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The only Master’s specialisation in the Netherlands covering the function of our epigenome, a key factor in regulating gene expression and in a wide range of diseases. Read more

Master's specialisation in Medical Epigenomics

The only Master’s specialisation in the Netherlands covering the function of our epigenome, a key factor in regulating gene expression and in a wide range of diseases.
Our skin cells, liver cells and blood cells all contain the same genetic information. Yet these are different types of cells, each performing their own specific tasks. How is this possible? The explanation lies in the epigenome: a heritable, cell-type specific set of chromosomal modifications, which regulates gene expression. Radboud University is specialised in studying the epigenome and is the only university in the Netherlands to offer a Master’s programme in this field of research.

Health and disease

The epigenome consists of small and reversible chemical modifications of the DNA or histone proteins, such as methylation, acetylation and phosphorylation. It changes the spatial structure of DNA, resulting in gene activation or repression. These processes are crucial for our health and also play a role in many diseases, like autoimmune diseases, cancer and neurological disorders. As opposed to modifications of the genome sequence itself, epigenetic modifications are reversible. You can therefore imagine the great potential of drugs that target epigenetic enzymes, so-called epi-drugs.

Big data

In this specialisation, you’ll look at a cell as one big and complex system. You’ll study epigenetic mechanisms during development and disease from different angles. This includes studying DNA and RNA by next-generation sequencing (epigenomics) and analysing proteins by mass spectrometry (proteomics). In addition, you‘ll be trained to design computational strategies that allow the integration of these multifaceted, high-throughput data sets into one system.

Why study Medical Epigenomics at Radboud University?

- Radboud University combines various state-of-the-art technologies – such as quantitative mass spectrometry and next-generation DNA sequencing – with downstream bioinformatics analyses in one department. This is unique in Europe.
- This programme allows you to work with researchers from the Radboud Institute for Molecular Life sciences (RIMLS), one of the leading multidisciplinary research institutes within this field of study worldwide.
- We have close contacts with high-profile medically oriented groups on the Radboud campus and with international institutes (EMBL, Max-Planck, Marie Curie, Cambridge, US-based labs, etc). As a Master’s student, you can choose to perform an internship in one of these related departments.
- Radboud University coordinates BLUEPRINT, a 30 million Euro European project focusing on the epigenomics of leukaemia. Master’s students have the opportunity to participate in this project.

Career prospects

As a Master’s student of Medical Epigenomics you’re trained in using state-of-the art technology in combination with biological software tools to study complete networks in cells in an unbiased manner. For example, you’ll know how to study the effects of drugs in the human body.
When you enter the job market, you’ll have:
- A thorough background of epigenetic mechanisms in health and disease, which is highly relevant in strongly rising field of epi-drug development
- Extensive and partly hands-on experience in state-of-the-art ‘omics’ technologies: next-generation sequencing, quantitative mass spectrometry and single cell technologies;
- Extensive expertise in designing, executing and interpreting scientific experiments in data-driven research;
- The computational skills needed to analyse large ‘omics’ datasets.

With this background, you can become a researcher at a:
- University or research institute;
- Pharmaceutical company, such as Synthon or Johnson & Johnson;
- Food company, like Danone or Unilever;
- Start-up company making use of -omics technology.

Apart from research into genomics and epigenomics, you could also work on topics such as miniaturising workflows, improving experimental devices, the interface between biology and informatics, medicine from a systems approach.

Or you can become a:
- Biological or medical consultant;
- Biology teacher;
- Policy coordinator, regarding genetic or medical issues;
- Patent attorney;
- Clinical research associate;

PhD positions at Radboud University

Each year, the Molecular Biology department (Prof. Henk Stunnenberg, Prof. Michiel Vermeulen) and the Molecular Developmental Biology department (Prof. Gert-Jan Veenstra) at the RIMLS offer between five and ten PhD positions. Of course, many graduates also apply for a PhD position at related departments in the Netherlands, or abroad.

