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The Master's in Cancer, Stem Cells and Developmental Biology guides you in exploring the mysteries of embryonic growth, stem cells, evolution and development in relation to health and disease. Read more

Cancer, Stem Cells and Developmental Biology

The Master's in Cancer, Stem Cells and Developmental Biology guides you in exploring the mysteries of embryonic growth, stem cells, evolution and development in relation to health and disease.

This Master's programme combines research in the fields of oncology,molecular developmental biology and genetics in animals and humans. During the major (9 months) and minor (6 months) research projects on topics of your own choice, you learn sophisticated modern techniques of genomics, proteomics and bioinformatics. It is possible to complete the minor research project in a laboratory of your choice abroad. During the two year research programme, you are required to take 10 weeks of theoretical courses in the areas grouped in five broad subject areas. You may choose your favourite courses from the list of courses organized by our programme, as well as by other programmes and institutes. Moreover, you are required to attend seminars that present research covering the full range of topics related to biomedical and life sciences.

A final Master's thesis, based on literature research on a relevant topic, completes your programme. It should present a clear overview of recent literature on the topic of interest and demonstrate your ability to critically evaluate hypotheses and results, present your own views and draw conclusions that may lead to the formulation of new research goals.

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The Institute of Genetic Medicine brings together a strong team with an interest in clinical and developmental genetics. Our research focuses on the causes of genetic disease at the molecular and cellular level and its treatment. Read more
The Institute of Genetic Medicine brings together a strong team with an interest in clinical and developmental genetics. Our research focuses on the causes of genetic disease at the molecular and cellular level and its treatment. Research areas include: genetic medicine, developmental genetics, neuromuscular and neurological genetics, mitochondrial genetics and cardiovascular genetics.

As a research postgraduate in the Institute of Genetic Medicine you will be a member of our thriving research community. The Institute is located in Newcastle’s Life Science Centre. You will work alongside a number of research, clinical and educational organisations, including the Northern Genetics Service.

We offer supervision for MPhil in the following research areas:

Cancer genetics and genome instability

Our research includes:
-A major clinical trial for chemoprevention of colon cancer
-Genetic analyses of neuroblastoma susceptibility
-Research into Wilms Tumour (a childhood kidney cancer)
-Studies on cell cycle regulation and genome instability

Cardiovascular genetics and development

We use techniques of high-throughput genetic analyses to identify mechanisms where genetic variability between individuals contributes to the risk of developing cardiovascular disease. We also use mouse, zebrafish and stem cell models to understand the ways in which particular gene families' genetic and environmental factors are involved in the normal and abnormal development of the heart and blood vessels.

Complex disease and quantitative genetics

We work on large-scale studies into the genetic basis of common diseases with complex genetic causes, for example autoimmune disease, complex cardiovascular traits and renal disorders. We are also developing novel statistical methods and tools for analysing this genetic data.

Developmental genetics

We study genes known (or suspected to be) involved in malformations found in newborn babies. These include genes involved in normal and abnormal development of the face, brain, heart, muscle and kidney system. Our research includes the use of knockout mice and zebrafish as laboratory models.

Gene expression and regulation in normal development and disease

We research how gene expression is controlled during development and misregulated in diseases, including the roles of transcription factors, RNA binding proteins and the signalling pathways that control these. We conduct studies of early human brain development, including gene expression analysis, primary cell culture models, and 3D visualisation and modelling.

Genetics of neurological disorders

Our research includes:
-The identification of genes that in isolation can cause neurological disorders
-Molecular mechanisms and treatment of neurometabolic disease
-Complex genetics of common neurological disorders including Parkinson's disease and Alzheimer's disease
-The genetics of epilepsy

Kidney genetics and development

Kidney research focuses on:
-Atypical haemolytic uraemic syndrome (aHUS)
-Vesicoureteric reflux (VUR)
-Cystic renal disease
-Nephrolithiasis to study renal genetics

The discovery that aHUS is a disease of complement dysregulation has led to a specific interest in complement genetics.

Mitochondrial disease

Our research includes:
-Investigation of the role of mitochondria in human disease
-Nuclear-mitochondrial interactions in disease
-The inheritance of mitochondrial DNA heteroplasmy
-Mitochondrial function in stem cells

Neuromuscular genetics

The Neuromuscular Research Group has a series of basic research programmes looking at the function of novel muscle proteins and their roles in pathogenesis. Recently developed translational research programmes are seeking therapeutic targets for various muscle diseases.

Stem cell biology

We research human embryonic stem (ES) cells, germline stem cells and somatic stem cells. ES cell research is aimed at understanding stem cell pluripotency, self-renewal, survival and epigenetic control of differentiation and development. This includes the functional analysis of genes involved in germline stem cell proliferation and differentiation. Somatic stem cell projects include programmes on umbilical cord blood stem cells, haematopoietic progenitors, and limbal stem cells.

Pharmacy

Our new School of Pharmacy has scientists and clinicians working together on all aspects of pharmaceutical sciences and clinical pharmacy.

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The only Master’s specialisation in the Netherlands covering the function of our epigenome, a key factor in regulating gene expression and in a wide range of diseases. Read more

Master's specialisation in Medical Epigenomics

The only Master’s specialisation in the Netherlands covering the function of our epigenome, a key factor in regulating gene expression and in a wide range of diseases.
Our skin cells, liver cells and blood cells all contain the same genetic information. Yet these are different types of cells, each performing their own specific tasks. How is this possible? The explanation lies in the epigenome: a heritable, cell-type specific set of chromosomal modifications, which regulates gene expression. Radboud University is specialised in studying the epigenome and is the only university in the Netherlands to offer a Master’s programme in this field of research.

