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Masters Degrees (Cancer Stem Cell)

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Cell-to-cell signalling in development and disease. Do you have a clear and specific interest in cancer, stem cells or developmental biology? Our Master’s programme. Read more

Cell-to-cell signalling in development and disease

Do you have a clear and specific interest in cancer, stem cells or developmental biology? Our Master’s programme Cancer, Stem Cells and Developmental Biology combines research in three areas: oncology, molecular developmental biology and genetics. The focus is on molecular and cellular aspects of development and disease, utilising different model systems (mice, zebrafish, C. elegans, organoids and cell lines). The programme will guide you through the mysteries of embryonic growth, stem cells, signalling, gene regulation, evolution, and development as they relate to health and disease.

The right choice for you?

Given that fundamental developmental processes are so often impacted by disease, an understanding of these processes is vital to the better understanding of disease treatment and prevention. Adult physiology is regulated by developmental genes and mechanisms which, if deregulated, may result in pathological conditions. If you have a specific interest in cancer, stem cells or developmental biology, this Master’s programme is the right choice for you. Cancer, Stem Cells and Developmental Biology offers you international, high ranked research training and education that builds on novel methodology in genomics, proteomics, metabolomics and bioinformatics technology applied to biomedical and developmental systems and processes.

What you’ll learn

In the Cancer, Stem Cells and Developmental Biology programme you will learn to focus on understanding processes underlying cancer and developmental biology using techniques and applications of post-genomic research, including microarray analysis, next generation sequencing, proteomics, metabolomics and advanced microscopy techniques. You explore research questions concerning embryonic growth, stem cells, signaling pathways, gene regulation, evolution and development in relation to health and disease using various model systems. As a Master’s student you will take theory courses and seminars, as well as master classes led by renowned specialists in the field. The courses are interactive, and challenge you to further improve your writing and presenting skills.

Why study Cancer, Stem Cells and Developmental Biology at Utrecht University?

Compared to most other Master’s programmes in cancer and stem cell biology in the Netherlands, in Utrecht we offer:

  • Strong focus on fundamental molecular aspects of disease related questions, particularly questions related to cancer and the use of stem cells in regenerative medicine
  • A unique emphasis on Developmental Biology, a process with many connections to cancer
  • The opportunity to carry out two extensive research projects at renowned research groups
  • An intensive collaboration with national and international research institutes, allowing you to do your internship at prestigious partner institutions all around the world

Career in Cancer, Stem Cells and Developmental Biology

As a MSc graduate trained in both fundamental and disease-oriented aspects of biomedical genetics you are in great demand. You’ll be prepared for PhD study in one of the participating or associated groups. Alternatively, leaving after obtaining your MSc degree you will profit from a solid education in molecular genetics, in addition to your specialised knowledge of developmental biology. You’ll find your way to biotechnology, the pharmaceutical industry or education.



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The Institute of Genetic Medicine brings together a strong team with an interest in clinical and developmental genetics. Our research focuses on the causes of genetic disease at the molecular and cellular level and its treatment. Read more
The Institute of Genetic Medicine brings together a strong team with an interest in clinical and developmental genetics. Our research focuses on the causes of genetic disease at the molecular and cellular level and its treatment. Research areas include: genetic medicine, developmental genetics, neuromuscular and neurological genetics, mitochondrial genetics and cardiovascular genetics.

As a research postgraduate in the Institute of Genetic Medicine you will be a member of our thriving research community. The Institute is located in Newcastle’s Life Science Centre. You will work alongside a number of research, clinical and educational organisations, including the Northern Genetics Service.

We offer supervision for MPhil in the following research areas:

Cancer genetics and genome instability

Our research includes:
-A major clinical trial for chemoprevention of colon cancer
-Genetic analyses of neuroblastoma susceptibility
-Research into Wilms Tumour (a childhood kidney cancer)
-Studies on cell cycle regulation and genome instability

Cardiovascular genetics and development

We use techniques of high-throughput genetic analyses to identify mechanisms where genetic variability between individuals contributes to the risk of developing cardiovascular disease. We also use mouse, zebrafish and stem cell models to understand the ways in which particular gene families' genetic and environmental factors are involved in the normal and abnormal development of the heart and blood vessels.

Complex disease and quantitative genetics

We work on large-scale studies into the genetic basis of common diseases with complex genetic causes, for example autoimmune disease, complex cardiovascular traits and renal disorders. We are also developing novel statistical methods and tools for analysing this genetic data.

Developmental genetics

We study genes known (or suspected to be) involved in malformations found in newborn babies. These include genes involved in normal and abnormal development of the face, brain, heart, muscle and kidney system. Our research includes the use of knockout mice and zebrafish as laboratory models.

Gene expression and regulation in normal development and disease

We research how gene expression is controlled during development and misregulated in diseases, including the roles of transcription factors, RNA binding proteins and the signalling pathways that control these. We conduct studies of early human brain development, including gene expression analysis, primary cell culture models, and 3D visualisation and modelling.

Genetics of neurological disorders

Our research includes:
-The identification of genes that in isolation can cause neurological disorders
-Molecular mechanisms and treatment of neurometabolic disease
-Complex genetics of common neurological disorders including Parkinson's disease and Alzheimer's disease
-The genetics of epilepsy

Kidney genetics and development

Kidney research focuses on:
-Atypical haemolytic uraemic syndrome (aHUS)
-Vesicoureteric reflux (VUR)
-Cystic renal disease
-Nephrolithiasis to study renal genetics

The discovery that aHUS is a disease of complement dysregulation has led to a specific interest in complement genetics.

Mitochondrial disease

Our research includes:
-Investigation of the role of mitochondria in human disease
-Nuclear-mitochondrial interactions in disease
-The inheritance of mitochondrial DNA heteroplasmy
-Mitochondrial function in stem cells

Neuromuscular genetics

The Neuromuscular Research Group has a series of basic research programmes looking at the function of novel muscle proteins and their roles in pathogenesis. Recently developed translational research programmes are seeking therapeutic targets for various muscle diseases.

