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Masters Degrees (Epigenetic)

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Master's specialisation in Medical Epigenomics. The only Master’s specialisation in the Netherlands covering the function of our epigenome, a key factor in regulating gene expression and in a wide range of diseases. Read more

Master's specialisation in Medical Epigenomics

The only Master’s specialisation in the Netherlands covering the function of our epigenome, a key factor in regulating gene expression and in a wide range of diseases.

Our skin cells, liver cells and blood cells all contain the same genetic information. Yet these are different types of cells, each performing their own specific tasks. How is this possible? The explanation lies in the epigenome: a heritable, cell-type specific set of chromosomal modifications, which regulates gene expression. Radboud University is specialised in studying the epigenome and is the only university in the Netherlands to offer a Master’s programme in this field of research.

Health and disease

The epigenome consists of small and reversible chemical modifications of the DNA or histone proteins, such as methylation, acetylation and phosphorylation. It changes the spatial structure of DNA, resulting in gene activation or repression. These processes are crucial for our health and also play a role in many diseases, like autoimmune diseases, cancer and neurological disorders. As opposed to modifications of the genome sequence itself, epigenetic modifications are reversible. You can therefore imagine the great potential of drugs that target epigenetic enzymes, so-called epi-drugs.

Big data

In this specialisation, you’ll look at a cell as one big and complex system. You’ll study epigenetic mechanisms during development and disease from different angles. This includes studying DNA and RNA by next-generation sequencing (epigenomics) and analysing proteins by mass spectrometry (proteomics). In addition, you‘ll be trained to design computational strategies that allow the integration of these multifaceted, high-throughput data sets into one system.

Why study Medical Epigenomics at Radboud University?

- Radboud University combines various state-of-the-art technologies – such as quantitative mass spectrometry and next-generation DNA sequencing – with downstream bioinformatics analyses in one department. This is unique in Europe.

- This programme allows you to work with researchers from the Radboud Institute for Molecular Life sciences (RIMLS), one of the leading multidisciplinary research institutes within this field of study worldwide.

- We have close contacts with high-profile medically oriented groups on the Radboud campus and with international institutes (EMBL, Max-Planck, Marie Curie, Cambridge, US-based labs, etc). As a Master’s student, you can choose to perform an internship in one of these related departments.

- Radboud University coordinates BLUEPRINT, a 30 million Euro European project focusing on the epigenomics of leukaemia. Master’s students have the opportunity to participate in this project.

Career prospects

As a Master’s student of Medical Epigenomics you’re trained in using state-of-the art technology in combination with biological software tools to study complete networks in cells in an unbiased manner. For example, you’ll know how to study the effects of drugs in the human body.

When you enter the job market, you’ll have:

- A thorough background of epigenetic mechanisms in health and disease, which is highly relevant in strongly rising field of epi-drug development

- Extensive and partly hands-on experience in state-of-the-art ‘omics’ technologies: next-generation sequencing, quantitative mass spectrometry and single cell technologies;

- Extensive expertise in designing, executing and interpreting scientific experiments in data-driven research;

- The computational skills needed to analyse large ‘omics’ datasets.

With this background, you can become a researcher at a:

- University or research institute;

- Pharmaceutical company, such as Synthon or Johnson & Johnson;

- Food company, like Danone or Unilever;

- Start-up company making use of -omics technology.

Apart from research into genomics and epigenomics, you could also work on topics such as miniaturising workflows, improving experimental devices, the interface between biology and informatics, medicine from a systems approach.

Or you can become a:

- Biological or medical consultant;

- Biology teacher;

- Policy coordinator, regarding genetic or medical issues;

- Patent attorney;

- Clinical research associate;

PhD positions at Radboud University

Each year, the Molecular Biology department (Prof. Henk Stunnenberg, Prof. Michiel Vermeulen) and the Molecular Developmental Biology department (Prof. Gert-Jan Veenstra) at the RIMLS offer between five and ten PhD positions. Of course, many graduates also apply for a PhD position at related departments in the Netherlands, or abroad.

Our approach to this field

- Systems biology

In the Medical Epigenomics specialisation you won’t zoom in on only one particular gene, protein or signalling pathway. Instead, you’ll regard the cell as one complete system. This comprehensive view allows you to, for example, model the impact of one particular epigenetic mutation on various parts and functions of the cell, or study the effects of a drug in an unbiased manner. One of the challenges of this systems biology approach is the processing and integration of large amounts of data. That’s why you’ll also be trained in computational biology. Once graduated, this will be a great advantage: you’ll be able to bridge the gap between biology, technology and informatics , and thus have a profile that is desperately needed in modern, data-driven biology.

- Multiple OMICS approaches

Studying cells in a systems biology approach means connecting processes at the level of the genome (genomics), epigenome (epigenomics), transcriptome (transcriptomics), proteome (proteomics), etc. In the Medical Epigenomics specialisation, you’ll get acquainted with all these different fields of study.

- Patient and animal samples

Numerous genetic diseases are not caused by genetic mutations, but by epigenetic mutations that influence the structure and function of chromatin. Think of:

- Autoimmune diseases, like rheumatoid arthritis and lupus

- Cancer, in the forms of leukaemia, colon cancer, prostate cancer and cervical cancer

- Neurological disorders, like Rett Syndrome, Alzheimer, Parkinson, Multiple Sclerosis, schizophrenia and autism

We investigate these diseases on a cellular level, focusing on the epigenetic mutations and the impact on various pathways in the cell. You’ll get the chance to participate in that research, and work with embryonic stem cell, patient, Xenopus or zebra fish samples.

See the website http://www.ru.nl/masters/medicalbiology/epigenomics



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OVERVIEW. The MSc in Cancer Medicine will provide students with new knowledge of how precision medicine can improve and shape future healthcare. Read more

OVERVIEW

The MSc in Cancer Medicine will provide students with new knowledge of how precision medicine can improve and shape future healthcare. Students will gain hands-on experience of molecular techniques and the equipment/devices used in a modern molecular laboratory; the course will provide training in laboratory and research skills that are applicable across multiple scientific disciplines in a supportive learning environment. Students will be able to evaluate how novel therapeutic approaches can be used to stratify patients into treatment groups for better clinical management (stratified / precision medicine). They will observe the delivery of precision medicine through tours of the Northern Ireland Cancer Centre.