Health and disease

The epigenome consists of small and reversible chemical modifications of the DNA or histone proteins, such as methylation, acetylation and phosphorylation. It changes the spatial structure of DNA, resulting in gene activation or repression. These processes are crucial for our health and also play a role in many diseases, like autoimmune diseases, cancer and neurological disorders. As opposed to modifications of the genome sequence itself, epigenetic modifications are reversible. You can therefore imagine the great potential of drugs that target epigenetic enzymes, so-called epi-drugs.

Big data

In this specialisation, you’ll look at a cell as one big and complex system. You’ll study epigenetic mechanisms during development and disease from different angles. This includes studying DNA and RNA by next-generation sequencing (epigenomics) and analysing proteins by mass spectrometry (proteomics). In addition, you‘ll be trained to design computational strategies that allow the integration of these multifaceted, high-throughput data sets into one system.

Why study Medical Epigenomics at Radboud University?

- Radboud University combines various state-of-the-art technologies – such as quantitative mass spectrometry and next-generation DNA sequencing – with downstream bioinformatics analyses in one department. This is unique in Europe.
- This programme allows you to work with researchers from the Radboud Institute for Molecular Life sciences (RIMLS), one of the leading multidisciplinary research institutes within this field of study worldwide.
- We have close contacts with high-profile medically oriented groups on the Radboud campus and with international institutes (EMBL, Max-Planck, Marie Curie, Cambridge, US-based labs, etc). As a Master’s student, you can choose to perform an internship in one of these related departments.
- Radboud University coordinates BLUEPRINT, a 30 million Euro European project focusing on the epigenomics of leukaemia. Master’s students have the opportunity to participate in this project.

Career prospects

As a Master’s student of Medical Epigenomics you’re trained in using state-of-the art technology in combination with biological software tools to study complete networks in cells in an unbiased manner. For example, you’ll know how to study the effects of drugs in the human body.
When you enter the job market, you’ll have:
- A thorough background of epigenetic mechanisms in health and disease, which is highly relevant in strongly rising field of epi-drug development
- Extensive and partly hands-on experience in state-of-the-art ‘omics’ technologies: next-generation sequencing, quantitative mass spectrometry and single cell technologies;
- Extensive expertise in designing, executing and interpreting scientific experiments in data-driven research;
- The computational skills needed to analyse large ‘omics’ datasets.

With this background, you can become a researcher at a:
- University or research institute;
- Pharmaceutical company, such as Synthon or Johnson & Johnson;
- Food company, like Danone or Unilever;
- Start-up company making use of -omics technology.

Apart from research into genomics and epigenomics, you could also work on topics such as miniaturising workflows, improving experimental devices, the interface between biology and informatics, medicine from a systems approach.

Or you can become a:
- Biological or medical consultant;
- Biology teacher;
- Policy coordinator, regarding genetic or medical issues;
- Patent attorney;
- Clinical research associate;

PhD positions at Radboud University

Each year, the Molecular Biology department (Prof. Henk Stunnenberg, Prof. Michiel Vermeulen) and the Molecular Developmental Biology department (Prof. Gert-Jan Veenstra) at the RIMLS offer between five and ten PhD positions. Of course, many graduates also apply for a PhD position at related departments in the Netherlands, or abroad.

Our approach to this field

- Systems biology
In the Medical Epigenomics specialisation you won’t zoom in on only one particular gene, protein or signalling pathway. Instead, you’ll regard the cell as one complete system. This comprehensive view allows you to, for example, model the impact of one particular epigenetic mutation on various parts and functions of the cell, or study the effects of a drug in an unbiased manner. One of the challenges of this systems biology approach is the processing and integration of large amounts of data. That’s why you’ll also be trained in computational biology. Once graduated, this will be a great advantage: you’ll be able to bridge the gap between biology, technology and informatics , and thus have a profile that is desperately needed in modern, data-driven biology.

- Multiple OMICS approaches
Studying cells in a systems biology approach means connecting processes at the level of the genome (genomics), epigenome (epigenomics), transcriptome (transcriptomics), proteome (proteomics), etc. In the Medical Epigenomics specialisation, you’ll get acquainted with all these different fields of study.

- Patient and animal samples
Numerous genetic diseases are not caused by genetic mutations, but by epigenetic mutations that influence the structure and function of chromatin. Think of:
- Autoimmune diseases, like rheumatoid arthritis and lupus
- Cancer, in the forms of leukaemia, colon cancer, prostate cancer and cervical cancer
- Neurological disorders, like Rett Syndrome, Alzheimer, Parkinson, Multiple Sclerosis, schizophrenia and autism

We investigate these diseases on a cellular level, focusing on the epigenetic mutations and the impact on various pathways in the cell. You’ll get the chance to participate in that research, and work with embryonic stem cell, patient, Xenopus or zebra fish samples.

See the website http://www.ru.nl/masters/medicalbiology/epigenomics

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This MSc offers a comprehensive guide to all aspects of modern day drug design. It is taught by research scientists, clinicians and industry experts. Read more
This MSc offers a comprehensive guide to all aspects of modern day drug design. It is taught by research scientists, clinicians and industry experts. Our graduates have progressed to undertake or obtain PhDs or medical studentships, or have found employment in both the private and public sector.

Degree information

The programme covers all aspects of drug design, including genomics, bioinformatics, structural biology, cheminformatics, molecular modelling and fragment-based drug design, drug target selection, intellectual property and marketing. New therapies and research areas such as antibodies, siRNA, stem cells and high throughput screening are covered. Students will develop essential skills such as research methods and techniques of drug design.

Students undertake modules to the value of 180 credits. The programme consists of eight core modules (120 credits) and a research project (60 credits). A Postgraduate Diploma (120 credits) is also offered. A Postgraduate Certificate (60 credits) is also offered. There are no optional modules for this programme.