Our approach to this field

- Systems biology
In the Medical Epigenomics specialisation you won’t zoom in on only one particular gene, protein or signalling pathway. Instead, you’ll regard the cell as one complete system. This comprehensive view allows you to, for example, model the impact of one particular epigenetic mutation on various parts and functions of the cell, or study the effects of a drug in an unbiased manner. One of the challenges of this systems biology approach is the processing and integration of large amounts of data. That’s why you’ll also be trained in computational biology. Once graduated, this will be a great advantage: you’ll be able to bridge the gap between biology, technology and informatics , and thus have a profile that is desperately needed in modern, data-driven biology.

- Multiple OMICS approaches
Studying cells in a systems biology approach means connecting processes at the level of the genome (genomics), epigenome (epigenomics), transcriptome (transcriptomics), proteome (proteomics), etc. In the Medical Epigenomics specialisation, you’ll get acquainted with all these different fields of study.

- Patient and animal samples
Numerous genetic diseases are not caused by genetic mutations, but by epigenetic mutations that influence the structure and function of chromatin. Think of:
- Autoimmune diseases, like rheumatoid arthritis and lupus
- Cancer, in the forms of leukaemia, colon cancer, prostate cancer and cervical cancer
- Neurological disorders, like Rett Syndrome, Alzheimer, Parkinson, Multiple Sclerosis, schizophrenia and autism

We investigate these diseases on a cellular level, focusing on the epigenetic mutations and the impact on various pathways in the cell. You’ll get the chance to participate in that research, and work with embryonic stem cell, patient, Xenopus or zebra fish samples.

See the website http://www.ru.nl/masters/medicalbiology/epigenomics

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The Faculty of Engineering and Science offers advanced research training opportunities across a broad range of subject areas, including chemical, pharmaceutical, biomedical, environmental and sports sciences. Read more
The Faculty of Engineering and Science offers advanced research training opportunities across a broad range of subject areas, including chemical, pharmaceutical, biomedical, environmental and sports sciences. The research activities within the Department are supported by state of the art analytical and computer facilities.

Upon acceptance to a programme, students normally register initially for an MPhil, and at the end of the first year, the student is examined by viva voce for consideration for transfer to PhD. Upon completion of the Doctoral training, students are ideally equipped to work in an academic or industrial research environment.

Recent research project topics include:

- Solar energy conversion

- Synthesis of biologically active molecules

- Fragment-based drug discovery

- In situ monitoring of chemical reactions

- Treatment of contaminated soils by accelerated carbonation

- Production of novel silicate-based sorbents

- Integrated production of biodiesel from oilseed rape

- Pathogenesis of autoimmune diseases

- Bioremediation and composting technologies

- Expert Cognition and Training

The aims of the programme are:

- To develop, create and interpret new knowledge, through original research or other advanced scholarship, of a quality to satisfy peer review, extend the forefront of the discipline, and merit publication

- To systematically acquire an understanding of a substantial body of knowledge which is at the forefront of an academic discipline or area of professional practice

- To demonstrate the ability to conceptualise, design and implement a project for the generation of new knowledge, applications or understanding at the forefront of the discipline, and to adjust the project design in the light of unforeseen problems

- To show a detailed understanding of applicable techniques for research and advanced academic enquiry.

Visit the website http://www2.gre.ac.uk/study/courses/pg/res/scires

What you'll study

Research areas may include:

- Materials analysis
- Molecular spectroscopy, Advanced spectral analysis
- Biomaterials
- Formulation chemistry, Biophysical chemistry
- Pharmaceutical science
- Gene therapy
- Biochemistry, Cell biology
- Forensic science
- Environmental geochemistry
- Sports science and human performance
- Applied cognitive science

Fees and finance

Your time at university should be enjoyable and rewarding, and it is important that it is not spoilt by unnecessary financial worries. We recommend that you spend time planning your finances, both before coming to university and while you are here. We can offer advice on living costs and budgeting, as well as on awards, allowances and loans.

Find out more about our fees and the support available to you at our:

- Postgraduate finance pages (http://www.gre.ac.uk/finance/pg)
- International students' finance pages (http://www.gre.ac.uk/finance/international)

Assessment

Students are assessed through their thesis and an oral examination.