Stem cell biology

We research human embryonic stem (ES) cells, germline stem cells and somatic stem cells. ES cell research is aimed at understanding stem cell pluripotency, self-renewal, survival and epigenetic control of differentiation and development. This includes the functional analysis of genes involved in germline stem cell proliferation and differentiation. Somatic stem cell projects include programmes on umbilical cord blood stem cells, haematopoietic progenitors, and limbal stem cells.

Pharmacy

Our new School of Pharmacy has scientists and clinicians working together on all aspects of pharmaceutical sciences and clinical pharmacy.

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This Master's degree in Cell and Gene Therapy provides an in-depth education in this cutting-edge and rapidly developing field. Read more

This Master's degree in Cell and Gene Therapy provides an in-depth education in this cutting-edge and rapidly developing field. It is delivered by scientists and clinicians researching, developing and testing new treatments for genetically inherited and acquired diseases using gene delivery technology, stem cell manipulation and DNA repair techniques.

About this degree

The degree covers all aspects of the subject, including basic biomedical science, molecular basis of disease, current and developing technologies and clinical applications. Students also receive vocational training in research methodology and statistics, how to perform a research project and complete a practical laboratory-based project.

Students undertake modules to the value of 180 credits.

The programme consists of four core modules (60 credits), four optional modules (60 credits) and a research dissertation (60 credits).

A Postgraduate Diploma (120 credits, full-time nine months or flexible up to five years) is offered

A Postgraduate Certificate (60 credits, full-time 12 weeks, part-time nine months, or up to two years flexible) is offered.

Core modules

  • Molecular Aspects of Cell and Gene Therapy
  • Clinical Applications of Cell and Gene Therapy
  • Research Methodology and Statistics
  • Stem Cell and Tissue Repair

Research Methodology and Statistics is not a core module for the PG Certificate. Students of the PG Certificate can choose an optional module.

Optional modules

  • Foundations of Biomedical Sciences
  • Applied Genomics
  • HIV Frontiers from Research to Clinics
  • Molecular and Genetic Basis of Paediatric Disease
  • Understanding Research and Critical Appraisal: Biomedicine
  • Laboratory Methods in Biomedical Science
  • Research Methodology and Statistics

Dissertation/report

All MSc students undertake an independent research project which culminates in a dissertation.

Teaching and learning

Teaching includes lectures, seminars, problem classes and tutorials. Assessment varies depending on the module, but includes written coursework, multiple-choice questions, written examinations, a practical analysis examination and the dissertation of up to 10,000 words

Further information on modules and degree structure is available on the department website: Cell and Gene Therapy MSc

Careers

This programme aims to equip students for careers in research, education, medicine and business in academic, clinical and industrial settings. Examples of potential careers could include academic research and/or lecturing in a university or other higher education setting, conducting clinical trials as part of a team of clinicians, scientists and allied health professionals, monitoring and analysing the results of clinical trials as part of a clinical trials unit, developing new therapies or intellectual property in the pharmaceutical industry or other business ventures.

Several of our graduates have gone on to secure PhD places. You can read testimonials from past students which include their destinations following graduation.

Recent career destinations for this degree

  • Biomedical Scientist, Science Health Society
  • Post-Doctoral Fellow, University of London
  • PhD in Cell and Gene Therapy, UCL
  • Research Assistant, The Magdi-Yacoub Institute / Heart Science
  • Scientist, Unspecified Pharmaceuticals Company

Careers data is taken from the ‘Destinations of Leavers from Higher Education’ survey undertaken by HESA looking at the destinations of UK and EU students in the 2013–2015 graduating cohorts six months after graduation.

Why study this degree at UCL?

The UCL Great Ormond Street Institute of Child Health (UCL GOS ICH), and its clinical partner Great Ormond Street Hospital (GOSH), is the largest centre in Europe devoted to clinical, basic research and postgraduate education in children's health, including haematopoietic stem cell transplantation (HSCT) and gene therapy.

The UCL School of Life & Medical Sciences (SLMS) has the largest concentration of clinicians and researchers active in cell and gene therapy research in Europe. This is reflected by the many groups conducting high-quality research and clinical trials in the field including researchers at UCL GOS ICH, the Division of Infection & Immunity, the Institute of Ophthalmology, the Institute for Women's Health, the Institute of Genetics and the Cancer Institute.

Research Excellence Framework (REF)

The Research Excellence Framework, or REF, is the system for assessing the quality of research in UK higher education institutions. The 2014 REF was carried out by the UK's higher education funding bodies, and the results used to allocate research funding from 2015/16.

The following REF score was awarded to the department: Great Ormond Street Institute of Child Health

80%: Clinical Medicine subjects; 81%: Public Health, Health Services and Primary Care subjects rated 4* (‘world-leading’) or 3* (‘internationally excellent’)

Learn more about the scope of UCL's research, and browse case studies, on our Research Impact website.



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Why study at Roehampton. Develop advanced research skills required in preparation for your career within biomedical research, a clinical environment, or in the health industry. Read more

Why study at Roehampton

  • Develop advanced research skills required in preparation for your career within biomedical research, a clinical environment, or in the health industry.
  • Collaborate with leading, internationally renowned experts in the field who will teach topical and current issues in biomedicine.
  • Conduct your own research project in our state-of-the-art molecular biology laboratories equipped with microscopy analysers, autoradiography, flow cytometry, high sensitivity HPLC and LC-MS, and neural stem cell and tissue culture facilities.
  • We are the most research-intensive modern university in the UK (Research Excellence Framework 2014).
  • Roehampton is ranked best modern university in London (Sunday Times Good University Guide 2016).

Course summary

This innovative degree offers a fascinating opportunity to study modern and topical research areas in Cell Biomedicine. You will gain the essential skills required to prepare for your career in either biomedical research, a clinical setting or within the health industry.

This postgraduate degree will provide you with advanced research training in medical aspects of cell biology and pathology and you will conduct your own lab based research project. With a focus on research methods, you will take you research methods to the next level in producing your own research design, understanding ethics in research projects and best practice in handling statistical data-sets. The programme includes a variety of subject-specific lectures, seminars, tutorials and practical work that will give keep you up-to-date with the current advances in the field. You will learn the theoretical and technological aspects of cellular biomedicine and their practical applications within industry.