Core modules
-Bioinformatics and Structural Biology
-Target Identification and High Throughput Screening
-Cheminformatics and Computer Drug Design
-Biological Molecules as Therapeutics - Antibodies, siRNA, and Stem Cells
-Biophysical Screening Methods, Protein NMR and Phenotypic Screening
-Fragment Based Drug Design (FBDD)
-Target Selection - Scientific Grounds
-Target Selection - Commercial and Intellectual Property

Dissertation/report
All MSc students undertake an independent research project which can take the form of a literature project, wet lab/computer modelling based project or an external project with an industrial sponsor.

Teaching and learning
The programme is delivered through a combination of lectures, tutorials, self study, practical sessions and discussion groups. The research project forms one third of the programme. Each of the taught modules is assessed by unseen written examination (50%) and coursework (50%). The research project is assessed by the dissertation and viva.

Careers

The programme will provide a good background for students looking to establish a career in drug design/discovery and related industries (biotech, pharma, national research laboratories and NHS agencies), and for industry professionals seeking to gain a greater understanding of new methodology. The knowledge and transferable skills delivered will also be useful for those intent on further PhD or medical studies.

Top career destinations for this degree:
-Industrial Chemistry, University of Oxford
-PhD Researcher (Molecular Biology), EMBL (European Molecular Biology Laboratory)
-Cancer Research, Imperial College London
-PhD Drug Design, University College London (UCL)
-PhD Oncology, Tianjin University

Employability
Graduates from this programme have progressed to PhD/medical studentships at different universities and research institutes around the world, including Oxford, UCL, Grenoble, EMBL, and in the USA and China. Many alumni have secured positions in research teaching and technical sales in the private and public sectors.

Why study this degree at UCL?

UCL is listed among the top five universities in the TImes Higher Education QS World University Rankings 2015/16 and is located in the centre of one of the world's finest cities. UCL is one of Europe's best and largest centres for biomedical research.

At the Wolfson Institute for Biomedical Research, we have pioneered multidisciplinary research with a particular emphasis on translating that research into useful clinical benefit. Our research expertise includes: medicinal chemistry, computational drug design, neuronal development and signalling, cell cycle control, intensive care medicine, stem cells, mitochondrial biology and cancer.

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Overview. The MRes courses are designed to provide students with intensive laboratory-based training in research methods, supported by in-depth understanding. Read more
Overview
The MRes courses are designed to provide students with intensive laboratory-based training in research methods, supported by in-depth understanding. The aim is to prepare graduates to make contributions, as individuals and members of a team, to research-oriented activities in the biomedical industries and related service sectors, or academia. The courses are also well-suited to students wishing to upgrade a first degree, change field, or gain valuable laboratory experience before employment or a PhD. The Strathclyde Institute of Pharmacy and Biomedical Sciences represents the largest Pharmacy research group in the UK, with 55% of its staff rated as either world-leading or internationally excellent in terms of originality, significance and rigour (data: Research Assessment Exercise 2008). The University of Strathclyde has invested £30M in a world-class, pioneering centre for biomedical and pharmaceutical sciences teaching and research, opened Aug 2010. Students will find themselves in stimulating, unique environment on account of the strongly multidisciplinary nature of the Institute. Combining fundamental and applied research across the areas of bioscience and pharmacy, SIPBS builds on its record of success in drug and vaccine discovery and development. The Institute engages with industry and the health services, ensuring that its excellent fundamental research is translated into products that are of benefit to health and society. For more information on SIPBS go to http://www.strath.ac.uk/sipbs

Course outline

An MRes degree is focussed on research and students will spend 8 months undertaking a laboratory-based project.
To support their chosen research project, students choose advanced-level taught courses in a named specialisation, from the following areas:

Taught classes delivered through lectures, workshops and practical classes in four areas:
1. Transferable skills training in data mining, interpretation and presentation; experimental planning, personal effectiveness, ethics in research
2. Commercialisation and entrepreneurship
3. MRes-specific classes relevant to subject area

Biomedical Sciences

Example research projects:
1. Antileishmanial activity of extracts and compounds from Monodora myristica
2. Imaging and modelling of cancer development
3. Endothelial progenitor cell expression and differentiation
4. Targeted radiotherapy for cancer
5. The involvement of pulmonary veins in atrial fibrillation: electrical properties
6. Reducing bacterial resistance to antibiotics
7. Development of neural stem cells with increased levels of the autophagy cell survival pathway
8. Investigating the role of Sigma 54 in Pseudomonas aeruginosa virulence
9. Transcriptional network analysis of the Escherichia coli core stress response.
10. Identification of novel anti-microbial compounds targeted at biofilm formation

Drug Delivery systems

Example research projects
1. Nanoparticulate formulations of insulin and their analysis
2. Mesoporous silicas for oral delivery of cyclosporine
3. Bioprocessing of biopharmaceuticals
4. Modified and time-delayed oral solid-dose release formulations
5. Nasal formulations of poorly soluble compounds
6. Reducing bacterial resistance to antibiotics: establishing, optimising and implementing a high throughput assay to discover natural product derived inhibitors of metallo beta-lactamase.
7. Imaging of dermal formulations using Raman microscopy techniques
8. Antileishmanial activity of extracts and compounds from Monodora myristica
9. Anti-trypanosomal active triterpenoids from some African Propolis
10. Investigation into the potential therapeutic properties of marine organisms
11. Photo-triggered adhesion of mammalian cells

Drug Discovery

Projects in the areas of :
1. Drug Delivery
2. Molecular Biology
3. Pharmacology
4. Pharmaceutical Materials and Formulation
5. Toxicology

Neuroscience

Projects in the areas of:
1. Electrophysiology
2. Stem cell biology for regenerative purposes
3. Cell biology
4. Inflammation
5. In vitro culture systems
6. Functional genetics

How to Apply
Applicants should apply through the University of Strathclyde on-line application form: http://pgr.strath.ac.uk indicating "Masters by Research", and named specialisation as appropriate. Applicants are not required to submit a detailed research proposal at this stage.