There are optional modules in the second semester allowing students to explore.the fundamental principles of Carcinogenesis and the translational approaches (including cutting edge technologies) which allow cancer scientists and clinicians to advance our understanding and treatment of cancers. The Precision Cancer Medicine stream provides a comprehensive overview of the current understanding of the Hallmarks of Cancer from the role of genetic/epigenetic alterations, cell cycle control and metastases/angiogenesis to the development of applications to help diagnose cancers earlier, improve treatments, rationally design clinical trials and reduce chemotherapy drug resistance.

The Radiation Oncology stream will develop skills in understanding the biological principles of radiotherapy and its clinical applications in the treatment of cancer. This will include the physical and chemical basis of radiation interactions and the biological consequences of radiation exposures. Clinical aspects of Radiation Oncology will be covered including principle of advanced radiotherapy delivery, cancer imaging techniques and biomarker discovery.

Importantly, both streams show how our improved understanding of the molecular processes driving cancer growth and spread can be ‘translated’ through research-intensive MSc projects to improve the treatment and survival of cancer patients.

For further information email  or send us a message on WhatsApp

CANCER MEDICINE HIGHLIGHTS

The strong links between us and the biotech and biopharmaceutical sectors provides a stimulating translational environment, while also expanding your career opportunities.

GLOBAL OPPORTUNITIES

INDUSTRY LINKS

  • The strong links between us and the biotech and biopharmaceutical sectors provides a stimulating translational environment, while also expanding your career opportunities.

WORLD CLASS FACILITIES

  • The Programme will be taught in the Centre for Cancer Research & Cell Biology a purpose-built institute at the heart of the Health Sciences Campus, boasting state-of-the-art research facilities

INTERNATIONALLY RENOWNED EXPERTS

  • We have an international reputation in this area, achieved through; high-impact peer review publications; significant international research funding and the establishment of successful spin-out companies.

COURSE STRUCTURE

Semester 1

Research Translational: from Concept to Commercialisation (Full Year)

  • This module covers the principles of disease biology and new technological developments that increase our understanding of disease processes. It develops an appreciation of the importance of innovation, business awareness and leadership skills in the translation of discovery science to clinical implementation.

Diagnosis and Treatment (Semester 1)

  • This module provides a comprehensive overview of the diagnosis and treatment of the common solid and haematological malignancies, including breast, ovarian, genitourinary and gastrointestinal cancers as well as the leukaemias. An overview of the common diagnostic pathways in clinical practice will be provided, and this will including gaining an understanding of imaging modalities and histopathological techniques in routine use. 

Cancer Biology (Semester 1)

  • This module provides a comprehensive overview of the fundamental principles of carcinogenesis highlighting how normal control processes are bypassed during tumour formation. The pathogenic mechanisms to be discussed will range from genomic alterations in key gene families, to epigenetic mechanisms of gene control, alterations in kinase activities or protein turnover, or activation of aberrant phenotypes such as invasion and angiogenesis.Semester 2

Students will make a selection from the following modules:

  • Precision Cancer Stream
  • Cancer Genetics & Genomics
  • Translational Cancer Medicine

OR

  • Radiation Oncology and Medical Physics (ROMP)
  • Biology of Radiotherapy

Clinical Radiation

Building on the biological basis of radiotherapy, this module will develop knowledge and skills in understanding clinical radiotherapy and medical imaging. Through the delivery of a multidisciplinary taught programme, students will cover clinical tumour and normal tissue biology, radiological imaging and the design of radiotherapy treatment plans. This will develop the clinical rationale for radiotherapy in the treatment of cancer and highlight emerging treatment combinations and techniques for biomarker discovery in radiation oncology.Biology and Imaging

Research Project

You will undertake a project in the Centre for Cancer Research and Cell Biology.

Dissertation

This module comprises the write-up contribution to the overall research element of the programme, with the Research Project (SCM 8067). The Dissertation will represent the student’s personal studies in the literature, a description of their experimental execution of their project, data presentation, analysis and interpretation, followed by critical discussion and conclusions.

For further information email  or send us a message on WhatsApp



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OVERVIEW. The. Oncology Drug Discovery MSc. course is designed to provide an insight into how existing and future drug targets are identified from biological samples isolated from the cancer clinic. Read more

OVERVIEW

The Oncology Drug Discovery MSc course is designed to provide an insight into how existing and future drug targets are identified from biological samples isolated from the cancer clinic. This will include an industrial viewpoint into what makes an interesting target and how, through an iterative process, this target is validated. In addition, lectures will be provided to discuss how ‘hit’ compounds are identified, in both the academic and industrial setting, using compound screen assays and fragment based screening technologies. We will also provide an insight in computational methods for generating chemical ‘hits’. The module will also cover how these ‘hit’ compounds are prosecuted into tool compounds or Lead Optimisation candidates (LO), both historic and modern, that are used to further validate a potential drug target.

During this second module we will provide an insight into the challenges of moving a compound from an LO candidate to a pre-clinical candidate. How bio-marker companion tests are developed, validated and are used to underpin clinical trials. The lectures will also provide a keen insight into novel formulation strategies currently under development within Queen’s University Belfast. In addition, we will also provide an insight into the development of bio-therapeutics, such as antibodies, that are proving to be a powerful alternative to small molecule based therapeutics.

For further information email  or send us a message on WhatsApp

ONCOLOGY DRUG DISCOVERY HIGHLIGHTS

The strong links between us and the biotech and bio-pharmaceutical sectors provides a stimulating translational environment, while also expanding your career opportunities.

GLOBAL OPPORTUNITIES

INDUSTRY LINKS

  • Research projects will be provided by both academic staff and local biotech companies in ground-breaking research areas with a strong focus on clinical applications.

WORLD CLASS FACILITIES

  • The Oncology Drug Discovery course will be taught and mentored within the Centre for Cancer Research and Cell Biology: a purpose-built institute at the heart of the Health Sciences Campus, boasting state-of-the-art research facilities.

INTERNATIONALLY RENOWNED EXPERTS

  • We have an international reputation in this area, achieved through: high-impact peer review publications significant international research funding, the establishment of successful spin-out companies.

 

COURSE STRUCTURE

Research Project

  • You will undertake a lab based project in a number of different facets of the drug development, such as hit identification, hit compound development and therapeutic antibody development pathway working with both academic and biotech groups.Semester 1

Research Translational: from Concept to Commercialisation (Full Year)

  • This module covers the principles of disease biology and new technological developments that increase our understanding of disease processes. It develops an appreciation of the importance of innovation, business awareness and leadership skills in the translation of discovery science to clinical implementation.

