Our research aims to enhance understanding of disease processes in animals and to translate that understanding into improved therapies for both animal and human disease.
Research focuses on:
Most of our research is carried out within The Roslin Institute, which is incorporated with the School and is the major centre of research.
Studentships are of 3 or 4 years duration and students will be expected to complete a novel piece of research which will advance our understanding of the field. To help them in this goal, students will be assigned a principal and assistant supervisor, both of whom will be active scientists at the Institute.
Student progress is monitored in accordance with School Postgraduate (PG) regulations by a PhD thesis committee (which includes an independent external assessor and chair). There is also dedicated secretarial support to assist these committees and the students with regard to University and Institute matters.
All student matters are overseen by the Schools PG studies committee. An active staff:student liaison committee and a social committee, which is headed by our postgraduate liaison officer, provide additional support.
Students are expected to attend a number of generic training courses offered by the Transkills Programme of the University and to participate in regular seminars and laboratory progress meetings. All students will also be expected to present their data at national and international meetings throughout their period of study.
The Veterinary Campus at Easter Bush includes the new “state-of- the-art” Roslin Institute Building, the Small Animal and Large Animal Hospitals, the Riddell-Swan Cancer Imaging Centre as well as the New Vet School. Our facilities include: rodent, bird and livestock animal units and associated lab areas; comprehensive bioinformatic and genomic capability; a range of bioimaging facilities; extensive molecular biology and cell biology labs; café and auditorium where we regularly host workshops and invited speakers.
Normal growth of an animal, from the fertilised egg through to end of life maturity, requires concerted action of all the genes found in the animal genome. Not all genes are active at any one stage or in any one cell type. Gene expression is dynamic yet programmed. Sometimes this programming goes awry and disease ensues. Research in the Division of Developmental Biology aims to characterise, understand and ultimately exploit the ever changing profile of gene expression found in mammals. This will allow the development of a better understanding of biology which in turn will enable new biotech, agricultural and biomedical advances to become reality.
We believe that a supported, active and innovative post-graduate student community is essential if we are to deliver our goals. This community represents the scientists, entrepreneurs, communicators and regulators of the future.
Research in the Division of Developmental Biology aims to enhance fundamental knowledge of the control of cellular growth and differentiation aiming to underpin the development of better disease intervention strategies.
We will advance our understanding of function in these essential biological processes through mechanistic studies at the cell, tissue and whole animal level with particular focus on:
Within the Division of Developmental Biology we have 19 Group Leaders plus 2 Career Track Fellows who supervise about 30 students at any one time.
Studentships are of 3 or 4 years duration and students will be expected to complete a novel piece of research which will advance our understanding of the field. To help them in this goal, students will be assigned a principal and assistant supervisor, both of whom will be active scientists at the Institute. Student progress is monitored in accordance with School Postgraduate (PG) regulations by a PhD thesis committee (which includes an independent external assessor and chair). There is also dedicated secretarial support to assist these committees and the students with regard to University and Institute matters.
All student matters are overseen by the Schools PG studies committee. The Roslin Institute also has a local PG committee and will provide advice and support to students when requested. An active staff:student liaison committee and a social committee, which is headed by our postgraduate liaison officer, provide additional support.
Students are expected to attend a number of generic training courses offered by the Transkills Programme of the University and to participate in regular seminars and laboratory progress meetings. All students will also be expected to present their data at national and international meetings throughout their period of study.
In 2011 The Roslin Institute moved to a new state-of-the-art building on the University of Edinburgh's veterinary campus at Easter Bush. Our facilities include: rodent, bird and livestock animal units and associated lab areas; comprehensive bioinformatic and genomic capability; a range of bioimaging facilities; extensive molecular biology and cell biology labs; café and auditorium where we regularly host workshops and invited speakers.
Research in the Division of Genetics and Genomics aims to advance understanding of complex animal systems and the development of improved predictive models through the application of numerical and computational approaches in the analysis, interpretation, modelling and prediction of complex animal systems from the level of the DNA and other molecules, through cellular and gene networks, tissues and organs to whole organisms and interacting populations of organisms.
The biology and traits of interest include: growth and development, body composition, feed efficiency, reproductive performance, responses to infectious disease and inherited diseases.
Research encompasses basic research in bioscience and mathematical biology and strategic research to address grand challenges, e.g. food security.
Research is focussed on, but not restricted to, target species of agricultural importance including cattle, pigs, poultry, sheep; farmed fish such as salmon; and companion animals. The availability of genome sequences and the associated genomics toolkits enable genetics research in these species.
Expertise includes genetics (molecular, quantitative), physiology (neuroendocrinology, immunology), ‘omics (genomics, functional genomics) with particular strengths in mathematical biology (quantitative genetics, epidemiology, bioinformatics, modelling).
The Division has 18 Group Leaders and 4 career track fellows who supervise over 30 postgraduate students.
Studentships are of 3 or 4 years duration and students will be expected to complete a novel piece of research which will advance our understanding of the field. To help them in this goal, students will be assigned a principal and assistant supervisor, both of whom will be active scientists at the Institute. Student progress is monitored in accordance with School Postgraduate (PG) regulations by a PhD thesis committee (which includes an independent external assessor and chair). There is also dedicated secretarial support to assist these committees and the students with regard to University and Institute matters.
All student matters are overseen by the Schools PG studies committee. The Roslin Institute also has a local PG committee and will provide advice and support to students when requested. An active staff:student liaison committee and a social committee, which is headed by our postgraduate liaison officer, provide additional support.
Students are expected to attend a number of generic training courses offered by the Transkills Programme of the University and to participate in regular seminars and laboratory progress meetings. All students will also be expected to present their data at national and international meetings throughout their period of study.