Career options

Graduates from this programme can pursue careers in industry, government and academia.

Find out how to apply here - http://www2.gre.ac.uk/study/apply

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Memorial's School of Pharmacy provides cutting-edge research in an up-close and personal environment. The School of Pharmacy provides graduate students with the opportunity to conduct original research related to Drug Discovery and Delivery, Health Outcomes, and the Scholarship of Teaching and Learning. Read more
Memorial's School of Pharmacy provides cutting-edge research in an up-close and personal environment. The School of Pharmacy provides graduate students with the opportunity to conduct original research related to Drug Discovery and Delivery, Health Outcomes, and the Scholarship of Teaching and Learning. There are several research laboratories, including separate rooms for organic synthesis/natural products chemistry, a cell culture facility, pharmacology labs and state of the art computer networks. All offices and research laboratories in the Health Sciences Centre are connected as a part of the MUNet, a high-speed network linking the campus with the world.

Graduate supervisors in Memorial’s School of Pharmacy are engaged in research in the following areas:

Drug Discovery and Delivery:
1) Neuropharmacology / Mechanisms of Toxicity and Protection in Neurons
2) Cardiovascular Pharmacology-Pharmacokinetics / Mechanisms of Cellular Failure in Autoimmune Diseases
3) Computational Chemistry and Structural Biochemistry / Computer-aided Drug Design and High-Throughput Screening, Drug-Protein and Protein-Protein Complexations

Health Outcomes:
1) Pharmacoepidemiology
2) Adult and Childhood Obesity

The Pharmacology of Teaching and Learning:
1) Interprofessional Practice and Education

The MSc (Pharm) program involves courses and a thesis, and can be completed in two years of full-time study.

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Aspiring to contribute to the development of new therapies for metabolic, infectious and immunological diseases or cancer? Radboud University's internationally acclaimed Research Master's programme in Molecular Mechanisms of Disease provides an excellent foundation for a career in academic or commercial research. Read more

Understanding the molecular basis of disease

Aspiring to contribute to the development of new therapies for metabolic, infectious and immunological diseases or cancer? Radboud University's internationally acclaimed Research Master's programme in Molecular Mechanisms of Disease provides an excellent foundation for a career in academic or commercial research.

Only by dissecting the molecular mechanisms that trigger and advance diseases and dysfunctions can we design effective treatments and medicines. The Research Master's in Molecular Mechanisms of Disease (MMD) offers you an intensive two-year programme that provides you with in-depth knowledge and research experience of disease-related molecular mechanisms. In addition, you will acquire skills such as academic writing and presentation skills and learn how to successfully apply for grants and market yourself.

Passion for molecular biomedical research

As an MMD student you will be part of the unique research community that is found within the Radboud Institute for Molecular Life Sciences (RIMLS). Like you, RIMLS researchers have a strong passion for research. They will assist you throughout the programme with guidance and expertise, supporting you in acquiring knowledge and developing excellent research skills. The RIMLS is one of the research institutes of the Radboud university medical center, so their research is closely linked to the clinic and thus aimed at translating results into treatments for patients. Examples include the translation of insights into the biology of antigen-presenting cells into new immunological cancer therapies and understanding the mutations underlying blindness into the development of gene therapies for patients with inherited blindness.

See the website http://www.ru.nl/masters/mmd

Why study Molecular Mechanisms of Disease at Radboud University?

- You will follow a broad biomedical programme that allows you to specialise in your specific field-of-interest.
- You will have intense daily contact with established researchers.
- You will participate in group-oriented education and be part of a small group of highly motivated national and international students.
- A personal mentor will help you to reflect on your study programme and career perspective.
- You will do two 6-months research internships one of which will be abroad.
- There is a 92% pass rate of MMD students within the two years.
- International MMD students can apply for scholarships from the Radboudumc Study Fund.

Career prospects

There is considerable demand for experts in the molecular biomedical sciences as well as in their application to the development of treatments for diseases such as cancer, autoimmune and inflammatory disorders, and metabolic diseases.