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This Biomedical Sciences degree offers research training for students in order to gain all the required Biomedical Sience entry requirements to proceed to a PhD. Read more
This Biomedical Sciences degree offers research training for students in order to gain all the required Biomedical Sience entry requirements to proceed to a PhD. It is largely based on individual research projects rather than coursework, and allows you to specialise in a particular area of study.

Why this programme

◾Ranked world top 100 for Biological Sciences
◾The Masters in Biomedical Science provides training in a wide range of modern molecular biology techniques required to pursue a research career.
◾You will gain valuable practical research experience by using the skills and techniques acquired during the programme to complete two extensive research projects.
◾The Biomedical Science programme is distinctive in that students complete two different extensive research projects of their choice, allowing them to acquire a wide range of knowledge and skills directly relevant to the study of human disease.
◾If you are aiming to study for a higherBiomedical Science degree , this programme is designed for you.
◾If you want to enter the pharmaceutical and biotechnology industries, this programme provides excellent training; and is an ideal introduction for overseas students who may wish to proceed to PhD biomedical science studies in the UK.
◾You can choose to specialise within a particular discipline or area, which can be important for career development, see programme structure below for more information.

Programme structure

The overall aims of the programme are:
◾to provide students with the knowledge, skills and confidence needed to pursue a career in laboratory research.
◾to provide students with a theoretical and practical understanding of advanced techniques used in modern biomedical sciences research.
◾to provide students with the opportunity to practice research skills in the laboratory by completing two extensive research projects.

MRes students have the opportunity to specialise in a particular discipline or area, which can be important for their career development. The specialisations are:
◾Biotechnology
◾Cancer Studies
◾Cardiovascular Studies
◾Cell Engineering
◾Integrative Mammalian Biology SFC funded places available

◾Medical Biochemistry and Molecular Biology
◾Molecular Genetics
◾Neuroscience
◾Proteomics

To qualify for a specialisation, students must select two research projects in a cognate research area.

Research projects

The central and most important part of the MRes is the two research projects that students undertake. Students choose both projects themselves in the subject areas that interest them and that will allow them to follow the career path they wish to follow. The MRes programme has a huge number of projects which students can choose from, across a wide spectrum of biomedical science.

The following are examples of the types of projects offered, to illustrate the range of subject areas.

• Making blood from human embryonic stem cells

• A gene-microarray based approach to the detection of recombinant human erythropoietin doping in endurance athletes

• Neuropathology of trypanosomiasis

• Development of a new technique for stem cell transfection

• Cloning and analysis of an inflammatory factor in cancer and autoimmune disease

• Analysis of viral induced cancer

Each year students have about 100 different projects to choose from and all students find research topics that interest them.

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This course blends theory and practice to help you develop the skills required for a career in molecular and cellular biology. Our teaching focuses on integrated mammalian biology and animal models of human disease, drawing on our pioneering biomedical research. Read more

About the course

This course blends theory and practice to help you develop the skills required for a career in molecular and cellular biology. Our teaching focuses on integrated mammalian biology and animal models of human disease, drawing on our pioneering biomedical research.

Where your masters can take you

Graduates with skills in stem cell and regenerative medicine are in demand. Your degree will prepare you for a career in research in academia or industry, or in a clinical-related field. Our graduates are working all over the world – from the UK to China, India and the USA – and over half go on to doctoral study.

Learn from the experts

The 2014 Research Excellence Framework (REF) rates us No 1 in the UK for research in this field. Our international reputation attracts highly motivated staff and students. Sheffield is a vibrant place to take a masters based on pioneering research.

Regular seminars from distinguished international experts help you to connect your studies to the latest developments. We’re also part of collaborative research groups for developmental biology, cell biology, physiology, pharmacology, neuroscience, models of human disease, stem cell science and regenerative medicine.

Our three research centres focus on translating laboratory research to the clinical environment: Bateson Centre, the Centre for Stem Cell Biology, and the Centre for Membrane Interactions and Dynamics.

Leaders in our field

We have a long track record of groundbreaking discoveries. These include breakthroughs in human stem cells for hearing repair, and the generation of animal models for Parkinson’s disease, schizophrenia, muscular dystrophies and their use for therapeutic studies.

Labs and equipment

We have purpose-built facilities for drosophila, zebrafish, chick and mouse genetics and for molecular physiology. Other facilities provide all the tools you’ll need to examine and analyse a range of cellular structures. We have an electron and a light microscopy centre, a PCR robotics facility, a flow cytometry unit and an RNAi screening facility.

Teaching and assessment

There are lectures, practical classes, tutorials and seminars. In small group teaching classes you’ll discuss, debate and present on scientific and ethical topics. Laboratory placements within the department provide you with one-to-one attention, training and support to do your individual research project. Assessment is by formal examinations, coursework assignments, debates, poster presentations and a dissertation.

Our teaching covers ethics, practical scientific skills and an overview of the current literature. You’ll also develop useful career skills such as presentation, communication and time management.

Core modules

Literature Review; Practical Research Project; Analysis of Current Science; Ethics and Public Understanding.

Examples of optional modules

Integrated Mammalian Biology; Practical Cell Biology; Practical Developmental Genetics; Cancer Biology; Modelling Human Diseases; Epithelia in Health and Disease.

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This Master's degree in Cell and Gene Therapy provides an in-depth education in this cutting-edge and rapidly developing field. Read more
This Master's degree in Cell and Gene Therapy provides an in-depth education in this cutting-edge and rapidly developing field. It is delivered by scientists and clinicians researching, developing and testing new treatments for genetically inherited and acquired diseases using gene delivery technology, stem cell manipulation and DNA repair techniques.