Diagnosis and Treatment of Cancer

  • This module provides a comprehensive overview of the diagnosis and treatment of the common solid and haematological malignancies, including breast, ovarian, genitourinary and gastrointestinal cancers as well as the leukaemias

Cancer Biology

  • This module provides a comprehensive overview of the fundamental principles of carcinogenesis, highlighting how normal control processes are bypassed during tumour formation. The pathogenic mechanisms to be discussed will range from genomic alterations in key gene families, to epigenetic mechanisms of gene control, alterations in kinase activities or protein turnover, or activation of aberrant phenotypes such as invasion and angiogenesis.Semester 2

Target Identification and Development in Drug Discovery

  • This module describe how novel drug targets are identified and validated and identifies how biochemical assays are developed and employed in the drug discovery process. It also evaluates the alternative approaches used in the drug discovery to identify new chemical matter. It describes and defines chemical approaches used in developing ‘hit’ chemical compounds and identifies drug target classes and their drug-like pharmacophores.

Drug optimization, drug delivery and clinical trials

  • This module evaluates the issues associated the drug development process and describes the development, validation and use of bio-markers in the drug discovery process. It discusses the practices employed in clinical trials and defines the processes employed in licensing of new chemical equity and the role it plays in the drug discovery process.

For further information email  or send us a message on WhatsApp



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The. Georgina Gatenby Scholarship. is recruiting a Masters by Research student to carry out research on lung cancer. Read more

The Georgina Gatenby Scholarship is recruiting a Masters by Research student to carry out research on lung cancer. The succesfull applicant will have a BSc in Biochemistry and an interest in cell biology, and will have the opportunity to develop skills in molecular cloning, protein expression, mammalian cell culture, sub-cellular fractionation and image analysis. S/he will be a capable communicator and willing to engage with funders to explain goals and progress. 

The project will be co-supervised by Dr Dawn Coverley and Professor Jennifer Potts and will focus on the CIZ1B protein and its link with lung cancer. The underpinning research question concerns the effect of cancer-associated CIZ1 mis-splicing on CIZ1 function and will involve structural analysis of the nuclear matrix anchor domain. Results will be related to cellular function with focus on the emerging role of CIZ1 in maintenance of epigenetic state using the inactive X chromosome as a model.



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Fungal biology research will focus on yeasts, filamentous fungi and lichens. Projects will investigate the physiology, biochemistry, molecular genetics and genomics of these organisms, for example in the use of fungi as cell factories for the production of proteins and pharmaceuticals. Read more
Fungal biology research will focus on yeasts, filamentous fungi and lichens. Projects will investigate the physiology, biochemistry, molecular genetics and genomics of these organisms, for example in the use of fungi as cell factories for the production of proteins and pharmaceuticals. Other areas include stress response mechanisms and cell individuality in yeasts and filamentous fungi, the genetics of sexual reproduction in pathogenic fungi and those used in the biotechnology and food sectors, and the epigenetic control of gene transcription.

APPLICATION PROCEDURES

After identifying which Masters you wish to pursue please complete an on-line application form
https://pgapps.nottingham.ac.uk/
Mark clearly on this form your choice of course title, give a brief outline of your proposed research and follow the automated prompts to provide documentation. Once the School has your application and accompanying documents (eg referees reports, transcripts/certificates) your application will be matched to an appropriate academic supervisor and considered for an offer of admission.

COURSE STRUCTURE
The MRes degree course consists of two elements:
160 credits of assessed work. The assessed work will normally be based entirely on a research project and will be the equivalent of around 10 ½ months full-time research work. AND
20 credits of non-assessed generic training. Credits can be accumulated from any of the courses offered by the Graduate School. http://www.nottingham.ac.uk/gradschool/research-training/index.phtml The generic courses should be chosen by the student in consultation with the supervisor(s).

ASSESSMENT
The research project will normally be assessed by a dissertation of a maximum of 30,000 to 35,000 words, or equivalent as appropriate*. The examiners may if they so wish require the student to attend a viva.
*In consultation with the supervisor it maybe possible for students to elect to do a shorter research project and take a maximum of 40 credits of assessed modules.

The School of Life Sciences will provide each postgraduate research student with a laptop for their exclusive use for the duration of their studies in the School.

SCHOLARSHIPS FOR INTERNATIONAL STUDENTS
http://www.nottingham.ac.uk/studywithus/international-applicants/scholarships-fees-and-finance/scholarships/masters-scholarships.aspx

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The increasing impact of genetics in healthcare and the development of newer sophisticated technologies requires contributions from research scientists, clinical laboratory scientists and clinicians to investigate the causes of, and therefore permit optimal management for, diseases for which alterations in the genome, either at the DNA sequence level or epigenetic level, play a significant role. Read more
The increasing impact of genetics in healthcare and the development of newer sophisticated technologies requires contributions from research scientists, clinical laboratory scientists and clinicians to investigate the causes of, and therefore permit optimal management for, diseases for which alterations in the genome, either at the DNA sequence level or epigenetic level, play a significant role. Collaboration between staff from the University of Glasgow and the NHS West of Scotland Genetics Service enables the MSc in Medical Genetics and Genomics to provide a state-of-the-art view of the application of modern genetic and genomic technologies in medical genetics research and diagnostics, and in delivery of a high quality genetics service to patients, as well as in design of targeted therapies.