In 2011 The Roslin Institute moved to a new state-of-the-art building on the University of Edinburgh's veterinary campus at Easter Bush. Our facilities include: rodent, bird and livestock animal units and associated lab areas; comprehensive bioinformatic and genomic capability; a range of bioimaging facilities; extensive molecular biology and cell biology labs; café and auditorium where we regularly host workshops and invited speakers.
The University's genomics facility Edinburgh Genomics is closely associated with the Division of Genetics and Genomics and provides access to the latest genomics technologies, including next-generation sequencing, SNP genotyping and microarray platforms (genomics.ed.ac.uk).
In addition to the Edinburgh Compute and Data Facility’s high performance computing resources, The Roslin Institute has two compute farms, including one with 256 GB of RAM, which enable the analysis of complex ‘omics data sets.
The University of Edinburgh Centre for Genomics and Experimental Medicine (CGEM) is part of the MRC / University of Edinburgh Institute of Genetics and Molecular Medicine (IGMM). CGEM’s mission is to use genetics and genomics to understand the mechanisms of disease and design novel intervention strategies. Our research has consistently obtained the highest possible ranking in national assessments of research excellence.
We undertake detailed studies of populations, families and individuals to study a wide range of health related conditions. We use state-of-the-art genetic, epigenetic, genomic, statistical, bioinformatic, biological and molecular approaches in model systems and clinical studies for systematic investigation of disease aetiology. With this knowledge, we aim to improve disease prediction, prevention and prognosis. Our translational agenda encompasses the development of new medicines and genetically-informed use of existing medicines in clinical trials.
A principal aim of both CGEM and the IGMM is develop fully integrated, multi-disciplinary research programmes across the whole spectrum of basic, clinical and translational research. We have state of the art imaging, DNA sequencing and drug discovery units, a bioinformatics service and excellent lab facilities.
Research on Infection and Immunity aims to enhance understanding of the mechanisms of host defence against infection, and translate this understanding into prevention and treatment.
The research programmes include a wide range of activities including studies of host/pathogen interactions (including work on viruses, bacteria, parasites and spongiform encephalopathy agents), the immune systems of animals and how they respond to pathogen challenge, genetic resistance to disease and epidemiology of disease. These activities are underpinned by major programmes in animals genomics and bioinformatics.
Studentships are of 3 or 4 years duration and students will be expected to complete a novel piece of research which will advance our understanding of the field. To help them in this goal, students will be assigned a principal and assistant supervisor, both of whom will be active scientists at the Institute. Student progress is monitored in accordance with School Postgraduate (PG) regulations by a PhD thesis committee (which includes an independent external assessor and chair). There is also dedicated secretarial support to assist these committees and the students with regard to University and Institute matters.
All student matters are overseen by the Schools PG studies committee. The Roslin Institute also has a local PG committee and will provide advice and support to students when requested. An active staff:student liaison committee and a social committee, which is headed by our postgraduate liaison officer, provide additional support.
Students are expected to attend a number of generic training courses offered by the Transkills Programme of the University and to participate in regular seminars and laboratory progress meetings. All students will also be expected to present their data at national and international meetings throughout their period of study.
In 2011 the Roslin Institute moved to a new state-of-the-art building on the University of Edinburgh's veterinary campus at Easter Bush. Our facilities include: rodent, bird and livestock animal units and associated lab areas; comprehensive bioinformatic and genomic capability; a range of bioimaging facilities; extensive molecular biology and cell biology labs; café and auditorium where we regularly host workshops and invited speakers.
The Neurobiology Division conducts research in the fields of neurobiology and neuropathology. We investigate mechanisms that regulate normal brain function as well as the causes and consequences of dysfunction during ageing and in acute or chronic neurodegenerative disease.
The division has an excellent track-record in the supervision and training of postgraduate students by staff highly experienced in teaching and research. It has 13 Group Leaders and 1 career track fellow who supervise more than 10 postgraduate students.
Why our work is important
Some of our current research focuses on:
In addressing these fundamental questions we contribute to the improvement of both animal and human health, livestock productivity and welfare.
Students will be able to take advantage of our multidisciplinary tools including proteomics, bio-imaging, computer-aided behavioural analysis, genetics, molecular biology, in vitro cell models, transgenic rodent models and natural diseases of large animals to dissect biological networks in the nervous and immune systems. The Roslin Institute is uniquely placed to transfer our experience of rodent models into livestock species such as sheep and pigs.
Studentships are of 3 or 4 years duration and students will be expected to complete a novel piece of research which will advance our understanding of the field. To help them in this goal, students will be assigned a principal and assistant supervisor, both of whom will be active scientists at the Institute. Student progress is monitored in accordance with School Postgraduate (PG) regulations by a PhD thesis committee (which includes an independent external assessor and chair). There is also dedicated secretarial support to assist these committees and the students with regard to University and Institute matters.
All student matters are overseen by the Schools PG studies committee. The Roslin Institute also has a local PG committee and will provide advice and support to students when requested. An active staff:student liaison committee and a social committee, which is headed by our postgraduate liaison officer, provide additional support.
Students are expected to attend a number of generic training courses offered by the Transkills Programme of the University and to participate in regular seminars and laboratory progress meetings. All students will also be expected to present their data at national and international meetings throughout their period of study.
In 2011 the Roslin Institute moved to a new state-of-the-art building on the University of Edinburgh's veterinary campus at Easter Bush. Our facilities include: rodent, bird and livestock animal units and associated lab areas; comprehensive bioinformatic and genomic capability; a range of bioimaging facilities; extensive molecular biology and cell biology labs; café and auditorium where we regularly host workshops and invited speakers.