Degree information

The degree covers all aspects of the subject, including basic biomedical science, molecular basis of disease, current and developing technologies and clinical applications. Students also receive vocational training in research methodology and statistics, how to perform a research project and complete a practical laboratory-based project.

Students undertake modules to the value of 180 credits.

The programme consists of four core modules (60 credits), four optional modules (60 credits) and a research dissertation (60 credits). A Postgraduate Diploma (120 credits, full-time nine months or flexible up to five years) is offered. A Postgraduate Certificate (60 credits, full-time 12 weeks, part-time nine months, or up to two years flexible) is offered.

Core modules
-Molecular Aspects of Cell and Gene Therapy
-Clinical Applications of Cell and Gene Therapy
-Research Methodology and Statistics
-Stem Cell and Tissue Repair

Research Methodology and Statistics is not a core module for the PG Certificate. Students of the PG Certificate can choose an optional module.

Optional modules
-Foundations of Biomedical Sciences
-Applied Genomics
-HIV Frontiers from Research to Clinics
-Molecular and Genetic Basis of Paediatric Disease
-Understanding Research and Critical Appraisal: Biomedicine
-Laboratory Methods in Biomedical Science
-Research Methodology and Statistics

Dissertation/report
All MSc students undertake an independent research project which culminates in a dissertation.

Teaching and learning
Teaching includes lectures, seminars, problem classes and tutorials. Assessment varies depending on the module, but includes written coursework, multiple-choice questions, written examinations, a practical analysis examination and the dissertation.

Careers

The majority of our graduates have gone on to secure PhD places. Please see our programme website to read testimonials from past students which include their destinations following graduation.

Employability
This novel programme aims to equip students for careers in research, education, medicine and business in academic, clinical and industrial settings. Examples of potential careers could include academic research and/or lecturing in a university or other higher education setting, conducting clinical trials as part of a team of clinicians, scientists and allied health professionals, monitoring and analysing the results of clinical trials as part of a clinical trials unit, developing new therapies or intellectual property in the pharmaceutical industry or other business ventures.

Why study this degree at UCL?

The Institute of Child Health (ICH), and its clinical partner Great Ormond Street Hospital (GOSH), is the largest centre in Europe devoted to clinical, basic research and post-graduate education in children's health, including haematopoietic stem cell transplantation (HSCT) and gene therapy.

The UCL School of Life & Medical Sciences (SLMS) has the largest concentration of clinicians and researchers active in cell and gene therapy research in Europe. This is reflected by the many groups conducting high-quality research and clinical trials in the field including researchers at the Institute of Child Health, the Division of Infection and Immunity, the Institute of Ophthalmology, the Institute for Women's Health, the Institute of Genetics and the Cancer Institute.

Keywords: Stem Cells, Therapy, Genomics, Regenerative Medicine, Gene Editing

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This programme offers a fascinating range of subjects, including molecular biology, genetics, biochemistry, microbiology, immunology, tissue engineering, clinical medicine, laboratory management and statistics. Read more
This programme offers a fascinating range of subjects, including molecular biology, genetics, biochemistry, microbiology, immunology, tissue engineering, clinical medicine, laboratory management and statistics.

It is accredited by the Institute of Biomedical Science and is based at one of the largest transfusion centres in the world, enabling visits to manufacturing, testing and tissue typing sections. You will learn from specialist lecturers based at the University, NHS Blood and Transplant (NHSBT), and NHS hospitals, and have an opportunity to become fully embedded in an NHS environment while you develop your knowledge.

The programme will give you extensive practical experience of transfusion and transplantation, allowing you to gain skills that directly relate to your future career. As well as being academically interesting, this continually developing area of healthcare science has a major impact on patients' quality of life.

The programme:
-Is one of just two specialist full-time courses in transfusion and transplantation, and is a recommended course at level seven in the Career Framework for Health.
-Gives you the opportunity to carry out your MSc project with NHSBT research staff within the transfusion centre.
-Has high contact hours, with teaching each day and practical classes.
-Includes a large skills component (eg writing in different formats, conference and publication skills, assignments with specific study aims).
-Includes laboratory management, a key skill required at level seven.
-Attracts a diverse range of students (about 50 per cent overseas students), including new graduates, those working in blood centres or blood transfusion/haematology in hospitals, or training to lecture in transfusion.

Programme structure

The programme comprises eight taught units that run from September to March and a research project that begins in May and runs until August. Example project topics have included:
-A study on red cell antibody formation in trauma patients
-Optimisation of platelet antigen detection using recombinant proteins
-Expression of red cell membrane proteins during large-scale red cell culture
-A comparison of stem cell mobilisation drugs for stem cell transplantation

Taught units
-Transfusion and Transplantation Science:
-Pathology of Transfusion and Transplantation Science
-Provision of Blood, Cells, Tissues and Organs
-Clinical Transfusion and Transplantation
-Transfusion and Transplantation in Practice (two units)
-Biostatistics
-Research and Laboratory Management

Assessments are designed to teach skills such as comprehension, scientific writing in different formats and conference skills, and to further knowledge in subject areas not covered in the lectures. Students must pass the taught component to be able to progress to the project.

Part-time students complete the Postgraduate Certificate components in their first year and the Postgraduate Diploma in the second. The project is usually taken during year three to complete the MSc.

Careers

Some of the career paths that graduates have followed include: blood transfusion and fetal medicine research, working for a bone marrow donor laboratory or bone marrow registry, biostatistics, graduate entry to medical school, NHS Clinical Scientist Training programme, and progression to PhD study in several areas including cancer biology and stem cell regeneration.