You will be taught by enthusiastic, research active experts in the field who conduct research in a diverse range of topics that you can choose to study such as cellular and molecular mechanisms of cancer, microbial resistance to antibiotics, immune mechanisms of disease, stem cell research and molecular modelling in cell biology.

You will conduct your research project in our state-of-the-art laboratories equipped with microscopy analysers, autoradiography, flow cytometry, high sensitivity HPLC and LC-MS, and neural stem cell and tissue culture facilities.

You will automatically be a part of our Health Sciences Research Centre, a community of leading experts who are currently investigating a range of topical issues. You will participate in engaging discussions within research seminars on the latest developments within neuroscience and the health sciences.

Content

In this postgraduate programme, you will be trained in medical aspects of cell biology and pathology with a focus on the lab based research project. The programme has a strong focus on research methods and will provide you with necessary skills in research design, ethics and statistical methods.

You will learn the most recent advances in cellular biomedicine by being part of engaging subject-specific lectures, seminars, tutorials and conducting your own research. You will study the theoretical and technological and their practical applications in cellular biomedicine.

Modules:

  • Research Project
  • Research Methods
  • Cells, Disease and Therapy
  • Communication

Career options

This postgraduate programme provides both a solid academic basis and practical hands-on experience in the area of cellular biomedical sciences. It will prepare you for careers in academia, clinical research, the health industry or within government organisations.

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Programme Description. The Cell Signalling in Health and Disease MRes is a research-based qualification with a taught component that is of an equivalent standard to an MSc. Read more

Programme Description

The Cell Signalling in Health and Disease MRes is a research-based qualification with a taught component that is of an equivalent standard to an MSc. The course provides a springboard into a career that involves a working knowledge of scientific research in academia and industry.

The course is designed for graduates with a BSc in the life sciences or other science disciplines, and for intercalating and fully qualified MBBS or BDS students. It can be taken either as a stand-alone qualification or as an entry route onto a PhD or MD.

The taught component of the course includes subject-specific content in the area of cell signalling in health and disease. You have the flexibility to develop your own bespoke course by selecting additional, complementary modules. You will also participate in training in general research principles, and other professional and key skills.

Your research project comprises the major element of the course. This project will involve 24 weeks of research in an area of cell signalling in health and disease under the supervision of an expert academic researcher in the field.

The course allows you to experience an internationally competitive research area, predominantly in academia but also potentially in industry.

Cell Signalling in Health and Disease MRes is closely linked to a suite of MRes courses that you may also be interested in:

Faculty of Medical Sciences Graduate School

Our Medical Sciences Graduate School is dedicated to providing you with information, support and advice throughout your research degree studies. We can help and advise you on a variety of queries relating to your studies, funding or welfare.

Our Research Student Development Programme supports and complements your research whilst developing your professional skills and confidence.

You will make an on-going assessment of your own development and training needs through personal development planning (PDP) in the ePortfolio system. Our organised external events and development programme have been mapped against the Vitae Researcher Development Framework to help you identify how best to meet your training and development needs.



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We invite postgraduate research proposals in a number of disease areas that impact significantly on patient care. We focus on exploring the mechanisms of disease, understanding the ways disease impacts patients’ lives, utilising new diagnostic and therapeutic techniques and developing new treatments. Read more

We invite postgraduate research proposals in a number of disease areas that impact significantly on patient care. We focus on exploring the mechanisms of disease, understanding the ways disease impacts patients’ lives, utilising new diagnostic and therapeutic techniques and developing new treatments.

As a student you will be registered with a University research institute, for many this is the Institute for Cellular Medicine (ICM). You will be supported in your studies through a structured programme of supervision and training via our Faculty of Medical Sciences Graduate School.

We undertake the following areas of research and offer MPhil, PhD and MD supervision in:

Applied immunobiology (including organ and haematogenous stem cell transplantation)

Newcastle hosts one of the most comprehensive organ transplant programmes in the world. This clinical expertise has developed in parallel with the applied immunobiology and transplantation research group. We are investigating aspects of the immunology of autoimmune diseases and cancer therapy, in addition to transplant rejection. We have themes to understand the interplay of the inflammatory and anti-inflammatory responses by a variety of pathways, and how these can be manipulated for therapeutic purposes. Further research theme focusses on primary immunodeficiency diseases.

Dermatology

There is strong emphasis on the integration of clinical investigation with basic science. Our research include:

  • cell signalling in normal and diseased skin including mechanotransduction and response to ultraviolet radiation
  • dermatopharmacology including mechanisms of psoriatic plaque resolution in response to therapy
  • stem cell biology and gene therapy
  • regulation of apoptosis/autophagy
  • non-melanoma skin cancer/melanoma biology and therapy.

We also research the effects of UVR on the skin including mitochondrial DNA damage as a UV biomarker.

Diabetes

This area emphasises on translational research, linking clinical- and laboratory-based science. Key research include:

  • mechanisms of insulin action and glucose homeostasis
  • insulin secretion and pancreatic beta-cell function
  • diabetic complications
  • stem cell therapies
  • genetics and epidemiology of diabetes.

Diagnostic and therapeutic technologies

Focus is on applied research and aims to underpin future clinical applications. Technology-oriented and demand-driven research is conducted which relates directly to health priority areas such as:

  • bacterial infection
  • chronic liver failure
  • cardiovascular and degenerative diseases.

This research is sustained through extensive internal and external collaborations with leading UK and European academic and industrial groups, and has the ultimate goal of deploying next-generation diagnostic and therapeutic systems in the hospital and health-care environment.

Kidney disease

There is a number of research programmes into the genetics, immunology and physiology of kidney disease and kidney transplantation. We maintain close links between basic scientists and clinicians with many translational programmes of work, from the laboratory to first-in-man and phase III clinical trials. Specific areas:

  • haemolytic uraemic syndrome
  • renal inflammation and fibrosis
  • the immunology of transplant rejection
  • tubular disease
  • cystic kidney disease.