Why this programme

◾This is a fully up-to-date Medical Genetics degree delivered by dedicated, multi-award-winning teaching and clinical staff of the University, with considerable input from hospital-based Regional Genetics Service clinicians and clinical scientists.
◾The full spectrum of genetic services is represented, from patient and family counselling to diagnostic testing of individuals and screening of entire populations for genetic conditions: eg the NHS prenatal and newborn screening programmes.
◾The MSc Medical Genetics Course is based on the south side of the River Clyde in the brand new (2015) purpose built Teaching & Learning Centre, at the Queen Elizabeth University Hospitals (we are located 4 miles from the main University Campus). The Centre also houses state of the art educational resources, including a purpose built teaching laboratory, computing facilities and a well equipped library. The West of Scotland Genetic Services are also based here at the Queen Elizabeth Campus allowing students to learn directly from NHS staff about the latest developments to this service.
◾The Medical Genetics MSc Teaching Staff have won the 2014 UK-wide Prospects Postgraduate Awards for the category of Best Postgraduate Teaching Team (Science, Technology & Engineering). These awards recognise and reward excellence and good practice in postgraduate education.
◾The close collaboration between university and hospital staff ensures that the Medical Genetics MSc provides a completely up-to-date representation of the practice of medical genetics and you will have the opportunity to observe during clinics and visit the diagnostic laboratories at the new Southern General Hospital laboratory medicine building.
◾The Medical Genetics degree explores the effects of mutations and variants as well as the current techniques used in NHS genetics laboratory diagnostics and recent developments in diagnostics (including microarray analysis and the use of massively parallel [“next-generation”] sequencing).
◾New developments in medical genetics are incorporated into the lectures and interactive teaching sessions very soon after they are presented at international meetings or published, and you will gain hands-on experience and guidance in using software and online resources for genetic diagnosis and for the evaluation of pathogenesis of DNA sequence variants.
◾You will develop your skills in problem solving, experimental design, evaluation and interpretation of experimental data, literature searches, scientific writing, oral presentations, poster presentations and team working.
◾This MSc programme will lay the academic foundations on which some students may build in pursuing research at PhD level in genetics or related areas of biomedical science or by moving into related careers in diagnostic services.
◾The widely used textbook “Essential Medical Genetics” is co-authored by a member of the core teaching team, Professor Edward Tobias.
◾For doctors: The Joint Royal Colleges of Physicians’ Training Board (JRCPTB) in the UK recognises the MSc in Medical Genetics and Genomics (which was established in 1984) as counting for six months of the higher specialist training in Clinical Genetics.
◾The Medical Council of Hong Kong recognises the MSc in Medical Genetics and Genomics from University of Glasgow in it's list of Quotable Qualifications.

Programme structure

Genetic Disease: from the Laboratory to the Clinic

This course is designed in collaboration with the West of Scotland Regional Genetics Service to give students a working knowledge of the principles and practice of Medical Genetics and Genomics which will allow them to evaluate, choose and interpret appropriate genetic investigations for individuals and families with genetic disease. The link from genotype to phenotype, will be explored, with consideration of how this knowledge might contribute to new therapeutic approaches.

Case Investigations in Medical Genetics and Genomics

Students will work in groups to investigate complex clinical case scenarios: decide appropriate testing, analyse results from genetic tests, reach diagnoses where appropriate and, with reference to the literature, generate a concise and critical group report.

Clinical Genomics

Students will take this course OR Omic Technologies for Biomedical Sciences OR Frontiers in Cancer Science.

This course will provide an overview of the clinical applications of genomic approaches to human disorders, particularly in relation to clinical genetics, discussion the methods and capabilities of the new technologies. Tuition and hands-on experience in data analysis will be provided, including the interpretation of next generation sequencing reports.

Omic technologies for the Biomedical Sciences: from Genomics to Metabolomics

Students will take this course OR Clinical Genomics OR Frontiers in Cancer Science.

Visit the website for further information

Career prospects

Research: About half of our graduates enter a research career and most of these graduates undertake and complete PhDs; the MSc in Medical Genetics and Genomics facilitates acquisition of skills relevant to a career in research in many different bio-molecular disciplines.

Diagnostics: Some of our graduates enter careers with clinical genetic diagnostic services, particularly in molecular genetics and cytogenetics.

Clinical genetics: Those of our graduates with a prior medical / nursing training often utilise their new skills in careers as clinical geneticists or genetic counsellors.

Other: Although the focus of teaching is on using the available technologies for the purpose of genetic diagnostics, many of these technologies are used in diverse areas of biomedical science research and in forensic DNA analysis. Some of our numerous graduates, who are now employed in many countries around the world, have entered careers in industry, scientific publishing, education and medicine.

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The Institute of Genetic Medicine brings together a strong team with an interest in clinical and developmental genetics. Our research focuses on the causes of genetic disease at the molecular and cellular level and its treatment. Read more
The Institute of Genetic Medicine brings together a strong team with an interest in clinical and developmental genetics. Our research focuses on the causes of genetic disease at the molecular and cellular level and its treatment. Research areas include: genetic medicine, developmental genetics, neuromuscular and neurological genetics, mitochondrial genetics and cardiovascular genetics.

As a research postgraduate in the Institute of Genetic Medicine you will be a member of our thriving research community. The Institute is located in Newcastle’s Life Science Centre. You will work alongside a number of research, clinical and educational organisations, including the Northern Genetics Service.

We offer supervision for MPhil in the following research areas:

Cancer genetics and genome instability

Our research includes:
-A major clinical trial for chemoprevention of colon cancer
-Genetic analyses of neuroblastoma susceptibility
-Research into Wilms Tumour (a childhood kidney cancer)
-Studies on cell cycle regulation and genome instability

Cardiovascular genetics and development

We use techniques of high-throughput genetic analyses to identify mechanisms where genetic variability between individuals contributes to the risk of developing cardiovascular disease. We also use mouse, zebrafish and stem cell models to understand the ways in which particular gene families' genetic and environmental factors are involved in the normal and abnormal development of the heart and blood vessels.

Complex disease and quantitative genetics

We work on large-scale studies into the genetic basis of common diseases with complex genetic causes, for example autoimmune disease, complex cardiovascular traits and renal disorders. We are also developing novel statistical methods and tools for analysing this genetic data.

Developmental genetics

We study genes known (or suspected to be) involved in malformations found in newborn babies. These include genes involved in normal and abnormal development of the face, brain, heart, muscle and kidney system. Our research includes the use of knockout mice and zebrafish as laboratory models.

Gene expression and regulation in normal development and disease

We research how gene expression is controlled during development and misregulated in diseases, including the roles of transcription factors, RNA binding proteins and the signalling pathways that control these. We conduct studies of early human brain development, including gene expression analysis, primary cell culture models, and 3D visualisation and modelling.

Genetics of neurological disorders

Our research includes:
-The identification of genes that in isolation can cause neurological disorders
-Molecular mechanisms and treatment of neurometabolic disease
-Complex genetics of common neurological disorders including Parkinson's disease and Alzheimer's disease
-The genetics of epilepsy

Kidney genetics and development

Kidney research focuses on:
-Atypical haemolytic uraemic syndrome (aHUS)
-Vesicoureteric reflux (VUR)
-Cystic renal disease
-Nephrolithiasis to study renal genetics

The discovery that aHUS is a disease of complement dysregulation has led to a specific interest in complement genetics.