Graduates in MMD are equipped with cutting-edge knowledge of multidisciplinary research in the mechanisms of disease and in state-of-the-art diagnostic methods and technologies. During the programme, you will develop a highly critical, independent approach to problem-solving. You will also acquire the basic management skills needed to lead R&D projects in the biotechnology and pharmaceutical industries.

Most of our graduates will enter an international PhD programme to continue with research in academia or industry.

PhD opportunities

The MSc Molecular Mechanisms of Disease aims to provide all skills and knowledge necessary to rapidly enter an international PhD programme. In the Netherlands and many places in Europe, it is impossible to start a PhD programme directly after obtaining a Bachelor's degree. This research Master’s programme seriously increases your chances for obtaining an excellent PhD training position by giving you a mature perspective and a broad range of experimental approaches. In fact, over 90% of our graduates has started a (funded) PhD project.

The Radboud Institute for Molecular Life Sciences (RIMLS) recruits about fifty PhD students a year. MMD graduates are excellent candidates for these positions. Furthermore, the Radboud university medical centre offers the opportunity for its research-oriented Master's students to write their own research project. The best candidates are awarded a fully funded four-year PhD studentship at the department of their choice.

Our approach to this field

The molecular regulation of cellular processes is crucial for human development, and maintenance of health throughout life. It's evident that cellular malfunction is the cause of common multi-factorial diseases such as diabetes, immune and inflammatory disorders, renal disease, cardiovascular, metabolic and neurodegenerative diseases as well as obesity and cancer.

The Radboud Institute for Molecular Life Sciences (RIMLS) Graduate School plays a key role in developing new therapies for the fight against such diseases. RIMLS aims to improve diagnostics and develop new treatments by generating basic knowledge in the molecular biomedical life sciences and translating it into clinical application and experimental research in patients.

The RIMLS – which is part of Radboud university medical center – offers an exclusive Master's programme in Molecular Mechanisms of Disease. Top researchers and clinicians teach the programme.

Key themes

The MMD programme is organised along three major educational themes which reflect the main research areas present in the RIMLS and which each include both a fundamental and a disease-related aspect:
- Theme 1 Infection, Immunity and Regenerative Medicine / Immunity-related Disorders and Immunotherapy
- Theme 2 Metabolism, Transport and Motion / Metabolic Disorders
- Theme 3 Cell Growth and Differentiation / Developmental Disorders and Malignancies

See the website http://www.ru.nl/masters/mmd

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The Institute of Genetic Medicine brings together a strong team with an interest in clinical and developmental genetics. Our research focuses on the causes of genetic disease at the molecular and cellular level and its treatment. Read more
The Institute of Genetic Medicine brings together a strong team with an interest in clinical and developmental genetics. Our research focuses on the causes of genetic disease at the molecular and cellular level and its treatment. Research areas include: genetic medicine, developmental genetics, neuromuscular and neurological genetics, mitochondrial genetics and cardiovascular genetics.

As a research postgraduate in the Institute of Genetic Medicine you will be a member of our thriving research community. The Institute is located in Newcastle’s Life Science Centre. You will work alongside a number of research, clinical and educational organisations, including the Northern Genetics Service.

We offer supervision for MPhil in the following research areas:

Cancer genetics and genome instability

Our research includes:
-A major clinical trial for chemoprevention of colon cancer
-Genetic analyses of neuroblastoma susceptibility
-Research into Wilms Tumour (a childhood kidney cancer)
-Studies on cell cycle regulation and genome instability

Cardiovascular genetics and development

We use techniques of high-throughput genetic analyses to identify mechanisms where genetic variability between individuals contributes to the risk of developing cardiovascular disease. We also use mouse, zebrafish and stem cell models to understand the ways in which particular gene families' genetic and environmental factors are involved in the normal and abnormal development of the heart and blood vessels.

Complex disease and quantitative genetics

We work on large-scale studies into the genetic basis of common diseases with complex genetic causes, for example autoimmune disease, complex cardiovascular traits and renal disorders. We are also developing novel statistical methods and tools for analysing this genetic data.