The liver

We have particular interests in:

  • primary biliary cirrhosis (epidemiology, immunobiology and genetics)
  • alcoholic and non-alcoholic fatty liver disease
  • fibrosis
  • the genetics of other autoimmune and viral liver diseases

Magnetic Resonance (MR), spectroscopy and imaging in clinical research

Novel non-invasive methodologies using magnetic resonance are developed and applied to clinical research. Our research falls into two categories:

  • MR physics projects involve development and testing of new MR techniques that make quantitative measurements of physiological properties using a safe, repeatable MR scan.
  • Clinical research projects involve the application of these novel biomarkers to investigation of human health and disease.

Our studies cover a broad range of topics (including diabetes, dementia, neuroscience, hepatology, cardiovascular, neuromuscular disease, metabolism, and respiratory research projects), but have a common theme of MR technical development and its application to clinical research.

Musculoskeletal disease (including auto-immune arthritis)

We focus on connective tissue diseases in three, overlapping research programmes. These programmes aim to understand:

  • what causes the destruction of joints (cell signalling, injury and repair)
  • how cells in the joints respond when tissue is lost (cellular interactions)
  • whether we can alter the immune system and ‘switch off’ auto-immune disease (targeted therapies and diagnostics)

This research theme links with other local, national and international centres of excellence and has close integration of basic and clinical researchers and hosts the only immunotherapy centre in the UK.

Pharmacogenomics (including complex disease genetics)

Genetic approaches to the individualisation of drug therapy, including anticoagulants and anti-cancer drugs, and in the genetics of diverse non-Mendelian diseases, from diabetes to periodontal disease, are a focus. A wide range of knowledge and experience in both genetics and clinical sciences is utilised, with access to high-throughput genotyping platforms.

Reproductive and vascular biology

Our scientists and clinicians use in situ cellular technologies and large-scale gene expression profiling to study the normal and pathophysiological remodelling of vascular and uteroplacental tissues. Novel approaches to cellular interactions have been developed using a unique human tissue resource. Our research themes include:

  • the regulation of trophoblast and uNk cells
  • transcriptional and post-translational features of uterine function
  • cardiac and vascular remodelling in pregnancy

We also have preclinical molecular biology projects in breast cancer research.

Respiratory disease

We conduct a broad range of research activities into acute and chronic lung diseases. As well as scientific studies into disease mechanisms, there is particular interest in translational medicine approaches to lung disease, studying human lung tissue and cells to explore potential for new treatments. Our current areas of research include:

  • acute lung injury - lung infections
  • chronic obstructive pulmonary disease
  • fibrotic disease of the lung, both before and after lung transplantation.

Pharmacology, Toxicology and Therapeutics

Our research projects are concerned with the harmful effects of chemicals, including prescribed drugs, and finding ways to prevent and minimise these effects. We are attempting to measure the effects of fairly small amounts of chemicals, to provide ways of giving early warning of the start of harmful effects. We also study the adverse side-effects of medicines, including how conditions such as liver disease and heart disease can develop in people taking medicines for completely different medical conditions. Our current interests include: environmental chemicals and organophosphate pesticides, warfarin, psychiatric drugs and anti-cancer drugs.

Pharmacy

Our new School of Pharmacy has scientists and clinicians working together on all aspects of pharmaceutical sciences and clinical pharmacy.



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Taught at our Parkgate Road Campus in Chester, this course is designed to give a comprehensive training in the research and analytical skills in cell and molecular biology. Read more
Taught at our Parkgate Road Campus in Chester, this course is designed to give a comprehensive training in the research and analytical skills in cell and molecular biology.

This MRes has been designed to enhance knowledge of recent advancements in cellular and molecular biology, as well as to develop subject-specific practical and analytical skills. In addition, you will gain experience of undertaking an extended period of research (6-7 months), which will aid your career progression as a molecular bio-scientist.

The programme will involve undertaking two core 20 credit taught modules, followed by an extended period of laboratory research, and submission of a Research report and review, 140 credits.

Why Study Cell and Molecular Biology Pathway with us?

Our lecturers range from enthusiastic early career academics through to internationally acknowledged senior researchers. We are actively involved in undertaking innovative research projects using ‘cutting-edge’ approaches, within the field of molecular and cellular life sciences.

Some of our current projects are listed below:
- Environmental toxicology
- Protection against the ageing
- Calcium signalling
- Biochemistry & pharmacology of intracellular Ca2+ transporters
- Stem cells
- Tissue regeneration
- Pathology of bone disease
- Progression of kidney and bladder cancers
- Novel drug delivery systems via nanoparticles and cell penetrating peptides
- Molecular basis of cancer development
- Novel approaches to cancer therapies
- Molecular immunology
- Development of analytical approaches to detect biomarkers of disease

What will I learn?

The MRes will involve undertaking two core 20 credit taught modules which consists of a mixture of lectures, workshops and practical classes in:
- Advances in Cell and Molecular Biology (BI7144)
- Skills for Molecular and Cellular Bioscientists (BI7145)

Followed by an extended period of laboratory research (140 credits) in an area that allies with the interests of our academic staff.

How will I be taught?

The two taught modules will each comprise of a series of lectures, small group discussion sessions, workshops and practical classes. Nominally each taught module has about 30-40 of contact hours associated with them. The rest of the time allocated for these modules will be for further reading, coursework preparation and revision.

The remainder of the programme will comprise of the 6 to 7 month research project which will involve regular meetings and guidance with your research supervisor. This is followed by the preparation of two reports.

How will I be assessed?

The research dissertation will be assessed by the production of a research report in the format of a scientific paper and a research review (80%).

The taught modules will be assessed by the production of practical and theoretical reports and class tests (20%).

Postgraduate Visit Opportunities

If you are interested in this courses we have a number of opportunities to visit us and our campuses. To find out more about these options and to book a visit, please go to: https://www1.chester.ac.uk/study/postgraduate/postgraduate-visit-opportunities

Request a Prospectus

If you would like to know more about the University please request a prospectus at: http://prospectus.chester.ac.uk/form.php

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Master's specialisation in Medical Epigenomics. The only Master’s specialisation in the Netherlands covering the function of our epigenome, a key factor in regulating gene expression and in a wide range of diseases. Read more

Master's specialisation in Medical Epigenomics

The only Master’s specialisation in the Netherlands covering the function of our epigenome, a key factor in regulating gene expression and in a wide range of diseases.