Mitochondrial disease

Our research includes:
-Investigation of the role of mitochondria in human disease
-Nuclear-mitochondrial interactions in disease
-The inheritance of mitochondrial DNA heteroplasmy
-Mitochondrial function in stem cells

Neuromuscular genetics

The Neuromuscular Research Group has a series of basic research programmes looking at the function of novel muscle proteins and their roles in pathogenesis. Recently developed translational research programmes are seeking therapeutic targets for various muscle diseases.

Stem cell biology

We research human embryonic stem (ES) cells, germline stem cells and somatic stem cells. ES cell research is aimed at understanding stem cell pluripotency, self-renewal, survival and epigenetic control of differentiation and development. This includes the functional analysis of genes involved in germline stem cell proliferation and differentiation. Somatic stem cell projects include programmes on umbilical cord blood stem cells, haematopoietic progenitors, and limbal stem cells.

Pharmacy

Our new School of Pharmacy has scientists and clinicians working together on all aspects of pharmaceutical sciences and clinical pharmacy.

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The Cancer MSc reflects the depth and breadth of research interests, from basic science to translational medicine, within the UCL Cancer Institute. Read more

The Cancer MSc reflects the depth and breadth of research interests, from basic science to translational medicine, within the UCL Cancer Institute. The programme, taught by research scientists and academic clinicians, provides students with an in-depth look at the biology behind the disease processes which lead to cancer.

About this degree

This programme offers a foundation in understanding cancer as a disease process and its associated therapies. Students learn about the approaches taken to predict, detect, monitor and treat cancer, alongside the cutting-edge research methods and techniques used to advance our understanding of this disease and design better treatment strategies.

Students undertake modules to the value of 180 credits.

The programme consists of two core modules (60 credits), four specialist modules (60 credits) and a research project (60 credits).

A Postgraduate Diploma (120 credits, full-time nine months) is offered.

A Postgraduate Certificate (60 credits, full-time 12 weeks) is offered.

Core modules

  • Basic Biology and Cancer Genetics
  • Cancer Therapeutics

Specialist modules

  • Behavioural Science and Cancer
  • Biomarkers in Cancer
  • Cancer Clinical Trials
  • Haematological Malignancies and Gene Therapy

Dissertation/report

All MSc students undertake a laboratory project, clinical trials project or systems biology/informatics project, which culminates in a 10,000–12,000 word dissertation and an oral research presentation.

Teaching and learning

Students develop their knowledge and understanding of cancer through lectures, self-study, database mining, wet-lab based practicals, clinical trial evaluations, laboratory training, assigned reading and self-learning. Each taught module is assessed by an unseen written examination and/or coursework. The research project is assessed by the dissertation (75%) and oral presentation (25%).

Further information on modules and degree structure is available on the department website: Cancer MSc

Careers

The knowledge and skills developed will be suitable for those in an industrial or healthcare setting, as well as those individuals contemplating a PhD or medical studies in cancer.

Employability

Skills include critical evaluation of scientific literature, experimental planning and design interpretation of data and results, presentation/public speaking skills, time management, working with a team, working independently and writing for various audiences.

Why study this degree at UCL?

UCL is one of Europe's largest and most productive centres of biomedical science, with an international reputation for leading basic, translational and clinical cancer research.

The UCL Cancer Institute brings together scientists from various disciplines to synergise multidisciplinary research into cancer, whose particular areas of expertise include: the biology of leukaemia, the infectious causes of cancer, the design of drugs that interact with DNA, antibody-directed therapies, the molecular pathology of cancer, signalling pathways in cancer, epigenetic changes in cancer, gene therapy, cancer stem cell biology, early phase clinical trials, and national and international clinical trials in solid tumours and blood cancers.

Research Excellence Framework (REF)

The Research Excellence Framework, or REF, is the system for assessing the quality of research in UK higher education institutions. The 2014 REF was carried out by the UK's higher education funding bodies, and the results used to allocate research funding from 2015/16.

The following REF score was awarded to the department: Cancer Institute

80% rated 4* (‘world-leading’) or 3* (‘internationally excellent’)

Learn more about the scope of UCL's research, and browse case studies, on our Research Impact website.



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This vocational training programme is for recent biology, biomedical, biochemistry and medical graduates who want to develop a career in the field of clinical embryology and assisted reproductive technology (ART) and/or the associated reproductive sciences. Read more

This vocational training programme is for recent biology, biomedical, biochemistry and medical graduates who want to develop a career in the field of clinical embryology and assisted reproductive technology (ART) and/or the associated reproductive sciences. It provides a detailed knowledge of the underpinning theory and practices and is a laboratory-based science degree not a clinically-based infertility treatment course.

The programme emphasises all aspects of practical training for clinical embryology and assisted reproduction technology. You’ll receive hands-on training from specialist practitioners in andrology, gamete handling, IVF, ICSI, embryo culture, gamete and embryo freezing, vitrification and biopsy and will interact with established, clinical embryologists and reproductive medicine specialists. You’ll also be trained in research methods.

You will be part of a world-renowned School, being taught by and working with internationally recognised scholars.

More information

The programme has been developed by the Division of Reproduction and Early Development within the Leeds Institute of Genetics, Health and Therapeutics, in association with the clinicians and embryologists working at the Leeds Centre of Reproductive Medicine in the Leeds NHS Trust. The programme leaders have over 20 years of experience of training clinical embryologists, reproductive medicine practitioners and reproductive scientists.

You can also study this subject at Postgraduate Diploma level. 

Through a series of compulsory modules you’ll learn about:

  • the cell and molecular biology of human reproduction, fertility, andrology and embryology
  • the management and efficient running of an ART laboratory
  • the practices, genetic and epigenetic concepts of micromanipulation and techniques, such as intracytoplasmic sperm injection (ICSI) and pre-implantation genetic diagnosis (PGD)
  • advances in cryobiology and its application to gamete and embryo freezing and fertility preservation.

The programme also gives you valuable insights into the theory underpinning clinical treatments and the ethical and legal controversies surrounding assisted reproduction in humans.