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If you’re an international fee-paying student you could be eligible for a £3,000 discount when you start your course in January 2017. Read more
If you’re an international fee-paying student you could be eligible for a £3,000 discount when you start your course in January 2017.
http://www.shu.ac.uk/VCAwardJanuary2017

Enhance your knowledge and skills in biosciences with an emphasis on biotechnology and increase your competitiveness in the job market. Whether you are a new graduate or already employed and seeking to further your career prospects, this course offers a solid career development path. You can also choose this course if you wish to pursue research in biotechnology at PhD level.

Biotechnology is the application of biological processes and is underpinned by:
-Cell biology
-Molecular biology
-Bioinformatics
-Structural biology.

It encompasses a wide range of technologies for modifying living organisms or their products according to human needs.

Applications of biotechnology span medicine, technology and engineering. Important biotechnological advances including:
-The production of therapeutic proteins using cloned DNA, for example insulin and clotting factors.
-The application of stem cells to treat human disease.
-The enhancement of crop yields and plants with increased nutritional value.
-Herbicide and insect resistant plants.
-Production of recombinant antibodies for the treatment of disease.
-Edible vaccines, in the form of modified plants.
-Development of biosensors for the detection of biological and inorganic analytes.

You gain:
-Up-to-date knowledge of the cellular and molecular basis of biological processes.
-An advanced understanding of DNA technology and molecular biotechnology.
-Knowledge of developing and applying biotechnology to diagnosis and treatment of human diseases.
-Practical skills applicable in a range of bioscience laboratories.
-The transferable and research skills to enable you to continue developing your knowledge and improving your employment potential.

The course is led by internationally recognised academics who are actively involved in biotechnology research and its application to the manipulation of proteins, DNA, mammalian cells and plants. Staff also have expertise in the use of nanoparticles in drug delivery and the manipulation of microbes in industrial and environmental biotechnology.

You are supported throughout your studies by a personal tutor.

You begin your studies focusing on the fundamentals of advanced cell biology and molecular biology before specialising in both molecular and plant biotechnology. Practical skills are developed throughout the course and you gain experience in molecular biology techniques such as PCR and sub cloning alongside tissue culture.

Core to the program is the practical module where you gain experience in a range of techniques used in the determination of transcription and translational levels, for example.

All practicals are supported by experienced academic staff, skilled in the latest biotechnological techniques.

Research and statistical skills are developed throughout the program. Towards the end of the program you apply your skills on a two month research project into a current biotechnological application. Employability skills are developed throughout the course in two modules.

For more information, see the website: https://www.shu.ac.uk/study-here/find-a-course/mscpgdippgcert-biotechnology

What is biotechnology

Biotechnology is the basis for the production of current leading biopharmaceuticals and has already provided us with the 'clot-busting' drug, tissue plasminogen activator for the treatment of thrombosis and myocardial infarction. It also holds the promise of new treatments for neurodegeneration and cancer through recombinant antibodies. Recombinant proteins are also found throughout everyday life from washing powders to cheese as well as many industrial applications.

Genetically modified plants have improved crop yields and are able to grow in a changing environment. Manipulation of cellular organisms through gene editing methods have also yielded a greater understanding of many disease states and have allowed us to understand how life itself functions.

Course structure

Full time – 14 months to Masters. Part time – typically 2 years to Masters. The Diploma and Certificate are shorter. Starts September and January.

The masters (MSc) award is achieved by successfully completing 180 credits. The Postgraduate Certificate (PgCert) is achieved by successfully completing 60 credits. The Postgraduate Diploma (PgDip) is achieved by successfully completing 120 credits.

Core modules
-Cell biology (15 credits)
-Biotechnology (15 credits)
-Plant biotechnology (15 credits)
-Molecular biology (15 credits)
-Applied biomedical techniques (15 credits)
-Professional development (15 credits)
-Research methods and statistics (15 credits)
-Research project (60 credits)

Options (choose one from)
-Human genomics and proteomics (15 credits)
-Cellular and molecular basis of disease (15 credits)
-Cellular and molecular basis of cancer (15 credits)

Assessment
Assessment methods include written examinations and coursework including: problem-solving exercises; case studies; reports from practical work; in-depth critical analysis; oral presentations. Research project assessment includes a written report and viva.

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This MSc programme in Biomedical Sciences offers research training for student intending to proceed to a career in biomedical sciences, either directly or through a PhD. Read more
This MSc programme in Biomedical Sciences offers research training for student intending to proceed to a career in biomedical sciences, either directly or through a PhD. It is based on a research project and coursework.

Why this programme

◾Ranked world top 100 for Biological Sciences
◾The programme provides training in a wide range of modern molecular biology techniques required to pursue a research career in biomedical science.
◾You will gain valuable practical research experience by using the skills and techniques acquired during the programme to complete an in depth research project.
◾If you are aiming to study for a higher degree, or enter a biomedical career, then this programme is designed specifically for you.
◾If you want to enter the pharmaceutical and biotechnology industries, this programme provides excellent training.
◾It is an ideal introduction for overseas students who may wish to proceed to PhD studies in the UK, Europe or the USA.
◾This course is similar to the MRes Biomedical Sciences, but instead has more teaching in the first part of the programme, and one research project, which starts later in the year. This allows students more time to acquire knowledge and skills before they start their research work.

Programme structure

The overall aims of the programme are:
◾to provide students with the knowledge, skills and confidence needed to pursue a career in laboratory research.
◾to provide students with a theoretical and practical understanding of advanced techniques used in modern biomedical sciences research.
◾to provide students with the opportunity to practice research skills in the laboratory by completing an extensive research project in an area of their choice.