Our skin cells, liver cells and blood cells all contain the same genetic information. Yet these are different types of cells, each performing their own specific tasks. How is this possible? The explanation lies in the epigenome: a heritable, cell-type specific set of chromosomal modifications, which regulates gene expression. Radboud University is specialised in studying the epigenome and is the only university in the Netherlands to offer a Master’s programme in this field of research.

Health and disease

The epigenome consists of small and reversible chemical modifications of the DNA or histone proteins, such as methylation, acetylation and phosphorylation. It changes the spatial structure of DNA, resulting in gene activation or repression. These processes are crucial for our health and also play a role in many diseases, like autoimmune diseases, cancer and neurological disorders. As opposed to modifications of the genome sequence itself, epigenetic modifications are reversible. You can therefore imagine the great potential of drugs that target epigenetic enzymes, so-called epi-drugs.

Big data

In this specialisation, you’ll look at a cell as one big and complex system. You’ll study epigenetic mechanisms during development and disease from different angles. This includes studying DNA and RNA by next-generation sequencing (epigenomics) and analysing proteins by mass spectrometry (proteomics). In addition, you‘ll be trained to design computational strategies that allow the integration of these multifaceted, high-throughput data sets into one system.

Why study Medical Epigenomics at Radboud University?

- Radboud University combines various state-of-the-art technologies – such as quantitative mass spectrometry and next-generation DNA sequencing – with downstream bioinformatics analyses in one department. This is unique in Europe.

- This programme allows you to work with researchers from the Radboud Institute for Molecular Life sciences (RIMLS), one of the leading multidisciplinary research institutes within this field of study worldwide.

- We have close contacts with high-profile medically oriented groups on the Radboud campus and with international institutes (EMBL, Max-Planck, Marie Curie, Cambridge, US-based labs, etc). As a Master’s student, you can choose to perform an internship in one of these related departments.

- Radboud University coordinates BLUEPRINT, a 30 million Euro European project focusing on the epigenomics of leukaemia. Master’s students have the opportunity to participate in this project.

Career prospects

As a Master’s student of Medical Epigenomics you’re trained in using state-of-the art technology in combination with biological software tools to study complete networks in cells in an unbiased manner. For example, you’ll know how to study the effects of drugs in the human body.

When you enter the job market, you’ll have:

- A thorough background of epigenetic mechanisms in health and disease, which is highly relevant in strongly rising field of epi-drug development

- Extensive and partly hands-on experience in state-of-the-art ‘omics’ technologies: next-generation sequencing, quantitative mass spectrometry and single cell technologies;

- Extensive expertise in designing, executing and interpreting scientific experiments in data-driven research;

- The computational skills needed to analyse large ‘omics’ datasets.

With this background, you can become a researcher at a:

- University or research institute;

- Pharmaceutical company, such as Synthon or Johnson & Johnson;

- Food company, like Danone or Unilever;

- Start-up company making use of -omics technology.

Apart from research into genomics and epigenomics, you could also work on topics such as miniaturising workflows, improving experimental devices, the interface between biology and informatics, medicine from a systems approach.

Or you can become a:

- Biological or medical consultant;

- Biology teacher;

- Policy coordinator, regarding genetic or medical issues;

- Patent attorney;

- Clinical research associate;

PhD positions at Radboud University

Each year, the Molecular Biology department (Prof. Henk Stunnenberg, Prof. Michiel Vermeulen) and the Molecular Developmental Biology department (Prof. Gert-Jan Veenstra) at the RIMLS offer between five and ten PhD positions. Of course, many graduates also apply for a PhD position at related departments in the Netherlands, or abroad.

Our approach to this field

- Systems biology

In the Medical Epigenomics specialisation you won’t zoom in on only one particular gene, protein or signalling pathway. Instead, you’ll regard the cell as one complete system. This comprehensive view allows you to, for example, model the impact of one particular epigenetic mutation on various parts and functions of the cell, or study the effects of a drug in an unbiased manner. One of the challenges of this systems biology approach is the processing and integration of large amounts of data. That’s why you’ll also be trained in computational biology. Once graduated, this will be a great advantage: you’ll be able to bridge the gap between biology, technology and informatics , and thus have a profile that is desperately needed in modern, data-driven biology.

- Multiple OMICS approaches

Studying cells in a systems biology approach means connecting processes at the level of the genome (genomics), epigenome (epigenomics), transcriptome (transcriptomics), proteome (proteomics), etc. In the Medical Epigenomics specialisation, you’ll get acquainted with all these different fields of study.

- Patient and animal samples

Numerous genetic diseases are not caused by genetic mutations, but by epigenetic mutations that influence the structure and function of chromatin. Think of:

- Autoimmune diseases, like rheumatoid arthritis and lupus

- Cancer, in the forms of leukaemia, colon cancer, prostate cancer and cervical cancer

- Neurological disorders, like Rett Syndrome, Alzheimer, Parkinson, Multiple Sclerosis, schizophrenia and autism

We investigate these diseases on a cellular level, focusing on the epigenetic mutations and the impact on various pathways in the cell. You’ll get the chance to participate in that research, and work with embryonic stem cell, patient, Xenopus or zebra fish samples.

See the website http://www.ru.nl/masters/medicalbiology/epigenomics

Radboud University Master's Open Day 10 March 2018



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The Transplantation MRes enables you to experience an internationally competitive research area, predominantly in academia but also potentially in industry. Read more

The Transplantation MRes enables you to experience an internationally competitive research area, predominantly in academia but also potentially in industry. The MRes can be taken either as a stand-alone qualification or provide an entry route onto a PhD or MD.

The course is designed for graduates with a BSc in the life sciences and is also suitable for graduates from other science disciplines and intercalating and fully qualified MBBS or BDS students.

What you'll learn

There is a taught component with subject-specific content in the area of Transplantation. Subject-based modules provide a broad exposure to diverse aspects of transplantation, from clinical concepts to cutting edge scientific development. There will be a unique opportunity to gain insights into the speciality of transplantation sciences in the context of transplantation of haematopoietic stem cells, corneal/limbal stem cells and a variety of solid organs.

