Our MRes Experimental Cancer Medicine master's course will give nurses, doctors and clinical researchers the skills needed to work in early phase clinical studies.
You will learn how to master experimental cancer through a combination of traditional teaching and hands-on learning, spending a year as a member of the Experimental Cancer Medicine Team at The Christie while also taking four structured taught units.
The taught units will see you learn the details of designing and delivering Phase 1 clinical studies, understanding the pre-clinical data required before a clinical programme can commence, and how to optimise early clinical studies to provide evidence for progressing a promising drug into Phase II/III clinical testing.
Alongside the taught elements, you will be allocated to one or more clinical trials that are being conducted by The Christie experimental cancer medicine team. You will have a named trainer and be exposed to tasks required in the setup, delivery, interpretation and audit of a clinical study.
Nursing and physician students will be expected to participate in patient care, including new and follow-on patient clinics, treatment and care-giving episodes with patients.
For clinical trials coordinators, no direct patient contact is envisaged and duties will involve clinical trial setup, protocol amendments, database setup, data entry, costing and billing for clinical research.
You will be able to choose two aspects of your direct clinical trial research experience to write up for your two research projects in a dissertation format. This will give you the skills and knowledge required to critically report medical, scientific and clinically related sciences for peer review.
The primary purpose of the MRes in Experimental Cancer Medicine is to provide you with the opportunity to work within a premier UK Phase 1 cancer clinical trials unit and, through a mix of taught and experiential learning, master the discipline of Experimental Cancer Medicine.
Extensive practical experience
You will spend most of your time gaining hands-on experience within The Christie's Experimental Cancer Medicine Team.
Meet the course team
Dr Natalie Cook is a Senior Clinical Lecturer in Experimental Cancer Medicine at the University and Honorary Consultant in Medical Oncology at The Christie. She completed a PhD at Cambridge, investigating translational therapeutics and biomarker assay design in pancreatic cancer.
Professor Hughes is Chair of Experimental Cancer Medicine at the University and Strategic Director of the Experimental Cancer Medicine team at The Christie. He is a member of the research strategy group for Manchester Cancer Research Centre. He serves on the Biomarker evaluation review panel for CRUK grant applications.
Professor Hughes was previously Global Vice-President for early clinical development at AstraZeneca, overseeing around 100 Phase 0/1/2 clinical studies. He was previously Global Vice-President for early phase clinical oncology, having been involved in over 200 early phase clinical studies.
Dr Matthew Krebs is a Clinical Senior Lecturer in Experimental Cancer Medicine at the University and Honorary Consultant in Medical Oncology at The Christie.
He has a PhD in circulating biomarkers and postdoctoral experience in single cell and ctDNA molecular profiling. He is Principal Investigator on a portfolio of phase 1 clinical trials and has research interests in clinical development of novel drugs for lung cancer and integration of biomarkers with experimental drug development.
Our course is structured around a 2:1 split between clinical-based research projects and taught elements respectively.
Taught course units will predominantly use lectures and workshops.
For the research projects, teaching and learning will take place through one-to-one mentoring from a member of the Experimental Cancer Medicine team.
The clinical and academic experience of contributors to this course will provide you with an exceptional teaching and learning experience.
You will be assessed through oral presentations, single best answer exams, written reports and dissertation.
For each research project, you will write a dissertation of 10,000 to 15,000 words. Examples of suitable practical projects include the following.
Publication-based/dissertation by publication
Service development/professional report/ report based dissertation
Adapted systematic review (qualitative data)
Full systematic review that includes data collection (quantitative data)
Qualitative or quantitative empirical research
Qualitative secondary data analysis/analysis of existing quantitative data
Quantitative secondary data analysis/analysis of existing qualitative data/theoretical study/narrative review
Teaching will take place within The Christie NHS Foundation Trust , Withington.
Practical support and advice for current students and applicants is available from the Disability Advisory and Support Service. Email: [email protected]
This course is relevant to physician, nursing and clinical research students who are considering a career in Phase 1 clinical studies.
The course provides a theoretical and experiential learning experience and offers a foundation for roles within other experimental cancer medicine centres within the UK and EU, as well as careers in academia, the pharmaceutical industry, clinical trials management and medicine.
The MRes is ideal for high-calibre graduates and professionals wishing to undertake directly channelled research training in the clinical and medical oncology field.