Projects

An important part of the MSc is your choice of research project; there are a huge number of choices available from a wide spectrum of biomedical science. Please see examples below:

• Making blood from human embryonic stem cells

• A gene-microarray based approach to the detection of recombinant human erythropoietin doping in endurance athletes

• Neuropathology of trypanosomiasis

• Development of a new technique for stem cell transfection

• Cloning and analysis of an inflammatory factor in cancer and autoimmune disease

• Analysis of viral induced cancer

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Molecular Medicine is a broad discipline that relates to the study of the molecular mechanisms of disease and their application in developing therapies for the clinic. Read more
Molecular Medicine is a broad discipline that relates to the study of the molecular mechanisms of disease and their application in developing therapies for the clinic. It is an exciting time to be a biomedical scientist, with the forefront of healthcare research currently focused on personalised medicine, stem cells and the prospect of gene editing. This taught Masters aims to provide students with an in-depth grounding in contemporary molecular medicine. The Department of Biology has considerable research expertise spanning several areas relevant to molecular medicine, including cancer, immunology, microbiology, neuroscience and parasitology.

Key features

-Learn how basic biomedical research is conducted and translated by scientists in one of the UK’s top-ranked biological sciences departments
-Develop the skills to pursue a PhD in biomedical research or other specialist career path within the healthcare/pharmaceutical sector.

Taught modules

-Molecular Basis of Disease
-Data Analysis and Programming in the Biosciences
-Research, Professional and Team Skills
-Optional modules in topics including cancer, neuroscience, cell and tissue engineering, and microbiology.

Research projects

After receiving training in core laboratory techniques and experimental design, students will undertake an Independent Study Module under the supervision of a biomedical researcher in the Department of Biology or as an external placement. Recent external placement destinations include MicroLab Devices, Leeds; Cancer Research UK, London; Computomics GmbH & Co, Tübingen; Forsite Diagnostics Ltd, York; MRC Harwell, Oxford; Smith & Nephew, York; GSK, London; Francis Crick Institute, London; and AstraZeneca, Cambridge.

Research and transferable skills

We will equip students with the key skills of the modern researcher, including critical thinking, data interpretation, statistics, programming, and the written, oral and graphical presentation of scientific data and ideas.

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This programme focuses on interdisciplinary research in the field of innovation and usage of drugs, for example vaccines, gene therapeutics, medical nutrition and antibodies. Read more

DRUG INNOVATION: A UNIQUE PROGRAMME

This programme focuses on interdisciplinary research in the field of innovation and usage of drugs, for example vaccines, gene therapeutics, medical nutrition and antibodies.

Typical research questions addressed in the field of Drug Innovation include:
* How do we make new drugs against resistant microorganisms?
* Which proteins can we target for personalized cancer medicine?
* Can we differentiate stem cells by means of proteomics?
* How can we imprint the immune system to become tolerant?
* What is the connection between gut microbes and brains disease?
* Can we deliver proteins and gens to diseased cells, by learning from viruses and bacteria?
* How can we innovate and speed up the regulatory process of weighing benefit and risk?
* Which biomarkers predict for quality adjusted life years?

As a graduate you will be eligible for many PhD programmes and be able to contribute to drug innovation within research institutes, pharmaceutical and biotechnology companies or health care organisations.

Our programme offers a diverse suite of elective courses. This means you can concentrate on the topics of most interest to you.

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The Department of Oncology and the Department for Continuing Education’s CPD Centre offer a part-time MSc in Experimental Therapeutics that brings together some of Oxford's leading clinicians and scientists to deliver an advanced modular programme designed for those in full-time employment, both in the UK and overseas. Read more
The Department of Oncology and the Department for Continuing Education’s CPD Centre offer a part-time MSc in Experimental Therapeutics that brings together some of Oxford's leading clinicians and scientists to deliver an advanced modular programme designed for those in full-time employment, both in the UK and overseas.

The Programme draws on the world-class research and teaching in experimental therapeutics at Oxford University and offers a unique opportunity to gain an understanding of the principles that underpin clinical research and to translate this into good clinical and research practice.

Visit the website https://www.conted.ox.ac.uk/about/msc-in-experimental-therapeutics

The first deadline for applications is Friday 20 January 2017

If your application is completed by this January deadline and you fulfil the eligibility criteria, you will be automatically considered for a graduate scholarship. For details see: http://www.ox.ac.uk/admissions/graduate/fees-and-funding/graduate-scholarships.

Programme details

The MSc in Experimental Therapeutics is a part-time course consisting of six modules and a research project and dissertation. The programme is normally completed in two to three years. Students are full members of the University of Oxford and are matriculated as members of an Oxford college.

The modules in this programme can also be taken as individual short courses. It is possible to transfer credit from up to three previously completed modules into the MSc programme, if the time elapsed between commencement of the accredited module(s) and registration for the MSc is not more than two years.

Programme modules:

- The Structure of Clinical Trials and Experimental Therapeutics
- Drug Development, Pharmacokinetics and Imaging
- Pharmacodynamics, Biomarkers and Personalised Therapy
- Adverse Drug Reactions, Drug Interactions, and Pharmacovigilance
- How to do Research on Therapeutic Interventions: Protocol Preparation
- Biological Therapeutics

Course aims

The aim of the MSc programme is to provide students with the necessary training and practical experience to enable them to understand the principles that underpin clinical research, and to enable them to translate that understanding into good clinical and research practice.