Course structure

Compulsory modules

  • Research in Reproduction, Embryology & Assisted Reproduction Technology 60 credits
  • Fundamentals of Clinical Embryology 45 credits
  • IVF and Embryo Culture 35 credits
  • Micromanipulation 15 credits
  • Cryobiology and Cryopreservation 15 credits
  • Ethics and Law for Embryologists 10 credits

Learning and teaching

The programme is delivered using a blended learning approach, which combines lectures, seminars, tutorials, interactive group discussions, presentations and problem-based-learning sessions or case studies, with self-directed learning.

Theoretical training is complemented by the original research conducted by the student and by an extensive series of laboratory-based ART practical and skills training sessions.

The course content is enhanced by extensive online resources and the provision of printed versions of all module workbooks, as appropriate.

Assessment

Course assessments will include essays, presentations, projects, practical log books, a research dissertation and examinations.

Career opportunities

The Clinical Embryology and Associated Reproductive Technology MSc equips graduates to pursue a career in human assisted reproduction (eg clinical embryology, infertility treatment) and/or research in the reproductive sciences.

Careers support

We encourage you to prepare for your career from day one. That’s one of the reasons Leeds graduates are so sought after by employers.

The Careers Centre and staff in your faculty provide a range of help and advice to help you plan your career and make well-informed decisions along the way, even after you graduate. Find out more at the Careers website.




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This M.Sc. program in Translational Oncology will provide high-quality training for basic scientists and clinicians in the theoretical and practical aspects of the causes and treatment of cancer. Read more
This M.Sc. program in Translational Oncology will provide high-quality training for basic scientists and clinicians in the theoretical and practical aspects of the causes and treatment of cancer. A major focus of the programme is the cellular genetic and epigenetic basis of cancer. The course also covers the scientific and clinical challenges pertinent to the management of site specific cancers, and all aspects of cancer treatment from standard therapies to 'individualised' molecular targeted therapies. The focus of the course is research led teaching in the practical aspects of translational cancer research. This innovative M.Sc. program in Translational Oncology is aimed at scientists and doctors in training who wish to:

Develop their research skills
Broaden their expertise in oncology
Develop advanced knowledge in specific areas of scientific, translational and clinical oncology.

The proposed course will offer an opportunity for graduates from a variety of backgrounds to specifically train in translational oncology in advance of undertaking an MD or PhD. Modules are taught using a variety of methods including lectures, tutorials, workshops and laboratory practicals. Lectures are provided by leaders in the field of translational oncology from both scientific and medical backgrounds. The core modules are Cellular and Molecular Oncology, Cancer Epigenetics, Disease Specific Cancers, Radiation / Chemotherapy and Molecular Targeted Therapies, Tumour Immunology, Molecular Pathology and Imaging, Clinical Statsitics and Research Skills. Students can tailor the course to their interests with optional modules in Obesity, metabolism and Cancer, Gemomic Instability, Cancer Drug Development, Tumour Microenvironment, Clinical Pharmacology, and Surgical Oncology and Economics. Students will be required to submit a dissertation based on an emperical research project conducted in one of the many oncology groups located within or affiliated with Trinity College Dublin and the Institute of Molecular Medicine. Opportunities for national and international placements to conduct research projects will also be available in collaborating universities, hospitals and industry.

All applicants should provide two academic or clinical references confirming their eligibility and suitability for the course, before their application can be considered. Applicants should also include a 500 word personal statement addressing why they are interested in the course, their suitability for the programme and how it will impact on their future career development. Applications for admission to the course should be made through the online system no later than July 31st. Late applications will be considered provided places are available.

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The UBC Department of Medical Genetics is an inspiring and productive community of scholars of genetics and genomics; an outstanding provider of knowledge… Read more

The UBC Department of Medical Genetics is an inspiring and productive community of scholars of genetics and genomics; an outstanding provider of knowledge, technical expertise, and compassionate care for our patients. The Department is composed of dozens of faculty members at the forefront of their fields who use cutting edge genetic, epigenetic, genomic, and bioinformatic methodologies to gain insight into diseases such as cancer, diabetes, obesity, neurodegenerative and neurological disorders, and other genetic diseases. Research is highly interactive and often involves local, national, and international collaborations which further enrich the research experience.

Individual labs conduct clinical and/or translational research and basic experimental research engaging a wide variety of approaches including the use of model organisms such as mice, flies (D. melanogaster), worms (C. elegans), and yeast (S. cerevisiae).

What makes the program unique?

The mission of the Department of Medical Genetics is to pursue basic and clinical research for diagnosis, prevention and treatment of genetic disease. Our goal is to be a world leader in the research, clinical practice and teaching of Genetic Medicine.

Research focus

Research in the Department of Medical Genetics covers the study of human genetics with areas of focus in mammalian development, regulation of gene expression, genetic diseases due to single gene or complex inheritance, birth defects, reproduction, cancer, immunology, genomics, bioinformatics, ethics and population health.

  • Research Areas of Expertise:
  • Cancer Genetics and Genomics;
  • Developmental Genetics & Birth Defects;
  • Epigenetics, Epigenomics & Chromosome Transmission;
  • Gene Expression, Genomics & Bioinformatics;
  • Genetic Epidemiology & Human Gene Mapping;
  • Neurogenetics & Immunogenetics;
  • Stem Cells & Gene Therapy;
  • Pharmacogenomics;
  • Proteomics; and
  • Clinical Genetics, Genetic Counselling and Ethics & Policy.

Program components

Medical Genetics Rotation Program: MSc and PhD applicants who have applied for the September-start, and who are highest ranked by the Medical Genetics Admissions Committee, will be offered the opportunity to join the Medical Genetics Rotation Program. The four top-ranked applicants offered these positions will also receive one-year Rotation Program Awards. Rotation Program students rotate through three different laboratories before choosing a final, thesis lab. Rotations are for nine-weeks each, from September to April. The Rotation Program is open to Canadians, Permanent Residents of Canada, and international applicants.