The modules aim to:

  • provide sound understanding of the scientific basis underlying the therapeutic benefits and adverse effects of clinical transplants
  • highlight the research areas where applications of immunology and cell biology can improve transplant outcome and patient wellbeing
  • provide a view of bench to bedside translational links between scientific research and clinical practice

The course emphasises the clinical practice driven research, which prepares students for a future career in either medical practice or broad biomedical research. 

Main topics covered include:

  • transplantation immunology related to cellular and molecular basis of allogeneic immune responses, tolerance, immunosuppression
  • the genetic and molecular basis of HLA system, non-HLA immunogenetics, histocompatibility, impact of HLA matching in choice of donor and transplant outcome
  • transplantation pathology related to graft-versus-host disease following haematopoietic stem cell transplant, rejection following solid organ transplant, tissue damage and loss of graft function
  • manipulation of haematopoietic stem cells for clinical use
  • development of novel therapeutic strategies to aid improvement of clinical transplant outcome

It has the flexibility for you to develop your own bespoke course by choosing additional, complementary modules from a wide selection. You will also undertake training in general research principles and other professional and key skills.

Your project

The research project comprises the major element of the course. This project will involve 24 weeks’ carrying out research in the area of transplantation under the supervision of an expert academic researcher in the field.

Our MRes courses

Transplantation MRes is closely linked to a suite of MRes courses that you may also be interested in:

Faculty of Medical Sciences Graduate School

Our Medical Sciences Graduate School is dedicated to providing you with information, support and advice throughout your research degree studies. We can help and advise you on a variety of queries relating to your studies, funding or welfare.

Our Research Student Development Programme supports and complements your research whilst developing your professional skills and confidence.

You will make an on-going assessment of your own development and training needs through personal development planning (PDP) in the ePortfolio system. Our organised external events and development programme have been mapped against the Vitae Researcher Development Framework to help you identify how best to meet your training and development needs.



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This programme offers a fascinating range of subjects, including molecular biology, genetics, biochemistry, microbiology, immunology, tissue engineering, clinical medicine, laboratory management and statistics. Read more
This programme offers a fascinating range of subjects, including molecular biology, genetics, biochemistry, microbiology, immunology, tissue engineering, clinical medicine, laboratory management and statistics.

It is accredited by the Institute of Biomedical Science and is based at one of the largest transfusion centres in the world, enabling visits to manufacturing, testing and tissue typing sections. You will learn from specialist lecturers based at the University, NHS Blood and Transplant (NHSBT), and NHS hospitals, and have an opportunity to become fully embedded in an NHS environment while you develop your knowledge.

The programme will give you extensive practical experience of transfusion and transplantation, allowing you to gain skills that directly relate to your future career. As well as being academically interesting, this continually developing area of healthcare science has a major impact on patients' quality of life.

The programme:
-Is one of just two specialist full-time courses in transfusion and transplantation, and is a recommended course at level seven in the Career Framework for Health.
-Gives you the opportunity to carry out your MSc project with NHSBT research staff within the transfusion centre.
-Has high contact hours, with teaching each day and practical classes.
-Includes a large skills component (eg writing in different formats, conference and publication skills, assignments with specific study aims).
-Includes laboratory management, a key skill required at level seven.
-Attracts a diverse range of students (about 50 per cent overseas students), including new graduates, those working in blood centres or blood transfusion/haematology in hospitals, or training to lecture in transfusion.

Programme structure

The programme comprises eight taught units that run from September to March and a research project that begins in May and runs until August. Example project topics have included:
-A study on red cell antibody formation in trauma patients
-Optimisation of platelet antigen detection using recombinant proteins
-Expression of red cell membrane proteins during large-scale red cell culture
-A comparison of stem cell mobilisation drugs for stem cell transplantation

Taught units
-Transfusion and Transplantation Science:
-Pathology of Transfusion and Transplantation Science
-Provision of Blood, Cells, Tissues and Organs
-Clinical Transfusion and Transplantation
-Transfusion and Transplantation in Practice (two units)
-Biostatistics
-Research and Laboratory Management

Assessments are designed to teach skills such as comprehension, scientific writing in different formats and conference skills, and to further knowledge in subject areas not covered in the lectures. Students must pass the taught component to be able to progress to the project.

Part-time students complete the Postgraduate Certificate components in their first year and the Postgraduate Diploma in the second. The project is usually taken during year three to complete the MSc.

Careers

Some of the career paths that graduates have followed include: blood transfusion and fetal medicine research, working for a bone marrow donor laboratory or bone marrow registry, biostatistics, graduate entry to medical school, NHS Clinical Scientist Training programme, and progression to PhD study in several areas including cancer biology and stem cell regeneration.

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This course blends theory and practice to help you develop the skills required for a career in molecular and cellular biology. Our teaching focuses on integrated mammalian biology and animal models of human disease, drawing on our pioneering biomedical research. Read more

About the course

This course blends theory and practice to help you develop the skills required for a career in molecular and cellular biology. Our teaching focuses on integrated mammalian biology and animal models of human disease, drawing on our pioneering biomedical research.

Where your masters can take you

Graduates with skills in stem cell and regenerative medicine are in demand. Your degree will prepare you for a career in research in academia or industry, or in a clinical-related field. Our graduates are working all over the world – from the UK to China, India and the USA – and over half go on to doctoral study.

Learn from the experts

The 2014 Research Excellence Framework (REF) rates us No 1 in the UK for research in this field. Our international reputation attracts highly motivated staff and students. Sheffield is a vibrant place to take a masters based on pioneering research.

Regular seminars from distinguished international experts help you to connect your studies to the latest developments. We’re also part of collaborative research groups for developmental biology, cell biology, physiology, pharmacology, neuroscience, models of human disease, stem cell science and regenerative medicine.

Our three research centres focus on translating laboratory research to the clinical environment: Bateson Centre, the Centre for Stem Cell Biology, and the Centre for Membrane Interactions and Dynamics.

Leaders in our field

We have a long track record of groundbreaking discoveries. These include breakthroughs in human stem cells for hearing repair, and the generation of animal models for Parkinson’s disease, schizophrenia, muscular dystrophies and their use for therapeutic studies.