By the end of the MSc programme, students should understand the following core principles:

- Development, marketing and regulations of drugs
- Pharmaceutical factors that affect drug therapy
- Pharmacokinetics, pharmacogenetics and pharmacodynamics
- Adverse drug reactions, drug interactions, and pharmacovigilance
- Designing phase I, II and III clinical trials for a range of novel therapeutic interventions (and imaging agents).
- Application of statistics to medicine
- Laboratory assays used to support trial end-points
- Use of non-invasive imaging in drug development
- Application of analytical techniques

By the end of the programme, students should be equipped to:

- demonstrate a knowledge of the principles, methods and techniques for solving clinical research problems and translate this into good clinical and research practice
- apply skills gained in techniques and practical experience from across the medical and biological sciences
- develop skills in managing research-based work in experimental therapeutics
- carry out an extended research project involving a literature review, problem specification and analysis in experimental therapeutics and write a short dissertation

Guidance from the UK Royal College of Physician's Faculty of Pharmaceutical Medicine

The Faculty have confirmed that if enrolled for Pharmaceutical Medicine Specialty Training (PMST), trainees may be able to use knowledge provided by Experimental Therapeutics modules to cover aspects of a module of the PMST curriculum. Trainees are advised to discuss this with their Educational Supervisor.

Experimental Therapeutics modules may also be used to provide those pursuing the Faculty's Diploma in Pharmaceutical Medicine (DPM) with the necessary knowledge required to cover the Diploma syllabus. Applicants for the DPM exam are advised to read the DPM syllabus and rules and regulations.

Members of the Faculty of Pharmaceutical Medicine who are registered in the Faculty's CPD scheme can count participation in Experimental Therapeutics modules towards their CPD record. Non-members may wish to obtain further advice about CPD credit from their Royal College or Faculty.

Assessment methods

To complete the MSc, students need to:

Attend the six modules and complete an assessed written assignment for each module.
Complete a dissertation on a topic chosen in consultation with a supervisor and the Course Director.

Dissertation:
The dissertation is founded on a research project that builds on material studied in the taught modules. The dissertation should normally not exceed 15,000 words.

The project will normally be supervised by an academic supervisor from the University of Oxford, and an employer-based mentor.

The following are topics of dissertations completed by previous students on the course:

- The outcomes of non-surgical management of tubal pregnancy; a 6 month study of the South East London population

- Analysis of the predictive and prognostic factors of outcome in a cohort of patients prospectively treated with perioperative chemotherapy for adenocarcinoma of the stomach or of the gastroesophageal junction

- Evolution of mineral and bone disorder in early Chronic Kidney Disease (CKD): the role of FGF23 and vitamin D

- Survey of patients' knowledge and perception of the adverse drug reporting scheme (yellow cards) in primary care

- The predictive role of ERCC1 status in oxaliplatin based Neoadjuvant for metastatic colorectal cancer (CRC) to the liver

- Endothelial Pathophysiology in Dengue - Dextran studies during acute infection

- Literature review of the use of thalidomide in cancer

- An investigation into the phenotypical and functional characteristics of mesenchymal stem cells for clinical application

- Identification of genetic variants that cause capecitabine and bevacizumab toxicity

- Bridging the evidence gap in geriatric medicines via modelling and simulations

Teaching methods

The class-based modules will include a period of preparatory study, a week of intensive face-to-face lectures and tutorials, followed by a period for assignment work. Attendance at modules will be a requirement for study. Some non-classroom activities will be provided at laboratory facilities elsewhere in the University. The course will include taught material on research skills. A virtual learning environment (VLE) will provide between-module support.

The taught modules will include group work, discussions, guest lectures, and interaction and feedback with tutors and lecturers. Practical work aims to develop the students' knowledge and understanding of the subject.

Find out how to apply here - http://www.ox.ac.uk/admissions/graduate/applying-to-oxford

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Haematologists specialise in disorders of the blood and blood-forming tissues, and their contribution to patient care is fundamental and wide-ranging. Read more
Haematologists specialise in disorders of the blood and blood-forming tissues, and their contribution to patient care is fundamental and wide-ranging. Whether you’re analysing data from patients' samples, matching donated blood with someone who needs a transfusion or researching cures for blood cancers, your work will improve and save countless lives.


Why study MSc Biomedical Science -Haematology and Transfusion Science at Middlesex?

Our Biomedical Science courses have a burgeoning international reputation, due to our world-class research in areas including biomarkers, public health and bio modelling. Our Centre for Investigative and Diagnostic Oncology has pioneered techniques for cancer diagnosis and treatment, and the Haematology department is very active in research into blood cancers, HIV and AIDS.

Our course has a strong practical element, with an emphasis on developing laboratory skills and gaining hands-on experience of diagnostic techniques. Our teaching and research facilities surpass those at some UK medical schools, with £3 million specialist labs equipped with the most up-to-date technology- the perfect place to work on your own research project. You’ll learn to use cutting-edge equipment, including MALDI-TOF mass spectrometers and flow cyto meters; we have a molecular biology laboratory for techniques such as DNA sequencing, real-time PCR, electrophoresis and HPLC, fully-equipped proteomics facilities, a microbiology lab and an incredibly modern cell culture facility.

Course highlights

- Course leader Dr Colin Casimir is famed for his research into the biology of haemopoietic stem cells and gene therapy for haematologic conditions. He is the holder of a number of international patents, and his research has been published in top international journals, including the British Journal of Haematology.
- Other teaching staff include Dr Stephen Butler, a world expert on cancer biomarkers and reproductive biochemistry; Dr Ajit Shah, a former principal scientist at GlaxoSmithKline; and Dr Lucy Ghali, an expert in immunohistochemistry. Guest lecturers include Peter Gregory, haematology services manager at Barnet and Chase Farm Hospitals Trust.
- Our staff are supportive and hands-on – ever-ready with advice on your studies, they’re also known for their strong pastoral care and for going the extra mile for their students. All our teaching staff are involved in research.
- The course is accredited by the Institute of Biomedical Science, so on graduation you’ll have fulfilled the academic requirement for Licentiate membership of the institute; you can apply for student membership while you study.
- We work with London hospitals and NHS laboratories to ensure you’re fully versed in both the latest practice and the latest research. - You’ll visit diagnostic laboratories and of course, our location gives you easy access to the British Library, the Science Museum, the Royal Institution and more.

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