Career options

The MSc program in Medical Genetics is a research-based, thesis-based program which generally takes two - three years to complete. Graduates find employment in the public and private sector, and also pursue further studies in the field of Medical Genetics. Following is a brief sample of occupations that our graduates are pursuing:

Training:

  • Genetic Counselling
  • Medical Doctor
  • Clinical Genetics Technology

Industry / Clinical Careers:

  • Molecular Diagnostic Technologist
  • Research Associate
  • Data Management Coordinator
  • Research Program Manager
  • Online Marketing Coordinator
  • Scientific Sales Representative
  • Research and Development Scientist


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Modern genetics has today evolved beyond its traditional boundaries to become a fundamental part of biology and medicine. Read more
Modern genetics has today evolved beyond its traditional boundaries to become a fundamental part of biology and medicine. The Department reflects this pervasiveness, with research interests encompassing several high impact themes, including functional genomics and systems biology, developmental genetics, epigenetic Inheritance, evolution and population genetics, microbial genetics, and cell biology. The Department of Genetics hosts between 50 and 65 postgraduate students across 25 research groups, researching a wide range of biological problems, from population genetics and ecology, to the detailed analysis of genome sequence. The Department is based in a historic building on the Downing Site but has research groups located in the Gurdon Institute, Cambridge Systems Biology Centre and Sainsbury Labs as well as an impressive range of local, national and international collaborations.

MPhil students in the Department will undertake a 1-year project under the supervision of one of our Group Leaders, where they will develop an original research question and address this through laboratory or computer based research. They will receive training in appropriate research methods and in literature research skills to prepare them for writing an MPhil thesis within the year.

See the website http://www.graduate.study.cam.ac.uk/courses/directory/blgempmbs

Course detail

By the end of the programme, students will have:

- a comprehensive understanding of techniques, and a thorough knowledge of the literature, applicable to their own research;
- demonstrated originality in the application of knowledge, together with a practical
- understanding of how research and enquiry are used to create and interpret knowledge in their field;
- shown abilities in the critical evaluation of current research and research techniques and methodologies;
- demonstrated some self-direction and originality in tackling and solving problems, and acted autonomously in the planning and implementation of research.

Format

- Supervision meetings once every one or two weeks.

- Weekly Departmental seminars.

- Annual Research In Genetics day with poster sessions

Assessment

Thesis required of not more than 20,000 words in length, excluding figures, tables, footnotes, appendices and bibliography. The examination will include an oral examination on the thesis and on the general field of knowledge within which it falls.

Continuing

Candidates wishing to progress to the PhD degree after successful completion of an MPhil will be considered by the Departmental Graduate Education Committee on a case by case basis. Candidates will be expected to have identified a suitable research group to host the PhD research and identify an appropriate source of funding.

How to apply: http://www.graduate.study.cam.ac.uk/applying

Funding Opportunities

There are no specific funding opportunities advertised for this course. For information on more general funding opportunities, please follow the link below.

General Funding Opportunities http://www.graduate.study.cam.ac.uk/finance/funding

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The Pre-Masters in Biomedical Science (Graduate Diploma in Biomedical Science) provides a discipline-specific pathway (a pre-masters year) into the taught Biomedical Blood Science masters level programme. Read more

Overview

The Pre-Masters in Biomedical Science (Graduate Diploma in Biomedical Science) provides a discipline-specific pathway (a pre-masters year) into the taught Biomedical Blood Science masters level programme. It is a one-year full-time programme designed for both home and international students, with a background in life sciences, who wish to study at postgraduate level for the MSc in Biomedical Blood Science. The programme is open to science graduates who do not meet the academic criteria for a direct entry into the MSc. The MSc in Biomedical Blood Science is accredited by the Institute of Biomedical Science (IBMS). The IBMS is the professional body of Biomedical Scientists within the United Kingdom. The IBMS aims to promote and develop the role of Biomedical Science within healthcare to deliver the best possible service for patient care and safety.

See the website https://www.keele.ac.uk/pgtcourses/biomedicalsciencegraduatediploma/

Course Aims

The overall aim is to provide the students with the academic background necessary for the masters programme and to enable them to develop and practise the subject specific academic skills required for the intensive pace of study at masters level. The course also aims to allow international students to benefit from English language support that will help them to develop their academic English language skills.

Intended learning outcomes of the programme reflect what successful students should know, understand or to be able to do by the end of the programme. Programme specific learning outcomes are provided in the Programme Specification available by request; but, to summarise, the overarching course aims are as follows:

- To provide students with core knowledge, understanding and skills relevant to Biomedical Science

- To produce skilled and motivated graduates who are suitably prepared for the MSc in Biomedical Science and for further study.

- To cultivate interest in the biosciences, particularly at the cellular and molecular level, within a caring and intellectually stimulating environment.

- To get an accurate insight into the role of Biomedical Scientists in the diagnosis, treatment and monitoring of disease.

- To develop an understanding of the analytical, clinical and diagnostic aspects of Cellular Pathology, Clinical Biochemistry, Medical Microbiology, Blood Transfusion, Clinical Immunology and Haematology pathology laboratories.

- To promote the development of a range of key skills, for use in all areas where numeracy and an objective, scientific approach to problem-solving are valued.

- To provide students with a wide range of learning activities and a diverse assessment strategy in order to fully develop their employability and academic skills, ensuring both professional and academic attainment.

- To promote the development of critical thinking, autonomous learning, independent research and communication skills to help prepare the students for the MSc in Biomedical Blood Science and for a lifetime of continued professional development.

Course Content

All the modules in this one year programme are compulsory. The programme consists of a total of 90 credits made up of one 30 credit module and four 15 credit modules. An additional English module (English for Academic Purposes) will be offered for non-native English speakers if required. This module will not form part of the overall award, but successful completion is required for progression to the Masters programme.

Modules:
- Biomedical Science and Pathology (30 credits):
The module provides the student with the knowledge and understanding of the pathobiology of human disease associated with Cellular Pathology, Clinical Immunology, Haematology, Clinical Biochemistry, Medical Microbiology and Clinical Virology. It also examines the analytical and clinical functions of three more of the major departments of a modern hospital pathology laboratory, including Haematology, Clinical Pathology, Clinical Immunology, Blood Transfusion, Clinical Biochemistry and Medical Microbiology. In addition, the module will give an accurate insight into the role of Biomedical Scientists and how they assist clinicians in the diagnosis, treatment and monitoring of disease.

- Biochemistry Research Project (non-experimental) (15 credits):
This module aims to introduce students to some of the key non-experimental research skills that are routinely used by biochemists and biomedical scientists, such as in depth literature searching, analysis of experimental data and the use of a computer as tool for both research (bioinformatics) and dissemination of information (web page construction). The student will research the literature on a specific topic, using library and web based resources and will produce a written review. In addition, the student will either process and interpret some raw experimental data provided to them.