Labs and equipment

We have purpose-built facilities for drosophila, zebrafish, chick and mouse genetics and for molecular physiology. Other facilities provide all the tools you’ll need to examine and analyse a range of cellular structures. We have an electron and a light microscopy centre, a PCR robotics facility, a flow cytometry unit and an RNAi screening facility.

Teaching and assessment

There are lectures, practical classes, tutorials and seminars. In small group teaching classes you’ll discuss, debate and present on scientific and ethical topics. Laboratory placements within the department provide you with one-to-one attention, training and support to do your individual research project. Assessment is by formal examinations, coursework assignments, debates, poster presentations and a dissertation.

Our teaching covers ethics, practical scientific skills and an overview of the current literature. You’ll also develop useful career skills such as presentation, communication and time management.

Core modules

Literature Review; Practical Research Project; Analysis of Current Science; Ethics and Public Understanding.

Examples of optional modules

Integrated Mammalian Biology; Practical Cell Biology; Practical Developmental Genetics; Cancer Biology; Modelling Human Diseases; Epithelia in Health and Disease.

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The Cancer MSc reflects the depth and breadth of research interests, from basic science to translational medicine, within the UCL Cancer Institute. Read more

The Cancer MSc reflects the depth and breadth of research interests, from basic science to translational medicine, within the UCL Cancer Institute. The programme, taught by research scientists and academic clinicians, provides students with an in-depth look at the biology behind the disease processes which lead to cancer.

About this degree

This programme offers a foundation in understanding cancer as a disease process and its associated therapies. Students learn about the approaches taken to predict, detect, monitor and treat cancer, alongside the cutting-edge research methods and techniques used to advance our understanding of this disease and design better treatment strategies.

Students undertake modules to the value of 180 credits.

The programme consists of two core modules (60 credits), four specialist modules (60 credits) and a research project (60 credits).

A Postgraduate Diploma (120 credits, full-time nine months) is offered.

A Postgraduate Certificate (60 credits, full-time 12 weeks) is offered.

Core modules

  • Basic Biology and Cancer Genetics
  • Cancer Therapeutics

Specialist modules

  • Behavioural Science and Cancer
  • Biomarkers in Cancer
  • Cancer Clinical Trials
  • Haematological Malignancies and Gene Therapy

Dissertation/report

All MSc students undertake a laboratory project, clinical trials project or systems biology/informatics project, which culminates in a 10,000–12,000 word dissertation and an oral research presentation.

Teaching and learning

Students develop their knowledge and understanding of cancer through lectures, self-study, database mining, wet-lab based practicals, clinical trial evaluations, laboratory training, assigned reading and self-learning. Each taught module is assessed by an unseen written examination and/or coursework. The research project is assessed by the dissertation (75%) and oral presentation (25%).

Further information on modules and degree structure is available on the department website: Cancer MSc

Careers

The knowledge and skills developed will be suitable for those in an industrial or healthcare setting, as well as those individuals contemplating a PhD or medical studies in cancer.

Employability

Skills include critical evaluation of scientific literature, experimental planning and design interpretation of data and results, presentation/public speaking skills, time management, working with a team, working independently and writing for various audiences.

Why study this degree at UCL?

UCL is one of Europe's largest and most productive centres of biomedical science, with an international reputation for leading basic, translational and clinical cancer research.

The UCL Cancer Institute brings together scientists from various disciplines to synergise multidisciplinary research into cancer, whose particular areas of expertise include: the biology of leukaemia, the infectious causes of cancer, the design of drugs that interact with DNA, antibody-directed therapies, the molecular pathology of cancer, signalling pathways in cancer, epigenetic changes in cancer, gene therapy, cancer stem cell biology, early phase clinical trials, and national and international clinical trials in solid tumours and blood cancers.

Research Excellence Framework (REF)

The Research Excellence Framework, or REF, is the system for assessing the quality of research in UK higher education institutions. The 2014 REF was carried out by the UK's higher education funding bodies, and the results used to allocate research funding from 2015/16.

The following REF score was awarded to the department: Cancer Institute

80% rated 4* (‘world-leading’) or 3* (‘internationally excellent’)

Learn more about the scope of UCL's research, and browse case studies, on our Research Impact website.



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Lead academic 2016. Dr Carolyn Staton. Translational oncology is the process by which laboratory research informs the development of new treatments for cancer. Read more

About the course

Lead academic 2016: Dr Carolyn Staton

Translational oncology is the process by which laboratory research informs the development of new treatments for cancer. It’s a rapidly advancing field with massive therapeutic and commercial potential.

Our MSc(Res) is taught by leading research scientists and clinicians. The course offers training in the theory and practice of translational oncology and provides you with transferable skills for your future career. It includes a six-month research project for which you’ll work as part of a team within the oncology research community at Sheffield.

Our study environment

You’ll be based in teaching hospitals that serve a population of over half a million people and refer a further two million. We also have close links with the University’s other health-related departments.

Our research funding comes from many sources including the NIHR, MRC, BBSRC, EPSRC, the Department of Health, EU, and prominent charities such as the Wellcome Trust, ARC, YCR, Cancer Research UK and BHF. Our partners and sponsors include Novartis, GlaxoSmithKline, Pfizer, Astra Zeneca and Eli Lilly.

You’ll also benefit from our collaboration with the Department of Biomedical Sciences.

How we teach

Classes are kept small (15–20 students) to make sure you get the best possible experience in laboratories and in clinical settings.

Our resources

We have a state-of-the-art biorepository and a £30m stem cell laboratory. The Sheffield Institute of Translational Neuroscience (SITraN) opened in November 2010. We also have microarray, genetics, histology, flow cytometry and high-throughput screening technology, and the latest equipment for bone and oncology research.

At our Clinical Research Facility, you’ll be able to conduct studies with adult patients and volunteers. The Sheffield Children’s Hospital houses a complementary facility for paediatric experimental medical research.

Hepatitis B policy

If your course involves a significant risk of exposure to human blood or other body fluids and tissue, you’ll need to complete a course of Hepatitis B immunisation before starting. We conform to national guidelines that are in place to protect patients, health care workers and students.

Core modules

Cellular and Molecular Basis of Cancer; Cancer Epidemiology; Cancer Diagnosis and Treatment; Tumour Microenvironment; Cancer Technologies and Clinical Research; Literature Review; Research Project.