Developmental genetics

We study genes known (or suspected to be) involved in malformations found in newborn babies. These include genes involved in normal and abnormal development of the face, brain, heart, muscle and kidney system. Our research includes the use of knockout mice and zebrafish as laboratory models.

Gene expression and regulation in normal development and disease

We research how gene expression is controlled during development and misregulated in diseases, including the roles of transcription factors, RNA binding proteins and the signalling pathways that control these. We conduct studies of early human brain development, including gene expression analysis, primary cell culture models, and 3D visualisation and modelling.

Genetics of neurological disorders

Our research includes:
-The identification of genes that in isolation can cause neurological disorders
-Molecular mechanisms and treatment of neurometabolic disease
-Complex genetics of common neurological disorders including Parkinson's disease and Alzheimer's disease
-The genetics of epilepsy

Kidney genetics and development

Kidney research focuses on:
-Atypical haemolytic uraemic syndrome (aHUS)
-Vesicoureteric reflux (VUR)
-Cystic renal disease
-Nephrolithiasis to study renal genetics

The discovery that aHUS is a disease of complement dysregulation has led to a specific interest in complement genetics.

Mitochondrial disease

Our research includes:
-Investigation of the role of mitochondria in human disease
-Nuclear-mitochondrial interactions in disease
-The inheritance of mitochondrial DNA heteroplasmy
-Mitochondrial function in stem cells

Neuromuscular genetics

The Neuromuscular Research Group has a series of basic research programmes looking at the function of novel muscle proteins and their roles in pathogenesis. Recently developed translational research programmes are seeking therapeutic targets for various muscle diseases.

Stem cell biology

We research human embryonic stem (ES) cells, germline stem cells and somatic stem cells. ES cell research is aimed at understanding stem cell pluripotency, self-renewal, survival and epigenetic control of differentiation and development. This includes the functional analysis of genes involved in germline stem cell proliferation and differentiation. Somatic stem cell projects include programmes on umbilical cord blood stem cells, haematopoietic progenitors, and limbal stem cells.

Pharmacy

Our new School of Pharmacy has scientists and clinicians working together on all aspects of pharmaceutical sciences and clinical pharmacy.

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The MSc in Molecular Medicine gives you the opportunity to develop as a scientist or scientifically-literate clinician through an advanced understanding of the molecular basis of many diseases and their treatments. Read more
The MSc in Molecular Medicine gives you the opportunity to develop as a scientist or scientifically-literate clinician through an advanced understanding of the molecular basis of many diseases and their treatments.

You’ll study how to apply molecular approaches to the diagnosis, prevention and treatment of a range of cancers, chronic, autoimmune and genetic diseases. You’ll also carry out a research project in one of these areas within a research group at the forefront of the field. Project supervision is assured by outstanding academics and clinicians working on cutting-edge research.

This flexible programme allows you to develop core scientific skills and follow your professional interests with a choice of optional modules. You'll be part of a world-renowned School and will be taught by internationally recognised scholars.

Throughout the programme you will:

- gain an in-depth knowledge and understanding of the principles, application and potential of molecular medicine
- learn techniques in the field of molecular biology, immunology, cell biology and chemistry
- develop the ability to carry out molecular, biological and bioinformatics research for investigation of human diseases
- be able to engage in research projects using the latest technologies that generate results with scientific impact and the potential for improving patient health
- learn to critically evaluate current issues in molecular medicine, translate research findings into clinical applications, and recognise commercial opportunities

Programme structure

Starting in September, the MSc in Molecular Medicine is a full time, twelve months programme which combines a seven month research project with some taught modules.

The MSc programme comprises of a 180 credits, consisting of:

A research project: 75 credits
Scientific core skills: 45 credits including Bioinformatics and Research Methods

A choice of student-selected modules: 60 credits

• Human Molecular Genetics
• Immunity and Disease
• Animal Models of Disease
• Stem Cell Biology
• Cancer Biology
• Genetic Epidemiology

Career Prospects

This exciting programme provides excellent training for:

- science graduates looking for an opportunity to go on to do doctoral research, enter academic medicine or pursue a career in industry, clinical service or a related discipline;
- clinicians interested in an clinical academic career.