- Advances in Medicine (15 credits):
This module will describe and promote the understanding of advances in medicine that have impacted on diagnosis, treatment, prevention of a range of diseases. It will highlight fast emerging areas of research which are striving to improve diagnosis including nanotechnology and new biochemical tests in the fields of heart disease, cancer and fertility investigations which will potentially improve patient care.

- Clinical Pathology (15 credits):
The majority of staff that contribute to the module are employees of the University Hospital of North Staffordshire (UHNS). Students will benefit from lectures and expertise in Clinical Diagnostic Pathology, Pharmacology, Biochemistry, Genetics and Inflammatory Diseases. Students will gain an insight into how patients are managed, from their very first presentation at the UHNS, from the perspective of diagnosis and treatment. The course will cover both standardised testing options and the development of new diagnostic procedures with a particular emphasis on genetic and epigenetic aspects of disease. Students will also gain an appreciation of the cost benefit of particular routes for diagnosis and treatment and the importance of identifying false positive and false negative results. Finally, the students will have the opportunity to perform their own extensive literature review of a disease-related topic that is not covered by the lectures on the course.

- Case Studies in Biomedical Science (15 credits):
This module aims to give you an understanding of the UK health trends and the factors that affect these trends. Through clinical case studies and small group tutorials, you will explore why the UK has some of the highest incidences of certain diseases and conditions in Europe and consider what factors contribute to making them some of the most common and/or rising health problems faced by this country. This will include understanding the relevant socioeconomic factors as well as understanding the bioscience of the disease process and its diagnosis and management. You will also focus on what is being done by Government and the NHS to tackle these major health problems.

- English for Academic Purposes (EAP ):
For non-native English speakers if required

Teaching & Assessment

In addition to the lecture courses and tutorials, problem based learning (PBL) using clinical scenarios is used for at least one module. Students will also be given the opportunity to undertake an independent non-experimental research project, supervised and supported by a member of staff. Web-based learning using the University’s virtual learning environment (KLE) is also used to give students easy access to a wide range of resources and research tools, and as a platform for online discussions and quizzes. Students will be given many opportunities to become familiar with word processing, spreadsheets and graphics software as well as computer-based routes to access scientific literature.

All modules are assessed within the semester in which they are taught. Most contain elements of both ‘in-course’ assessment (in the form of laboratory reports, essays, posters) and formal examination, although some are examined by ‘in-course’ assessment alone.

Additional Costs

Apart from additional costs for text books, inter-library loans and potential overdue library fines we do not anticipate any additional costs for this post graduate programme.

Find information on Scholarships here - http://www.keele.ac.uk/studentfunding/bursariesscholarships/

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Research profile. The University of Edinburgh Centre for Genomics and Experimental Medicine (CGEM) is part of the MRC / University of Edinburgh Institute of Genetics and Molecular Medicine (IGMM). Read more

Research profile

The University of Edinburgh Centre for Genomics and Experimental Medicine (CGEM) is part of the MRC / University of Edinburgh Institute of Genetics and Molecular Medicine (IGMM). CGEM’s mission is to use genetics and genomics to understand the mechanisms of disease and design novel intervention strategies. Our research has consistently obtained the highest possible ranking in national assessments of research excellence.

We undertake detailed studies of populations, families and individuals to study a wide range of health related conditions. We use state-of-the-art genetic, epigenetic, genomic, statistical, bioinformatic, biological and molecular approaches in model systems and clinical studies for systematic investigation of disease aetiology. With this knowledge, we aim to improve disease prediction, prevention and prognosis. Our translational agenda encompasses the development of new medicines and genetically-informed use of existing medicines in clinical trials.

Facilities

A principal aim of both CGEM and the IGMM is develop fully integrated, multi-disciplinary research programmes across the whole spectrum of basic, clinical and translational research. We have state of the art imaging, DNA sequencing and drug discovery units, a bioinformatics service and excellent lab facilities.



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Designed to prepare you to interact with the world’s most advanced biological and clinical datasets - this programme will prepare you for careers, or further graduate work, in the omics-enabled biosciences. Read more
Designed to prepare you to interact with the world’s most advanced biological and clinical datasets - this programme will prepare you for careers, or further graduate work, in the omics-enabled biosciences.

The future of biology is bioinformatics – computational analysis procedures that leverage state-of-the-art statistics and machine learning to gain insight into systems of exquisite complexity. We have entered an era of unprecedented expansion in the biological sciences, and our data now grows exponentially faster than Moore’s law.

The biological sciences have been transformed by the advent of omics. Enabled by revolutionary advances in molecular sequencing and mass spectrometry, it is now possible to sequence a genome in six hours, simultaneously assess the expression level of every gene in a genome, quantify the abundance of proteins and metabolites, and determine the epigenetic and regulatory landscape of individual cells. Hypotheses are generated through the integrative analysis of enormous datasets, and tested in high-throughput with third-generation genome-engineering technologies, including CRISPR.

Biology is now driven by data.

About the College of Medical and Dental Sciences

The College of Medical and Dental Sciences is a major international centre for research and education, make huge strides in finding solutions to major health problems including ageing, cancer, cardiovascular, dental, endocrine, inflammatory diseases, infection (including antibiotic resistance), rare diseases and trauma.
We tackle global healthcare problems through excellence in basic and clinical science, and improve human health by delivering tangible real-life benefits in the fight against acute and chronic disease.
Situated in the largest healthcare region in the country, with access to one of the largest and most diverse populations in Europe, we are positioned to address major global issues and diseases affecting today’s society through our eight specialist research institutes.
With over 1,000 academic staff and around £60 million of new research funding per year, the College of Medical and Dental Sciences is dedicated to performing world-leading research.
We care about our research and teaching and are committed to developing outstanding scientists and healthcare professionals of the future. We offer our postgraduate community a unique learning experience taught by academics who lead the way in research in their field.

Funding and Scholarships

There are many ways to finance your postgraduate study at the University of Birmingham. To see what funding and scholarships are available, please visit: http://www.birmingham.ac.uk/postgraduate/funding

Open Days

Explore postgraduate study at Birmingham at our on-campus open days.
Register to attend at: http://www.birmingham.ac.uk/postgraduate/visit

Virtual Open Days

If you can’t make it to one of our on-campus open days, our virtual open days run regularly throughout the year. For more information, please visit: http://www.pg.bham.ac.uk

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