Teaching and assessment

Teaching is by lectures, seminars, class discussions/workshops, interactive tutorials, practical demonstrations, student-led group work and patient encounters.

Alongside the taught modules students attend the Sheffield Cancer Research seminars which include question and answer sessions with the experts, and a series of professional skills development tutorials.

Assessment is by a combination of written seen exams, oral and poster presentations, case studies and written assignments. The research project is assessed by an oral presentation and a written dissertation.

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Overview. The MRes courses are designed to provide students with intensive laboratory-based training in research methods, supported by in-depth understanding. Read more
Overview
The MRes courses are designed to provide students with intensive laboratory-based training in research methods, supported by in-depth understanding. The aim is to prepare graduates to make contributions, as individuals and members of a team, to research-oriented activities in the biomedical industries and related service sectors, or academia. The courses are also well-suited to students wishing to upgrade a first degree, change field, or gain valuable laboratory experience before employment or a PhD. The Strathclyde Institute of Pharmacy and Biomedical Sciences represents the largest Pharmacy research group in the UK, with 55% of its staff rated as either world-leading or internationally excellent in terms of originality, significance and rigour (data: Research Assessment Exercise 2008). The University of Strathclyde has invested £30M in a world-class, pioneering centre for biomedical and pharmaceutical sciences teaching and research, opened Aug 2010. Students will find themselves in stimulating, unique environment on account of the strongly multidisciplinary nature of the Institute. Combining fundamental and applied research across the areas of bioscience and pharmacy, SIPBS builds on its record of success in drug and vaccine discovery and development. The Institute engages with industry and the health services, ensuring that its excellent fundamental research is translated into products that are of benefit to health and society. For more information on SIPBS go to http://www.strath.ac.uk/sipbs

Course outline

An MRes degree is focussed on research and students will spend 8 months undertaking a laboratory-based project.
To support their chosen research project, students choose advanced-level taught courses in a named specialisation, from the following areas:

Taught classes delivered through lectures, workshops and practical classes in four areas:
1. Transferable skills training in data mining, interpretation and presentation; experimental planning, personal effectiveness, ethics in research
2. Commercialisation and entrepreneurship
3. MRes-specific classes relevant to subject area

Biomedical Sciences

Example research projects:
1. Antileishmanial activity of extracts and compounds from Monodora myristica
2. Imaging and modelling of cancer development
3. Endothelial progenitor cell expression and differentiation
4. Targeted radiotherapy for cancer
5. The involvement of pulmonary veins in atrial fibrillation: electrical properties
6. Reducing bacterial resistance to antibiotics
7. Development of neural stem cells with increased levels of the autophagy cell survival pathway
8. Investigating the role of Sigma 54 in Pseudomonas aeruginosa virulence
9. Transcriptional network analysis of the Escherichia coli core stress response.
10. Identification of novel anti-microbial compounds targeted at biofilm formation

Drug Delivery systems

Example research projects
1. Nanoparticulate formulations of insulin and their analysis
2. Mesoporous silicas for oral delivery of cyclosporine
3. Bioprocessing of biopharmaceuticals
4. Modified and time-delayed oral solid-dose release formulations
5. Nasal formulations of poorly soluble compounds
6. Reducing bacterial resistance to antibiotics: establishing, optimising and implementing a high throughput assay to discover natural product derived inhibitors of metallo beta-lactamase.
7. Imaging of dermal formulations using Raman microscopy techniques
8. Antileishmanial activity of extracts and compounds from Monodora myristica
9. Anti-trypanosomal active triterpenoids from some African Propolis
10. Investigation into the potential therapeutic properties of marine organisms
11. Photo-triggered adhesion of mammalian cells

Drug Discovery

Projects in the areas of :
1. Drug Delivery
2. Molecular Biology
3. Pharmacology
4. Pharmaceutical Materials and Formulation
5. Toxicology

Neuroscience

Projects in the areas of:
1. Electrophysiology
2. Stem cell biology for regenerative purposes
3. Cell biology
4. Inflammation
5. In vitro culture systems
6. Functional genetics

How to Apply
Applicants should apply through the University of Strathclyde on-line application form: http://pgr.strath.ac.uk indicating "Masters by Research", and named specialisation as appropriate. Applicants are not required to submit a detailed research proposal at this stage.

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The MRes in Biomedical Research offers advanced research training in a broad range of laboratory based medical science. The emphasis of the course is how to do successful research and the research area is decided by the student. Read more
The MRes in Biomedical Research offers advanced research training in a broad range of laboratory based medical science. The emphasis of the course is how to do successful research and the research area is decided by the student. Participating departments include Biomolecular Medicine, Molecular Medicine, Cancer Medicine, Reproductive and Developmental Biology, Anaesthetics, Pain Medicine and Intensive Care, Biosurgery and Surgical Technology, Leukocyte Biology and Cardiovascular Sciences.

The research interests of the participating departments cover many aspects of molecular, cellular and physiological science including Bacterial virulence, Biomarkers of disease, Bioinformatics, Carcinogenesis, Cancer Biology, Cell Biology, Cell Signalling, Chemokines and their receptors, DNA damage and Repair, Electrophysiology, Immunosuppression, Leukocyte biology, Live cell imaging, Metabolomics/Metabonomics, Microbial Pathogenesis, Molecular Genetics, Molecular Motors, Molecular Pharmacology, Molecular Toxicology, Muscle Physiology, and Vascular Development, Neurological receptors, Nuclear receptors, Sepsis, Single molecule microscopy, Stem Cell Biology.

Students complete two research projects of their own choosing and through a core programme learn how to collect, analyse and interpret scientific research findings. They learn how to prepare data for publication, how to present and defend research data at scientific meetings and how to put together a grant application. The core programme also introduces students to advanced research techniques through a series of workshops and offers students a wide range of transferable skills courses. In addition to the core programme, the course comprises of other streams that offer further opportunities in specific areas. The course is an excellent grounding for students wishing to pursue a career in research and about 90% of past graduates have progressed to the PhD degree.

Please visit the course website for more information about how to apply, and for more information about the streams of specialism which run within the course.

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