Many of our past students are now doing PhDs across the UK or internationally. Some are working in NGOs or in the industry. Talented graduates from the MSc will be strongly supported to join PhD programmes in the institutes here at the University.

We anticipate that an MSc Molecular Medicine will be ideal preparation for those intending to secure clinical fellowships.

Why study at the University of Leeds?

The University of Leeds has been named University of the Year 2017 by The Times and The Sunday Times’ Good University Guide.

Teaching is stimulating and delivered by active scientists and clinicians, many of whom are world-leading in their research fields. You will benefit from small group teaching including lectures, workshops, laboratory practicals, seminars and tutorials.

Your research will be based in one of the internationally-renowned Institutes of the School of Medicine. You will be able to choose from a wide range of research opportunities in Biomedical and Clinical Sciences, Cancer and Pathology or Rheumatology.

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This well-established and highly competitive MSc provides students with specialist training in the basic scientific principles of modern neuroscience, and in the application of these principles to the understanding of a wide variety of neurological disorders. Read more
This well-established and highly competitive MSc provides students with specialist training in the basic scientific principles of modern neuroscience, and in the application of these principles to the understanding of a wide variety of neurological disorders. Students benefit from studying in an internationally renowned and research-intensive environment at the UCL Institute of Neurology.

Degree information

Participants gain knowledge of the clinical features and scientific basis of both common and unusual neurological disorders including a study of: genetics of CNS disorders; brain metabolism, neurotransmitters and neurodegeneration; autoimmune disease and repair mechanisms; peripheral nerve and muscle; epilepsy; nociception and pain; motor control; basal ganglia/movement disorders; hearing, balance, vision and eye-movements; stroke and head injury; cognition and dementia.

Students undertake modules to the value of 180 credits.

The programme consists of six core modules (90 credits), a library project (30 credits) and a research project (60 credits). There are no optional modules for this programme.

Core modules
-Cellular and Molecular Mechanisms of Disease
-Diseases of the Nervous System: Epilepsy, Pain, Tumours & Infection
-Peripheral Nerve, Muscle and Special Senses
-Motor Systems and Disease
-Higher Functions of the Brain
-Research Methods: Critical Appraisal and Introduction to Statistics

Dissertation/report
All students undertake a library project which is assessed by a 5,000-word essay, and an independent research project, which culminates in a dissertation of 10,000 words.

Teaching and learning
The programme is delivered through basic and clinical lectures, seminars and practical and interactive workshops. Lectures are supported by audio-visual aids and supplementary materials including handouts, reading lists and references to original papers. Assessment is through unseen and multiple-choice examination, essay, library project, dissertation and oral examination.

Careers

This programme offers an established entry route into both PhD studies in the UK and internationally, and to medicine at both undergraduate and graduate level.

Top career destinations for this degree:
-Research Assistant, Duke-NUS
-Research Assistant, UCL
-MBBS in Medicine, Barts Health NHS Trust and The London School of Medicine and Dentistry
-PhD in Clinical Medicine, University of Oxford
-PhD in Clinical Neuroscience, University College London (UCL)

Employability
Students are given the opportunity to take an original research project in a world-renowned centre of excellence. Publications routinely result from the best MSc projects.

Why study this degree at UCL?

The mission of the UCL Institute of Neurology is to carry out high-quality research, teaching and training in basic and clinical neurosciences. Together with our associated hospital, the National Hospital for Neurology and Neurosurgery, the institute promotes the translation of research that is of direct clinical relevance to improved patient care and treatment.

With its concentration of clinical and applied scientific activity the institute is a unique national resource for postgraduate training in neuroscience, and this MSc enhances the scientific skills of clinicians and provides non-clinical graduates with insight into clinical problems that will allow them to work alongside clinicians in clinical research projects.

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