This 1 year course leads to an internationally recognised MRes qualification that provides training in transferable skills essential for those wishing to pursue post-graduate PhD, commercial or industrial research opportunities. Focusing on parasites and the diseases that they cause, you will gain expert knowledge in the detection, prevention and control of protozoan as well as metazoan animal and human pathogens. You will be trained in specialisms including biochemistry, molecular biology, whole organism/cell culture and manipulation, bioinformatics, proteomics, transcriptomics, genomics, functional genomics, drug discovery, vaccinology, biomarker discovery, genetics/epigenetics, epidemiology, vector/intermediate host biology and ecology.
At the end of the course you will understand how interdisciplinary methods can be brought to bear on controlling some of the deadliest infectious organisms on the planet and be ready to pursue your career in parasitology.
Parasitism is the most successful lifestyle on the planet and leads to diverse and highly-damaging infectious diseases of agricultural, veterinary and biomedical significance. Therefore, a greater understanding of the parasite species responsible for these conditions and the means by which they are controlled remain a priority for scientists, health care professionals and farmers in this 21st Century. For example, it is recognised that parasitic worms infect greater than 1 billion people worldwide with some species causing between $700 million-$1 billion USDs in economic losses per annum. The development of novel, creative and integrated control strategies are urgently needed to combat the growing threat of changing parasite distributions due to climate change, human migration, animal transportation and farming practices. This MRes course will provide you with a range of vocational skills and prepare you for professional employment or further post-graduate PhD studies in Parasitology or related disciplines (i.e. infectious diseases, public health, epidemiology, etc.).
IBERS continuously maintained an excellent internationally-recognised reputation in parasitological research since the 1930s. One of the British Society of Parasitology’s founding members and two of its past presidents were IBERS Parasitologists. More recently, IBERS appointments and University investments have increased critical mass in Parasitology leading to the formation of the Parasitology and Epidemiology Research Group (in 2007) as well as the Barrett Centre for Helminth Control (in 2016). The creation of both research groupings has facilitated greater interactions with animal health and pharmaceutical/biotech companies as well as increased research grant capture derived from government, research council and charitable funding bodies.
With 360 members of staff (principle investigators, technicians and post-doctoral fellows), 1350 undergraduate students and more than 150 postgraduate students, IBERS is the largest research and teaching institute within Aberystwyth University. Excellence in teaching was recognised by outstanding scores in the National Student Satisfaction Survey (NSS 2017) and being awarded University of the Year for Teaching Quality by the Times and Sunday Times Good University Guide 2018. Employability data from the Recent Destinations of Leavers from Higher Education (DLHE, 2017) shows that 97% of IBERS graduates were in work or further study six months after leaving Aberystwyth University. The economic and social impact of IBERS research was recognised in 2011 when IBERS won the national BBSRC Excellence with Impact Award.
An aspect of this course that uniquely positions itself from other Masters level Parasitology courses in the UK is the 12-month dissertation project (Semesters 1-3). Working under the supervision of active researchers in the field, you will collaboratively develop a research project on diverse topics such as (but not inclusive) intermediate host and vector control, anthelmintic drug and target discovery, biomarker identification, visual cue selection for arthropod vectors, mathematical modelling of disease transmission, host responses to parasite biomolecules, parasite and host population studies and functional genomics manipulation of parasites. A list of available projects and supervisors will be advertised closer to the start of each academic year. Your supervisor/supervisory team will mentor you in hypothesis and discovery driven experimental design, provide training in lab-based and computer-assisted methodologies, arrange instruction in analytical techniques, aid in the trouble-shooting of experimental challenges, assist you in the interpretation of results and prepare you for successful oral presentations. You will also be guided in how to most efficiently communicate your results during the dissertation write-up. It is expected that during this year long research project you will become an expert in your topic.
Please refer to our couse web pages for full details of course modules.
This course is an ideal training programme for those wishing to:
- Pursue PhD studies;
- Work in industry, charities or funding bodies;
- Improve animal and human health;
- Influence governmental policies.
