MSc Genomic Medicine has been commissioned by NHS England / Health Education England to provide education and training in genomics for health professionals from different professional backgrounds such as medicine, nursing, public health, science and technology, for whom knowledge of genomics will impact on the way they deliver their service to patients and the public.
This programme can be tailored to meet your career aspirations and enables you to choose your module options, plan your programme route, and choose from October or March to begin your studies.
You can study part-time or undertake smaller numbers of, or even individual, modules to fit your study around your other commitments.
Southampton’s MSc Genomic Medicine comprises eight core modules delivered through intensive face-to-face study and independent learning.
Our core modules include an introduction to the genetics and genomics of rare and common diseases, cancer and infectious disease, informatics analysis, and a laboratory research project or dissertation.
Optional modules within the programme include the Ethics, Counselling Skills and Teaching the Teachers to Teach.
Teaching and learning
Using a mix of learning formats, our modules include two groups of two days' intensive face-to-face teaching interspersed with independent study.
The first core module will include an additional day of student contact to incorporate an induction to the University’s facilities and introduction to basic research skills such as literature searching and critical appraisal of scientific literature).
A variety of learning and teaching methods will be adopted to promote a wide range of skills and meet differing learning styles, including seminars, group work, practical demonstrations and exercises surrounding interpretation of data and clinical scenarios.
Experts from a range of academic and health care professional backgrounds are chosen to ensure a breadth and depth of perspective, giving a good balance between theories and principles, and practical management advice.
Independent study is delivered through a virtual learning environment, delivering a library of study materials including uploaded lectures, virtual patients and independent learning tasks, reference materials, links to online tutorials, student fora, and guest lecturer web chats.
A significant component of your research will comprise either an original project or a literature-based dissertation.
What you will gain
Students who complete the programme will be equipped to harness the unprecedented transformation of the 100,000 Genomes Project, bring benefit to their patients through improved diagnosis and personalised treatment, and disseminate knowledge to peers, patients and the public.