Throughout this course you will:
· Develop strong data collection/analysis, fieldwork and laboratory skills;
· Enhance your scientific communication and team work skills;
· Write for a range of audiences including academics and the wider public;
· Enhance your analytical abilities, critical thinking and problem solving skills;
· Develop study and research skills;
· Direct and sustain a self-initiated programme of study underpinned by good time management skills;
· Work effectively and independently;
· Hone your project management skills to deliver a demanding combination of research, analysis, communication and presentation
During the one year of full-time study students complete 40 60 credits of core modules centred on parasitology, parasite control and a further 20 credits focusing on laboratory techniques & research methodologies. The taught modules are assessed by scientific writing assignments (such as reports, critical reviews, essays and journalistic articles), presentations, contribution to group discussions in seminars and online assignments. The core element of this course is the 120 credit MRes Dissertation, during which students will have supervision meetings to give them guidance before undertaking a prolonged period of experimental work/data gathering, research, and writing up of the dissertation. All postgraduate students in IBERS also have a named personal tutor, with whom they can discuss personal or domestic concerns that impact on their studies. Subsequent successful submission of your dissertation leads to the award of an MRes.
We invite postgraduate research proposals in a number of disease areas that impact significantly on patient care. We focus on exploring the mechanisms of disease, understanding the ways disease impacts patients’ lives, utilising new diagnostic and therapeutic techniques and developing new treatments.
As a student you will be registered with a University research institute, for many this is the Institute for Cellular Medicine (ICM). You will be supported in your studies through a structured programme of supervision and training via our Faculty of Medical Sciences Graduate School.
We undertake the following areas of research and offer MPhil, PhD and MD supervision in:
Newcastle hosts one of the most comprehensive organ transplant programmes in the world. This clinical expertise has developed in parallel with the applied immunobiology and transplantation research group. We are investigating aspects of the immunology of autoimmune diseases and cancer therapy, in addition to transplant rejection. We have themes to understand the interplay of the inflammatory and anti-inflammatory responses by a variety of pathways, and how these can be manipulated for therapeutic purposes. Further research theme focusses on primary immunodeficiency diseases.
There is strong emphasis on the integration of clinical investigation with basic science. Our research include:
We also research the effects of UVR on the skin including mitochondrial DNA damage as a UV biomarker.
This area emphasises on translational research, linking clinical- and laboratory-based science. Key research include:
Focus is on applied research and aims to underpin future clinical applications. Technology-oriented and demand-driven research is conducted which relates directly to health priority areas such as:
This research is sustained through extensive internal and external collaborations with leading UK and European academic and industrial groups, and has the ultimate goal of deploying next-generation diagnostic and therapeutic systems in the hospital and health-care environment.
There is a number of research programmes into the genetics, immunology and physiology of kidney disease and kidney transplantation. We maintain close links between basic scientists and clinicians with many translational programmes of work, from the laboratory to first-in-man and phase III clinical trials. Specific areas:
We have particular interests in:
Novel non-invasive methodologies using magnetic resonance are developed and applied to clinical research. Our research falls into two categories:
Our studies cover a broad range of topics (including diabetes, dementia, neuroscience, hepatology, cardiovascular, neuromuscular disease, metabolism, and respiratory research projects), but have a common theme of MR technical development and its application to clinical research.
We focus on connective tissue diseases in three, overlapping research programmes. These programmes aim to understand:
This research theme links with other local, national and international centres of excellence and has close integration of basic and clinical researchers and hosts the only immunotherapy centre in the UK.
Genetic approaches to the individualisation of drug therapy, including anticoagulants and anti-cancer drugs, and in the genetics of diverse non-Mendelian diseases, from diabetes to periodontal disease, are a focus. A wide range of knowledge and experience in both genetics and clinical sciences is utilised, with access to high-throughput genotyping platforms.
Our scientists and clinicians use in situ cellular technologies and large-scale gene expression profiling to study the normal and pathophysiological remodelling of vascular and uteroplacental tissues. Novel approaches to cellular interactions have been developed using a unique human tissue resource. Our research themes include:
We also have preclinical molecular biology projects in breast cancer research.
We conduct a broad range of research activities into acute and chronic lung diseases. As well as scientific studies into disease mechanisms, there is particular interest in translational medicine approaches to lung disease, studying human lung tissue and cells to explore potential for new treatments. Our current areas of research include:
Our research projects are concerned with the harmful effects of chemicals, including prescribed drugs, and finding ways to prevent and minimise these effects. We are attempting to measure the effects of fairly small amounts of chemicals, to provide ways of giving early warning of the start of harmful effects. We also study the adverse side-effects of medicines, including how conditions such as liver disease and heart disease can develop in people taking medicines for completely different medical conditions. Our current interests include: environmental chemicals and organophosphate pesticides, warfarin, psychiatric drugs and anti-cancer drugs.
Our new School of Pharmacy has scientists and clinicians working together on all aspects of pharmaceutical sciences and clinical pharmacy.